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Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 772 - 784
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Index Medicus | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 674 - 682
B cells have been shown to be refractory to reprogramming and B-cell-derived induced pluripotent stem cells (iPSC) have only been generated from murine B cells... 
MULTIPLE-MYELOMA | CD34(+) CELLS | PERIPHERAL-BLOOD CELLS | ONCOLOGY | CORD BLOOD | HEMATOPOIETIC SPECIFICATION | GENERATION | HEMATOLOGY | EFFICIENT | T-CELLS | LINES | LYMPHOCYTES | Myeloid Cells - cytology | Leukocytes, Mononuclear - metabolism | Humans | Molecular Sequence Data | Octamer Transcription Factor-3 - genetics | SOXB1 Transcription Factors - genetics | SOXB1 Transcription Factors - immunology | Myeloid Cells - immunology | Base Sequence | Leukocytes, Mononuclear - immunology | Cell Differentiation | Octamer Transcription Factor-3 - immunology | V(D)J Recombination - immunology | CCAAT-Enhancer-Binding Proteins - genetics | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | B-Lymphocytes - metabolism | Induced Pluripotent Stem Cells - metabolism | Fetal Blood - immunology | B-Lymphocytes - cytology | Gene Expression | Cell Separation | Proto-Oncogene Proteins c-myc - immunology | Fetal Blood - cytology | Fetal Blood - metabolism | Sendai virus - genetics | Cellular Reprogramming - immunology | B-Lymphocytes - immunology | CCAAT-Enhancer-Binding Proteins - immunology | Myeloid Cells - metabolism | Leukocytes, Mononuclear - cytology | Induced Pluripotent Stem Cells - immunology | Proto-Oncogene Proteins c-myc - genetics | Primary Cell Culture | Genetic Vectors | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 10/2018, Volume 175, Issue 2, pp. 488 - 501.e22
Detection of viruses by innate immune sensors induces protective antiviral immunity. The viral DNA sensor cyclic GMP-AMP synthase (cGAS) is necessary for... 
HIV-1 | macrophages | HIV-2 | dendritic cells | innate immunity | NONO | capsid | cGAS | STING | innate immune sensors | DNA SENSOR | TRANSMISSION | LONG NONCODING RNA | DENDRITIC CELLS | SENSOR CGAS | PATHWAY | FORM | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | RETROVIRUSES | GMP-AMP SYNTHASE | CELL BIOLOGY | Dendritic Cells - immunology | Humans | Octamer Transcription Factors - immunology | Nucleotidyltransferases - physiology | HIV Infections - immunology | Signal Transduction - immunology | Capsid Proteins - physiology | Cell Nucleus - metabolism | Octamer Transcription Factors - physiology | Nuclear Matrix-Associated Proteins - physiology | Capsid Proteins - immunology | HIV-2 - genetics | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Capsid - metabolism | Macrophages - immunology | RNA-Binding Proteins - physiology | Capsid Proteins - metabolism | Nuclear Matrix-Associated Proteins - immunology | RNA-Binding Proteins - immunology | Nuclear Matrix-Associated Proteins - metabolism | HIV-1 - genetics | Host-Pathogen Interactions | DNA, Viral - immunology | Immunity, Innate - immunology | HIV-1 - immunology | HIV-2 - immunology | DNA, Viral - genetics | RNA-Binding Proteins - metabolism | Antiviral agents | Viral proteins | Dendritic cells | HIV testing | Sensors | HIV (Viruses) | Macrophages | Health aspects | Cyclic guanylic acid | Protein binding | Life Sciences | Genetics | Human genetics
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2008, Volume 205, Issue 2, pp. 409 - 421
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 12/2012, Volume 30, Issue 12, pp. 2700 - 2708
The immunogenicity of human pluripotent stem cells plays a major role in their potential use in the clinic. We show that, during their reprogramming,... 
Reprogramming | Immunogenicity | Pluripotent stem cells | Induced pluripotent stem cells | HLA CLASS-I | INDUCTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENERATION | DIFFERENTIATION | HEMATOLOGY | EXPRESSION | ANTIGEN | beta 2-Microglobulin - biosynthesis | Humans | NF-kappa B - immunology | NF-kappa B - metabolism | beta 2-Microglobulin - immunology | Immunochemistry | Transcription Factor RelA - genetics | Microarray Analysis | Transcription Factor RelA - immunology | Histocompatibility Antigens Class I - biosynthesis | Octamer Transcription Factor-3 - immunology | Induced Pluripotent Stem Cells - cytology | Cell Differentiation - physiology | Cellular Reprogramming - genetics | Induced Pluripotent Stem Cells - physiology | Down-Regulation | Cells, Cultured | Histocompatibility Antigens Class I - immunology | Histocompatibility Antigens Class I - genetics | Octamer Transcription Factor-3 - antagonists & inhibitors | Cellular Reprogramming - immunology | Cellular Reprogramming - drug effects | Cell Differentiation - immunology | NF-kappa B - genetics | Transcription Factor RelA - metabolism | Cell Differentiation - drug effects | NF-kappa B - biosynthesis | Transcription Factor RelA - biosynthesis | Interferon-gamma - immunology | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Fibroblasts - cytology | Induced Pluripotent Stem Cells - immunology | Interferon-gamma - pharmacology | Index Medicus
Journal Article