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NATURE CELL BIOLOGY, ISSN 1465-7392, 10/2012, Volume 14, Issue 10, pp. 1024 - 1024
Autophagy targets pathogens, damaged organelles and protein aggregates for lysosomal degradation. These ubiquitylated cargoes are recognized by specific... 
LOCALIZATION | BIOGENESIS | PHOSPHORYLATION | UBIQUITIN | OPTINEURIN | MUTATIONS | PROTEINS | HUNTINGTIN | BINDING | GOLGI-COMPLEX | CELL BIOLOGY
Journal Article
Toxicological Sciences, ISSN 1096-6080, 10/2016, Volume 153, Issue 2, pp. 372 - 381
Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects ∼5 million people around the world. PD etiopathogenesis is poorly understood... 
rotenone | Optineurin | autophagy | Optineurin Expression in Rodent Model of Parkinson’s Disease | Parkinson’s disease
Journal Article
Developmental Cell, ISSN 1534-5807, 05/2019, Volume 49, Issue 4, pp. 509 - 525.e12
The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our... 
ALFY | mitophagy | autophagy | optineurin | TAX1BP1 | p62/SQSTM1 | NDP52 | NIPSNAP1 | NIPSNAP2 | Parkin
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 01/2013, Volume 20, Issue 1, pp. 21 - 30
Ubiquitination has long been recognised as a key determinator of protein fate by tagging proteins for proteasomal degradation. Most recently, the ability of... 
mitophagy | autophagy | Optineurin | phosphorylation | ubiquitin | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | P62/SQSTM1 | P62 | CONJUGATION SYSTEMS | CELL-DEATH | CELL BIOLOGY | PARKIN | PROTEIN-DEGRADATION | PROTEASOME | PAGETS-DISEASE | BINDING | Autophagy - physiology | Ubiquitination - physiology | Signal Transduction | Humans | Ubiquitin - metabolism | Review
Journal Article
Journal Article
Current Opinion in Neurobiology, ISSN 0959-4388, 08/2019, Volume 57, pp. 94 - 101
Autophagy and endo-lysosomal degradation are two parallel degradation pathways essential for maintaining neuronal health and function. Autophagosomes and... 
AXONS | BASSOON | TRANSPORT | DAMAGED MITOCHONDRIA | DISEASE | DYNAMICS | MITOPHAGY | MACROAUTOPHAGY | OPTINEURIN | PROTEINS | NEUROSCIENCES | Neurons
Journal Article