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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 8, pp. 1653 - 1664
Both the inhibition of inflammatory flares and the treatment of hyperuricemia itself are included in the management of gout. Extending our efforts to... 
Xanthine oxidase | NOD-like receptor 3 | Anti-hyperuricemia | Gout | Toll-like receptor 4 | CHEMISTRY, MEDICINAL | HYPERURICEMIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | NLRP3 INFLAMMASOME | INHIBITOR | ARTHRITIS | Oxidases | Purines | Iron compounds | Sensors | Drug therapy
Journal Article
2016, Proposed Re-evaluation Decision, Volume PRVD2016-11.
Web Resource
Journal Article
Medicinal Chemistry, ISSN 1573-4064, 05/2018, Volume 14, Issue 3, pp. 281 - 292
Background: In the last decade, the concept of uncharged reactivators potentially able to penetrate the CNS has been introduced as an alternative to the... 
Organophosphate | Non-quaternary oximes | Anxiety | Quaternary oximes | Acetylcholinesterase | Neurotransmission | Oxime reactivators | organophosphate | EFFICIENT UNCHARGED REACTIVATORS | CHEMISTRY, MEDICINAL | neurotransmission | acetylcholinesterase | TOXICITY | HI-6 | BLOOD-BRAIN-BARRIER | quaternary oximes | non-quaternary oximes | PHOSPHYLATED CHOLINESTERASES | ALDOXIME | ACTING OXIME REACTIVATORS | NERVE AGENTS | oxime reactivators | PRALIDOXIME | INHIBITED HUMAN ACETYLCHOLINESTERASE | Antidotes - pharmacology | Antidotes - toxicity | Antidotes - chemical synthesis | Cholinesterase Reactivators - chemical synthesis | Cholinesterase Inhibitors - toxicity | Cholinesterase Reactivators - pharmacology | Rats | Sarin - toxicity | Organophosphate Poisoning - drug therapy | Cholinesterase Inhibitors - chemical synthesis | Oximes - chemical synthesis | Blood-Brain Barrier - drug effects | Paraoxon - toxicity | Animals | Oximes - toxicity | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Computer Simulation | Oximes - pharmacology | Cholinesterase Reactivators - toxicity | Mice | Organophosphates - toxicity | Oximes | Antidotes | Toxicity | Quaternary | Central nervous system | Affinity | Biocompatibility | Activation | Poisoning | Bioavailability | Physicochemical properties | Lipophilicity | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2012, Volume 22, Issue 24, pp. 7588 - 7592
Journal Article
Oximes in organophosphorus poisoning, 12/2005
Acute organic insecticide poisoning is a major health problem all over the world, particularly in the developing countries, where organophosphates (OPs) are... 
Anticholinergics, Manifestations, Organophosphate, Oximes, Poisoning
Journal
The Plant Journal, ISSN 0960-7412, 11/2015, Volume 84, Issue 3, pp. 558 - 573
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2014, Volume 78, pp. 455 - 467
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2010, Volume 333, Issue 3, pp. 696 - 706
Journal Article