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Journal Article
Structure, ISSN 0969-2126, 01/2018, Volume 26, Issue 1, pp. 7 - 19.e5
Orexin peptides in the brain regulate physiological functions such as the sleep-wake cycle, and are thus drug targets for the treatment of insomnia. Using... 
X-ray crystallography | GPCR | subtype selective ligand | X-ray free-electron laser | serial femtosecond crystallography | orexin receptor | ACTIVATION | SODIUM | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATOMIC CHARGES | X-RAY-DIFFRACTION | FREE-ENERGIES | DISCOVERY | FAMILY | CELL BIOLOGY | BIOPHYSICS | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | PROTEINS | Baculoviridae - metabolism | Triazoles - chemistry | Humans | Crystallography - methods | Baculoviridae - genetics | Aminopyridines - metabolism | Spodoptera | Aminopyridines - chemistry | Orexin Receptor Antagonists - metabolism | Thermodynamics | Sf9 Cells | Azepines - chemistry | Synchrotrons | Cloning, Molecular | Orexin Receptors - genetics | Orexin Receptor Antagonists - chemistry | Protein Interaction Domains and Motifs | Orexin Receptors - chemistry | Binding Sites | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Orexin Receptors - metabolism | Genetic Vectors - chemistry | Orexins - metabolism | Sulfonamides - chemistry | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Triazoles - metabolism | Animals | Hydrogen Bonding | Protein Conformation, beta-Strand | Azepines - metabolism | Sulfonamides - metabolism | Orexins - chemistry | Protein Binding | Kinetics | Peptides | Lasers | Analysis | Crystals | Physiological aspects | Drug discovery | Structure
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2017, Volume 57, Issue 1, pp. 509 - 533
Journal Article
Nature, ISSN 0028-0836, 02/2019, Volume 566, Issue 7744, pp. 383 - 387
Sleep is integral to life(1). Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular... 
SYSTEM | CELLS | NARCOLEPSY | METAANALYSIS | HYPOCRETIN | MULTIDISCIPLINARY SCIENCES | OREXIN | DIFFERENTIATION | DURATION | STEM | REVEALS | Hypothalamic Area, Lateral - metabolism | Male | Monocytes - metabolism | Hematopoiesis - drug effects | Sleep Deprivation - prevention & control | Antigens, Ly - metabolism | Female | Hematopoiesis - physiology | Sleep - physiology | Neutrophils - metabolism | Myelopoiesis - drug effects | Orexins - biosynthesis | Orexins - pharmacology | Atherosclerosis - pathology | Orexin Receptors - metabolism | Orexins - metabolism | Sleep - drug effects | Sleep Deprivation - metabolism | Atherosclerosis - metabolism | Orexins - deficiency | Monocytes - drug effects | Sleep Deprivation - physiopathology | Animals | Orexin Receptors - deficiency | Mice | Atherosclerosis - prevention & control | Bone Marrow Cells - metabolism | Physiological aspects | Sleep | Hematopoiesis | Health aspects | Risk factors | Atherosclerosis | Development and progression | Orexins | Neutrophils | Health risks | Hypothalamus (lateral) | Nervous system | Neuropeptides | Leukocytes (neutrophilic) | Hypothalamus | Monocytosis | Sleep disorders | Molecular modelling | Rodents | Arteriosclerosis | Stem cells | Bone marrow | Supplementation | Myelopoiesis | Lesions | Ly-6 antigen | Cardiovascular diseases | Alzheimers disease
Journal Article