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STEM CELLS, ISSN 1066-5099, 11/2016, Volume 34, Issue 11, pp. 2721 - 2732
Prenatal folic acid (FA) supplementation prevents neural tube defects. Folate receptor alpha (FRα) is critical for embryonic development, including neural... 
Oct4 | Sox2 | Enhancer/promoters | Folate receptor alpha | miR‐138 | Multipotency | Klf4 | miR‐let‐7 | Cranial neural crest cells | miR-138 | miR-let-7 | SURVIVAL | TUBE | TRANSCRIPTIONAL NETWORK | MOUSE | PAX3 | PLURIPOTENCY | MICRORNAS | FOLIC-ACID | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | TARGET GENE | HEMATOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Folic Acid - pharmacology | MicroRNAs - antagonists & inhibitors | Transcriptional Activation | MicroRNAs - metabolism | Neural Stem Cells - cytology | SOXB1 Transcription Factors - agonists | Neural Crest - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - genetics | p300-CBP Transcription Factors - genetics | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - agonists | Kruppel-Like Transcription Factors - metabolism | PAX3 Transcription Factor - genetics | Female | Promoter Regions, Genetic | Neural Crest - cytology | Ribonuclease III - genetics | Ribonuclease III - metabolism | Signal Transduction | Neural Stem Cells - drug effects | PAX3 Transcription Factor - deficiency | Folate Receptor 1 - antagonists & inhibitors | Transcription Factors - genetics | Mice, Knockout | Neural Crest - drug effects | Octamer Transcription Factor-3 - agonists | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Animals | Histones - genetics | Folate Receptor 1 - genetics | Folate Receptor 1 - metabolism | Octamer Transcription Factor-3 - metabolism | Folic Acid - metabolism | Protein Binding | Mice | MicroRNAs - genetics | Histones - metabolism | Antagomirs - metabolism | Antagomirs - genetics | Kruppel-Like Transcription Factors - genetics | Neural Stem Cells - metabolism | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Genes | Cell proliferation | Chromatin | Immunoprecipitation | Oct-4 protein | Effector cells | Event-related potentials | Nuclei | Folic acid | Defects | Embryogenesis | KLF4 protein | Coding | Supplementation | Prenatal experience | Neural tube defects | MiRNA | Neural crest | Promoters | Embryonic growth stage | Polymerase chain reaction | Gene silencing | Stem cells | Neural stem cells | Skull
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2014, Volume 383, Issue 1-2, pp. 147 - 158
Valproic acid (VPA) has been shown to increase the reprogramming efficiency of induced pluripotent stem cells (iPSC) from somatic cells, but the mechanism by... 
Oct4 | Nuclear receptor | Muscle | Akt | VPA | iPSC | IPSC | PROGENITOR CELLS | DEFINED FACTORS | CONSTITUTIONAL ISOMERS | INDUCTION | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | ENDOCRINOLOGY & METABOLISM | SMALL-MOLECULE COMPOUNDS | HUMAN FIBROBLASTS | DIFFERENTIATION | EXPRESSION | TOR Serine-Threonine Kinases - metabolism | Muscle Cells - drug effects | Molecular Sequence Data | Phosphatidylinositol 3-Kinases - metabolism | Valproic Acid - analogs & derivatives | Valproic Acid - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Cellular Reprogramming | Octamer Transcription Factor-3 - genetics | TOR Serine-Threonine Kinases - genetics | Base Sequence | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Proto-Oncogene Proteins c-akt - metabolism | Induced Pluripotent Stem Cells - metabolism | Nuclear Receptor Subfamily 2, Group C, Member 1 - genetics | Nuclear Receptor Subfamily 2, Group C, Member 1 - metabolism | Promoter Regions, Genetic | Induced Pluripotent Stem Cells - drug effects | Signal Transduction | Gene Expression Regulation | Muscle Cells - metabolism | Muscle Cells - cytology | Octamer Transcription Factor-3 - agonists | Phosphatidylinositol 3-Kinases - genetics | Animals | COUP Transcription Factor II - genetics | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Protein Binding | Mice | COUP Transcription Factor II - metabolism | Valproic acid | Divalproex | Activated | Receptors | Pathways | Cooperation | Stem cells | Upstream | Hormones | Isomers
Journal Article
Circulation Research, ISSN 0009-7330, 02/2009, Volume 104, Issue 4, pp. e30 - e41
Human induced pluripotent stem (iPS) cells hold great promise for cardiovascular research and therapeutic applications, but the ability of human iPS cells to... 
Action potential | Differentiation | Embryonic stem cells | Induced pluripotent stem cells | Cardiomyocyte | CARDIAC & CARDIOVASCULAR SYSTEMS | differentiation | embryonic stem cells | CARDIAC MYOCYTES | INDUCTION | action potential | LINES | OCT4 | cardiomyocyte | HUMAN FIBROBLASTS | PERIPHERAL VASCULAR DISEASE | induced pluripotent stem cells | GENERATION | HEMATOLOGY | DEVELOP | Embryonic Stem Cells - metabolism | RNA-Binding Proteins - genetics | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Myocardial Contraction - drug effects | SOXB1 Transcription Factors - metabolism | Action Potentials | Octamer Transcription Factor-3 - genetics | Cell Differentiation - genetics | SOXB1 Transcription Factors - genetics | Time Factors | Cell Line | Nanog Homeobox Protein | Transduction, Genetic | Sarcomeres - metabolism | Pluripotent Stem Cells - physiology | Gene Expression Regulation | Adrenergic beta-Agonists - pharmacology | Embryonic Stem Cells - physiology | Homeodomain Proteins - genetics | Pluripotent Stem Cells - metabolism | Phenotype | Myocytes, Cardiac - drug effects | Embryonic Stem Cells - drug effects | Myocytes, Cardiac - physiology | Isoproterenol - pharmacology | Octamer Transcription Factor-3 - metabolism | Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Cell Stem Cell, ISSN 1934-5909, 04/2009, Volume 4, Issue 4, pp. 301 - 312
Journal Article
Molecular Therapy, ISSN 1525-0016, 11/2017, Volume 25, Issue 11, pp. 2502 - 2512
Unlike the epidermis, which regenerates continually, hair follicles anchored in the subcutis periodically regenerate by spontaneous repetitive cycles of growth... 
stem cells | β-catenin | hair follicles | E-cadherin | anagen | MEDICINE, RESEARCH & EXPERIMENTAL | KERATINOCYTES | NATURAL VITAMIN-E | ADULT | TRANSIENT ACTIVATION | MULTIPOTENT STEM-CELLS | WNT/BETA-CATENIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GLUTAMATE-INDUCED NEURODEGENERATION | SKIN | FOLLICLE | MOLECULAR-BASIS | Cadherins - metabolism | Male | Protein Transport - drug effects | Tocotrienols - pharmacology | Octamer Transcription Factor-3 - genetics | Cell Nucleus - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Kruppel-Like Transcription Factors - metabolism | Regeneration - genetics | Cadherins - genetics | Nanog Homeobox Protein - genetics | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Mice, Inbred C57BL | beta Catenin - agonists | Gene Expression Regulation | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Hair Follicle - drug effects | Regeneration - drug effects | Animals | Hair Follicle - metabolism | Octamer Transcription Factor-3 - metabolism | Hair Follicle - growth & development | Cadherins - antagonists & inhibitors | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Nucleus - drug effects | Kruppel-Like Transcription Factors - genetics | Phytochemicals - pharmacology | SOX9 Transcription Factor - genetics | Nanog Homeobox Protein - metabolism | Hair | Immunoglobulins | Sox9 protein | Diabetes mellitus | Oct-4 protein | Fetuses | c-Myc protein | Epidermis | Histology | Gene expression | Follicles | Nuclear transport | Studies | Cell growth | Alopecia | KLF4 protein | Vitamin E | Stem cells | Degeneration | Skin | Pluripotency | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0150936
Understanding the mechanisms that regulate pluripotency of embryonic stem cells (ESCs) is important to ensure their safe clinical use. CHIR99021 (CHIR)-induced... 
OCT4 | ACTIVATION | GROUND-STATE | GENE | STABILITY | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | PLURIPOTENCY | DIFFERENTIATION | MICRORNAS | MODULATION | Receptors, Estrogen - metabolism | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | Humans | Molecular Sequence Data | MicroRNAs - metabolism | Mouse Embryonic Stem Cells - cytology | Mouse Embryonic Stem Cells - drug effects | Mouse Embryonic Stem Cells - metabolism | Octamer Transcription Factor-3 - genetics | Kruppel-Like Transcription Factors - agonists | Kruppel-Like Transcription Factors - metabolism | Base Sequence | 3' Untranslated Regions | Gene Ontology | Cell Line | Nanog Homeobox Protein | Receptors, Estrogen - genetics | Molecular Sequence Annotation | Gene Expression Regulation | Pyrimidines - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - metabolism | Homeodomain Proteins - genetics | beta Catenin - genetics | Animals | Wnt Signaling Pathway - drug effects | Octamer Transcription Factor-3 - metabolism | Mice | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Pyridines - pharmacology | Kruppel-Like Transcription Factors - genetics | Veterinary colleges | Biotechnology | Transcription factors | Wnt protein | Laboratories | Genes | Oct-4 protein | Embryo cells | c-Myc protein | Stem cell transplantation | Activation | Myc protein | Kinases | Veterinary medicine | KLF4 gene | β-catenin | KLF4 protein | Life sciences | Bioinformatics | Deoxyribonucleic acid--DNA | Kruppel protein | Repressing | MiRNA | Signaling | DNA microarrays | 3' Untranslated regions | MicroRNAs | Stem cells | Pluripotency | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e13831
Background: Cancer stem cells (CSCs) have increased resistance to cancer chemotherapy. They can be enriched as drug-surviving CSCs (D-CSCs) by growth with... 
DRUG | SIDE POPULATION | ACTIVATION | GROWTH | BIOLOGY | TRANILAST | CYCLE PROGRESSION | ABC TRANSPORTERS | CHEMOTHERAPY | IN-VITRO PROPAGATION | MAMMARY-GLAND | ortho-Aminobenzoates - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Lung Neoplasms - metabolism | Transplantation, Heterologous | Mammary Neoplasms, Experimental - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Flow Cytometry | Lung Neoplasms - secondary | Neoplastic Stem Cells - metabolism | RNA Interference | Mammary Neoplasms, Experimental - pathology | Receptors, Aryl Hydrocarbon - metabolism | Female | Aldehyde Dehydrogenase - metabolism | Mammary Neoplasms, Experimental - prevention & control | Receptors, Aryl Hydrocarbon - genetics | Cytochrome P-450 CYP1A1 - metabolism | Mice, SCID | Blotting, Western | Breast Neoplasms - prevention & control | Receptors, Aryl Hydrocarbon - agonists | Animals | Lung Neoplasms - prevention & control | Breast Neoplasms - pathology | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Antimitotic agents | Herbicides | Chemotherapy | Polycyclic aromatic hydrocarbons | Dioxin | Stem cells | Breast cancer | Drug resistance | Antineoplastic agents | Cancer | TCDD | Hydrocarbons | Knowledge | Cancer therapies | Cyclin-dependent kinase 4 | Anticancer properties | Metastases | Genotype & phenotype | Fibroblasts | Biocompatibility | Inhibition | Mitoxantrone | Growth factors | Antigens | Narcotics | Cultures | Biomarkers | Ligands | Drugs | Biotechnology | Laboratories | Oct-4 protein | Xenotransplantation | Genes | Stem cell transplantation | Aldehyde dehydrogenase | Cell adhesion & migration | Allografts | Aromatic compounds | Xenografts | Translocation | Colonies | Cytochrome P450 | Agar | siRNA | Pharmacology | Tumor cell lines | c-Kit protein | ErbB-2 protein | Medicine | Lungs | Cell lines | Breast | Diabetes | Tumors
Journal Article
Life Sciences, ISSN 0024-3205, 09/2014, Volume 112, Issue 1-2, pp. 33 - 40
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e103485
Genetically unmodified cardiomyocytes mandated for cardiac regenerative therapy is conceivable by "foot-print free" reprogramming of somatic cells to induced... 
MULTIDISCIPLINARY SCIENCES | GENERATION | CARDIOMYOCYTES | MODEL | INDUCED DEVELOPMENTAL TOXICITY | FIBROBLASTS | VECTOR | MURINE | Humans | Middle Aged | Ion Channels - drug effects | Male | Ion Channels - physiology | Stage-Specific Embryonic Antigens - genetics | Octamer Transcription Factor-3 - genetics | Cell Differentiation - genetics | Stage-Specific Embryonic Antigens - metabolism | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | Cholinergic Agonists - pharmacology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Membrane Potentials - drug effects | Gene Expression | Cellular Reprogramming Techniques - methods | Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - physiology | Myocytes, Cardiac - cytology | Pluripotent Stem Cells - physiology | RNA, Messenger - genetics | Cells, Cultured | Cardiotonic Agents - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Cellular Reprogramming - drug effects | Pluripotent Stem Cells - metabolism | Carbachol - pharmacology | Microscopy, Confocal | Myocytes, Cardiac - physiology | Fibroblasts - drug effects | Isoproterenol - pharmacology | Octamer Transcription Factor-3 - metabolism | Myocytes, Cardiac - metabolism | Fibroblasts - cytology | Proteins | Messenger RNA | Analysis | Stem cells | Heart | Tetrodotoxin | Transcription | Calcium | Mesoderm | Isoproterenol | Regeneration (physiology) | Penicillin | Fibroblasts | Ion channels | Heart diseases | Evaluation | Calcium channels | Feasibility studies | Cardiomyocytes | Pharmacology | Potassium channels | Gene expression | Embryos | Feet | Medicine | Regeneration | Sodium | Ribonucleic acids | Somatic cells | Plasmids | Potassium | Pluripotency | Inhibitory postsynaptic potentials | Structure-function relationships
Journal Article
Journal Article