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Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, pp. 43412 - 43412
This study was conducted to investigate impacts of dietary protein levels on gut bacterial community and gut barrier. The intestinal microbiota of finishing... 
POSTWEANING DIARRHEA | HOST METABOLISM | CELLS | FINISHING PIGS | HOMEOSTASIS | PIGLETS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MODULATING INTESTINAL PERMEABILITY | BUTYRATE | PROMOTES | Dietary Proteins - administration & dosage | Peptostreptococcus - drug effects | Tight Junction Proteins - genetics | Receptors, G-Protein-Coupled - metabolism | Colon - drug effects | Ileum - metabolism | Escherichia - metabolism | Escherichia - classification | Fatty Acids, Volatile - metabolism | Intestinal Mucosa - drug effects | Occludin - metabolism | Genetic Variation | Polycomb Repressive Complex 1 - genetics | Dietary Proteins - metabolism | Ileum - drug effects | Swine | Shigella - metabolism | Tight Junction Proteins - metabolism | Firmicutes - isolation & purification | Intestinal Mucosa - microbiology | Peptostreptococcus - isolation & purification | Colon - metabolism | Gastrointestinal Microbiome - drug effects | Claudin-1 - genetics | Escherichia - drug effects | Receptors, G-Protein-Coupled - genetics | Escherichia - isolation & purification | Firmicutes - drug effects | Animal Feed | Peptostreptococcus - classification | Intestinal Mucosa - metabolism | Polycomb Repressive Complex 1 - metabolism | Shigella - classification | Gastrointestinal Microbiome - physiology | Clostridium - isolation & purification | Shigella - drug effects | Clostridium - classification | Occludin - genetics | Claudin-1 - metabolism | Biogenic Amines - metabolism | Diet, Protein-Restricted - methods | Firmicutes - metabolism | Digestion - drug effects | Firmicutes - classification | Shigella - isolation & purification | Peptostreptococcus - metabolism | Digestion - physiology | Gene Expression Regulation - drug effects | Animals | Clostridium - metabolism | Colon - microbiology | Ileum - microbiology | Clostridium - drug effects | Amines | Digestive system | Mucosa | Ileum | Studies | Proteins | Protein composition | Metabolites | Intestine | Fish | Intestinal microflora | Colon | Digestive tract | Biogenic amines | Colonization | Index Medicus
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 336 - 349
Aberrant modulation of mitochondrial dynamic network, which shifts the balance of fusion and fission towards fission, is involved in brain damage of various... 
Mdivi-1 | Inflammation | Early brain injury | Blood-brain barrier disruption | Subarachnoid hemorrhage | Apoptosis | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEX I INHIBITOR | HIPPOCAMPAL-NEURONS | RAT MODEL | MITOCHONDRIAL FISSION | CELL-DEATH | SIGNALING PATHWAY | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | Interleukin-6 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Proto-Oncogene Proteins c-bcl-2 - agonists | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Subarachnoid Space - drug effects | Occludin - metabolism | Matrix Metalloproteinase 9 - metabolism | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | Subarachnoid Hemorrhage - mortality | Zonula Occludens-1 Protein - metabolism | Interleukin-6 - metabolism | Subarachnoid Hemorrhage - drug therapy | Interleukin-1beta - antagonists & inhibitors | Zonula Occludens-1 Protein - genetics | NF-kappa B - antagonists & inhibitors | Endoplasmic Reticulum Stress - drug effects | Interleukin-6 - genetics | bcl-2-Associated X Protein - metabolism | Dynamins - genetics | Rats | Subarachnoid Hemorrhage - genetics | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Survival Analysis | Subarachnoid Space - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dynamins - metabolism | Mitochondrial Dynamics - genetics | Claudin-5 - metabolism | Occludin - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondria - genetics | Quinazolinones - pharmacology | bcl-2-Associated X Protein - genetics | Dynamins - antagonists & inhibitors | Claudin-5 - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Subarachnoid Hemorrhage - pathology | bcl-2-Associated X Protein - antagonists & inhibitors | Blood-Brain Barrier - drug effects | Animals | Mitochondrial Dynamics - drug effects | NF-kappa B - genetics | Subarachnoid Space - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Stroke (Disease) | Proteins | Medical research | Brain | Neurons | Analysis | Medicine, Experimental | Brain damage | Injuries | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 20, pp. 17536 - 17542
Apolipoprotein E (apoE) is a major apolipoprotein in the brain. The epsilon 4 allele of apoE is a major risk factor for Alzheimer disease, and apoE deficiency... 
CHOLESTEROL-METABOLISM | PROTEIN-KINASE-C | RECEPTOR-RELATED PROTEIN | LIPOPROTEIN RECEPTORS | LDL-RECEPTOR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | ENDOTHELIAL-CELLS | A-BETA | PLAQUE-FORMATION | Protein Kinase C - genetics | Apolipoprotein E4 - genetics | Humans | Astrocytes - pathology | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Occludin | Phosphorylation - genetics | Protein Isoforms - metabolism | Pericytes - pathology | Protein Kinase C - metabolism | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Tight Junctions - metabolism | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Apolipoprotein E4 - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Pericytes - metabolism | Cells, Cultured | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Permeability | Apolipoprotein E3 - metabolism | Blood-Brain Barrier - metabolism | Gene Knock-In Techniques | Mice, Knockout | Blood-Brain Barrier - pathology | Apolipoprotein E3 - genetics | Animals | Models, Biological | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Endothelial Cells - pathology | Enzyme Activation - genetics | Tight Junctions - pathology | Astrocytes - metabolism | Protein Isoforms - genetics | Index Medicus | HDL | Neurobiology | PKC | Alzheimer Disease | Apolipoproteins | Endothelium | Tight Junction | Blood-Brain Barrier
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 04/2018, Volume 67, Issue 4, pp. 769 - 781
Tight junctions (TJs) involve close apposition of transmembrane proteins between cells. Although TJ proteins have been studied in detail, the role of lipids is... 
STARGARDT-3 MACULAR DYSTROPHY | NEONATAL LETHALITY | ELOVL4 PROTEIN | ENDOCRINOLOGY & METABOLISM | BARRIER FUNCTION | RETINOPATHY | FATTY-ACIDS | ENDOTHELIAL-CELL PERMEABILITY | TANDEM MASS-SPECTROMETRY | OCCLUDIN PHOSPHORYLATION | EXPRESSION | Retina - metabolism | Humans | Claudin-5 - metabolism | Retinal Vessels - ultrastructure | Vascular Endothelial Growth Factor A - metabolism | Capillary Permeability - genetics | Occludin - metabolism | Endothelial Cells - ultrastructure | Cattle | Interleukin-1beta - metabolism | Diabetes Mellitus, Experimental - complications | Membrane Proteins - metabolism | Diabetic Retinopathy - etiology | Eye Proteins - genetics | Zonula Occludens-1 Protein - metabolism | Diabetes Mellitus, Experimental - metabolism | Tight Junctions - metabolism | Ceramides - metabolism | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Diabetic Retinopathy - metabolism | Diabetic Retinopathy - genetics | Blood-Retinal Barrier - metabolism | Tight Junctions - ultrastructure | Animals | Eye Proteins - metabolism | Mice | Complications and side effects | Diabetic retinopathy | Diabetes | Research | Gene expression | Vascular endothelial growth factor | Risk factors | Retinopathy | Cytokines | Tight junctions | Diabetes mellitus | Lipids | Retina | Permeability | Fatty acids | Zonula occludens-1 protein | Membrane proteins | Proteins | Apposition | Ultrastructure | Index Medicus | Abridged Index Medicus | Complications | 0107
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 21, pp. 14645 - 14656
Anthrolysin O (ALO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis , the etiologic agent for anthrax. Growing evidence... 
LISTERIA-MONOCYTOGENES | TIGHT JUNCTIONS | CELLS | CONFORMATIONAL-CHANGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO MODEL | MEMBRANE INSERTION | THETA-TOXIN | PORE-FORMING TOXINS | PERFRINGOLYSIN-O | BIOLOGICAL WEAPON | Solubility - drug effects | Epithelial Cells - metabolism | Membrane Glycoproteins - metabolism | Calcium - metabolism | Bacteriocins - chemistry | Epithelial Cells - drug effects | Humans | Membrane Glycoproteins - chemistry | Protein Multimerization | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Hemolysin Proteins - chemistry | Occludin | Protein Binding - drug effects | Protein Structure, Quaternary | Membrane Proteins - metabolism | Bacteriocins - metabolism | Epithelial Cells - cytology | Bacillus anthracis - metabolism | Tight Junctions - drug effects | Caco-2 Cells | Protein Structure, Tertiary | Tight Junctions - metabolism | Amino Acid Sequence | Permeability - drug effects | Intracellular Space - drug effects | Protein Structure, Secondary | Perforin - chemistry | Models, Molecular | Bacillus anthracis - cytology | Cholesterol - metabolism | Bacterial Toxins - chemistry | Bacterial Toxins - metabolism | Intracellular Space - metabolism | Ionomycin - pharmacology | Bacterial Proteins - metabolism | Perforin - metabolism | Hemolysin Proteins - metabolism | Intestines - cytology | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | HUMAN POPULATIONS | PATHOGENESIS | ELEMENTS | CALCIUM | LIGHT SCATTERING | CRYSTAL STRUCTURE | DIMERIZATION | MATERIALS SCIENCE | BACILLUS | FUNCTIONS | PROTEINS | ULTRACENTRIFUGATION
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2454 - 2468
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed.... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | NEURITE OUTGROWTH | NITRIC-OXIDE SYNTHASE | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | VASCULAR-PERMEABILITY | ENDOTHELIAL GROWTH-FACTOR | HUMAN GLIOBLASTOMA-MULTIFORME | Membrane Glycoproteins - metabolism | Humans | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Occludin | Brain - metabolism | Inflammation - metabolism | Nitric Oxide Synthase Type III - metabolism | Demyelinating Diseases | Multiple Sclerosis - metabolism | Interleukin-1beta - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Nuclear Proteins - metabolism | Permeability | Blood-Brain Barrier - metabolism | Membrane Glycoproteins - genetics | Membrane Proteins | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Lymphocytes - pathology | Animals | Brain - pathology | Multiple Sclerosis - pathology | Mice | Primary Cell Culture | Vascular Endothelial Growth Factor A - physiology | Astrocytes - metabolism | Physiological aspects | Central nervous system diseases | Research | Blood-brain barrier | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus
Journal Article
Neurochemistry International, ISSN 0197-0186, 2009, Volume 54, Issue 3, pp. 253 - 263
Blood–brain barrier (BBB) characteristics are induced and maintained by cross-talk between brain microvessel endothelial cells and neighbouring elements of the... 
Astrocytes | Pericytes | In vitro BBB model (rat) | Tight junction | Transendothelial electrical resistance | Co-culture | P-Glycoprotein | Drug permeability | Blood–brain barrier | Brain endothelial cells | Blood-brain barrier | DRUG | PERMEABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGIOPOIETIN-1 | INDUCTION | GLIAL-CELLS | NEUROSCIENCES | MESSENGER-RNA | IN-VITRO MODEL | CULTURES | EXPRESSION | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pericytes - ultrastructure | Phosphoproteins - metabolism | Blood-Brain Barrier - ultrastructure | Occludin | Microcirculation - physiology | Endothelial Cells - ultrastructure | Membrane Proteins - metabolism | Capillaries - metabolism | Rhodamine 123 - pharmacokinetics | Tight Junctions - metabolism | Microscopy, Electron, Transmission | Capillaries - ultrastructure | Endothelial Cells - metabolism | Pericytes - metabolism | Cells, Cultured | Rats | Claudin-5 | Cerebral Arteries - ultrastructure | Membrane Potentials - physiology | Blood-Brain Barrier - metabolism | Astrocytes - ultrastructure | Tight Junctions - ultrastructure | Animals | Carrier Proteins - metabolism | Zonula Occludens-1 Protein | Cell Membrane Permeability - physiology | Cerebral Arteries - metabolism | Models, Biological | Cell Membrane Permeability - drug effects | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Astrocytes - metabolism | Proteins | Drug resistance in microorganisms | Brain | Fluorescein | Physiological aspects | Glucose | Universities and colleges | Permeability | Dextrose | Endothelium | Index Medicus
Journal Article
Journal Article
Journal of Nutrition, ISSN 0022-3166, 2016, Volume 146, Issue 3, pp. 501 - 508
Background: The tight junctions (TJs) are essential for maintenance of the intestinal mucosal barrier integrity. Results of our recent work show that dietary... 
AMPK | Tight junction | CaMKK2 | L-glutamine | Intestinal epithelial cells | intestinal epithelial cells | PERMEABILITY | MEMBRANE | BARRIER FUNCTION | COMPONENTS | CALCIUM REGULATION | SUPPLEMENTATION | NUTRITION & DIETETICS | AMINO-ACIDS | HEALTH | EXPRESSION | tight junction | CACO-2 CELLS | Intestines - drug effects | AMP-Activated Protein Kinases - metabolism | Intestinal Mucosa - metabolism | Phosphorylation | Epithelial Cells - metabolism | Claudin-4 - genetics | Enterocytes - metabolism | Epithelial Cells - drug effects | Zonula Occludens-2 Protein - metabolism | Intestinal Mucosa - drug effects | Occludin - metabolism | Occludin - genetics | Swine | Claudin-4 - metabolism | Cell Membrane - metabolism | Glutamine - pharmacology | Zonula Occludens-1 Protein - metabolism | Cell Membrane - drug effects | Tight Junctions - drug effects | Animals, Newborn | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Signal Transduction | Enterocytes - cytology | Gene Expression Regulation | Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics | Zonula Occludens-2 Protein - genetics | Animals | Enterocytes - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Junctional Adhesion Molecules - genetics | Cell Proliferation - drug effects | AMP-Activated Protein Kinases - genetics | Junctional Adhesion Molecules - metabolism | Intestines - cytology | Physiological aspects | Dosage and administration | Food and nutrition | Protein kinases | Intestinal mucosa | Methods | Glutamine | Permeability | Dietary supplements | Membrane proteins | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1208 - 1218.e2
Journal Article