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overcoming multidrug-resistance (205) 205
index medicus (133) 133
cancer (112) 112
nanoparticles (98) 98
humans (95) 95
drug delivery systems (89) 89
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drug delivery (49) 49
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chemistry, multidisciplinary (43) 43
drug resistance (43) 43
micelles (43) 43
co-delivery (42) 42
vehicles (42) 42
mesoporous silica nanoparticles (40) 40
multidrug resistance (38) 38
breast-cancer (37) 37
p-glycoprotein (36) 36
drug carriers - chemistry (34) 34
in-vivo (34) 34
materials science, multidisciplinary (33) 33
tumors (33) 33
tumor (31) 31
nanoparticles - chemistry (30) 30
paclitaxel (29) 29
anthracyclines (28) 28
polymeric micelles (28) 28
therapy (28) 28
apoptosis (27) 27
cell line, tumor (27) 27
neoplasms - drug therapy (27) 27
drug therapy (26) 26
cancer-therapy (25) 25
female (25) 25
antineoplastic agents - pharmacology (24) 24
drug resistance in microorganisms (24) 24
antineoplastic agents - administration & dosage (22) 22
cancer therapy (22) 22
cancer-cells (22) 22
health aspects (22) 22
tumortherapie (22) 22
analysis (21) 21
engineering, biomedical (21) 21
mice (21) 21
nanotechnology (21) 21
antineoplastic agents - chemistry (20) 20
chemistry, physical (20) 20
gold nanoparticles (20) 20
nanocarriers (20) 20
toxicity (20) 20
biochemistry & molecular biology (19) 19
doxorubicin - pharmacology (19) 19
drug resistance, neoplasm - drug effects (19) 19
nanopartikel (19) 19
polymers (19) 19
wirkstofffreisetzung (19) 19
cancer therapies (18) 18
cytotoxicity (18) 18
polyethylene glycol (18) 18
biocompatibility (17) 17
delivery (17) 17
doxorubicin - chemistry (17) 17
hydrogen-ion concentration (17) 17
doxorubicin - administration & dosage (16) 16
drug delivery systems - methods (16) 16
physics, applied (16) 16
polyethylene glycols - chemistry (16) 16
polymer science (16) 16
block-copolymer (15) 15
breast cancer (15) 15
cellular uptake (15) 15
drug-resistance (15) 15
gene delivery (15) 15
mcf-7 cells (15) 15
mice, inbred balb c (15) 15
polymers - chemistry (15) 15
review (15) 15
targeted delivery (15) 15
anticancer drug (14) 14
care and treatment (14) 14
controlled-release (14) 14
mice, nude (14) 14
polymeric nanoparticles (14) 14
release (14) 14
vitamin-e tpgs (14) 14
anticancer properties (13) 13
antimitotic agents (13) 13
antineoplastic agents (13) 13
biomedical materials (13) 13
copolymers (13) 13
drug resistance, neoplasm (13) 13
liposomes (13) 13
multidrug-resistance (13) 13
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1. Full Text Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
by Wang, Jinglu and Seebacher, Nicole and Shi, Huirong and Kan, Quancheng and Duan, Zhenfeng
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 48, pp. 84559 - 84571
The development of multidrug resistance (MDR) is one of the major challenges to the success of traditional chemotherapy treatment in cancer patients. Most... 
Prevention | Pgp | MDR | Drug resistance | Pgp inhibitor | BLOCK-COPOLYMERS | X-RECEPTOR AGONIST | PHASE I/II TRIAL | PREVIOUSLY UNTREATED PATIENTS | P-GLYCOPROTEIN | CELL BIOLOGY | CELL LUNG-CANCER | IN-VITRO | OVERCOMING DRUG-RESISTANCE | GENE AMPLIFICATION | drug resistance | OVARIAN TUMOR XENOGRAFTS | prevention
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2. Full Text Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier
by Lin, Sen and Lin, Sen and Xie, Peiling and Xie, Peiling and Luo, Mengmeng and Luo, Mengmeng and Li, Qing and Li, Qing and Li, Ling and Li, Ling and Zhang, Jinzhao and Zhang, Jinzhao and Zheng, Qinxiang and Zheng, Qinxiang and Chen, Hao and Chen, Hao and Nan, Kaihui and Nan, Kaihui
Nano Research, ISSN 1998-0124, 7/2018, Volume 11, Issue 7, pp. 3619 - 3635
Multidrug resistance proteins (MDRPs), which are implicated in the mediation of multidrug resistance in tumors, represent the main obstacle to successful... 
Condensed Matter Physics | Biomedicine, general | co-delivery nanoparticle | Biotechnology | multidrug resistance | Materials Science | Materials Science, general | Atomic/Molecular Structure and Spectra | legumain | doxorubicin | Nanotechnology | curcumin | PHYSICS, APPLIED | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHITOSAN | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | HYALURONIC-ACID | BREAST-CANCER | NANOPARTICLES | IN-VITRO | OVERCOMING DRUG-RESISTANCE | MCF-7/ADR CELLS | NANOGELS | EXPRESSION | TARGETED DELIVERY | Proteins | Drug resistance in microorganisms | Anthracyclines | Chemotherapy | Biological products | Analysis | Mediation | Cancer | Toxicity | Multidrug resistance | Cytotoxicity | Drug resistance | Doxorubicin | Nuclei | Anticancer properties | Nanoparticles | Synergistic effects | Legumain | Curcumin | Inhibition | Chitosan | Tumors
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3. Full Text A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
by Li, Jun and Xu, Ruitong and Lu, Xiao and He, Jing and Jin, Shidai
International Journal of Nanomedicine, ISSN 1176-9114, 11/2017, Volume 12, pp. 8043 - 8056
Multidrug resistance (MDR) is one of the major obstacles in successful chemotherapy. The combination of chemotherapy drugs and multidrug-resistant reversing... 
Overcoming multidrug resistant | Dasatinib | Redox responsive | Co-delivery | Paclitaxel | paclitaxel | overcoming multidrug resistant | COMBINATION THERAPY | MESOPOROUS SILICA NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | OVARIAN-CANCER | DRUG-RESISTANCE | KINASE INHIBITOR | POLYMERIC MICELLES | ANTITUMOR-ACTIVITY | redox responsive | P-GLYCOPROTEIN | co-delivery | BREAST-CANCER | IN-VITRO | dasatinib | PHARMACOLOGY & PHARMACY | Drugs | Drug resistance in microorganisms | Drug delivery systems | Dosage and administration | Breast cancer | Research | Drug therapy | Vehicles | Medical research | Clinical trials | Glycoproteins | Kinases | Drug resistance | Cancer therapies | Ovarian cancer | Nanoparticles | Biomedical materials | Chemotherapy | Polymers | Tumors | redox-responsive
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4. Full Text Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells
by Goler-Baron, Vicky and Sladkevich, Irina and Assaraf, Yehuda G
Biochemical Pharmacology, ISSN 0006-2952, 05/2012, Volume 83, Issue 10, pp. 1340 - 1348
Extracellular vesicles (EVs) formed between neighbor breast cancer cells mediate ABCG2-dependent multidrug resistance (MDR) via intravesicular drug... 
Extracellular vesicles (EVs) | PI3K-Akt signaling | Overcoming multidrug resistance (MDR) | Chemotherapy | ABC transporters | Breast cancer | RAT-LIVER | GEFITINIB | DRUG-RESISTANCE | LUNG-CANCER | PROTEIN BCRP/ABCG2 | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | FOLATE DEPRIVATION | EXPRESSION | ERLOTINIB | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Phosphorylation | Signal Transduction | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Breast Neoplasms - drug therapy | Blotting, Western | Breast Neoplasms - metabolism | Breast Neoplasms - enzymology | Breast Neoplasms - pathology | ATP-Binding Cassette Transporters - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-akt - metabolism | Drug resistance in microorganisms | Care and treatment | Cancer cells | Drug resistance | Cells | Cancer
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5. Full Text A new insight into the reversal of multidrug resistance in cancer by nanodrugs
by Jiang, HY and Guo, DB and Chen, D and Wu, Y and Jin, X and Zhu, XY
BIOMATERIALS SCIENCE, ISSN 2047-4830, 08/2019, Volume 7, Issue 8, pp. 3489 - 3496
Although nanodrugs have been shown to evade P-glycoprotein (P-gp) recognition and reverse multi-drug resistance (MDR) in cancer, a specific mechanism of how... 
THERAPEUTICS | MATERIALS SCIENCE, BIOMATERIALS | OVERCOMING DRUG-RESISTANCE | EFFLUX PUMP | DOXORUBICIN | NANOPARTICLE DELIVERY | POLYMERIC MICELLE | ABC TRANSPORTERS | COPOLYMER MICELLES | CHEMOTHERAPY | P-GLYCOPROTEIN
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6. Full Text Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
by Kamaly, Nazila and Yameen, Basit and Wu, Jun and Farokhzad, Omid C
Chemical Reviews, ISSN 0009-2665, 02/2016, Volume 116, Issue 4, pp. 2602 - 2663
OVERCOMING MULTIDRUG-RESISTANCE | SELF-ASSEMBLED MICELLES | EFFICIENT INTRACELLULAR RELEASE | TARGETED DOXORUBICIN DELIVERY | BIOLOGICAL RESPONSE MODIFIERS | INTENSITY FOCUSED ULTRASOUND | IN-VITRO PROPERTIES | RING-OPENING POLYMERIZATION | PLURONIC BLOCK-COPOLYMERS | CHEMISTRY, MULTIDISCIPLINARY | NONVIRAL GENE DELIVERY | Pharmaceutical Preparations - metabolism | Nanoparticles - chemistry | Pharmaceutical Preparations - chemistry | Drug Liberation | Polymers - chemistry | Polymers - metabolism | Drug Delivery Systems
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7. Full Text Supramolecular Vesicles Based on Complex of Trp-Modified Pillar[5]arene and Galactose Derivative for Synergistic and Targeted Drug Delivery
by Yang, Kui and Chang, Yincheng and Wen, Jia and Lu, Yuchao and Pei, Yuxin and Cao, Shoupeng and Wang, Feng and Pei, Zhichao
Chemistry of Materials, ISSN 0897-4756, 04/2016, Volume 28, Issue 7, pp. 1990 - 1993
SYSTEM | OVERCOMING MULTIDRUG-RESISTANCE | NANOPARTICLES | RESONANCE LIGHT-SCATTERING | DNA | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | RELEASE | CANCER | PEPTIDE
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8. Full Text Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy
by Zhang, Ruiyun and Xing, Ruirui and Jiao, Tifeng and Ma, Kai and Chen, Chengjun and Ma, Guanghui and Yan, Xuehai
ACS Applied Materials & Interfaces, ISSN 1944-8244, 06/2016, Volume 8, Issue 21, pp. 13262 - 13269
There are tremendous challenges from both tumor and its therapeutic formulations affecting the effective treatment of tumor, including tumor recurrence, and... 
Research | nanodrugs | self-assembly | antitumor therapy | photodynamic therapy | codelivery | PROTEIN | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOSCIENCE & NANOTECHNOLOGY | SIRNA DELIVERY | COMBINATION | CANCER-THERAPY | NANOPARTICLES | IN-VITRO | OVERCOMING DRUG-RESISTANCE | BIOMEDICAL APPLICATIONS | MULTIDRUG-RESISTANCE
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9. Full Text Recent advances in hyluronic acid-decorated nanocarriers for targeted cancer therapy
by Wickens, JM and Alsaab, HO and Kesharwani, P and Bhise, K and Amin, MCIM and Tekade, RK and Gupta, U and Iyer, AK
DRUG DISCOVERY TODAY, ISSN 1359-6446, 04/2017, Volume 22, Issue 4, pp. 665 - 680
The cluster-determinant 44 (CD44) receptor has a high affinity for hyaluronic acid (HA) binding and is a desirable receptor for active targeting based on its... 
OVERCOMING MULTIDRUG-RESISTANCE | DRUG-DELIVERY | REDOX-SENSITIVE MICELLES | PHARMACOLOGY & PHARMACY | POLYMERIC MICELLES | MIXED MICELLES | IN-VIVO EVALUATION | COPOLYMER MICELLES | EPITHELIAL OVARIAN-CANCER | HYALURONIC-ACID | NEGATIVE BREAST-CANCER
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10. Full Text Targeting the ubiquitin-proteasome pathway to overcome anti-cancer drug resistance
by Narayanan, Silpa and Cai, Chao-Yun and Assaraf, Yehuda G and Guo, Hui-Qin and Cui, Qingbin and Wei, Liuya and Huang, Juan-Juan and Ashby, Charles R and Chen, Zhe-Sheng
Drug Resistance Updates, ISSN 1368-7646, 01/2020, Volume 48, p. 100663
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11. Full Text Peptide–drug conjugates as effective prodrug strategies for targeted delivery
by Wang, Yin and Cheetham, Andrew G and Angacian, Garren and Su, Hao and Xie, Lisi and Cui, Honggang
Advanced Drug Delivery Reviews, ISSN 0169-409X, 02/2017, Volume 110-111, pp. 112 - 126
Peptide–drug conjugates (PDCs) represent an important class of therapeutic agents that combine one or more drug molecules with a short peptide through a... 
Peptide–drug conjugates | Conjugated chemistry | Drug delivery | Drug amphiphiles | Cancer | CANCER-CELLS | Peptide-drug conjugates | OVERCOMING MULTIDRUG-RESISTANCE | REAL-TIME ANALYSIS | MOLECULAR TRANSPORTERS | THERANOSTIC PLATINUM(IV) PRODRUG | CELLULAR UPTAKE | THERAPY IN-VIVO | AGGREGATION-INDUCED EMISSION | PHARMACOLOGY & PHARMACY | SUPRAMOLECULAR FILAMENTS | RATIONAL DESIGN | Chemotherapy | Peptides | Analysis | Transdermal medication | Medical colleges | Biomedical engineering | cancer | drug delivery | conjugated chemistry | peptide–drug conjugates | drug amphiphiles
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12. Full Text Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy
by Tang, Dongyang and Zhao, Xin and Yang, Tie and Wang, Cheng
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 1, pp. 380 - 389
An effective chemotherapy is usually subject to an insufficient loading of hydrophobic drugs as well as severe side effects. In order to address these dilemmas... 
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13. Full Text Hyaluronic acid for anticancer drug and nucleic acid delivery
by Dosio, Franco and Arpicco, Silvia and Stella, Barbara and Fattal, Elias
Advanced Drug Delivery Reviews, ISSN 0169-409X, 02/2016, Volume 97, pp. 204 - 236
Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible, biodegradable, non-toxic, and non-immunogenic; moreover, HA... 
Conjugates | Drug delivery systems | Anticancer agents | Hyaluronic acid | Nanotechnology | CD44 | OVERCOMING MULTIDRUG-RESISTANCE | MOLECULAR-WEIGHT HYALURONAN | SELF-ASSEMBLED NANOPARTICLES | REDOX-SENSITIVE MICELLES | MESOPOROUS SILICA NANOPARTICLES | IN-VIVO BIODISTRIBUTION | MULTIWALLED CARBON NANOTUBES | POLYMERIC MICELLES | TUMOR-TARGETED DELIVERY | NANOSTRUCTURED LIPID CARRIERS | PHARMACOLOGY & PHARMACY | Hyaluronic Acid - administration & dosage | Humans | Hyaluronic Acid - chemistry | Drug Carriers - administration & dosage | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Excipients - administration & dosage | Drug Carriers - chemistry | Animals | Excipients - chemistry | Nucleic Acids - chemistry | Nanostructures - administration & dosage | Hydrogels - administration & dosage | Nanostructures - chemistry | Nucleic Acids - administration & dosage | Hydrogels - chemistry | Drugs | Antimitotic agents | Nucleic acids | Antineoplastic agents | Vehicles
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14. Full Text Large Pore‐Sized Hollow Mesoporous Organosilica for Redox‐Responsive Gene Delivery and Synergistic Cancer Chemotherapy
by Wu, Meiying and Meng, Qingshuo and Chen, Yu and Zhang, Lingxia and Li, Mengli and Cai, Xiaojun and Li, Yaping and Yu, Pengcheng and Zhang, Linlin and Shi, Jianlin
Advanced Materials, ISSN 0935-9648, 03/2016, Volume 28, Issue 10, pp. 1963 - 1969
A stability‐difference‐selective bond‐breakage strategy for the fabrication of largepore‐sized hollow mesoporous organosilica nanoparticles (HMONs) is... 
gene delivery | cancer therapy | multidrug resistance | nanoparticles | large pores | OVERCOMING MULTIDRUG-RESISTANCE | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | RNA | DRUG-DELIVERY | SPHERES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | BREAST-CANCER | CO-DELIVERY | FACILE SYNTHESIS | SILICA NANOPARTICLES | BIOMEDICAL APPLICATIONS | ULTRALARGE PORES | Gene Transfer Techniques | Photoelectron Spectroscopy | Oxidation-Reduction | Humans | Oxides - chemistry | Silicon Dioxide - chemistry | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - chemistry | Drug Carriers - chemistry | Neoplasms - drug therapy | Nanotubes - chemistry | Alloys - chemistry | Metals - chemistry | Catalysis | Porosity | Antimitotic agents | Chemotherapy | Genes | Genetic aspects | Drug resistance | Antineoplastic agents | Cancer | Nanoparticles | Drug delivery systems | Strategy | Bonding | Doxorubicin | Modulators
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