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1. Full Text Common variants of human TERT and TERC genes and susceptibility to sporadic Alzheimers disease
by Scarabino, D and Broggio, E and Gambina, G and Pelliccia, F and Corbo, R.M
Experimental Gerontology, ISSN 0531-5565, 02/2017, Volume 88, pp. 19 - 24
Studies investigating telomere length in association with cognitive decline, dementia, and sporadic Alzheimer's disease (AD) have frequently found shorter... 
Age at disease onset | TERC genotypes | TERT genotypes | Alzheimer's disease susceptibility | MORTALITY | CELLS | LENGTH | CELLULAR SENESCENCE | HUMAN TELOMERASE GENE | PROTEIN TERT | GERIATRICS & GERONTOLOGY | LUNG-CANCER | LONGEVITY | TANDEM REPEATS | ASSOCIATION | Genetic Predisposition to Disease | Humans | Linear Models | Logistic Models | Male | Longevity - genetics | RNA - genetics | Telomere Shortening | Telomerase - genetics | Age of Onset | Aged, 80 and over | Female | Italy | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Telomeres | Genes | Genetic research | Disease susceptibility | Genetic aspects | Single nucleotide polymorphisms | Alzheimer's disease | Telomerase | Medical research | Medicine, Experimental | Development and progression | Index Medicus
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2. Full Text Genome-wide DNA methylation differences between late-onset alzheimer's disease and cognitively normal controls in human frontal cortex
by Bakulski, Kelly M and Dolinoy, Dana C and Sartor, Maureen A and Paulson, Henry L and Konen, John R and Lieberman, Andrew P and Albin, Roger L and Hu, Howard and Rozek, Laura S
Journal of Alzheimer's Disease, ISSN 1387-2877, 2012, Volume 29, Issue 3, pp. 571 - 588
Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset Alzheimer's disease (LOAD), but little has been done on a genome-wide... 
DNA methylation | late onset Alzheimer's disease | prefrontal cortex | epigenetics | COMMON VARIANTS | CLU | NEUROSCIENCES | CD2AP | IDENTIFIES VARIANTS | GENE-EXPRESSION | PROTEINS | EPHA1 | ASSOCIATION | CD33 | AGE | Frontal Lobe - metabolism | Membrane Proteins - genetics | Oligonucleotide Array Sequence Analysis - methods | Epigenesis, Genetic | Humans | Middle Aged | Male | DNA Methylation - genetics | Gene Expression Profiling | Nerve Tissue Proteins - genetics | Case-Control Studies | Genome, Human - genetics | Alzheimer Disease - pathology | Nerve Tissue Proteins - metabolism | Aged, 80 and over | CpG Islands - genetics | Female | Aged | Membrane Proteins - metabolism | Alzheimer Disease - genetics | Frontal Lobe - pathology | Neurodegenerative diseases | RNA | biomarkers | Data processing | Population studies | Promoters | Membrane proteins | Cortex (frontal) | Post-translation | Models | Alzheimer's disease | Bayesian analysis | Age | CpG islands | Index Medicus
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3. Early diagnosis of Alzheimer's disease: Is MCI too late?
by Petersen, Ronald C
Current Alzheimer Research, ISSN 1567-2050, 08/2009, Volume 6, Issue 4, pp. 324 - 330
The field of aging and dementia research is advancing rapidly toward the stage of earlier identification of clinical symptoms. Ultimately, clinicians would... 
Aging | Mild cognitive impairment | Alzheimer's disease | DEMENTIA | ATROPHY | CONVERSION | SUBTYPES | RISK | NEUROSCIENCES | BIOMARKERS | PUBLIC-HEALTH IMPACT | aging | PROGRESSION | ONSET
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4. Full Text Cognitively-related basic activities of daily living impairment greatly increases the risk of death in alzheimers disease
by Liang, Fu-Wen and Chan, Wenyaw and Chen, Ping-Jen and Zimmerman, Carissa and Waring, Stephen and Doody, Rachelle
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0160671 - e0160671
Introduction Some Alzheimer's disease (AD) patients die without ever developing cognitively impaired basic activities of daily living (basic ADL), which may... 
SURVIVAL | MORTALITY | DEMENTIA | PREDICTORS | MULTIDISCIPLINARY SCIENCES | INSTITUTIONALIZATION | DURATION | ONSET | PROBABILITIES | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Male | Disease Progression | Activities of Daily Living | Cognition Disorders - mortality | Alzheimer Disease - mortality | Aged, 80 and over | Adult | Female | Aged | Psychological aspects | Activities of daily living | Prognosis | Development and progression | Research | Health aspects | Alzheimer's disease | Nursing homes | Neurodegenerative diseases | Comorbidity | Mortality | Memory | Health risks | Impairment | Risk | Survival | Patients | Medicine | Variables | Survival analysis | Regression models | Education | Medical prognosis | Death | Alzheimers disease | Age | Dementia | Geriatrics | Index Medicus
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5. Full Text NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN ALZHEIMERS-DISEASE
by RICH, JB and RASMUSSON, DX and FOLSTEIN, MF and CARSON, KA and KAWAS, C and BRANDT, J
NEUROLOGY, ISSN 0028-3878, 01/1995, Volume 45, Issue 1, pp. 51 - 55
We reviewed the records of 210 patients in the Johns Hopkins Alzheimer's Disease Research Center to evaluate the role of nonsteroidal anti-inflammatory drugs... 
SYSTEM | TRIAL | ONSET | CLINICAL NEUROLOGY
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6. Full Text Analyzing the genes related to Alzheimer's disease via a network and pathway-based approach
by Hu, Yan-Shi and Xin, Juncai and Hu, Ying and Zhang, Lei and Wang, Ju
Alzheimer's Research and Therapy, ISSN 1758-9193, 04/2017, Volume 9, Issue 1, pp. 29 - 29
Background: Our understanding of the molecular mechanisms underlying Alzheimer's disease (AD) remains incomplete. Previous studies have revealed that genetic... 
Pathway crosstalk | Functional enrichment analysis | Alzheimer's disease | Network analysis | SYSTEM | PROTEIN | BETA-PEPTIDE | GUT MICROBIOTA | MODEL | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | CLINICAL NEUROLOGY | RISK-FACTOR | METABOLISM | BRAIN | ONSET | Genetic Predisposition to Disease - genetics | Metabolic Flux Analysis - methods | Genetic Association Studies | Humans | Gene Expression Profiling - methods | Signal Transduction - genetics | Gene Regulatory Networks | Nerve Tissue Proteins - genetics | Brain - metabolism | Metabolic Networks and Pathways - genetics | Computer Simulation | Alzheimer Disease - epidemiology | Models, Genetic | Alzheimer Disease - genetics | Genetic Predisposition to Disease - epidemiology | Studies | Proteins | Medical imaging | Ontology | Disease | Pathogenesis | Rodents | Genomes | Mutation | Gene expression | Kinases | Index Medicus
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7. Full Text Metabolic syndrome and cognitive decline in early Alzheimer's disease and healthy older adults
by Watts, Amber S and Loskutova, Natalia and Burns, Jeffrey M and Johnson, David K
Journal of Alzheimer's Disease, ISSN 1387-2877, 2013, Volume 35, Issue 2, pp. 253 - 265
Metabolic syndrome (MetS) is a cluster of risk factors (i.e., abdominal obesity, hypertension, dyslipidemia, glucose and insulin dysregulation) that is... 
metabolic syndrome | factor analysis | cognitive decline | Alzheimer's disease | MEASUREMENT INVARIANCE | POPULATION | RISK-FACTORS | DEMENTIA | APOLIPOPROTEIN-E GENOTYPE | NEUROSCIENCES | DIABETES-MELLITUS | INSULIN-RESISTANCE | CHOLESTEROL LEVELS | CARDIOVASCULAR-DISEASE | ASSOCIATION | Predictive Value of Tests | Alzheimer Disease - complications | Humans | Middle Aged | Male | Factor Analysis, Statistical | Psychomotor Performance - physiology | Disease Progression | Metabolic Syndrome - complications | Neuropsychological Tests | Cognition Disorders - complications | Age of Onset | Aged, 80 and over | Biomarkers | Female | Aged | Nonlinear Dynamics | Alzheimer Disease - psychology | Cognition Disorders - psychology | Memory - physiology | Metabolic Syndrome - psychology | Index Medicus
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8. Full Text The french series of autosomal dominant early onset alzheimer's disease cases: Mutation spectrum and cerebrospinal fluid biomarkers
by Wallon, David and Rousseau, Stéphane and Rovelet-Lecrux, Anne and Quillard-Muraine, Muriel and Guyant-Maréchal, Lucie and Martinaud, Olivier and Pariente, Jérémie and Puel, Michèle and Rollin-Sillaire, Adeline and Pasquier, Florence and Le Ber, Isabelle and Sarazin, Marie and Croisile, Bernard and Boutoleau-Bretonnière, Claire and Thomas-Antérion, Catherine and Paquet, Claire and Moreaud, Olivier and Gabelle, Audrey and Sellal, François and Sauvée, Mathilde and Laquerrière, Annie and Duyckaerts, Charles and Delisle, Marie-Bernadette and Streichenberger, Nathalie and Lannes, Béatrice and Frebourg, Thierry and Hannequin, Didier and Campion, Dominique and GMAJ Project and collaborators of GMAJ project and The collaborators of the GMAJ project
Journal of Alzheimer's Disease, ISSN 1387-2877, 2012, Volume 30, Issue 4, pp. 847 - 856
We describe 56 novel autosomal dominant early-onset Alzheimer disease (ADEOAD) families with PSEN1, PSEN2, and A beta PP mutations or duplications, raising the... 
genetics | PSEN2 | AβPP | early-onset | PSEN1 | CSF biomarkers | Alzheimer's disease | A beta PP | GENE-MUTATIONS | DIAGNOSIS | CEREBRAL AMYLOID ANGIOPATHY | DEMENTIA | SPASTIC PARAPARESIS | NEUROSCIENCES | PRESENILIN-1 MUTATION | APP DUPLICATION | VARIABLE PHENOTYPE | BETA-DEPOSITION | CLINICAL PHENOTYPE | France - epidemiology | Humans | Middle Aged | Presenilin-1 - genetics | Male | Alzheimer Disease - cerebrospinal fluid | Mutation - genetics | Amyloid beta-Protein Precursor - genetics | Presenilin-2 - genetics | Genetic Markers - genetics | Age of Onset | Alzheimer Disease - epidemiology | Female | Aged | Biomarkers - cerebrospinal fluid | Alzheimer Disease - genetics | Index Medicus | Neurodegenerative diseases | biomarkers | Cerebrospinal fluid | Mutation | Age | Amyloid precursor protein | Presenilin-2 | Presenilin-1 | Biological Markers | Neurons and Cognition | Genetic Markers | Alzheimer Disease | Life Sciences | France | Amyloid beta-Protein Precursor
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9. Full Text Involvement of 5-lipoxygenase in Alzheimer's disease: A role for DNA methylation
by Di Francesco, Andrea and Arosio, Beatrice and Gussago, Cristina and Dainese, Enrico and Mari, Daniela and D'Addario, Claudio and MacCarrone, Mauro
Journal of Alzheimer's Disease, ISSN 1387-2877, 2013, Volume 37, Issue 1, pp. 3 - 8
Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we... 
peripheral blood mononuclear cells | DNA methylation | fatty acid amide hydrolase | 5-lipoxygenase | biomarker | Alzheimer's disease | PUTATIVE ROLE | MECHANISMS | POLYMORPHISM | NEUROSCIENCES | CYCLOOXYGENASES | LIPOXYGENASES | NEURONAL 5-LIPOXYGENASE | MOUSE MODEL | PROMOTER | EXPRESSION | ONSET | Alzheimer Disease - diagnosis | Follow-Up Studies | Humans | Aged, 80 and over | Female | Leukocytes, Mononuclear - enzymology | Male | Aged | Arachidonate 5-Lipoxygenase - biosynthesis | Alzheimer Disease - enzymology | DNA Methylation - physiology | Index Medicus
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10. Full Text Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease
by Brai, Emanuele and Alina Raio, Noemi and Alberi, Lavinia
Acta neuropathologica communications, ISSN 2051-5960, 07/2016, Volume 4, Issue 1, pp. 64 - 64
Background: Notch1 signaling is a cellular cascade with a fundamental role from brain development to adult brain function. Reduction in Notch1 affects synaptic... 
Tau | Cerebrospinal fluid | Sporadic Alzheimer’s disease | Notch1 | Amyloid plaques | PROLYL-ISOMERASE PIN1 | CLEARANCE | ACTIVATION | Sporadic Alzheimer's disease | NEUROSCIENCES | PRESENILINS MEDIATE | MOUSE MODELS | AMYLOID-BETA PEPTIDE | DYSFUNCTION | BRAIN | ONSET | GENOME-WIDE ASSOCIATION | Immunohistochemistry | Thiazoles - metabolism | Liver - pathology | Humans | Middle Aged | Cerebral Cortex - pathology | tau Proteins - metabolism | Male | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Aged, 80 and over | Female | Disease Models, Animal | Plaque, Amyloid - pathology | Liver - metabolism | Hippocampus - pathology | Receptor, Notch1 - metabolism | Blotting, Western | Hippocampus - metabolism | Animals | Alzheimer Disease - metabolism | Cell Line, Tumor | Plaque, Amyloid - metabolism | Aged | Mice | Biomarkers - cerebrospinal fluid | Advertising executives | Brain | Neurons | Alzheimer's disease | Analysis | Injuries | Index Medicus
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11. Full Text Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus
by Ephrat Levy-Lahad and Wilma Wasco and Parvoneh Poorkaj and Donna M. Romano and Junko Oshima and Warren H. Pettingell and Chang-en Yu and Paul D. Jondro and Stephen D. Schmidt and Kai Wang and Annette C. Crowley and Ying-Hui Fu and Suzanne Y. Guenette and David Galas and Ellen Nemens and Ellen M. Wijsman and Thomas D. Bird and Gerard D. Schellenberg and Rudolph E. Tanzi
Science, ISSN 0036-8075, 8/1995, Volume 269, Issue 5226, pp. 973 - 977
A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2). The predicted amino acid sequence for STM2 is homologous to that of... 
Polymerase chain reaction | Age of onset | Complementary DNA | Genes | DNA | Alleles | Genetic loci | Reports | Genetic mutation | Chromosomes | Genotypes | MULTIDISCIPLINARY SCIENCES | PRECURSOR PROTEIN GENE | MUTATION | MARKERS | KINDREDS | CATHEPSIN-E | LINKAGE | Amino Acid Sequence | Presenilin-2 | Gene Expression | Membrane Proteins - genetics | Humans | Middle Aged | DNA, Complementary - genetics | Molecular Sequence Data | Male | Chromosome Mapping | Lod Score | Point Mutation | Membrane Proteins - chemistry | Pedigree | Base Sequence | Alzheimer Disease - ethnology | Cloning, Molecular | Germany - ethnology | Adult | Female | Aged | Mutation | Alzheimer Disease - genetics | Chromosomes, Human, Pair 1 - genetics | Alzheimer's disease | Genetic aspects | Alzheimers disease | Index Medicus
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12. Full Text Regional differences in white matter breakdown between frontotemporal dementia and early-onset Alzheimer's disease
by Lu, Po H and Lee, Grace J and Shapira, Jill and Jimenez, Elvira and Mather, Michelle J and Thompson, Paul M and Bartzokis, George and Mendez, Mario F
Journal of Alzheimer's Disease, ISSN 1387-2877, 2014, Volume 39, Issue 2, pp. 261 - 269
Background: White matter abnormalities have been associated with both behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD).... 
myelin | white matter | magnetic resonance imaging | early onset | diffusion tensor imaging | frontotemporal dementia | behavioral variant | Alzheimer's disease | SYSTEM | BRAIN ATROPHY | VARIANTS | HUMANS | PATTERNS | MYELINATED NERVE-FIBERS | NEUROSCIENCES | DAMAGE | COGNITIVE DECLINE | DIFFUSION TENSOR MRI | MORPHOMETRY | Affective Symptoms - diagnosis | Humans | Middle Aged | Male | Frontotemporal Dementia - diagnosis | Alzheimer Disease - pathology | Diffusion Tensor Imaging | Alzheimer Disease - diagnosis | Psychiatric Status Rating Scales | Anisotropy | Nerve Fibers, Myelinated - pathology | Corpus Callosum - pathology | Brain - pathology | Female | Aged | Affective Symptoms - pathology | Frontal Lobe - pathology | Frontotemporal Dementia - pathology | Index Medicus | Age
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13. Full Text Genetic Determinants of Survival in Patients with Alzheimer's Disease
by Wang, Xingbin and Lopez, Oscar and Sweet, Robert A and Becker, James T and Dekosky, Steven T and Barmada, Mahmud M and Feingold, Eleanor and Demirci, F. Yesim and Kamboh, M. Ilyas
Journal of Alzheimer's Disease, ISSN 1387-2877, 2015, Volume 45, Issue 2, pp. 651 - 658
There is a strong genetic basis for late-onset of Alzheimer's disease (LOAD), and thus far >20 genes/loci have been identified that affect the risk of LOAD. In... 
Gene-based analysis | late-onset Alzheimer's disease | genome-wide association studies | survival | MORTALITY | COMMON VARIANTS | POPULATION | DEMENTIA | PROMOTER POLYMORPHISM | NEUROSCIENCES | APOLIPOPROTEIN-E | IDENTIFIES VARIANTS | INCREASED RISK | INTERLEUKIN-10 GENE | GENOME-WIDE ASSOCIATION
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14. Full Text OXPHOS, pyrimidine nucleotides, and Alzheimer's disease: a pharmacogenomics approach
by Pesini, Alba and Pesini, Alba and Iglesias, Eldris and Iglesias, Eldris and Garrido, Nuria and Garrido, Nuria and Bayona-Bafaluy, M. Pilar and Bayona-Bafaluy, M Pilar and Montoya, Julio and Montoya, Julio and Ruiz-Pesini, Eduardo and Ruiz-Pesini, Eduardo
Journal of Alzheimer's disease : JAD, ISSN 1387-2877, 2014, Volume 42, Issue 1, pp. 87 - 96
We present a new hypothesis on the contribution of a dysfunction of the oxidative phosphorylation system, through a decrease in the de novo synthesis of... 
coenzyme $Q_{10} | de novo pyrimidine biosynthesis | dihydroorotate dehydrogenase | mitochondrial DNA | Alzheimer's disease | coenzyme Q 10 | oxidative phosphorylation | DE-NOVO SYNTHESIS | MITOCHONDRIAL BIOGENESIS | AMYLOID PRECURSOR PROTEIN | LATE-ONSET ALZHEIMERS | NEUROSCIENCES | CDP-CHOLINE | CHOLINE PLUS CYTIDINE | DOCOSAHEXAENOIC ACID | IN-VIVO | PC12 CELLS | coenzyme Q | TRANSGENIC MICE | Pharmacogenetics - methods | DNA, Mitochondrial - metabolism | Pyrimidine Nucleotides - biosynthesis | Humans | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Oxidative Phosphorylation - drug effects | Animals | Alzheimer Disease - metabolism | Neurons - metabolism | Alzheimer Disease - genetics | Neurons - drug effects | Nootropic Agents - pharmacology | Index Medicus
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15. Full Text A FAMILIAL ALZHEIMERS-DISEASE LOCUS ON CHROMOSOME-1
by LEVYLAHAD, E and WIJSMAN, EM and NEMENS, E and ANDERSON, L and GODDARD, KAB and WEBER, JL and BIRD, TD and SCHELLENBERG, GD
SCIENCE, ISSN 0036-8075, 08/1995, Volume 269, Issue 5226, pp. 970 - 973
The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci... 
HETEROGENEITY | TYPE-4 ALLELE | GENE | MULTIDISCIPLINARY SCIENCES | CONSTRUCTION | MUTATION | MARKERS | BETA-PROTEIN | LINKAGE ANALYSIS | AMYLOID PRECURSOR PROTEIN | APOLIPOPROTEIN-E | Haplotypes | Cell Line | Humans | Middle Aged | Genotype | Male | Chromosome Mapping | Genetic Markers | Lod Score | Pedigree | Age of Onset | Alleles | Alzheimer Disease - ethnology | Germany - ethnology | Aged, 80 and over | Adult | Female | Aged | Alzheimer Disease - genetics | Chromosomes, Human, Pair 1 - genetics | Index Medicus
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16. Full Text Neuropsychological indicators of preclinical Alzheimer's disease among depressed older adults
by Rushing, Nicole C and Sachs-Ericsson, Natalie and Steffens, David C
Aging, Neuropsychology, and Cognition, ISSN 1382-5585, 01/2014, Volume 21, Issue 1, pp. 99 - 128
Older adults with major depressive disorder (MDD) may also have preclinical Alzheimer's disease (AD). Differential diagnosis is quite challenging due to the... 
Depression | Neuropsychological assessment | Alzheimer's disease | Dementia | METAANALYSIS | PSYCHOLOGY, DEVELOPMENTAL | GERIATRIC DEPRESSION | MILD COGNITIVE IMPAIRMENT | LATE-LIFE DEPRESSION | PSYCHOLOGY, EXPERIMENTAL | SAMPLE | NEUROCOGNITIVE OUTCOMES | VASCULAR DEMENTIA | RISK-FACTOR | PROGRESSION | LATE-ONSET DEPRESSION | Predictive Value of Tests | Alzheimer Disease - complications | Follow-Up Studies | Humans | Middle Aged | Attention | Models, Psychological | Male | Memory Disorders - diagnosis | Orientation | Disease Progression | Alzheimer Disease - diagnosis | Neuropsychological Tests | Cognition Disorders - diagnosis | Memory Disorders - etiology | Cognition Disorders - etiology | Aged, 80 and over | Depression - complications | Female | Aged | Executive Function | Index Medicus
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