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Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 772 - 784
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 67 - 73
Despite their fundamental biological and clinical importance, the molecular mechanisms that regulate the first cell fate decisions in the human embryo are not... 
ANALYZER | HUMAN EMBRYOS | INNER CELL MASS | FGF | MULTIDISCIPLINARY SCIENCES | GENES | HUMAN ZYGOTES | GENERATION | CAS9 | NORMALIZATION | POU DOMAIN | Human Embryonic Stem Cells - cytology | Humans | Zygote - metabolism | Substrate Specificity | Male | Embryo, Mammalian - metabolism | Octamer Transcription Factor-3 - genetics | Ectoderm - metabolism | Gene Expression Regulation, Developmental | Female | Nanog Homeobox Protein - genetics | Human Embryonic Stem Cells - metabolism | Germ Layers - metabolism | Blastocyst - metabolism | Embryonic Development - genetics | CRISPR-Cas Systems - genetics | Gene Editing | Cell Lineage | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Octamer Transcription Factor-3 - metabolism | Mice | Octamer Transcription Factor-3 - deficiency | Nanog Homeobox Protein - metabolism | Embryonic development | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Genes | Oct-4 protein | Embryo cells | Genomes | CDX2 protein | Kinases | Trophectoderm | Proteins | Embryogenesis | Embryology | Cell fate | Null cells | Deoxyribonucleic acid--DNA | CRISPR | Gene expression | Ribonucleic acid--RNA | Embryos | Embryonic growth stage | Studies | Zygotes | Molecular modelling | Microinjection | Stem cells | Protein expression | Genetic engineering | Mutation | Pluripotency
Journal Article
Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 674 - 682
B cells have been shown to be refractory to reprogramming and B-cell-derived induced pluripotent stem cells (iPSC) have only been generated from murine B cells... 
DERIVATION | CD34(+) CELLS | MAINTENANCE | ONCOLOGY | HEMATOPOIETIC COMMITMENT | CORD BLOOD | GENERATION | HEMATOLOGY | EFFICIENT | EXPRESSION | T-CELLS | LINES | Myeloid Cells - cytology | Leukocytes, Mononuclear - metabolism | Humans | Molecular Sequence Data | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - genetics | SOXB1 Transcription Factors - immunology | Myeloid Cells - immunology | Base Sequence | Leukocytes, Mononuclear - immunology | Cell Differentiation | Octamer Transcription Factor-3 - immunology | V(D)J Recombination - immunology | CCAAT-Enhancer-Binding Proteins - genetics | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | B-Lymphocytes - metabolism | Induced Pluripotent Stem Cells - metabolism | Fetal Blood - immunology | B-Lymphocytes - cytology | Gene Expression | Cell Separation | Proto-Oncogene Proteins c-myc - immunology | Fetal Blood - cytology | Fetal Blood - metabolism | Sendai virus - genetics | Cellular Reprogramming - immunology | B-Lymphocytes - immunology | CCAAT-Enhancer-Binding Proteins - immunology | Myeloid Cells - metabolism | Leukocytes, Mononuclear - cytology | Induced Pluripotent Stem Cells - immunology | Proto-Oncogene Proteins c-myc - genetics | Primary Cell Culture | Genetic Vectors | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 10/2013, Volume 4, Issue 1, p. 2597
The possibility of generating neural stem/precursor cells (NPCs) from induced pluripotent stem cells (iPSCs) has opened a new avenue of research that might... 
REPLACEMENT | MULTIPLE-SCLEROSIS | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | GENE-EXPRESSION | CNS | REMYELINATION | MODEL | DIFFERENTIATION | STEM-CELL TRANSPLANTATION | BRAIN | Cell- and Tissue-Based Therapy - methods | Leukemia Inhibitory Factor - secretion | Demyelinating Diseases - therapy | Encephalomyelitis, Autoimmune, Experimental - immunology | Leukemia Inhibitory Factor - genetics | Neural Stem Cells - cytology | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Oligodendroglia - physiology | SOXB1 Transcription Factors - genetics | Kruppel-Like Transcription Factors - metabolism | Demyelinating Diseases - immunology | Neural Stem Cells - transplantation | Female | Cell Differentiation | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Induced Pluripotent Stem Cells - cytology | Biomarkers - metabolism | Injections, Spinal | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - pathology | Induced Pluripotent Stem Cells - physiology | Neural Stem Cells - physiology | Mice, Transgenic | Multiple Sclerosis - therapy | Encephalomyelitis, Autoimmune, Experimental - therapy | Animals | Octamer Transcription Factor-3 - metabolism | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Mice | Kruppel-Like Transcription Factors - genetics | Cell Movement
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2008, Volume 3, Issue 7, p. e2637
CD133 (prominin-1), a 5-transmembrane glycoprotein, has recently been considered to be an important marker that represents the subset population of cancer... 
SIDE POPULATION | CONTRIBUTE | PROTEIN | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PLURIPOTENCY | IDENTIFICATION | PROMOTER | TRANSCRIPTION FACTOR | TUMORS | HEMATOPOIETIC STEM | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Antigens, CD - immunology | Cell Survival | Humans | Lung Neoplasms - metabolism | Peptides - immunology | Carcinoma, Non-Small-Cell Lung - metabolism | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | AC133 Antigen | Antigens, CD - analysis | Octamer Transcription Factor-3 - genetics | Glycoproteins - immunology | Neoplastic Stem Cells - metabolism | Octamer Transcription Factor-3 - metabolism | Fluorescent Antibody Technique | ATP-Binding Cassette Transporters - metabolism | Cell Line, Tumor | Glycoproteins - analysis | Peptides - analysis | Apoptosis | RNA, Small Interfering - metabolism | Chemotherapy | Drug resistance | Lung cancer, Non-small cell | Cancer | Thoracic surgery | Oct-4 protein | Brain cancer | Genes | Lung cancer | Critical care | Caspase-3 | Doxorubicin | Proteins | Epidermal growth factor | Education | Ribose | Paclitaxel | Fibroblasts | Population | Drug dosages | Medical research | Glycoprotein | Poly(ADP-ribose) polymerase | Non-small cell lung carcinoma | Etoposide | Caspase | Adenosine diphosphate | siRNA | Breast cancer | Radiation therapy | Patients | Cisplatin | Medicine | Studies | Polymerase | Stem cells | In vivo methods and tests | Clinical medicine | Binding sites | Tumors
Journal Article
Journal Article