Biomaterials, ISSN 0142-9612, 04/2018, Volume 162, pp. 123 - 131
Starvation therapy to slow down the tumor growth by cutting off its energy supply has been proposed to be an alternative therapeutic strategy for cancer...
Liposome | Glucose oxidase | Starvation therapy | AQ4N | Tumor hypoxia-activated therapy | MATERIALS SCIENCE, BIOMATERIALS | PHOTODYNAMIC THERAPY | ENGINEERING, BIOMEDICAL | CELL METABOLISM | AGENT | NANOPARTICLES | PRODRUGS | IN-VIVO | RESISTANCE | RADIOTHERAPY | OVERCOME TUMOR HYPOXIA
Liposome | Glucose oxidase | Starvation therapy | AQ4N | Tumor hypoxia-activated therapy | MATERIALS SCIENCE, BIOMATERIALS | PHOTODYNAMIC THERAPY | ENGINEERING, BIOMEDICAL | CELL METABOLISM | AGENT | NANOPARTICLES | PRODRUGS | IN-VIVO | RESISTANCE | RADIOTHERAPY | OVERCOME TUMOR HYPOXIA
Journal Article
Advanced Materials, ISSN 0935-9648, 04/2016, Volume 28, Issue 14, pp. 2716 - 2723
Hollow Bi2Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising...
overcome tumor hypoxia | enhanced radiation therapy | oxygen carries | hollow structures | cation exchange | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | CATION-EXCHANGE | SHELL | PHOTODYNAMIC THERAPY | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOCRYSTALS | NANOMATERIALS | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | PHOTOTHERMAL ABLATION | HYPOXIA | CHEMISTRY, MULTIDISCIPLINARY | RADIATION-THERAPY | NANOTHERANOSTICS | DNA Damage - drug effects | Fluorocarbons - chemistry | Cell Survival - drug effects | Microscopy, Electron, Transmission | Metal Nanoparticles - chemistry | Polyethylene Glycols - chemistry | Cell Survival - radiation effects | Organoselenium Compounds - chemistry | Oxygen - metabolism | Transplantation, Homologous | Neoplasms - drug therapy | Bismuth - chemistry | Metal Nanoparticles - toxicity | Animals | Infrared Rays | Oxygen - chemistry | Cell Line, Tumor | Neoplasms - radiotherapy | Mice | Neoplasms - pathology | DNA Damage - radiation effects | Metal Nanoparticles - ultrastructure | Radiotherapy | Perfluorocarbons | Cancer
overcome tumor hypoxia | enhanced radiation therapy | oxygen carries | hollow structures | cation exchange | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | CATION-EXCHANGE | SHELL | PHOTODYNAMIC THERAPY | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOCRYSTALS | NANOMATERIALS | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | PHOTOTHERMAL ABLATION | HYPOXIA | CHEMISTRY, MULTIDISCIPLINARY | RADIATION-THERAPY | NANOTHERANOSTICS | DNA Damage - drug effects | Fluorocarbons - chemistry | Cell Survival - drug effects | Microscopy, Electron, Transmission | Metal Nanoparticles - chemistry | Polyethylene Glycols - chemistry | Cell Survival - radiation effects | Organoselenium Compounds - chemistry | Oxygen - metabolism | Transplantation, Homologous | Neoplasms - drug therapy | Bismuth - chemistry | Metal Nanoparticles - toxicity | Animals | Infrared Rays | Oxygen - chemistry | Cell Line, Tumor | Neoplasms - radiotherapy | Mice | Neoplasms - pathology | DNA Damage - radiation effects | Metal Nanoparticles - ultrastructure | Radiotherapy | Perfluorocarbons | Cancer
Journal Article
Advanced Functional Materials, ISSN 1616-301X, 03/2019, Volume 29, Issue 10, pp. 1806708 - n/a
Oxygen plays an essential role in the photodynamic therapy (PDT) of cancer. However, hypoxia inside tumors severely attenuates the therapeutic effect of PDT....
hypoxia | atovaquone | oxygen consumption rate | photodynamic therapy | verteporfin | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | TUMOR HYPOXIA | STABILITY | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CANCER | CHEMISTRY, MULTIDISCIPLINARY | OVERCOME | DELIVERY | PEG | SINGLET OXYGEN | LIMITATION | Nanoparticles | Verteporfin | Photochemotherapy | Cancer | Mitochondria | Drug delivery systems | Photodynamic therapy | Oxygen consumption | Hypoxia | In vivo methods and tests | Oxygen content | Tumors | Anticancer properties
hypoxia | atovaquone | oxygen consumption rate | photodynamic therapy | verteporfin | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | TUMOR HYPOXIA | STABILITY | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CANCER | CHEMISTRY, MULTIDISCIPLINARY | OVERCOME | DELIVERY | PEG | SINGLET OXYGEN | LIMITATION | Nanoparticles | Verteporfin | Photochemotherapy | Cancer | Mitochondria | Drug delivery systems | Photodynamic therapy | Oxygen consumption | Hypoxia | In vivo methods and tests | Oxygen content | Tumors | Anticancer properties
Journal Article
Biomaterials Science, ISSN 2047-4830, 07/2019, Volume 7, Issue 7, pp. 2740 - 2748
The tumor hypoxic microenvironment (THME) has a profound impact on tumor progression, and modulation of the THME has become an essential strategy to promote...
GOLD NANOPARTICLES | PEROXIDASE | MATERIALS SCIENCE, BIOMATERIALS | METAL-ORGANIC-FRAMEWORK | CISPLATIN | OXIDASE | RESISTANCE | CATALYST | OVERCOME TUMOR HYPOXIA | CANCER | DELIVERY
GOLD NANOPARTICLES | PEROXIDASE | MATERIALS SCIENCE, BIOMATERIALS | METAL-ORGANIC-FRAMEWORK | CISPLATIN | OXIDASE | RESISTANCE | CATALYST | OVERCOME TUMOR HYPOXIA | CANCER | DELIVERY
Journal Article
Advanced Materials, ISSN 0935-9648, 04/2016, Volume 28, Issue 14, pp. 2654 - 2654
Hollow Bi2Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With those nanoparticles, a new concept...
overcome tumor hypoxia | enhanced radiation therapy | oxygen carries | hollow structures | cation exchange | Antimitotic agents | Perfluorocarbons | Care and treatment | Radiotherapy | Antineoplastic agents | Health aspects | Cancer
overcome tumor hypoxia | enhanced radiation therapy | oxygen carries | hollow structures | cation exchange | Antimitotic agents | Perfluorocarbons | Care and treatment | Radiotherapy | Antineoplastic agents | Health aspects | Cancer
Journal Article
Drug Delivery, ISSN 1071-7544, 01/2017, Volume 24, Issue 1, pp. 1419 - 1428
Paclitaxel (PTX) is widely used as a radiosensitizer in the clinical treatment of cancer. However, the efficacy of chemoradiotherapy is limited by the...
paclitaxel | hypoxia | liposomes | Chemoradiotherapy | perfluorotributylamine | PERFLUOROCARBON | CANCER-THERAPY | RADIATION-THERAPY | DELIVERY | OXYGEN | NANOPARTICLES | RESISTANCE | PHARMACOLOGY & PHARMACY | ALBUMIN | OVERCOME TUMOR HYPOXIA | EMULSIONS | Fluorocarbons - chemistry | Paclitaxel - chemistry | Liposomes | Humans | Hypoxia | Cell cycle | Radiation therapy
paclitaxel | hypoxia | liposomes | Chemoradiotherapy | perfluorotributylamine | PERFLUOROCARBON | CANCER-THERAPY | RADIATION-THERAPY | DELIVERY | OXYGEN | NANOPARTICLES | RESISTANCE | PHARMACOLOGY & PHARMACY | ALBUMIN | OVERCOME TUMOR HYPOXIA | EMULSIONS | Fluorocarbons - chemistry | Paclitaxel - chemistry | Liposomes | Humans | Hypoxia | Cell cycle | Radiation therapy
Journal Article
ACS Biomaterials Science & Engineering, ISSN 2373-9878, 03/2018, Volume 4, Issue 3, pp. 1083 - 1091
Imaging-guided diagnosis and therapy has been highlighted in the area of nanomedicines. However, integrating multiple functions with high performance in one...
GOLD NANOPARTICLES | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | LIGHT | NANORODS | COMBINATION | Au-PLGA hybrid nanoparticles | catalase-mimicking activity chemo/photothermal therapy | PEROXIDASE | photoacoustic imaging | NANOSHELLS | IN-VIVO | OVERCOME TUMOR HYPOXIA | LIPOSOMES
GOLD NANOPARTICLES | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | LIGHT | NANORODS | COMBINATION | Au-PLGA hybrid nanoparticles | catalase-mimicking activity chemo/photothermal therapy | PEROXIDASE | photoacoustic imaging | NANOSHELLS | IN-VIVO | OVERCOME TUMOR HYPOXIA | LIPOSOMES
Journal Article
International journal of nanomedicine, ISSN 1176-9114, 2018, Volume 13, pp. 5925 - 5936
Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials - aimed at enhancing the...
hypoxia-inducible factor 1 | radiotherapy | hypoxia | nanomaterials | GOLD NANOPARTICLES | OXYGEN DELIVERY | POSTOPERATIVE CHEMORADIOTHERAPY | MULTIFUNCTIONAL NANOTHERANOSTICS | NANOSCIENCE & NANOTECHNOLOGY | BREAST-CANCER CELLS | RECTAL-CANCER | inducible factor 1 | CLINICAL-APPLICATIONS | IN-VIVO | PHARMACOLOGY & PHARMACY | OVERCOME TUMOR HYPOXIA | DRUG-DELIVERY SYSTEMS | Drugs | Ionizing radiation | Drug delivery systems | Radiotherapy | Perflubron | Vehicles | Tumors | Perfluorocarbons | Free radicals | Medical imaging | Laboratories | Brain cancer | Nanomaterials | Metastasis | Radiation therapy | Cancer therapies | Nanoparticles | Chemotherapy | X rays | Polyethylene glycol | Hypoxia | Deoxyribonucleic acid--DNA | nanoparticle | clinical translation
hypoxia-inducible factor 1 | radiotherapy | hypoxia | nanomaterials | GOLD NANOPARTICLES | OXYGEN DELIVERY | POSTOPERATIVE CHEMORADIOTHERAPY | MULTIFUNCTIONAL NANOTHERANOSTICS | NANOSCIENCE & NANOTECHNOLOGY | BREAST-CANCER CELLS | RECTAL-CANCER | inducible factor 1 | CLINICAL-APPLICATIONS | IN-VIVO | PHARMACOLOGY & PHARMACY | OVERCOME TUMOR HYPOXIA | DRUG-DELIVERY SYSTEMS | Drugs | Ionizing radiation | Drug delivery systems | Radiotherapy | Perflubron | Vehicles | Tumors | Perfluorocarbons | Free radicals | Medical imaging | Laboratories | Brain cancer | Nanomaterials | Metastasis | Radiation therapy | Cancer therapies | Nanoparticles | Chemotherapy | X rays | Polyethylene glycol | Hypoxia | Deoxyribonucleic acid--DNA | nanoparticle | clinical translation
Journal Article
The AAPS Journal, ISSN 1550-7416, 7/2015, Volume 17, Issue 4, pp. 813 - 827
With the advent of novel and personalized therapeutic approaches for cancer and inflammatory diseases, there is a growing demand for designing delivery systems...
Biochemistry, general | Biotechnology | hypoxia | multidrug resistance | Biomedicine | targeted biological therapies | Pharmacy | inflammatory disease | macrophage repolarization | Pharmacology/Toxicology | aerobic glycolysis | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | GENE DELIVERY | DRUG-DELIVERY | OVERCOME MULTIDRUG-RESISTANCE | BOWEL-DISEASE | HUMAN PROSTATE-CANCER | SMALL INTERFERING RNA | PHARMACOLOGY & PHARMACY | MACROPHAGE POLARIZATION | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Anti-Inflammatory Agents - pharmacology | Humans | Translational Medical Research | Tumor Microenvironment | Antineoplastic Agents - administration & dosage | Drug Delivery Systems | Neoplasms - drug therapy | Nanoparticles | Macrophages - metabolism | Animals | Inflammation - drug therapy | Anti-Inflammatory Agents - administration & dosage | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Drugs | Glucose metabolism | Chemotherapy | Drugstores | Drug therapy | Drug resistance | Health aspects | Cancer
Biochemistry, general | Biotechnology | hypoxia | multidrug resistance | Biomedicine | targeted biological therapies | Pharmacy | inflammatory disease | macrophage repolarization | Pharmacology/Toxicology | aerobic glycolysis | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | GENE DELIVERY | DRUG-DELIVERY | OVERCOME MULTIDRUG-RESISTANCE | BOWEL-DISEASE | HUMAN PROSTATE-CANCER | SMALL INTERFERING RNA | PHARMACOLOGY & PHARMACY | MACROPHAGE POLARIZATION | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Anti-Inflammatory Agents - pharmacology | Humans | Translational Medical Research | Tumor Microenvironment | Antineoplastic Agents - administration & dosage | Drug Delivery Systems | Neoplasms - drug therapy | Nanoparticles | Macrophages - metabolism | Animals | Inflammation - drug therapy | Anti-Inflammatory Agents - administration & dosage | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Drugs | Glucose metabolism | Chemotherapy | Drugstores | Drug therapy | Drug resistance | Health aspects | Cancer
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 06/2015, Volume 93, pp. 27 - 36
At present, the treatment of hepatocellular carcinoma (HCC) is an international problem. The delivery of a chemotherapeutic agent and chemosensitizer using...
Co-delivery lipid nanoparticles | Multidrug resistance | Tumor growth inhibition | Hepatocellular carcinoma | Curcumin | Synergistic effect | Doxorubicin | MOLECULAR-MECHANISM | CANCER-CELLS | THERAPEUTICS | APOPTOSIS | OVERCOME MULTIDRUG-RESISTANCE | DRUG-RESISTANCE | HYPOXIA | CHEMOTHERAPY | HEPATOCARCINOGENESIS | PHARMACOLOGY & PHARMACY | CHEMORESISTANCE | Carcinoma, Hepatocellular - chemically induced | Apoptosis - drug effects | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms, Experimental - chemically induced | Neovascularization, Pathologic | Drug Resistance, Neoplasm | Male | Doxorubicin - chemistry | Curcumin - administration & dosage | Drug Carriers | Dose-Response Relationship, Drug | Nanoparticles | Liver Neoplasms, Experimental - metabolism | Antineoplastic Agents, Phytogenic - administration & dosage | Lipids - chemistry | Carcinoma, Hepatocellular - drug therapy | Antibiotics, Antineoplastic - chemistry | Time Factors | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine | Biomarkers, Tumor - metabolism | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Nanomedicine | Doxorubicin - administration & dosage | Solubility | Antineoplastic Agents, Phytogenic - chemistry | Technology, Pharmaceutical - methods | Chemistry, Pharmaceutical | Antibiotics, Antineoplastic - administration & dosage | Drug Synergism | Particle Size | Animals | Liver Neoplasms, Experimental - drug therapy | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Delayed-Action Preparations | Drug Combinations | Carcinoma, Hepatocellular - metabolism | Anthracyclines
Co-delivery lipid nanoparticles | Multidrug resistance | Tumor growth inhibition | Hepatocellular carcinoma | Curcumin | Synergistic effect | Doxorubicin | MOLECULAR-MECHANISM | CANCER-CELLS | THERAPEUTICS | APOPTOSIS | OVERCOME MULTIDRUG-RESISTANCE | DRUG-RESISTANCE | HYPOXIA | CHEMOTHERAPY | HEPATOCARCINOGENESIS | PHARMACOLOGY & PHARMACY | CHEMORESISTANCE | Carcinoma, Hepatocellular - chemically induced | Apoptosis - drug effects | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms, Experimental - chemically induced | Neovascularization, Pathologic | Drug Resistance, Neoplasm | Male | Doxorubicin - chemistry | Curcumin - administration & dosage | Drug Carriers | Dose-Response Relationship, Drug | Nanoparticles | Liver Neoplasms, Experimental - metabolism | Antineoplastic Agents, Phytogenic - administration & dosage | Lipids - chemistry | Carcinoma, Hepatocellular - drug therapy | Antibiotics, Antineoplastic - chemistry | Time Factors | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine | Biomarkers, Tumor - metabolism | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Nanomedicine | Doxorubicin - administration & dosage | Solubility | Antineoplastic Agents, Phytogenic - chemistry | Technology, Pharmaceutical - methods | Chemistry, Pharmaceutical | Antibiotics, Antineoplastic - administration & dosage | Drug Synergism | Particle Size | Animals | Liver Neoplasms, Experimental - drug therapy | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Delayed-Action Preparations | Drug Combinations | Carcinoma, Hepatocellular - metabolism | Anthracyclines
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 11/2018, Volume 121, pp. 156 - 165
Dauricine (Dau) is a natural alkaloid exhibiting anti-proliferative activity against several different types of malignant cell. However, effects of Dau on...
MiR-199a | Chemosensitivity | Glycolysis | Hepatocellular carcinoma | Dauricine | APOPTOSIS | HEXOKINASE 2 | FOOD SCIENCE & TECHNOLOGY | PROLIFERATION | OVERCOMES SORAFENIB RESISTANCE | HYPOXIA | SUPPRESSION | CANCER STEM-CELLS | IN-VITRO | METABOLISM | LIVER | TOXICOLOGY | Tetrahydroisoquinolines - pharmacology | Aerobiosis | Liver Neoplasms - genetics | Humans | Liver Neoplasms - drug therapy | Oxidative Phosphorylation | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Glycolysis - drug effects | Kinesin - metabolism | Up-Regulation - drug effects | Animals | Carcinoma, Hepatocellular - drug therapy | Carrier Proteins - metabolism | Mice, Nude | Thyroid Hormones - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - metabolism | Cell Line, Tumor | Membrane Proteins - metabolism | Mice | Benzylisoquinolines - pharmacology | Carcinoma, Hepatocellular - metabolism | Drug Resistance, Neoplasm - drug effects | Glucose metabolism | Chemotherapy | Chemical tests and reagents | Analysis | Hepatoma | Glucose | Dextrose | Cancer
MiR-199a | Chemosensitivity | Glycolysis | Hepatocellular carcinoma | Dauricine | APOPTOSIS | HEXOKINASE 2 | FOOD SCIENCE & TECHNOLOGY | PROLIFERATION | OVERCOMES SORAFENIB RESISTANCE | HYPOXIA | SUPPRESSION | CANCER STEM-CELLS | IN-VITRO | METABOLISM | LIVER | TOXICOLOGY | Tetrahydroisoquinolines - pharmacology | Aerobiosis | Liver Neoplasms - genetics | Humans | Liver Neoplasms - drug therapy | Oxidative Phosphorylation | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Glycolysis - drug effects | Kinesin - metabolism | Up-Regulation - drug effects | Animals | Carcinoma, Hepatocellular - drug therapy | Carrier Proteins - metabolism | Mice, Nude | Thyroid Hormones - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - metabolism | Cell Line, Tumor | Membrane Proteins - metabolism | Mice | Benzylisoquinolines - pharmacology | Carcinoma, Hepatocellular - metabolism | Drug Resistance, Neoplasm - drug effects | Glucose metabolism | Chemotherapy | Chemical tests and reagents | Analysis | Hepatoma | Glucose | Dextrose | Cancer
Journal Article
ACS APPLIED MATERIALS & INTERFACES, ISSN 1944-8244, 08/2019, Volume 11, Issue 33, pp. 29579 - 29592
Tumor hypoxia and the short half-life of reactive oxygen species (ROS) with small diffusion distance have greatly limited the therapeutic effect of...
photodynamic therapy | MEMBRANE | MATERIALS SCIENCE, MULTIDISCIPLINARY | MITOCHONDRIA | NANOSCIENCE & NANOTECHNOLOGY | MECHANISMS | COMBINED CHEMOTHERAPY | MICROBUBBLES | COMBINATION | OVERCOME | DELIVERY | magnetic resonance imaging nanoparticle | RESISTANCE | Fenton reaction | EFFICIENT | mitochondrial targeting
photodynamic therapy | MEMBRANE | MATERIALS SCIENCE, MULTIDISCIPLINARY | MITOCHONDRIA | NANOSCIENCE & NANOTECHNOLOGY | MECHANISMS | COMBINED CHEMOTHERAPY | MICROBUBBLES | COMBINATION | OVERCOME | DELIVERY | magnetic resonance imaging nanoparticle | RESISTANCE | Fenton reaction | EFFICIENT | mitochondrial targeting
Journal Article
NANOMATERIALS, ISSN 2079-4991, 06/2019, Volume 9, Issue 6, p. 821
Nanoemulsions are pharmaceutical formulations composed of particles within a nanometer range. They possess the capacity to encapsulate drugs that are poorly...
GOLD NANOPARTICLES | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | targeted delivery | OVERCOME MULTIDRUG-RESISTANCE | NANOSCIENCE & NANOTECHNOLOGY | SOLID LIPID NANOPARTICLES | BREAST-CANCER | LUNG-CANCER | ANTICANCER ACTIVITY | IN-VITRO | cancer | INORGANIC NANOPARTICLES | multifunctional nanoemulsions | Drugs | Drug delivery systems | Toxicity | Lipids | Metastasis | Hydrophobicity | Cancer therapies | Cell surface | Nanoparticles | Vascular endothelial growth factor | Pharmaceutical sciences | Formulations | Antigens | Tumor cells | Multidrug resistance | Organs | Solubility | Nanoemulsions | Permeability | Pharmacy | Hypoxia | Charged particles | Prostate | Cell migration | Cancer | Tumors | Càncer | Nanopartícules | Experimental pharmacology | Sistemes d'alliberament de medicaments | Farmacologia experimental
GOLD NANOPARTICLES | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | targeted delivery | OVERCOME MULTIDRUG-RESISTANCE | NANOSCIENCE & NANOTECHNOLOGY | SOLID LIPID NANOPARTICLES | BREAST-CANCER | LUNG-CANCER | ANTICANCER ACTIVITY | IN-VITRO | cancer | INORGANIC NANOPARTICLES | multifunctional nanoemulsions | Drugs | Drug delivery systems | Toxicity | Lipids | Metastasis | Hydrophobicity | Cancer therapies | Cell surface | Nanoparticles | Vascular endothelial growth factor | Pharmaceutical sciences | Formulations | Antigens | Tumor cells | Multidrug resistance | Organs | Solubility | Nanoemulsions | Permeability | Pharmacy | Hypoxia | Charged particles | Prostate | Cell migration | Cancer | Tumors | Càncer | Nanopartícules | Experimental pharmacology | Sistemes d'alliberament de medicaments | Farmacologia experimental
Journal Article
British Journal of Haematology, ISSN 0007-1048, 02/2011, Volume 152, Issue 4, pp. 420 - 432
Summary Cell cycle regulators, such as cyclin‐dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased...
microenvironment | kinase inhibitor | cancer | myeloma | cyclin‐dependent kinases | Microenvironment | Myeloma | Kinase inhibitor | Cyclin-dependent kinases | Cancer | APOPTOSIS | REFRACTORY MULTIPLE-MYELOMA | SELICICLIB CYC202 | PLASMA-CELL | LENALIDOMIDE PLUS DEXAMETHASONE | DOWN-REGULATION | OVERCOMES DRUG-RESISTANCE | CDK INHIBITOR | R-ROSCOVITINE | cyclin-dependent kinases | HEMATOLOGY | TRANSCRIPTIONAL REGULATION | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Coculture Techniques | Humans | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Dose-Response Relationship, Drug | Multiple Myeloma - drug therapy | Drug Interactions | Transcription, Genetic | Antineoplastic Agents - pharmacology | Cyclin-Dependent Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Multiple Myeloma - enzymology | Cell Survival - drug effects | Bortezomib | Treatment Outcome | Down-Regulation - drug effects | Multiple Myeloma - pathology | Signal Transduction - drug effects | Survival Analysis | Cytokines - antagonists & inhibitors | Cell Cycle - drug effects | Stromal Cells - physiology | Cytokines - pharmacology | Drug Combinations | Multiple Myeloma - genetics | Drug Screening Assays, Antitumor | Medical colleges | Cell death | Oncology, Experimental | Multiple myeloma | Stem cells | Research | DNA binding proteins | Drug resistance | Phosphotransferases | Tumors | Transcription factors | Cell survival | Cytokines | Complications | Hypoxia-inducible factor 1 alpha | Stroma | Myc protein | Cyclin-dependent kinase 5 | Cyclin-dependent kinase | Cyclin-dependent kinase 2 | Interferon regulatory factor 4 | Cell cycle | Bone marrow | Tumorigenesis | Apoptosis
microenvironment | kinase inhibitor | cancer | myeloma | cyclin‐dependent kinases | Microenvironment | Myeloma | Kinase inhibitor | Cyclin-dependent kinases | Cancer | APOPTOSIS | REFRACTORY MULTIPLE-MYELOMA | SELICICLIB CYC202 | PLASMA-CELL | LENALIDOMIDE PLUS DEXAMETHASONE | DOWN-REGULATION | OVERCOMES DRUG-RESISTANCE | CDK INHIBITOR | R-ROSCOVITINE | cyclin-dependent kinases | HEMATOLOGY | TRANSCRIPTIONAL REGULATION | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Coculture Techniques | Humans | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Dose-Response Relationship, Drug | Multiple Myeloma - drug therapy | Drug Interactions | Transcription, Genetic | Antineoplastic Agents - pharmacology | Cyclin-Dependent Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Multiple Myeloma - enzymology | Cell Survival - drug effects | Bortezomib | Treatment Outcome | Down-Regulation - drug effects | Multiple Myeloma - pathology | Signal Transduction - drug effects | Survival Analysis | Cytokines - antagonists & inhibitors | Cell Cycle - drug effects | Stromal Cells - physiology | Cytokines - pharmacology | Drug Combinations | Multiple Myeloma - genetics | Drug Screening Assays, Antitumor | Medical colleges | Cell death | Oncology, Experimental | Multiple myeloma | Stem cells | Research | DNA binding proteins | Drug resistance | Phosphotransferases | Tumors | Transcription factors | Cell survival | Cytokines | Complications | Hypoxia-inducible factor 1 alpha | Stroma | Myc protein | Cyclin-dependent kinase 5 | Cyclin-dependent kinase | Cyclin-dependent kinase 2 | Interferon regulatory factor 4 | Cell cycle | Bone marrow | Tumorigenesis | Apoptosis
Journal Article
JOURNAL OF RADIATION RESEARCH, ISSN 0449-3060, 2000, Volume 41, Issue 3, pp. 201 - 212
Studies have shown that reduced oxygen tension (hypoxia) in solid tumours adversely affects the outcome of radiotherapy. Despite being an independent...
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 12/2011, Volume 18, Issue 34, pp. 5185 - 5195
Survival of patients affected by Multiple Myeloma (MM), a B-cell tumor of malignant plasma cells, has dramatically improved, owing to the recent introduction...
Immunomodulatory drugs | Angiogenesis | Bone marrow microenvironment | Hypoxia | Anti-angiogenic therapies | Proteasome inhibitors | Multiple Myeloma | PROGENITOR CELLS | hypoxia | CHEMISTRY, MEDICINAL | angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA T-CELLS | OVERCOMES DRUG-RESISTANCE | Bone Marrow microenvironment | MICROVESSEL DENSITY | BONE-MARROW ANGIOGENESIS | UNFOLDED PROTEIN RESPONSE | anti-angiogenic therapies | CLASS-I | UNDETERMINED SIGNIFICANCE | PHARMACOLOGY & PHARMACY | MONOCLONAL GAMMOPATHY | Proteasome Inhibitors | ENDOTHELIAL GROWTH-FACTOR | Multiple Myeloma - drug therapy | Animals | Neovascularization, Pathologic - drug therapy | Humans | Angiogenesis Inhibitors - therapeutic use | Multiple Myeloma - immunology | Multiple Myeloma - blood supply | Multiple Myeloma - enzymology | Enzyme Inhibitors - therapeutic use | Immunologic Factors - therapeutic use | Neovascularization, Pathologic - pathology
Immunomodulatory drugs | Angiogenesis | Bone marrow microenvironment | Hypoxia | Anti-angiogenic therapies | Proteasome inhibitors | Multiple Myeloma | PROGENITOR CELLS | hypoxia | CHEMISTRY, MEDICINAL | angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA T-CELLS | OVERCOMES DRUG-RESISTANCE | Bone Marrow microenvironment | MICROVESSEL DENSITY | BONE-MARROW ANGIOGENESIS | UNFOLDED PROTEIN RESPONSE | anti-angiogenic therapies | CLASS-I | UNDETERMINED SIGNIFICANCE | PHARMACOLOGY & PHARMACY | MONOCLONAL GAMMOPATHY | Proteasome Inhibitors | ENDOTHELIAL GROWTH-FACTOR | Multiple Myeloma - drug therapy | Animals | Neovascularization, Pathologic - drug therapy | Humans | Angiogenesis Inhibitors - therapeutic use | Multiple Myeloma - immunology | Multiple Myeloma - blood supply | Multiple Myeloma - enzymology | Enzyme Inhibitors - therapeutic use | Immunologic Factors - therapeutic use | Neovascularization, Pathologic - pathology
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 12/2019, Volume 314, p. 108822
Aldehyde dehydrogenase (ALDH) activity is not only a valuable marker for cancer cells with stem-like features, but also plays a vital role in drug resistance...
ALDH1A3 | GSEA | Melanoma patient prognosis | BRAF/MEK inhibitor response | ALDH1A1 | DNA METHYLATION | ALDEHYDE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BRAF | MECHANISMS | OVERCOME | CANCER STEM-CELLS | INTERFERON-ALPHA | PATHWAY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROGNOSTIC-SIGNIFICANCE
ALDH1A3 | GSEA | Melanoma patient prognosis | BRAF/MEK inhibitor response | ALDH1A1 | DNA METHYLATION | ALDEHYDE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BRAF | MECHANISMS | OVERCOME | CANCER STEM-CELLS | INTERFERON-ALPHA | PATHWAY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROGNOSTIC-SIGNIFICANCE
Journal Article