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Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2013, Volume 36, Issue 5, pp. 741 - 747
Preventing the onset of microalbuminuria in diabetic nephropathy is a problem that needs urgent rectification. The use of a mouse model for diabetes is vital... 
Journal Article
by Fang, ZJ and Li, P and Duo, WL and Jiang, T and Zhang, CY and Xiang, Y
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, ISSN 1000-3282, 02/2014, Volume 41, Issue 2, pp. 185 - 191
In previous study, our group have found that there is a significant increased level of miR-122 in the serum of ob/ob mice, an animal model of type 2 diabetes.... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | ob/ob mice | MICROVESICLES | SERUM | MICRORNAS | AldoA | CANCER | type 2 diabete | PATHOPHYSIOLOGY | MESSENGER-RNAS | BIOPHYSICS | BIOGENESIS | miR-122 | EXOSOMES | EXPRESSION
Journal Article
ENDOCRINE JOURNAL, ISSN 0918-8959, 2002, Volume 49, Issue 4, pp. 417 - 423
Withdrawal of estrogen by ovariectomy increases adiposity, but decreases the circulating levels of the ob gene product, leptin, which inhibits food intake. The... 
Journal Article
Journal of Oleo Science, ISSN 1345-8957, 2015, Volume 64, Issue 6, pp. 683 - 688
[Abstract] : We examined the effects of the dietary intake of medium- and long-chain triacylglycerol (MLCT) on hyperglycemia in diabetic ob/ob mice.... 
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 06/2019, Volume 95, Issue 6, pp. 1418 - 1432
Diabetic nephropathy (DN) is one of the most common complications of diabetes, and currently the first end-stage renal disease worldwide. New strategies to... 
IL-17A | BTBR ob/ob | inflammation | diabetic nephropathy
Journal Article
本實驗的目的是由遺傳性肥胖鼷鼠(ob/ob )體內鋅和甲狀腺素的含量,來探討鋅處 理對肥胖症的影響。取斷奶四週齡的小鼠,由體型和活力區分為胖鼠和非胖鼠,並將 雌雄分組,以基本飼料(basal diet)或高鋅飼料(basal diet + 200ppm Zn)餵食 八週,測量鼷鼠體重、體脂肪、體鋅及血清中T3... 
甲狀腺素 | ZN | | 遺傳性肥胖 | 鼷鼠 | OB-OB | BREEDS | 飼料
Dissertation
CELL METABOLISM, ISSN 1550-4131, 10/2018, Volume 28, Issue 4, pp. 656 - 656
We report a web-based tool for analysis of experiments using indirect calorimetry to measure physiological energy balance. CaIR simplifies the process to... 
PATHOGENESIS | ANCOVA | OBESITY | ENERGY-EXPENDITURE | OB/OB MICE | ENDOCRINOLOGY & METABOLISM | BODY-FAT MASS | IRREPRODUCIBILITY | WEIGHT | CELL BIOLOGY
Journal Article
NEURON, ISSN 0896-6273, 06/2004, Volume 42, Issue 6, pp. 983 - 991
Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the... 
ENERGY-BALANCE | GREEN FLUORESCENT PROTEIN | HYPOTHALAMIC NEUROPEPTIDE-Y | DIABETES-OBESITY SYNDROMES | MEDIOBASAL HYPOTHALAMUS | BONE-FORMATION | OB/OB MICE | PROOPIOMELANOCORTIN MESSENGER-RNA | ARCUATE NUCLEUS | NEUROSCIENCES | MELANOCORTIN-4 RECEPTOR
Journal Article
DIABETES, ISSN 0012-1797, 05/2011, Volume 60, Issue 5, pp. 1399 - 1413
OBJECTIVE Carbohydrate-responsive element-binding protein (ChREBP) is a key transcription factor that mediates the effects of glucose on glycolytic and... 
GENE | GLUCOSE-METABOLISM | PHOSPHORYLATION | INSULIN-RESISTANCE | OB/OB MICE | ENDOCRINOLOGY & METABOLISM | ELEMENT-BINDING PROTEIN | GLYCOSYLATION | O-GLCNAC MODIFICATION | HEPATIC STEATOSIS | TRANSFERASE
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2002, Volume 110, Issue 8, pp. 1093 - 1103
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling... 
SIGNAL | MEDICINE, RESEARCH & EXPERIMENTAL | RECOMBINANT LEPTIN | ENERGY-EXPENDITURE | GENE | OB-OB MICE | OB/OB MICE | MOUSE | WEIGHT-LOSS | MISSENSE MUTATION | ONSET
Journal Article
日本内科学会雑誌, ISSN 0021-5384, 1995, Volume 84, Issue 8, pp. 1226 - 1230
Journal Article
瘦蛋白是由脂肪細胞之肥胖基因所合成分泌,其為具有胜性質之賀爾蒙,分子量大 小為16-kDa。瘦蛋白主要扮演著能量、產熱(thermogenesis)及體重的調控。研究報導顯示 先天性缺乏瘦蛋白的老鼠(ob/ob mouse)是因肥胖基因因發生無意義的突變而導致有缺陷... 
肥胖 | Obesity | Leptin Receptor | 瘦蛋白 | Leptin | 先天性瘦蛋白缺乏老鼠 | 瘦蛋白受體 | ob/ob mouse
Dissertation
Akt是胰島素訊息路徑中的重要一環,位於PI... 
db/db | 胰島素阻抗 | ob/ob | 基因缺陷 | high-fat diet | Akt | gene deficient | 高脂飼料 | insulin resistance
Dissertation
實驗與脂肪細胞離體培養實驗,探討鋅對肥胖鼷鼠脂質代謝的影響。動物 D鼷鼠(ob/ob)及正常體重對照鼷鼠(+/?),經由飲水給予鋅處理(100 ppm) 銝△蘆`射1g/kg葡萄糖後的糖耐受性反應變化。脂肪細胞離體培 養實驗則旦儱郥{鼠之脂肪細胞進行培養,觀察培養液中添加鋅與胰島素... 
肥胖症 | | 胰島素 | 肥胖鼷鼠 | obese (ob/ob) mice | 糖耐反應 | glucose tolerance | 脂質代謝 | zinc | lipid | obesity
Dissertation
Journal of the Korean Society of Food Science and Nutrition, ISSN 1226-3311, 03/2017, Volume 46, Issue 3, pp. 389 - 393
Journal Article
DIABETES, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2928 - 2938
OBJECTIVE-To determine whether and by what mechanism systemic delivery of curcumin-containing liposomes improves insulin resistance in the leptin deficient... 
NKT CELLS | ACTIVATION | CURCUMIN | OB/OB MICE | ENDOCRINOLOGY & METABOLISM | REGULATORY T-CELLS | SENSITIVITY | PPAR-GAMMA | STEATOHEPATITIS | SUPPRESSION | ADIPOSE-TISSUE
Journal Article
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