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dna-binding proteins - genetics (58) 58
medicine (58) 58
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mouse (48) 48
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mice, knockout (46) 46
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Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 1, pp. 105 - 116
Journal Article
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7585, pp. 226 - 230
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3795 - 3808
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 5, pp. 1674 - 1674
The roles of microRNAs (miRNAs) and the miRNA processing machinery in the regulation of stem cell biology are not well understood. Here, we show that the p53... 
PNAS Plus: Significance Statements | LIMB | STEM-CELLS | METASTASIS | MULTIDISCIPLINARY SCIENCES | PLURIPOTENCY | EPITHELIAL DEVELOPMENT | MICRORNAS | P63 | EPIDERMAL MORPHOGENESIS | TAP63 | P53 | RNA-Binding Proteins - genetics | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Multipotent Stem Cells - metabolism | Transcription Factors - deficiency | MicroRNAs - metabolism | Gene Expression Profiling | Phosphoproteins - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Adult | Transcription, Genetic | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Nanog Homeobox Protein | RNA, Messenger - genetics | Keratinocytes - cytology | Phosphoproteins - genetics | Transcription Factors - genetics | Down-Regulation - genetics | Proteins - genetics | Transcription Factors - metabolism | Cell Lineage | Animals | Proteins - metabolism | Trans-Activators - deficiency | Embryo, Mammalian - cytology | Keratinocytes - metabolism | Multipotent Stem Cells - cytology | Octamer Transcription Factor-3 - metabolism | Phosphoproteins - deficiency | Trans-Activators - metabolism | Mice | MicroRNAs - genetics | RNA-Binding Proteins - metabolism | Chimera | Epidermis - cytology | PNAS Plus | Biological Sciences
Journal Article
Nature Neuroscience, ISSN 1097-6256, 06/2011, Volume 14, Issue 6, pp. 685 - 687
Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be... 
NEUROSCIENCES | CODES | SPECIFICATION | Octamer Transcription Factors - deficiency | Taste Buds - metabolism | Animals | Mice, Inbred C57BL | Male | Mice | Taste - physiology | Octamer Transcription Factors - metabolism | Cell Lineage - physiology | Mice, Knockout | Taste buds | Physiological aspects | Transcription factors | Genetic aspects | Research
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2010, Volume 30, Issue 27, pp. 9127 - 9139
The balance between self-renewal and differentiation of neural progenitor cells is an absolute requirement for the correct formation of the nervous system.... 
NUCLEAR FACTOR-I | STEM-CELLS | POSTMITOTIC NEURONS | FIBRILLARY ACIDIC PROTEIN | NEGATIVE AUTOREGULATION | PROMOTER ELEMENTS | TRANSCRIPTION | GENE-EXPRESSION | CENTRAL-NERVOUS-SYSTEM | RADIAL GLIA | NEUROSCIENCES | Transcription Factor HES-1 | Age Factors | Embryo, Mammalian | Homeodomain Proteins - metabolism | Gene Expression Regulation, Developmental - genetics | Octamer Transcription Factor-6 - genetics | Receptors, Kainic Acid - genetics | Cell Differentiation - genetics | Octamer Transcription Factor-6 - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Tumor Suppressor Proteins - genetics | Chromatin Immunoprecipitation - methods | Bromodeoxyuridine - metabolism | Cerebral Ventricles - embryology | NFI Transcription Factors - deficiency | Hippocampus - growth & development | Gene Expression Regulation, Developmental - physiology | Microarray Analysis - methods | Tumor Suppressor Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Telencephalon - cytology | Mice, Inbred C57BL | Telencephalon - embryology | Hippocampus - cytology | Mutation - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Mice, Knockout | NFI Transcription Factors - physiology | Nerve Tissue Proteins - metabolism | Electrophoretic Mobility Shift Assay - methods | Receptors, Kainic Acid - metabolism | Animals | Cell Count - methods | Promoter Regions, Genetic - physiology | Analysis of Variance | Stem Cells - physiology | Mice | Cerebral Ventricles - cytology
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2016, Volume 34, Issue 11, pp. 2721 - 2732
Prenatal folic acid (FA) supplementation prevents neural tube defects. Folate receptor alpha (FRα) is critical for embryonic development, including neural... 
Oct4 | Sox2 | Enhancer/promoters | Folate receptor alpha | miR‐138 | Multipotency | Klf4 | miR‐let‐7 | Cranial neural crest cells | miR-138 | miR-let-7 | SURVIVAL | TUBE | TRANSCRIPTIONAL NETWORK | MOUSE | PAX3 | PLURIPOTENCY | MICRORNAS | FOLIC-ACID | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | TARGET GENE | HEMATOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Folic Acid - pharmacology | MicroRNAs - antagonists & inhibitors | Transcriptional Activation | MicroRNAs - metabolism | Neural Stem Cells - cytology | SOXB1 Transcription Factors - agonists | Neural Crest - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - genetics | p300-CBP Transcription Factors - genetics | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - agonists | Kruppel-Like Transcription Factors - metabolism | PAX3 Transcription Factor - genetics | Female | Promoter Regions, Genetic | Neural Crest - cytology | Ribonuclease III - genetics | Ribonuclease III - metabolism | Signal Transduction | Neural Stem Cells - drug effects | PAX3 Transcription Factor - deficiency | Folate Receptor 1 - antagonists & inhibitors | Transcription Factors - genetics | Mice, Knockout | Neural Crest - drug effects | Octamer Transcription Factor-3 - agonists | Transcription Factors - metabolism | p300-CBP Transcription Factors - metabolism | Animals | Histones - genetics | Folate Receptor 1 - genetics | Folate Receptor 1 - metabolism | Octamer Transcription Factor-3 - metabolism | Folic Acid - metabolism | Protein Binding | Mice | MicroRNAs - genetics | Histones - metabolism | Antagomirs - metabolism | Antagomirs - genetics | Kruppel-Like Transcription Factors - genetics | Neural Stem Cells - metabolism | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Embryonic development | Chromatin | Biosynthesis | MicroRNA | Folic acid | Stem cells | Genes | Cell proliferation | Immunoprecipitation | Oct-4 protein | Effector cells | Event-related potentials | Nuclei | Defects | Embryogenesis | KLF4 protein | Coding | Supplementation | Prenatal experience | Neural tube defects | MiRNA | Neural crest | Promoters | Embryonic growth stage | Polymerase chain reaction | Gene silencing | Neural stem cells | Skull
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 07/2013, Volume 31, Issue 7, pp. 1350 - 1362
In this study, we demonstrate that sphere formation triggers immortalization and stable reprogramming of mouse fibroblasts. Cell contact signaling in spheres... 
Hypoxia | Adult stem cells | Reprogramming | Differentiation | PROLIFERATION | CANCER STEM-CELLS | DNA DEMETHYLATION | PLURIPOTENT | CELL & TISSUE ENGINEERING | CELL BIOLOGY | OXYGEN | GENE | ONCOLOGY | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | COMPONENT | GROWTH-FACTOR | HEMATOLOGY | EXPRESSION | Cell Hypoxia - physiology | Epithelial-Mesenchymal Transition - physiology | Homeodomain Proteins - metabolism | Multipotent Stem Cells - metabolism | Octamer Transcription Factor-3 - biosynthesis | Transcriptome | Stem Cells - cytology | Epithelial-Mesenchymal Transition - genetics | Stem Cells - metabolism | Gene Knockdown Techniques | DNA (Cytosine-5-)-Methyltransferases - metabolism | Octamer Transcription Factor-3 - genetics | Cell Differentiation - genetics | DNA Methylation | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Kruppel-Like Transcription Factors - metabolism | Kruppel-Like Transcription Factors - deficiency | Multipotent Stem Cells - physiology | Cell Differentiation - physiology | Fibroblasts - metabolism | Promoter Regions, Genetic | DNA (Cytosine-5-)-Methyltransferase 1 | Cytidine Deaminase - genetics | Cells, Cultured | Homeodomain Proteins - genetics | Animals | Multipotent Stem Cells - cytology | Cytidine Deaminase - metabolism | Octamer Transcription Factor-3 - metabolism | Stem Cells - physiology | Fibroblasts - cytology | Mice | Cell Hypoxia - genetics | Kruppel-Like Transcription Factors - genetics | Zinc Finger E-box-Binding Homeobox 1 | Methyltransferases | Gene expression | Analysis | Stem cells | Proteins | Spheres | Kinases
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2014, Volume 289, Issue 8, pp. 4778 - 4786
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2010, Volume 316, Issue 14, pp. 2365 - 2376
Previous gene targeting studies in mice have implicated the nuclear protein Krüppel-like factor 7 (KLF7) in nervous system development while cell culture... 
Cardiomyogenesis | Map2 | Neuritogenesis | BLBP/FABP7 | Osteogenesis | Adipogenesis | SELF-RENEWAL | NEURONAL DIFFERENTIATION | RECEPTOR | NERVE GROWTH-FACTOR | CELL BIOLOGY | IN-VITRO | GENE | ONCOLOGY | EMBRYONIC STEM-CELLS | TERMINAL DIFFERENTIATION | ES CELLS | EXPRESSION | Immunohistochemistry | Embryonic Stem Cells - cytology | Nanog Homeobox Protein | Cells, Cultured | Gene Expression Regulation | Gene Silencing | Rats | Neurons - cytology | Mesoderm - cytology | Neural Plate - cytology | Reverse Transcriptase Polymerase Chain Reaction | PC12 Cells | Blotting, Western | Homeodomain Proteins - genetics | Mice, Knockout | Octamer Transcription Factor-3 - genetics | Animals | Kruppel-Like Transcription Factors - metabolism | Female | Cell Differentiation | Mice | Kruppel-Like Transcription Factors - deficiency | Kruppel-Like Transcription Factors - genetics | Tyrosine | Phosphates | RNA | Neurons | Nerve growth factor | Embryonic stem cells | Gene expression | Monosaccharides | Anopheles | Epidermal growth factor | Horses | Genetic research | Fibroblast growth factors | Intermediate filament proteins | Sugars | Proteins | Cell culture | Cellular biology | Rodents | TRANSCRIPTION FACTORS | MICROTUBULES | CELL CULTURES | CATTLE | HORSES | 60 APPLIED LIFE SCIENCES | FIBROBLASTS | GROWTH FACTORS | POLYMERASE CHAIN REACTION | TYROSINE | IN VITRO | PHOSPHATES | CELL CYCLE | MICE | STEM CELLS | RECEPTORS | BRAIN
Journal Article