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Journal of Biological Chemistry, ISSN 0021-9258, 05/2017, Volume 292, Issue 20, pp. 8158 - 8173
Journal Article
EMBO Journal, ISSN 0261-4189, 09/2015, Volume 34, Issue 17, pp. 2291 - 2305
Journal Article
Circulation Research, ISSN 0009-7330, 04/2017, Volume 120, Issue 9, pp. 1426 - 1439
RATIONALE:Lymphatic vessels function to drain interstitial fluid from a variety of tissues. Although shear stress generated by fluid flow is known to trigger... 
Cell proliferation | lymphatic vessels | Calcium channel | vascular endothelial growth factor A | Capillary | calcium channel | TRANSCRIPTION FACTORS | VASCULAR DEVELOPMENT | CARDIAC & CARDIOVASCULAR SYSTEMS | cell proliferation | capillary | FLUID SHEAR-STRESS | VEGF EXPRESSION | INTERSTITIAL FLOW | T-CELL | KLF2 | LYMPHANGIOGENESIS | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | VALVE FORMATION | Cyclin-Dependent Kinase Inhibitor p57 - metabolism | Cell Proliferation | Cyclin-Dependent Kinase Inhibitor p57 - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Stress, Mechanical | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Kruppel-Like Transcription Factors - metabolism | Endothelium, Lymphatic - metabolism | Kruppel-Like Transcription Factors - deficiency | Lymphangiogenesis | Endothelium, Lymphatic - pathology | ORAI1 Protein - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - genetics | ORAI1 Protein - genetics | Endothelial Cells - metabolism | Gene Expression Regulation | Genotype | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | ORAI1 Protein - deficiency | Mechanotransduction, Cellular | Phenotype | Animals | Endothelium, Vascular - metabolism | Vascular Endothelial Growth Factor C - metabolism | Kruppel-Like Transcription Factors - genetics | Endothelium, Lymphatic - physiopathology | Calcium channels | Animal models | Lymphatic system | Fluid flow | Regulatory sequences | Shear stresses | Orai1 protein | Embryos | Blood | Endothelial cells | Cell growth | KLF4 protein | Rodents | Skin | Lung Kruppel-like factor | Vascular endothelial growth factor | Fibroblast growth factor receptors | Index Medicus | endothelial cell growth | lymphatic capillary | Signal Transduction | Growth Factors | Cytokines | Vascular Biology | lymphatic development | KLF4 | Endothelial shear stress | vascular endothelial growth factor | Cell Signaling | ORAI1 | Developmental Biology
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 06/2019, Volume 234, Issue 6, pp. 8727 - 8739
Stromal interaction molecules STIM1 and STIM2 are endoplasmic reticulum (ER) Ca sensors that initiate store-operated Ca entry (SOCE). The roles of... 
Orai1 | microtubules | EB1 | endoplasmic reticulum
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2018, Volume 115, Issue 15, pp. E3398 - E3407
Journal Article
by Dong, M and Zheng, N and Ren, L. J and Zhou, H and Liu, J
European Journal of Neurology, ISSN 1351-5101, 07/2017, Volume 24, Issue 7, pp. 912 - 919
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2018, Volume 32, Issue 1, pp. 404 - 416
Zinc, an essential micronutrient, has a cancer preventive role. Zinc deficiency has been shown to contribute to the progression of esophageal cancer. Orai1, a... 
Intracellular Ca2+ oscillations | Cancer prevention | Redox sensor | Histidine | DOMAIN | intracellular Ca2+ oscillations | cancer prevention | BIOCHEMISTRY & MOLECULAR BIOLOGY | redox sensor | RECEPTOR | CRAC CHANNELS | CANCER | DAMAGE | CELL BIOLOGY | INTRACELLULAR CA2 | BIOLOGY | ION CHANNELS | EXPRESSION | BINDING | histidine | PERMEATION | ORAI1 Protein - metabolism | Mutagenesis, Site-Directed | ORAI1 Protein - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Mutant Proteins - genetics | Mutant Proteins - metabolism | Chelating Agents - pharmacology | Ethylenediamines - pharmacology | Esophageal Neoplasms - pathology | Gene Knockdown Techniques | Carcinoma, Squamous Cell - drug therapy | G2 Phase Cell Cycle Checkpoints - drug effects | Calcium Signaling - drug effects | Models, Biological | ORAI1 Protein - antagonists & inhibitors | Esophageal Neoplasms - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Zinc - pharmacology | Esophageal Neoplasms - drug therapy | Amino Acid Substitution | Esophageal Squamous Cell Carcinoma | Cell proliferation | Epithelial cells | Oscillations | Fluorescence | Tissues | Calcium influx | Calcium signalling | Ethylenediamine | Signal transduction | Cell growth | Supplementation | Calcium channels | Squamous cell carcinoma | Nutrient deficiency | Calcium (intracellular) | Data processing | Orai1 protein | Zinc | Mutants | Esophagus | Cell lines | Intracellular | Esophageal cancer | Calcium ions | Cancer | Index Medicus | Research
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 825 - 12
STIM1 and Orai1 are key components of the Ca2+-release activated Ca2+ (CRAC) current. Orai1, which represents the subunit forming the CRAC channel complex, is... 
CHANNEL FUNCTION | OPERATED CALCIUM-ENTRY | ORAI CHANNELS | MULTIDISCIPLINARY SCIENCES | MUTATION | CA2+ SENSOR | STORE | INTERACTION MOLECULE-1 STIM1 | PLASMA-MEMBRANE | SAM DOMAIN | CRAC CHANNEL | Calcium - metabolism | Dyslexia - metabolism | Humans | Dyslexia - pathology | Green Fluorescent Proteins - genetics | Calcium - chemistry | ORAI1 Protein - chemistry | Migraine Disorders - pathology | Stromal Interaction Molecule 1 - chemistry | Neoplasm Proteins - genetics | Binding Sites | Blood Platelet Disorders - genetics | ORAI1 Protein - metabolism | Amino Acid Sequence | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Patch-Clamp Techniques | Migraine Disorders - genetics | Miosis - pathology | Luminescent Proteins - genetics | Muscle Fatigue - genetics | Miosis - metabolism | Blood Platelet Disorders - pathology | Ichthyosis - metabolism | Protein Multimerization | Erythrocytes, Abnormal - metabolism | Neoplasm Proteins - metabolism | Stromal Interaction Molecule 1 - genetics | Migraine Disorders - metabolism | Ichthyosis - pathology | Miosis - genetics | HEK293 Cells | Ichthyosis - genetics | Ion Transport | Protein Interaction Domains and Motifs | Spleen - pathology | Genes, Reporter | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | Protein Conformation, alpha-Helical | ORAI1 Protein - genetics | Bacterial Proteins - genetics | Gene Expression Regulation | Recombinant Proteins - genetics | Spleen - abnormalities | Dyslexia - genetics | Point Mutation | Stromal Interaction Molecule 1 - metabolism | Erythrocytes, Abnormal - pathology | Spleen - metabolism | Protein Binding | Bacterial Proteins - metabolism | Blood Platelet Disorders - metabolism | Amino Acid Substitution | Luminescent Proteins - metabolism | Calcium channels | STIM1 protein | Activation | Exposure | Orai1 protein | Elongation | Calcium ions | Index Medicus
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 07/2017, Volume 42, Issue 4, pp. 1366 - 1376
Background/Aims: Istaroxime is a validated inotropic Na+/K+ ATPase inhibitor currently in development for the treatment of various cardiac conditions. Recent... 
DU-145 prostate cancer cells | Orai1 | SOCE | FAK | Istaroxime | Migration | ELEVATED ORAI1 | OPERATED CA2+ ENTRY | PHYSIOLOGY | MEMBRANE ANDROGEN RECEPTORS | PRO-APOPTOTIC RESPONSES | CELL BIOLOGY | IN-VITRO | NA+/K+ ATPASE INHIBITOR | ACTIN REORGANIZATION | BREAST-TUMOR CELLS | RHABDOMYOSARCOMA CELLS | FOCAL ADHESION KINASE | Focal Adhesion Kinase 1 - genetics | Epithelial Cells - metabolism | Calcium Channels - metabolism | Calcium - metabolism | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Prostate - metabolism | Stromal Interaction Molecule 1 - genetics | Prostate - pathology | Fura-2 - chemistry | Prostate - drug effects | Etiocholanolone - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Calcium Channels - genetics | Focal Adhesion Kinase 1 - metabolism | ORAI1 Protein - metabolism | Fluorescent Dyes - chemistry | ORAI1 Protein - genetics | Signal Transduction | Etiocholanolone - analogs & derivatives | Epithelial Cells - pathology | Sodium Channel Blockers - pharmacology | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Cell Movement - drug effects | Stromal Interaction Molecule 1 - metabolism | ORAI1 Protein - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Focal Adhesion Kinase 1 - antagonists & inhibitors | Stromal Interaction Molecule 1 - antagonists & inhibitors | Index Medicus
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 12/2019, Volume 132, pp. 104588 - 104588
Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is... 
Orai1 | Tau | KCa3.1 | Astrocytes | Insulin | Index Medicus
Journal Article