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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 24, pp. E3349 - E3358
Journal Article
by Hu, SC and Guo, YJ and Wang, YL and Li, Y and Fu, T and Zhou, ZX and Wang, YR and Liu, JP and Pan, LF
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3459 - 12
Myosin VI plays crucial roles in diverse cellular processes. In autophagy, Myosin VI can facilitate the maturation of autophagosomes through interactions with... 
AUTOPHAGY RECEPTOR | PROTEIN | ACTIN | UBIQUITIN RECOGNITION | MULTIDISCIPLINARY SCIENCES | MOTOR | MITOCHONDRIA | DIMERIZATION | OPTINEURIN | ENDOCYTOSIS | BINDING | Interfaces | Cargo | Receptors | Myosin | Phagosomes | Tethering | Autophagy | Phagocytosis | Recognition | Crystal structure
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 3305 - 11
One enigma in biology is the generation, sensing and maintenance of membrane curvature. Curvature-mediating proteins have been shown to induce specific... 
PATTERN-FORMATION | EVOLUTION | INTERFACE | MULTIDISCIPLINARY SCIENCES | MEAN-CURVATURE | MOTOR | EQUATIONS | OPTINEURIN | PROTEINS | TRANSIENT PORES | BINDING | Stability | Fluorescence | Motors | Lipids | Biology | Mathematical morphology | Nanoparticles | Actin | Scaffolding | Myosin | Cytoskeleton | Curvature | Fluorescence microscopy
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 08/2019, Volume 431, Issue 17, pp. 3146 - 3156
Although the Ub-binding domain in ABIN proteins and NEMO (UBAN) is highly conserved, UBAN-containing proteins exhibit different Ub-binding properties,... 
ABIN-1 | UBAN | phosphorylation | ubiquitin | OPTN | SYSTEM | STRUCTURAL INSIGHTS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | OPTINEURIN | REPLACEMENT | REFINEMENT | TBK1 | NF-KAPPA-B | BINDING | Ubiquitin | Physiological aspects | Structure | Analysis | Crystals | Protein binding | BASIC BIOLOGICAL SCIENCES
Journal Article
Journal Article
Neuroscience Letters, ISSN 0304-3940, 04/2019, Volume 697, pp. 34 - 48
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4498 - 8
Juvenile onset open-angle glaucoma (JOAG) affects patients before 40 years of age, causing high intraocular pressure and severe optic nerve damage. To expand... 
GENE-MUTATIONS | SPANISH PATIENTS | VARIANTS | CONGENITAL GLAUCOMA | FAMILIES | MULTIDISCIPLINARY SCIENCES | POAG PATIENTS | PHENOTYPE | ALS | ABSENCE | OPTINEURIN | Glaucoma | Pathogenicity | Population studies | Optic nerve | Mutation
Journal Article
JOURNAL OF BIOCHEMISTRY, ISSN 0021-924X, 09/2018, Volume 164, Issue 3, pp. 223 - 229
Optineurin (OPTN) plays an important role in membrane trafficking processes such as exocytosis and autophagy. The sizes and rate of formation of accumulated... 
CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DAMAGED MITOCHONDRIA | image correlation spectroscopy | AMYOTROPHIC-LATERAL-SCLEROSIS | inclusion body | AUTOPHAGY RECEPTOR | optineurin | MEDIATED MITOPHAGY | DISEASE | MUTATIONS | vesicular trafficking | AGGREGATION | foci
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2019, Volume 74, Issue 2, pp. 347 - 362.e6
Selective autophagy recycles damaged organelles and clears intracellular pathogens to prevent their aberrant accumulation. How ULK1 kinase is targeted and... 
mitophagy | PINK1 | optineurin | mitochondria | FIP200 | TAX1BP1 | P62 | lysosome | ATG13 | Parkin | ATG PROTEINS | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIR MOTIF | AMPK | MITOPHAGY | KINASE ULK1 | MOLECULAR-BASIS | BINDING | DIRECT PHOSPHORYLATION | MITOCHONDRIAL FISSION | CELL BIOLOGY | Nervous system diseases | Peptides | Molecular biology | Analysis
Journal Article
Neuroscience, ISSN 0306-4522, 09/2018, Volume 388, pp. 139 - 151
Mutations in a ubiquitin (Ub)-binding adaptor protein optineurin have been found in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease with a... 
neurodegeneration | immunomodulation | IFN-β | optineurin | inflammation | microglia | IFN-beta | KAPPA-B ACTIVATION | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | BINDING KINASE 1 | INTERFERON-BETA | NEUROSCIENCES | I INTERFERON | AUTOPHAGY RECEPTOR | MOTOR-NEURON DEGENERATION | PATHWAY | Index Medicus
Journal Article