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PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 5, p. e10476
Journal Article
Trends in endocrinology and metabolism, ISSN 1043-2760, 2014, Volume 25, Issue 9, pp. 452 - 463
Highlights • Endothelial cells express four NADPH oxidase isoforms: NOX1, 2, 4, and 5. • NOX1, 2, and 5 make superoxide and cause endothelial dysfunction and... 
Endocrinology & Metabolism | hyperlipidemia | NADPH oxidases | vascular disease | selective NOX1/2 inhibitors | inflammation | reactive oxygen species | hypertension | diabetes | endothelial dysfunction | Hypertension | Vascular disease | Selective NOX1/2 inhibitors | Reactive oxygen species | Hyperlipidemia | Endothelial dysfunction | Inflammation | Diabetes | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | SPONTANEOUSLY HYPERTENSIVE-RATS | NITRIC-OXIDE SYNTHASE | LOW-DENSITY-LIPOPROTEIN | ANGIOTENSIN-II | REDOX SIGNALING PLATFORMS | INDUCED UP-REGULATION | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE PRODUCTION | CORONARY-ARTERY-DISEASE | NADPH Oxidases - chemistry | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Endothelium, Vascular - drug effects | Endothelium, Vascular - enzymology | Molecular Targeted Therapy | Membrane Glycoproteins - antagonists & inhibitors | NADPH Oxidases - genetics | Membrane Proteins - metabolism | Vascular Diseases - drug therapy | Membrane Proteins - genetics | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Mice, Transgenic | NADPH Oxidase 5 | NADPH Oxidase 4 | Vascular Diseases - enzymology | Enzyme Inhibitors - therapeutic use | NADPH Oxidase 2 | NADPH Oxidase 1 | Cardiovascular Agents - pharmacology | Membrane Glycoproteins - genetics | Mice, Knockout | Cardiovascular Agents - therapeutic use | Animals | Membrane Proteins - antagonists & inhibitors | Models, Biological | Oxidases | Blood circulation disorders | Superoxide | Peroxides | Endothelium
Journal Article
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 08/2016, Volume 97, pp. 95 - 108
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by progressive loss of motor neurons, gliosis, neuroinflammation... 
SOD1G93A mice | Thioridazine | NADPH oxidase | NOX | Amyotrophic lateral sclerosis | Perphenazine | Microglia | Phenothiazine | DUOX dual oxidase | List of abbreviations ALS amyotrophic lateral sclerosis | WST-1 2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt | PBS phosphate buffered saline | HOCl hypochlorous acid | BBB blood brain barrier | WT wild typ | 2-chloroethidium | 2-Cl-E | NOXO1 NADPH oxidase organiser type 1 | CNS central nervous system | DPI diphenyleneiodonium | ethidium | NOX NADPH oxidase | HE hydroethidine | qPCR quantitative polymerase chain reaction | MPO myeloperoxidase | LC/MS/MS Liquid chromatography-tandem mass spectrometry | GM-CSF granulocyte-macrophage colony-stimulating factor | PMA phorbol myristate acetate | TDP 43 TAR DNA binding protein 43 | DMEM Dulbecco's modified Eagle Medium | hydrogen peroxide | DNA deoxyribonucleic acid | ROS reactive oxygen species | superoxide radical anion | SOD superoxide dismutase | HBSS Hank's buffered salt solution | half maximal efficient concentration | 2-hydroxyethidium | NADPH nicotinamide adenine dinucleotide phosphate | NC non-carrier | FBS fetal bovine serum | 2-OH-E | FUS/TLS Fused in Sarcoma/Translocated in Sarcoma | DMSO Dimethylsulfoxide | SURVIVAL | SUPEROXIDE | HYDROETHIDINE | SOD1(G93A) mice | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPINAL-CORD | REACTIVE OXYGEN | MOTOR-NEURON DEGENERATION | NOX FAMILY | ENDOCRINOLOGY & METABOLISM | ALS MICE | INHIBITOR | Spinal Cord - drug effects | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Male | NADPH Oxidase 1 - genetics | Thioridazine - administration & dosage | Amyotrophic Lateral Sclerosis - drug therapy | Motor Neurons - pathology | Gene Expression Regulation - drug effects | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | NADPH Oxidase 2 - metabolism | Spinal Cord - pathology | Superoxide Dismutase-1 - genetics | Adult | Female | Aged | Mice | Perphenazine - administration & dosage | NADPH Oxidase 2 - genetics | Superoxide Dismutase-1 - antagonists & inhibitors | Disease Models, Animal | Oxidases | Nervous system diseases | Analysis | Oncology, Experimental | Superoxide | Research | Cancer
Journal Article
Biochemistry (Easton), ISSN 0006-2960, 04/2017, Volume 56, Issue 14, pp. 2024 - 2030
The flavoprotein d-amino acid oxidase has long served as a paradigm for understanding the mechanism of oxidation of amino acids by flavoproteins. Recently, a... 
MONOAMINE-OXIDASE | FLAVOPROTEIN TRYPTOPHAN 2-MONOOXYGENASE | CATALYSIS | OXIDATIVE HALF-REACTION | ENZYME | N-METHYLTRYPTOPHAN OXIDASE | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINETIC MECHANISM | PH-DEPENDENCE | ISOTOPE
Journal Article