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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2566 - 2575
Journal Article
Toxicology, ISSN 0300-483X, 2005, Volume 216, Issue 2, pp. 154 - 167
Many adverse drug reactions are caused by the cytochrome P450 (CYP) dependent activation of drugs into reactive metabolites. In order to reduce attrition due... 
Reactive metabolites | Cytotoxicity | Metabolism-mediated toxicity | CYP3A4 | In vitro screening | Adverse drug reactions (ADRs) | CYTOCHROME-P450 | MEDIATED CYTOTOXICITY | HUMAN HEPATOCYTE CULTURES | in vitro screening | CARBAMAZEPINE | adverse drug reactions (ADRs) | STABLE EXPRESSION | INDUCTION | metabolism-mediated toxicity | IDIOSYNCRATIC DRUG-REACTIONS | CHINESE-HAMSTER CELLS | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | reactive metabolites | HUMAN-LIVER-MICROSOMES | cytotoxicity | Microsomes - metabolism | Thiazoles - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Coculture Techniques | Humans | Thiazolidinediones - toxicity | Cytochrome P-450 Enzyme System - metabolism | Isoniazid - toxicity | Xenobiotics - toxicity | Chromans - metabolism | Flutamide - metabolism | Triazolam - toxicity | Microsomes - drug effects | Triazolam - metabolism | Adenosine Triphosphate - metabolism | Carbamazepine - toxicity | Toxicity Tests - methods | Xenobiotics - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Albendazole - toxicity | Tamoxifen - toxicity | Dapsone - metabolism | Dapsone - toxicity | Cell Line, Tumor | Glutathione - chemistry | Troglitazone | Buthionine Sulfoximine - pharmacology | Quinidine - toxicity | Amitriptyline - toxicity | Glutathione - metabolism | Flutamide - toxicity | Substrate Specificity | Piperazines - metabolism | Piperazines - toxicity | Ochratoxins - metabolism | Xenobiotics - chemistry | Tetrazolium Salts - metabolism | Carbamazepine - metabolism | Quinidine - metabolism | Tamoxifen - metabolism | Amitriptyline - metabolism | Glutathione - antagonists & inhibitors | Enzyme Activation - drug effects | Thiazolidinediones - metabolism | Ochratoxins - toxicity | Thiazoles - toxicity | Animals | Albendazole - metabolism | Chromans - toxicity | Isoniazid - metabolism | Phosphates | Metabolites | Ketoconazole | Cytochrome P-450 | Control systems | Xenobiotics | Glutathione
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2017, Volume 272, pp. 107 - 116
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2015, Volume 80, pp. 33 - 47
Ochratoxin A (OTA), a worldwide mycotoxin found in food and feeds, is a potent nephrotoxin in animals and humans. Porcine circovirus-associated disease... 
Oxidative stress | Porcine circovirus type 2 | Free radicals | Signaling pathway | Ochratoxin A | APOPTOSIS | KIDNEY PK15 CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | PHASE ARREST | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | MULTISYSTEMIC WASTING SYNDROME | KINASE ACTIVATION | EPIDEMIOLOGY | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Kidney - pathology | Porcine Postweaning Multisystemic Wasting Syndrome - pathology | Reactive Oxygen Species - agonists | Swine | Mitogen-Activated Protein Kinase 1 - genetics | Porcine Postweaning Multisystemic Wasting Syndrome - virology | Glutamate-Cysteine Ligase - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Virus Replication - drug effects | Kidney - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Epithelial Cells - pathology | Glomerulonephritis - virology | Circovirus - pathogenicity | Glomerulonephritis - drug therapy | Mitogen-Activated Protein Kinase 3 - metabolism | Epithelial Cells - virology | Glomerulonephritis - pathology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Glutamate-Cysteine Ligase - genetics | Oxidative Stress - drug effects | DNA, Viral - genetics | Kidney - virology | Viral Load - drug effects | Circovirus - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Porcine Postweaning Multisystemic Wasting Syndrome - drug therapy | Phosphorylation | NF-E2 Transcription Factor - genetics | DNA, Viral - biosynthesis | Glutathione - metabolism | Weaning | Epithelial Cells - drug effects | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Circovirus - drug effects | Glomerulonephritis - metabolism | NF-E2 Transcription Factor - metabolism | Ochratoxins - antagonists & inhibitors | Porcine Postweaning Multisystemic Wasting Syndrome - metabolism | Cell Line | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Glutathione - antagonists & inhibitors | Antioxidants - pharmacology | Ochratoxins - toxicity | Animals | Acetylcysteine - pharmacology | RNA | Ligases
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 12/2018, Volume 122, pp. 59 - 68
Because ochratoxin A (OTA) is widely found in foods, people are susceptible to OTA exposure. The mechanism leading to renal toxicity induced by OTA remains... 
NF-E2-related factor 2 | Oxidative stress | Aryl hydrocarbon receptor | Ochratoxin A | Kidney injury | Pregnane X receptor | LIPID-PEROXIDATION | FOOD SCIENCE & TECHNOLOGY | INJURY | INDUCTION | DRUG-METABOLIZING-ENZYMES | NAD(P)H-QUINONE OXIDOREDUCTASE | CANCER | ARYL-HYDROCARBON RECEPTOR | GLUTATHIONE | THERAPEUTIC TARGET | GENE-EXPRESSION | TOXICOLOGY | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Humans | Male | Pregnane X Receptor - metabolism | Gene Knockdown Techniques | Enzymes - genetics | Enzyme Induction - drug effects | Ochratoxins - administration & dosage | Pregnane X Receptor - genetics | Receptors, Aryl Hydrocarbon - metabolism | NF-E2-Related Factor 2 - genetics | Kidney Tubules, Proximal - enzymology | Enzymes - metabolism | Malondialdehyde - metabolism | Administration, Oral | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Mice, Inbred ICR | Ochratoxins - toxicity | Protein Transport | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Kidney Tubules, Proximal - metabolism | Hepatitis A Virus Cellular Receptor 1 - metabolism | Oxidative Stress - drug effects | Cell Line, Transformed | Kidney Tubules, Proximal - drug effects | Phosphates | Niacinamide | Cysteine | RNA | Ligases | Cytochrome P-450 | Heme | Physiological aspects | Glutamate | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e52051
The integrity of the gastrointestinal tract represents a crucial first level defence against ingested toxins. Among them, Nivalenol is a trichotecenes... 
SURVIVAL | TRICHOTHECENES | OCHRATOXIN-A | PROTEIN | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | NATURAL OCCURRENCE | FUSARIUM TOXINS | EXPOSURE | MYCOTOXINS | FOOD | Intestines - drug effects | Cell Line | Cell Survival - drug effects | Gap Junctions - metabolism | Intestinal Mucosa - metabolism | Actin Cytoskeleton - metabolism | Epithelial Cells - metabolism | Connexin 43 - metabolism | Apoptosis - drug effects | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Epithelial Cells - drug effects | Caspase 3 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Intestines - metabolism | Intestinal Mucosa - drug effects | Trichothecenes - pharmacology | Cell Movement - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Cell Cycle Checkpoints - drug effects | Gap Junctions - drug effects | Mycotoxins - pharmacology | Gastrointestinal system | Food contamination | Feed industry | Mycotoxicosis | Phosphorylation | Cereals | Bax protein | Bcl-2 protein | Epithelial cells | Adhesion tests | Connexin 43 | Kinases | Caspase-3 | Small intestine | Risk factors | Ingestion | Proteins | Nivalenol | Trichothecenes | Efficiency | Intestine | Actin | Rodents | Cell cycle | Gastric motility | Food | Medical research | Wound healing | Caspase | Gastrointestinal tract | Deoxynivalenol | Animal feed | Contaminants | Protein synthesis | S phase | Pharmacy | Cytoskeleton | Toxins | Focal adhesion kinase | Viability | Cell migration | Apoptosis | Pharmaceuticals
Journal Article