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Biomaterials, ISSN 0142-9612, 04/2018, Volume 162, pp. 123 - 131
Starvation therapy to slow down the tumor growth by cutting off its energy supply has been proposed to be an alternative therapeutic strategy for cancer... 
Liposome | Glucose oxidase | Starvation therapy | AQ4N | Tumor hypoxia-activated therapy | MATERIALS SCIENCE, BIOMATERIALS | PHOTODYNAMIC THERAPY | ENGINEERING, BIOMEDICAL | CELL METABOLISM | AGENT | NANOPARTICLES | PRODRUGS | IN-VIVO | RESISTANCE | RADIOTHERAPY | OVERCOME TUMOR HYPOXIA
Journal Article
Journal Article
Biomaterials Science, ISSN 2047-4830, 07/2019, Volume 7, Issue 7, pp. 2740 - 2748
The tumor hypoxic microenvironment (THME) has a profound impact on tumor progression, and modulation of the THME has become an essential strategy to promote... 
GOLD NANOPARTICLES | PEROXIDASE | MATERIALS SCIENCE, BIOMATERIALS | METAL-ORGANIC-FRAMEWORK | CISPLATIN | OXIDASE | RESISTANCE | CATALYST | OVERCOME TUMOR HYPOXIA | CANCER | DELIVERY
Journal Article
Advanced Materials, ISSN 0935-9648, 04/2016, Volume 28, Issue 14, pp. 2654 - 2654
Hollow Bi2Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With those nanoparticles, a new concept... 
overcome tumor hypoxia | enhanced radiation therapy | oxygen carries | hollow structures | cation exchange | Antimitotic agents | Perfluorocarbons | Care and treatment | Radiotherapy | Antineoplastic agents | Health aspects | Cancer
Journal Article
Drug Delivery, ISSN 1071-7544, 01/2017, Volume 24, Issue 1, pp. 1419 - 1428
Paclitaxel (PTX) is widely used as a radiosensitizer in the clinical treatment of cancer. However, the efficacy of chemoradiotherapy is limited by the... 
paclitaxel | hypoxia | liposomes | Chemoradiotherapy | perfluorotributylamine | PERFLUOROCARBON | CANCER-THERAPY | RADIATION-THERAPY | DELIVERY | OXYGEN | NANOPARTICLES | RESISTANCE | PHARMACOLOGY & PHARMACY | ALBUMIN | OVERCOME TUMOR HYPOXIA | EMULSIONS | Fluorocarbons - chemistry | Paclitaxel - chemistry | Liposomes | Humans | Hypoxia | Cell cycle | Radiation therapy
Journal Article
ACS Biomaterials Science & Engineering, ISSN 2373-9878, 03/2018, Volume 4, Issue 3, pp. 1083 - 1091
Imaging-guided diagnosis and therapy has been highlighted in the area of nanomedicines. However, integrating multiple functions with high performance in one... 
GOLD NANOPARTICLES | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | LIGHT | NANORODS | COMBINATION | Au-PLGA hybrid nanoparticles | catalase-mimicking activity chemo/photothermal therapy | PEROXIDASE | photoacoustic imaging | NANOSHELLS | IN-VIVO | OVERCOME TUMOR HYPOXIA | LIPOSOMES
Journal Article
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 06/2015, Volume 93, pp. 27 - 36
At present, the treatment of hepatocellular carcinoma (HCC) is an international problem. The delivery of a chemotherapeutic agent and chemosensitizer using... 
Co-delivery lipid nanoparticles | Multidrug resistance | Tumor growth inhibition | Hepatocellular carcinoma | Curcumin | Synergistic effect | Doxorubicin | MOLECULAR-MECHANISM | CANCER-CELLS | THERAPEUTICS | APOPTOSIS | OVERCOME MULTIDRUG-RESISTANCE | DRUG-RESISTANCE | HYPOXIA | CHEMOTHERAPY | HEPATOCARCINOGENESIS | PHARMACOLOGY & PHARMACY | CHEMORESISTANCE | Carcinoma, Hepatocellular - chemically induced | Apoptosis - drug effects | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms, Experimental - chemically induced | Neovascularization, Pathologic | Drug Resistance, Neoplasm | Male | Doxorubicin - chemistry | Curcumin - administration & dosage | Drug Carriers | Dose-Response Relationship, Drug | Nanoparticles | Liver Neoplasms, Experimental - metabolism | Antineoplastic Agents, Phytogenic - administration & dosage | Lipids - chemistry | Carcinoma, Hepatocellular - drug therapy | Antibiotics, Antineoplastic - chemistry | Time Factors | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine | Biomarkers, Tumor - metabolism | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Nanomedicine | Doxorubicin - administration & dosage | Solubility | Antineoplastic Agents, Phytogenic - chemistry | Technology, Pharmaceutical - methods | Chemistry, Pharmaceutical | Antibiotics, Antineoplastic - administration & dosage | Drug Synergism | Particle Size | Animals | Liver Neoplasms, Experimental - drug therapy | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Delayed-Action Preparations | Drug Combinations | Carcinoma, Hepatocellular - metabolism | Anthracyclines
Journal Article
Journal Article
by Hou, HB and Huang, XH and Wei, GQ and Xu, FN and Wang, Y and Zhou, SB
ACS APPLIED MATERIALS & INTERFACES, ISSN 1944-8244, 08/2019, Volume 11, Issue 33, pp. 29579 - 29592
Tumor hypoxia and the short half-life of reactive oxygen species (ROS) with small diffusion distance have greatly limited the therapeutic effect of... 
photodynamic therapy | MEMBRANE | MATERIALS SCIENCE, MULTIDISCIPLINARY | MITOCHONDRIA | NANOSCIENCE & NANOTECHNOLOGY | MECHANISMS | COMBINED CHEMOTHERAPY | MICROBUBBLES | COMBINATION | OVERCOME | DELIVERY | magnetic resonance imaging nanoparticle | RESISTANCE | Fenton reaction | EFFICIENT | mitochondrial targeting
Journal Article
British Journal of Haematology, ISSN 0007-1048, 02/2011, Volume 152, Issue 4, pp. 420 - 432
Summary Cell cycle regulators, such as cyclin‐dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased... 
microenvironment | kinase inhibitor | cancer | myeloma | cyclin‐dependent kinases | Microenvironment | Myeloma | Kinase inhibitor | Cyclin-dependent kinases | Cancer | APOPTOSIS | REFRACTORY MULTIPLE-MYELOMA | SELICICLIB CYC202 | PLASMA-CELL | LENALIDOMIDE PLUS DEXAMETHASONE | DOWN-REGULATION | OVERCOMES DRUG-RESISTANCE | CDK INHIBITOR | R-ROSCOVITINE | cyclin-dependent kinases | HEMATOLOGY | TRANSCRIPTIONAL REGULATION | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Coculture Techniques | Humans | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Dose-Response Relationship, Drug | Multiple Myeloma - drug therapy | Drug Interactions | Transcription, Genetic | Antineoplastic Agents - pharmacology | Cyclin-Dependent Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Multiple Myeloma - enzymology | Cell Survival - drug effects | Bortezomib | Treatment Outcome | Down-Regulation - drug effects | Multiple Myeloma - pathology | Signal Transduction - drug effects | Survival Analysis | Cytokines - antagonists & inhibitors | Cell Cycle - drug effects | Stromal Cells - physiology | Cytokines - pharmacology | Drug Combinations | Multiple Myeloma - genetics | Drug Screening Assays, Antitumor | Medical colleges | Cell death | Oncology, Experimental | Multiple myeloma | Stem cells | Research | DNA binding proteins | Drug resistance | Phosphotransferases | Tumors | Transcription factors | Cell survival | Cytokines | Complications | Hypoxia-inducible factor 1 alpha | Stroma | Myc protein | Cyclin-dependent kinase 5 | Cyclin-dependent kinase | Cyclin-dependent kinase 2 | Interferon regulatory factor 4 | Cell cycle | Bone marrow | Tumorigenesis | Apoptosis
Journal Article
JOURNAL OF RADIATION RESEARCH, ISSN 0449-3060, 2000, Volume 41, Issue 3, pp. 201 - 212
Studies have shown that reduced oxygen tension (hypoxia) in solid tumours adversely affects the outcome of radiotherapy. Despite being an independent... 
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 12/2019, Volume 314, p. 108822
Aldehyde dehydrogenase (ALDH) activity is not only a valuable marker for cancer cells with stem-like features, but also plays a vital role in drug resistance... 
ALDH1A3 | GSEA | Melanoma patient prognosis | BRAF/MEK inhibitor response | ALDH1A1 | DNA METHYLATION | ALDEHYDE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BRAF | MECHANISMS | OVERCOME | CANCER STEM-CELLS | INTERFERON-ALPHA | PATHWAY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROGNOSTIC-SIGNIFICANCE
Journal Article