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osterix (446) 446
index medicus (428) 428
animals (359) 359
osteoblast differentiation (273) 273
mice (259) 259
humans (203) 203
sp7 transcription factor (186) 186
differentiation (184) 184
cell biology (181) 181
expression (180) 180
transcription factor osterix (166) 166
osteogenesis (164) 164
bone-formation (161) 161
osteoblasts - metabolism (160) 160
transcription factors - metabolism (153) 153
transcription factors - genetics (151) 151
osteoblasts - cytology (148) 148
biochemistry & molecular biology (143) 143
runx2 (137) 137
gene expression (131) 131
cell differentiation (126) 126
osteoblast (120) 120
stem cells (120) 120
osteoblasts (117) 117
bone (113) 113
gene-expression (105) 105
article (96) 96
in-vitro (95) 95
cells (94) 94
endocrinology & metabolism (92) 92
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cell differentiation - drug effects (74) 74
male (72) 72
proliferation (70) 70
transcription factors (70) 70
bones (68) 68
mesenchymal stem-cells (68) 68
osteogenesis - genetics (67) 67
osteogenesis - physiology (67) 67
osteogenic differentiation (66) 66
core binding factor alpha 1 subunit - metabolism (65) 65
osteoblastogenesis (65) 65
rats (62) 62
cell differentiation - physiology (61) 61
osteoblasts - drug effects (59) 59
osteoporosis (59) 59
female (58) 58
cell proliferation (54) 54
osteogenesis - drug effects (54) 54
biocompatibility (53) 53
bone morphogenetic proteins (53) 53
orthopedics (53) 53
alkaline phosphatase - metabolism (52) 52
cell differentiation - genetics (52) 52
gene (51) 51
gene expression regulation (51) 51
phosphorylation (51) 51
biophysics (49) 49
genes (49) 49
transcription (49) 49
cbfa1 (48) 48
collagen (48) 48
developmental biology (48) 48
core binding factor alpha 1 subunit - genetics (47) 47
dentistry (47) 47
alkaline phosphatase (45) 45
activation (44) 44
bone growth (44) 44
medicine, research & experimental (44) 44
dentistry, oral surgery & medicine (43) 43
osteoblasts - physiology (43) 43
oncology (42) 42
bone marrow (41) 41
mesenchymal stromal cells - metabolism (41) 41
transcription factor (41) 41
mesenchymal stromal cells - cytology (40) 40
up-regulation (40) 40
cbfa-1 protein (39) 39
immunohistochemistry (39) 39
mice, inbred c57bl (38) 38
mice, knockout (37) 37
physiological aspects (37) 37
bone morphogenetic protein-2 (35) 35
rna, messenger - metabolism (35) 35
medicine (34) 34
musculoskeletal diseases (34) 34
osteocalcin (34) 34
multidisciplinary sciences (33) 33
stem-cells (33) 33
biomedical materials (32) 32
osterix expression (32) 32
phenotype (32) 32
stomatognathic system (32) 32
bone and bones - metabolism (31) 31
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1. Full Text Regulation of gene expression in osteoblasts
by Jensen, Eric D and Gopalakrishnan, Rajaram and Westendorf, Jennifer J
BioFactors, ISSN 0951-6433, 01/2010, Volume 36, Issue 1, pp. 25 - 32
In recent years, much progress has been made in understanding the factors that regulate the gene expression program that underlies the induction,... 
Lef1 | NFATc | Osterix | SMAD | Atf4 | miRs | Runx2 | HDAC | CLEIDOCRANIAL DYSPLASIA | BONE MORPHOGENETIC PROTEIN-2 | C-FOS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATING TRANSCRIPTION FACTOR-4 | SAETHRE-CHOTZEN-SYNDROME | BETA-CATENIN | COLLAGENASE-3 PROMOTER | OSTEOCALCIN GENE | ENDOCRINOLOGY & METABOLISM | PARATHYROID-HORMONE | HISTONE DEACETYLASE INHIBITORS | Transcription Factors - physiology | Histone Deacetylases - genetics | Epigenesis, Genetic | Humans | Core Binding Factor Alpha 1 Subunit - physiology | NFATC Transcription Factors - physiology | Smad Proteins - physiology | Calcineurin - physiology | T Cell Transcription Factor 1 - physiology | Animals | Gene Expression Regulation, Developmental | Transcription Factor AP-1 - physiology | Twist-Related Protein 1 - physiology | Lymphoid Enhancer-Binding Factor 1 - physiology | Sp7 Transcription Factor | Mice | Zinc Fingers - physiology | MicroRNAs - physiology | Osteoblasts - metabolism | Activating Transcription Factor 4 - physiology
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2. Full Text MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31
by Baglìo, Serena Rubina and Devescovi, Valentina and Granchi, Donatella and Baldini, Nicola
Gene, ISSN 0378-1119, 09/2013, Volume 527, Issue 1, pp. 321 - 331
Osteogenesis is the result of a complex sequence of events that involve the differentiation of mesenchymal stem cells (MSC) into osteoblasts. MSCs are... 
miRNA | Sp7 | MSC | Transcription factor | Osteogenesis | Antigens, Differentiation | Oligonucleotide Array Sequence Analysis | Humans | Transcriptome | Gene Expression Profiling | Journal Article | Bone Marrow Cells | MCF-7 Cells | Mesenchymal Stromal Cells | RNA Interference | Research Support, Non-U.S. Gov't | MicroRNAs | Sp7 Transcription Factor | Cell Differentiation | Transcription Factors | 3' Untranslated Regions | RNA, Messenger | TRANSCRIPTION FACTORS | OSTEOBLAST DIFFERENTIATION | INTERNATIONAL-SOCIETY | RNA | THERAPY POSITION STATEMENT | REPRESSION | GENETICS & HEREDITY | GENE-EXPRESSION | STROMAL CELLS | PROGRESSION | PROGRAM | RNA, Messenger - genetics | Bone Marrow Cells - physiology | Transcription Factors - genetics | RNA, Messenger - metabolism | Transcription Factors - metabolism | Antigens, Differentiation - metabolism | MicroRNAs - genetics | Mesenchymal Stromal Cells - physiology | Analysis | MicroRNA | Stem cells
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3. Full Text HIF-1α Inhibits Wnt Signaling Pathway by Activating Sost Expression in Osteoblasts
by Chen, Dafu and Li, Yang and Zhou, Zhiyu and Wu, Chengai and Xing, Yonggang and Zou, Xuenong and Tian, Wei and Zhang, Chi
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e65940
The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains... 
RECEPTOR-MEDIATED TRANSCRIPTION | SCLEROSTIN | PROTEIN | GROWTH-FACTOR VEGF | BONE-FORMATION | OSX | TRANSCRIPTION FACTOR OSTERIX | MULTIDISCIPLINARY SCIENCES | MASS | HYPOXIA | SKELETAL DEVELOPMENT | Glycoproteins - genetics | Cell Line | Cell Hypoxia - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Glycoproteins - metabolism | Wnt Signaling Pathway - physiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | Wnt Signaling Pathway - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice | RNA, Small Interfering | Cell Hypoxia - genetics | Osteoblasts - metabolism | Hypoxia-inducible factor 1 | Wnt protein | Transcription | Gene regulation | Activation | SOST protein | Gene deletion | Kinases | Osteoblasts | Deferoxamine | Ossification | Cartilage | Angiogenesis | Signal transduction | Transfection | Vitamin D | Clonal deletion | Rodents | Deletion | Biocompatibility | Inhibition | Vascular endothelial growth factor | Bone (endochondral) | Hypoxia-inducible factors | siRNA | Gene expression | Mutants | Polymerase chain reaction | Signaling | Molecular modelling | Hypoxia | Osteogenesis
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4. Parathyroid Hormone Regulates Osterix Promoter Activity In Vitro and Expression In Vivo
by Barbuto, Richard
11/2011
Osterix (Osx) is a transcription factor required for osteoblast differentiation and bone formation. We previously demonstrated that continuous parathyroid... 
parathyroid hormone | gene regulation | Osterix | 0419 | osteoblast
Dissertation
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5. Full Text Transcriptional regulation of bone sialoprotein gene expression by Osx
by Yang, Ya and Huang, Yehong and Zhang, Li and Zhang, Chi
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2016, Volume 476, Issue 4, pp. 574 - 579
Osteoporosis is the most common metabolic bone disease characterized by decreased bone mass, decreased bone strength, and increased risk of fracture. It is due... 
Osteoblast | Bone sialoprotein | Transcription | Osx | Bsp | Osterix | RECEPTOR-MEDIATED TRANSCRIPTION | OSTEOBLAST DIFFERENTIATION | PROTEIN | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROXYAPATITE | BIOPHYSICS | GROWTH | NUCLEATION | FACTOR OSTERIX OSX | Cell Line | Promoter Regions, Genetic | RNA, Small Interfering - genetics | Sequence Deletion | Mutagenesis, Site-Directed | Gene Expression Regulation | Transcription Factors - antagonists & inhibitors | Binding Sites - genetics | Transcription Factors - genetics | GC Rich Sequence | Mice, Knockout | Transcription Factors - metabolism | Cell Differentiation - genetics | Animals | Sp7 Transcription Factor | Integrin-Binding Sialoprotein - genetics | Mice | Osteoblasts - cytology | Osteoblasts - metabolism | Osteogenesis - genetics | Osteoporosis | Stem cells | Physiological aspects | Bones | Genetic aspects | Genetic transcription | Density | Index Medicus
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6. Full Text Vitamin C effects on 5-hydroxymethylcytosine and gene expression in osteoblasts and chondrocytes: Potential involvement of PHD2
by Lindsey, RC and Cheng, SH and Mohan, S
PLOS ONE, ISSN 1932-6203, 08/2019, Volume 14, Issue 8, p. e0220653
Vitamin C (ascorbic acid, AA) is a well-known regulator of bone and cartilage metabolism. However, the mechanisms of AA's action in these tissues are only... 
OSTERIX EXPRESSION | IN-VITRO | ACTIVATION | COLLAGEN | BONE-MINERAL DENSITY | PROTEASOMAL DEGRADATION | ALKALINE-PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | DIFFERENTIATION | ASCORBIC-ACID | PROLYL HYDROXYLASE | Growth | Nutrient interactions | Vitamin C | Physiological aspects | Bones | Genetic aspects | Cartilage cells | Gene expression | Health aspects | Osteoblasts | Ascorbic acid | Genes | Systematic review | Arthritis | Biochemistry | Bone (trabecular) | Proteins | Antioxidants | Cartilage | Osteoporosis | Demethylation | Biomedical materials | Cell cycle | DNA methylation | Biocompatibility | Prolyl hydroxylase | Bone density | Chondrogenesis | Deoxyribonucleic acid--DNA | Enzymes | Hydroxylase | Cartilage (articular) | Metabolism | Medicine | Studies | Osteoblastogenesis | Fractures | Womens health | Chondrocytes | Stem cells | Hypoxia | Nuclei (cytology) | Bone | Differentiation | Osteoarthritis | Cytoplasm | Health disparities | Cartilage diseases | Deoxyribonucleic acid | DNA
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7. Full Text Tracking gene expression during zebrafish osteoblast differentiation
by Li, Nan and Felber, Katharina and Elks, Phil and Croucher, Peter and Roehl, Henry H
Developmental Dynamics, ISSN 1058-8388, 02/2009, Volume 238, Issue 2, pp. 459 - 466
The transcription factors RUNX2 and OSX have been shown to act sequentially to direct mammalian osteoblast differentiation. RUNX2 is required during the early... 
runx2/cbfa1/osf1/pebp2αA | crossveinless2 | osteonectin | mesenchymal stem cell | cranial | collagen10a1 | neural crest | bone | osteoblast | osterix | osteoprogenetor | osteoblastogenesis | tcf7 | collagenIa2 | dermal bone | Mesenchymal stem cell | Osteoprogenetor | Cranial | Neural crest | Osteoblastogenesis | Dermal bone | Osteoblast | Bone | DANIO-RERIO | DEVELOPMENTAL BIOLOGY | FAMILY | ELEMENTS | runx2/cbfa1/osf1/pebp2 alpha A | BONE-FORMATION | CBFA1 | SKELETAL DEVELOPMENT | CELLS | ANATOMY & MORPHOLOGY | ISOFORM | IDENTIFICATION | Biomarkers - metabolism | Bone Matrix - metabolism | Transcription Factors - metabolism | Animals | Zebrafish Proteins - metabolism | Zebrafish - metabolism | Body Patterning | Sp7 Transcription Factor | Osteoblasts - cytology | Osteoblasts - metabolism | Zebrafish - embryology | Cell Differentiation - physiology
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8. Full Text T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-kappa B
by Song, JL and Liu, HL and Zhu, Q and Miao, YT and Wang, FY and Yang, F and Cheng, WJ and Xi, YB and Niu, XY and He, DY and Chen, GJ
BIOMED RESEARCH INTERNATIONAL, ISSN 2314-6133, 2018, Volume 2018, pp. 4901591 - 8
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation has been identified as an important... 
MEDICINE, RESEARCH & EXPERIMENTAL | CONTROLLED-TRIAL | IN-VITRO | OSTERIX | IGURATIMOD THERAPY | BONE-FORMATION | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ACTIVE RHEUMATOID-ARTHRITIS | DOUBLE-BLIND | CLINICAL-USE | MESENCHYMAL STEM-CELLS | Cell culture | Alkaline phosphatase | Phosphorylation | Transcription factors | Collagen (type I) | Calcium | Mesenchyme | Differentiation (biology) | Activation | Arthritis | Research | Kinases | Phosphatase | Osteoblasts | Proteins | Bone growth | Bone marrow | Biocompatibility | Bone loss | NF-κB protein | Osteocalcin | Manufacturers | Inflammation | Cell differentiation | Gene expression | Osteoblastogenesis | Damage detection | Rheumatoid arthritis | Stem cells | Bone | Osteogenesis
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9. Full Text COX2 is involved in hypoxia-induced TNF-α expression in osteoblast
by Xing, Yonggang and Wang, Renxian and Chen, Dafu and Mao, Jianping and Shi, Rui and Wu, Zhihong and Kang, Jun and Tian, Wei and Zhang, Chi
Scientific Reports, ISSN 2045-2322, 06/2015, Volume 5, Issue 1, p. 10020
Bone regeneration involves a series of events in a coordinated manner, including recruitment of mesenchymal stem cells, induction of immune response,... 
ANGIOGENESIS | BONE-FORMATION | VEGF | MULTIDISCIPLINARY SCIENCES | DISEASE | OSTEOGENESIS | TRANSCRIPTIONAL REGULATION | SKELETAL DEVELOPMENT | FACTOR OSTERIX OSX | Cell Line | Cell Hypoxia - drug effects | Animals | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - metabolism | Gene Expression Regulation | Mice | Osteoblasts - cytology | Osteoblasts - metabolism | Tumor Necrosis Factor-alpha - biosynthesis
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10. Full Text Expression of osterix is regulated by FGF and Wnt/β-catenin signalling during osteoblast differentiation
by Felber, Katharina and Elks, Philip M and Lecca, Maria and Roehl, Henry H
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144982
Osteoblast differentiation from mesenchymal cells is regulated by multiple signalling pathways. Here we have analysed the roles of Fibroblast Growth Factor... 
RETINOIC ACID | BONE-FORMATION | TRANSCRIPTION FACTOR OSTERIX | MAP-KINASE | ALKALINE-PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | FIBROBLAST-GROWTH-FACTOR | MESENCHYMAL STEM-CELLS | ZEBRAFISH DEVELOPMENT | MESODERM INDUCTION | Osteogenesis - physiology | Zebrafish Proteins - biosynthesis | Fibroblast Growth Factors - genetics | Wnt Signaling Pathway - physiology | Transcription Factors - biosynthesis | Transcription Factors - genetics | beta Catenin - metabolism | Zebrafish - genetics | beta Catenin - genetics | Fibroblast Growth Factors - metabolism | Animals | Zebrafish - metabolism | Sp7 Transcription Factor | Osteoblasts - cytology | Zebrafish Proteins - genetics | Osteoblasts - metabolism | Cell Differentiation - physiology | Fibroblast growth factor | Transcription factors | Wnt protein | Mesenchyme | Transgenic | Kinases | β-catenin | Signal transduction | Bone growth | Biomedical materials | Pathways | Transcription activation | Bone marrow | Biocompatibility | Zebrafish | Gene expression | Embryos | Chemical interference | Studies | Signaling | Osteoblastogenesis | Mutation | Kinetics | Bone | Differentiation | Osteogenesis
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11. Full Text Tet-mediated DNA demethylation is required for SWI/SNF-dependent chromatin remodeling and histone-modifying activities that trigger expression of the Sp7 osteoblast master gene during mesenchymal lineage commitment
by Sepulveda, Hugo and Villagra, Alejandro and Montecino, Martin
Molecular and Cellular Biology, ISSN 0270-7306, 10/2017, Volume 37, Issue 20
Here we assess histone modification, chromatin remodeling, and DNA methylation processes that coordinately control the expression of the bone master... 
Tet enzymes | Epigenetics | DNA demethylation | Sp7 | Osteoblast differentiation | METHYLATION | MAMMALIAN DNA | BONE MORPHOGENETIC PROTEIN-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | epigenetics | CELL BIOLOGY | HUMAN GENOME | osteoblast differentiation | TRANSCRIPTION FACTOR OSTERIX | EMBRYONIC STEM-CELLS | COMPASS FAMILY | RIC-8B GENE | DIFFERENTIATION | UP-REGULATION | Chromatin - metabolism | Transcriptional Activation - genetics | Chromosomal Proteins, Non-Histone - metabolism | Gene Expression Regulation - genetics | Epigenesis, Genetic | Humans | Chromatin Assembly and Disassembly - genetics | DNA - metabolism | Transcription Factors - metabolism | Cell Differentiation - genetics | Cell Lineage | DNA Methylation | Sp7 Transcription Factor | Histones - metabolism | Osteoblasts - metabolism
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12. Full Text Nanometer-scale features on micrometer-scale surface texturing: A bone histological, gene expression, and nanomechanical study
by Coelho, Paulo G and Takayama, Tadahiro and Yoo, Daniel and Jimbo, Ryo and Karunagaran, Sanjay and Tovar, Nick and Janal, Malvin N and Yamano, Seiichi and Malmö University and Faculty of Odontology
Bone, ISSN 8756-3282, 2014, Volume 65, pp. 25 - 32
Abstract Micro- and nanoscale surface modifications have been the focus of multiple studies in the pursuit of accelerating bone apposition or osseointegration... 
Orthopedics | Nanotopography | Osseointegration | Gene expression | Nanomechanics | OSTERIX | OSTEOBLAST DIFFERENTIATION | DEPOSITION | KNOWLEDGE | HYDROXYAPATITE-COATED IMPLANTS | ROUGHNESS | CALCIUM-PHOSPHATE | MINERALIZATION | ENDOCRINOLOGY & METABOLISM | ROOT FORM IMPLANTS | Gene Expression | Microscopy, Electron, Scanning | Bone and Bones - physiology | Rats | Male | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Biomechanical Phenomena | Animals | Base Sequence | Bone and Bones - metabolism | Surface Properties | Bone and Bones - ultrastructure | Genetic research | Hardness | Collagen | Analysis | Genes | MEDICINE | MEDICIN
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13. Full Text BMP-2 Induces Osterix Expression through Up-regulation of Dlx5 and Its Phosphorylation by p38
by Arnau Ulsamer and Ma. José Ortuño and Silvia Ruiz and Antonio R. G. Susperregui and Nelson Osses and José Luis Rosa and Francesc Ventura
Journal of Biological Chemistry, ISSN 0021-9258, 02/2008, Volume 283, Issue 7, pp. 3816 - 3826
Osterix, a zinc-finger transcription factor, is specifically expressed in osteoblasts and osteocytes of all developing bones. Because no bone formation occurs... 
PRX1 HOMEOBOX GENE | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | OSTEOBLAST DIFFERENTIATION |