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Nature (London), ISSN 1476-4687, 2017, Volume 550, Issue 7674, pp. 67 - 73
.... Here we use CRISPR-Cas9-mediated genome editing to investigate the function of the pluripotency transcription factor OCT4 during human embryogenesis... 
ANALYZER | HUMAN EMBRYOS | INNER CELL MASS | FGF | MULTIDISCIPLINARY SCIENCES | GENES | HUMAN ZYGOTES | GENERATION | CAS9 | NORMALIZATION | POU DOMAIN | Human Embryonic Stem Cells - cytology | Humans | Zygote - metabolism | Substrate Specificity | Male | Embryo, Mammalian - metabolism | Octamer Transcription Factor-3 - genetics | Ectoderm - metabolism | Gene Expression Regulation, Developmental | Female | Nanog Homeobox Protein - genetics | Human Embryonic Stem Cells - metabolism | Germ Layers - metabolism | Blastocyst - metabolism | Embryonic Development - genetics | CRISPR-Cas Systems - genetics | Gene Editing | Cell Lineage | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Octamer Transcription Factor-3 - metabolism | Mice | Octamer Transcription Factor-3 - deficiency | Nanog Homeobox Protein - metabolism | Embryonic development | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Genes | Oct-4 protein | Embryo cells | Genomes | CDX2 protein | Kinases | Trophectoderm | Proteins | Embryogenesis | Embryology | Cell fate | Null cells | Deoxyribonucleic acid--DNA | CRISPR | Gene expression | Ribonucleic acid--RNA | Embryos | Embryonic growth stage | Studies | Zygotes | Molecular modelling | Microinjection | Stem cells | Protein expression | Genetic engineering | Mutation | Pluripotency
Journal Article
Oncogene, ISSN 1476-5594, 2012, Volume 31, Issue 47, pp. 4898 - 4911
... is the most critical transcription factor since it can reprogram adult stem cells to iPS cells as a single factor (Kim et al., 2009a, b). Tumorigenesis and somatic cell... 
hypoxia | Oct4 | dedifferentiation | melanoma | cancer stem cell | INITIATING CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLURIPOTENCY | CELL BIOLOGY | SUBPOPULATION | ONCOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | GENERATION | MELANOMA-CELLS | DIFFERENTIATION | PROMOTES | Octamer Transcription Factor-3 - physiology | Neoplasm Transplantation | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Cell Dedifferentiation | Cell Hypoxia | Octamer Transcription Factor-3 - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Cell Shape | Genes, Reporter | Neoplastic Stem Cells - physiology | Melanoma - metabolism | Promoter Regions, Genetic | Nanog Homeobox Protein | Cell Survival | Spheroids, Cellular - metabolism | Melanoma - pathology | Mice, SCID | Homeodomain Proteins - genetics | Phenotype | Animals | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Mice, Inbred NOD | Mice | Kruppel-Like Transcription Factors - genetics | Cell Movement | Prognosis | Cancer cells | Melanoma | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Genotype & phenotype | Stem cells | Hypoxia | Skin cancer | Tumors | Transcription factors | Tumor cells | Oct-4 protein | Data processing | Chemotherapy | KLF4 protein | Veins | Xenografts | Differentiation | spheroids | Injuries | Cancer | Cancer stem cell | Dedifferentiation
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2016, Volume 354, Issue 6315, pp. aaf4445 - aaf4445
Journal Article
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2013, Volume 31, Issue 2, pp. 259 - 268
...). In particular, we demonstrate a regulatory feedback loop between the miR‐302 cluster and two transcription factors, NR2F2 and OCT4... 
OCT4 | MicroRNA | Reprogramming | Induced pluripotent stem cells | CARCINOMA-CELLS | NUCLEAR RECEPTORS | TRANSCRIPTIONAL REGULATORY CIRCUITRY | SELF-RENEWAL | PLURIPOTENCY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MIR-302 | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | HUMAN FIBROBLASTS | HUMAN SOMATIC-CELLS | HEMATOLOGY | RNA, Small Interfering - genetics | Kruppel-Like Transcription Factors - pharmacology | Humans | Adipocytes - cytology | MicroRNAs - metabolism | Adipocytes - drug effects | MicroRNAs - pharmacology | COUP Transcription Factor II - antagonists & inhibitors | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - pharmacology | SOXB1 Transcription Factors - genetics | Kruppel-Like Transcription Factors - metabolism | Luciferases | Microarray Analysis | Female | Proto-Oncogene Proteins c-myc - pharmacology | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | Genes, Reporter | Induced Pluripotent Stem Cells - metabolism | Promoter Regions, Genetic | Induced Pluripotent Stem Cells - drug effects | Octamer Transcription Factor-3 - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | Cellular Reprogramming - drug effects | Gene Expression Regulation - drug effects | Feedback, Physiological | Signal Transduction - drug effects | COUP Transcription Factor II - genetics | Cell Differentiation - drug effects | Adipocytes - metabolism | Octamer Transcription Factor-3 - metabolism | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | COUP Transcription Factor II - metabolism | Primary Cell Culture | Kruppel-Like Transcription Factors - genetics | Genes | Luciferase | Information management | DNA binding proteins | Embryonic stem cells | Gene expression | Skin cancer | Financial disclosure | Stem cell research | Messenger RNA | Analysis | Universities and colleges | Cardiology | Medical research | Efficiency | Stem cells | reprogramming | microRNA | induced pluripotent stem cells
Journal Article