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Synthesis, ISSN 0039-7881, 03/2017, Volume 49, Issue 6, pp. 1394 - 1400
Abstract SB612111 [(5 S ,7 S )-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5 H -benzo[7]annulen-5-ol] is a potent and... 
paper | modified synthesis | SB612111 | antagonist | NOP | PHARMACOLOGICAL CHARACTERIZATION | CHEMISTRY, ORGANIC | ORL1 | DISCOVERY | MEMBER | OPIOID RECEPTOR | THERAPEUTIC TARGET | GENE FAMILY | CDNA CLONING | SB-612111 | NOCICEPTIN/ORPHANIN FQ RECEPTOR
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2012, Volume 166, Issue 8, pp. 2289 - 2306
Journal Article
Journal Article
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 11/2012, Volume 167, Issue 5, pp. 1111 - 1125
BACKGROUND & PURPOSE Loperamide is a selective mu opioid receptor agonist acting locally in the gastrointestinal (GI) tract as an effective anti-diarrhoeal but... 
RAT | irritable bowel syndrome | DELTA | opioid | VISCERAL HYPERALGESIA | gastrointestinal secretion | KNOCKOUT MICE | ARRIVE GUIDELINES | MUSCLE-CELLS | INTESTINAL INFLAMMATION | visceral pain | IN-VIVO | motility | PHARMACOLOGY & PHARMACY | SYNDROME IBS | d opioid receptor | IRRITABLE-BOWEL-SYNDROME
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2015, Volume 77, Issue 10, pp. 850 - 858
Journal Article
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, ISSN 0190-9622, 10/2010, Volume 63, Issue 4, pp. 680 - 688
During the past two decades, systemic mu-opioid receptor antagonists (MORA) have been used in the treatment of various forms of chronic pruritus. In a number... 
pruritus | itch | OPIATE ANTAGONIST | INTRATHECAL MORPHINE | NALOXONE INFUSIONS | therapy | atopic dermatitis | CHRONIC CHOLESTASIS | INTRACTABLE PRURITUS | NALMEFENE THERAPY | DERMATOLOGY | opioid receptor antagonist | ATOPIC-DERMATITIS | DOUBLE-BLIND | UREMIC PRURITUS | sensory nerve fibers | ORAL NALTREXONE TREATMENT
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 03/2013, Volume 54, Issue 3, pp. 455 - 463
Kappa-opioid receptors (KOR) are believed to be involved in the pathophysiology of depression, anxiety disorders, drug abuse, and alcoholism. To date, only 1... 
synthesis | kappa opioid receptor | IN-SITU HYBRIDIZATION | KNOCKOUT MICE | antagonist | radioligand | MESSENGER-RNA | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | BINDING-SITES | VIVO BINDING | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | OPIATE RECEPTORS
Journal Article
Journal Article
Pain, ISSN 0304-3959, 05/2013, Volume 154, Issue 5, pp. 700 - 707
Calcitonin gene–related peptide (CGRP) antagonism reduces inflammatory pain. A peripheral site of action is assumed, as blockage of peripheral CGRP receptors...