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Journal of Gastroenterology, ISSN 0944-1174, 1/2014, Volume 49, Issue 1, pp. 138 - 147
Efficacy, safety and pharmacokinetics of simeprevir (TMC435), a once-daily, noncovalent, oral hepatitis C virus (HCV) NS3/4A protease inhibitor, was evaluated... 
Chronic hepatitis C | Medicine & Public Health | Colorectal Surgery | Hepatology | Direct-acting antiviral | Gastroenterology | Abdominal Surgery | Surgical Oncology | Sustained virologic response | Protease inhibitor | PLUS RIBAVIRIN | TELAPREVIR | MANAGEMENT | SAFETY | BOCEPREVIR | HCV | GASTROENTEROLOGY & HEPATOLOGY | RIBAVIRIN COMBINATION THERAPY | Recombinant Proteins - therapeutic use | Recurrence | Simeprevir | Humans | Middle Aged | Hepatitis C, Chronic - virology | Polyethylene Glycols - adverse effects | Male | RNA, Viral - blood | Recombinant Proteins - adverse effects | Polyethylene Glycols - therapeutic use | Viral Load | Young Adult | Ribavirin - administration & dosage | Adult | Female | Drug Therapy, Combination | Hepacivirus - isolation & purification | Drug Administration Schedule | Administration, Oral | Antiviral Agents - therapeutic use | Ribavirin - therapeutic use | Interferon-alpha - therapeutic use | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Polyethylene Glycols - administration & dosage | Recombinant Proteins - administration & dosage | Interferon-alpha - administration & dosage | Sulfonamides - therapeutic use | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Heterocyclic Compounds, 3-Ring - administration & dosage | Heterocyclic Compounds, 3-Ring - adverse effects | Heterocyclic Compounds, 3-Ring - therapeutic use | Sulfonamides - adverse effects | Aged | Interferon-alpha - adverse effects | Sulfonamides - administration & dosage | Medical research | Protease inhibitors | RNA | Proteases | Medicine, Experimental | Genetic aspects | Hepatitis C | Drug therapy | Hepatitis C virus | Original —LIVER, PANCREAS, AND BILIARY TRACT
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 07/2014, Volume 60, Issue 1, pp. 56 - 64
Journal Article
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 2014, Volume 8, Issue 5, p. e2804
Background: Mice lacking the type I interferon receptor (IFNAR(-/-) mice) reproduce relevant aspects of Crimean-Congo hemorrhagic fever (CCHF) in humans,... 
VITRO | PATHOGENESIS | ORAL RIBAVIRIN | RECEPTOR-KNOCKOUT MICE | CLINICAL PATHOLOGY | INFECTION | INFLUENZA-VIRUS | LETHAL | IN-VIVO ACTIVITIES | COXSACKIE-VIRUS | PARASITOLOGY | TROPICAL MEDICINE | Liver - virology | Liver - pathology | Antiviral Agents - toxicity | Pyrazines - administration & dosage | Hemorrhagic Fever, Crimean - virology | Cercopithecus aethiops | Male | Pyrazines - therapeutic use | Indoles - administration & dosage | Liver - immunology | Amides - toxicity | Pyrazines - toxicity | Ribavirin - administration & dosage | Female | Indoles - pharmacology | Receptor, Interferon alpha-beta - genetics | Vero Cells | Hemorrhagic Fever, Crimean - drug therapy | Disease Models, Animal | Amides - pharmacology | Antiviral Agents - pharmacology | Antiviral Agents - therapeutic use | Ribavirin - therapeutic use | Indoles - toxicity | Mice, Transgenic | Amides - therapeutic use | Antiviral Agents - administration & dosage | Liver - chemistry | Animals | Hemorrhagic Fever Virus, Crimean-Congo - drug effects | Ribavirin - toxicity | Indoles - therapeutic use | Mice | Pyrazines - pharmacology | Amides - administration & dosage | Ribavirin - pharmacology | Animal experimentation | Antiviral agents | Usage | Patient outcomes | Crimean hemorrhagic fever | Research | Drug therapy | Health aspects | Ribavirin | Pathology | Enzymes | Mutagenesis | Rodents | Fatalities | Viruses | Infections | RNA polymerase | Experiments | Fever | Immune system
Journal Article
Journal Article
Antiviral Research, ISSN 0166-3542, 2011, Volume 89, Issue 1, pp. 26 - 34
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 2, pp. 420 - 429
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 6, pp. 645 - 653
Summary Background Compared with other countries, patients with chronic hepatitis C infection in Japan tend to be older, have more advanced liver disease, and... 
Infectious Disease | INFECTIOUS DISEASES | SIMEPREVIR | INFECTION | CHRONIC HCV | Uridine Monophosphate - administration & dosage | Humans | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | Drug-Related Side Effects and Adverse Reactions - pathology | Young Adult | Benzimidazoles - administration & dosage | Time Factors | Ribavirin - administration & dosage | Aged, 80 and over | Adult | Female | Fluorenes - administration & dosage | Fluorenes - adverse effects | Uridine Monophosphate - adverse effects | Benzimidazoles - adverse effects | Hepacivirus - isolation & purification | Administration, Oral | Japan | Genotype | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Drug-Related Side Effects and Adverse Reactions - epidemiology | Asian Continental Ancestry Group | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | Aged | Hepacivirus - classification | Sofosbuvir | Care and treatment | Liver | Dosage and administration | Product development | Drug therapy, Combination | Hepatitis C virus | Hepatitis C | Health aspects | Ribavirin | Hepatitis | Genotype & phenotype | Liver cancer | Heart attacks | Liver diseases | Human immunodeficiency virus--HIV | Hepatology | Response rates | Interferon | Infections | Drug dosages | Patients
Journal Article