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1. Full Text Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension
by Tanihara, Hidenobu and Inoue, Toshihiro and Yamamoto, Tetsuya and Kuwayama, Yasuaki and Abe, Haruki and Araie, Makoto and K-115 Clinical Study Grp and K-115 Clinical Study Group
American Journal of Ophthalmology, ISSN 0002-9394, 2013, Volume 156, Issue 4, pp. 731 - 736.e2
Purpose To identify the optimal dose of a novel Rho kinase inhibitor, K-115, by assessing dose dependency of the intraocular pressure (IOP)-lowering effects... 
Ophthalmology | OUTFLOW FACILITY | OPHTHALMOLOGY | CELLS | Y-27632 | INTRAOCULAR-PRESSURE | Enzyme Inhibitors - adverse effects | Intraocular Pressure - drug effects | Isoquinolines - adverse effects | Prospective Studies | Double-Blind Method | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | rho-Associated Kinases - antagonists & inhibitors | Antihypertensive Agents - adverse effects | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Sulfonamides - adverse effects | Tonometry, Ocular | Female | Isoquinolines - administration & dosage | Sulfonamides - administration & dosage | Hypertension | Clinical trials | Medical colleges | Open-angle glaucoma | Glaucoma | Cataracts | Therapy | Review boards | Surgery | Standard deviation | Drug dosages | Patients | Index Medicus | Abridged Index Medicus
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2. Full Text A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study
by Weinreb, Robert N and Ong, Tuyen and Scassellati Sforzolini, Baldo and Vittitow, Jason L and Singh, Kuldev and Kaufman, Paul L and VOYAGER Study Grp and VOYAGER study group
British Journal of Ophthalmology, ISSN 0007-1161, 06/2015, Volume 99, Issue 6, pp. 738 - 745
AimTo assess the efficacy and safety of latanoprostene bunod (LBN) compared with latanoprost 0.005%, and to determine the optimum drug concentration(s) of LBN... 
TRIAL | MANAGEMENT | EFFICACY | CHANNEL | NITRIC-OXIDE | OUTFLOW FACILITY | OPHTHALMOLOGY | INTRAOCULAR-PRESSURE | MESHWORK CELL-VOLUME | PROGRESSION | XALATAN | Intraocular Pressure - drug effects | Double-Blind Method | Follow-Up Studies | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Prostaglandins F, Synthetic - adverse effects | Antihypertensive Agents - adverse effects | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Young Adult | Prostaglandins F, Synthetic - administration & dosage | Aged, 80 and over | Ophthalmic Solutions | Tonometry, Ocular | Adult | Female | Aged | Visual Acuity - physiology | Hypertension | Drug therapy | Eye diseases | Glaucoma | Clinical trials | Acids | Drug dosages | Cell adhesion & migration | Index Medicus | Drugs | Treatment Medical | Clinical Science | Clinical Trial | 1506 | Intraocular pressure
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3. Full Text One‐year clinical evaluation of 0.4% ripasudil (K‐115) in patients with open‐angle glaucoma and ocular hypertension
by Tanihara, Hidenobu and Inoue, Toshihiro and Yamamoto, Tetsuya and Kuwayama, Yasuaki and Abe, Haruki and Fukushima, Atsuki and Suganami, Hideki and Araie, Makoto and Uchino, Miki and Iwasaki, Miki and Ono, Koichi and Sekiyama, Eiichi and Takahashi, Yoshinori and Fujie, Keiko and Shin, Hideyo and Kaneko, Taku and Shiba, Hiroharu and Ijuin, Nobuo and Tani, Emiko and Manabe, Yoichi and Yamana, Yasuo and Arai, Mikki and Kurata, Yoshinori and Shirao, Makoto and Inoue, Kenji and Ono, Ryuichiro and Matsumoto, Jun and Hatano, Hiroshi and Ouchi, Keiko and Kitagawa, Atsuko and Mizote, Hideaki and Kato, Hitoshi and Wakiyama, Harumi and Migita, Masayoshi and Hashida, Setsuko and Kawabata, Hidehito and Shimizu, Kiyoshi and Yamabayashi, Shigeki and Sugiura, Torao and Kubota, Yasutaka and Taguchi, Koji and Miyata, Kazunori and Ohtani, Shinichiro and K-115 Clinical Study Grp and K-115 Clinical Study Group and the K-115 Clinical Study Group
Acta Ophthalmologica, ISSN 1755-375X, 02/2016, Volume 94, Issue 1, pp. e26 - e34
Purpose: To investigate the intra-ocular pressure (IOP)-lowering effects and safety of 0.4% ripasudil (K-115), a Rho kinase inhibitor, twice daily for 52... 
intra‐ocular pressure | K‐115 | ripasudil | glaucoma | rho kinase inhibitor | intra-ocular pressure | K-115 | TRIALS | SAFETY | PROTEIN-KINASE | RHO-KINASE INHIBITOR | INTRAOCULAR-PRESSURE | TIMOLOL | RABBITS | BRIMONIDINE | OPHTHALMOLOGY | APRACLONIDINE ALLERGY | Intraocular Pressure - drug effects | Isoquinolines - adverse effects | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Male | Antihypertensive Agents - therapeutic use | rho-Associated Kinases - antagonists & inhibitors | Antihypertensive Agents - adverse effects | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Sulfonamides - therapeutic use | Isoquinolines - therapeutic use | Ophthalmic Solutions | Sulfonamides - adverse effects | Tonometry, Ocular | Female | Aged | Drug Combinations | Adrenergic beta-Antagonists - therapeutic use | Hypertension | Complications and side effects | Care and treatment | Conjunctivitis | Open-angle glaucoma | Glaucoma | Studies | Prescription drugs | Index Medicus
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4. Full Text Latanoprostene Bunod 0.024% versus Timolol Maleate 0.5% in Subjects with Open-Angle Glaucoma or Ocular Hypertension the APOLLO Study
by Weinreb, Robert N and Scassellati Sforzolini, Baldo and Vittitow, Jason and Liebmann, Jeffrey
Ophthalmology, ISSN 0161-6420, 05/2016, Volume 123, Issue 5, pp. 965 - 973
Purpose To compare the diurnal intraocular pressure (IOP)-lowering effect of latanoprostene bunod (LBN) ophthalmic solution 0.024% every evening (qpm) with... 
TRIAL | OUTFLOW PHYSIOLOGY | RISK-FACTORS | SEGMENT | FACILITY | NITRIC-OXIDE | OPHTHALMOLOGY | FOLLOW-UP | INTRAOCULAR-PRESSURE | CILIARY MUSCLE | PROGRESSION | Intraocular Pressure - drug effects | Double-Blind Method | Ocular Hypertension - physiopathology | Humans | Middle Aged | Glaucoma, Open-Angle - physiopathology | Male | Antihypertensive Agents - therapeutic use | Prostaglandins F, Synthetic - therapeutic use | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Young Adult | Aged, 80 and over | Ophthalmic Solutions | Tonometry, Ocular | Adult | Female | Aged | Timolol - therapeutic use | Administration, Topical | Circadian Rhythm - drug effects | Adrenergic beta-Antagonists - therapeutic use | Hypertension | Timolol maleate | Open-angle glaucoma | Analysis | Index Medicus
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5. Full Text Adherence to Fixed-Combination Versus Unfixed Travoprost 0.004%/Timolol 0.5% for Glaucoma or Ocular Hypertension: a Randomized Trial
by Barnebey, Howard S and Robin, Alan L
American Journal of Ophthalmology, ISSN 0002-9394, 2016, Volume 176, pp. 61 - 69
Abstract Purpose To assess adherence to treatment with fixed-combination travoprost 0.004%/timolol 0.5% (TTFC) compared with separate containers of travoprost... 
Ophthalmology | OPEN-ANGLE GLAUCOMA | THERAPY | EFFICACY | DETERMINANTS | LATANOPROST | PERSISTENCE | OPHTHALMOLOGY | INTRAOCULAR-PRESSURE | MEDICATION ADHERENCE | HEALTH LITERACY | PROGRESSION | Single-Blind Method | Intraocular Pressure - drug effects | Follow-Up Studies | Instillation, Drug | Ocular Hypertension - physiopathology | Humans | Middle Aged | Ocular Hypertension - diagnosis | Antihypertensive Agents - administration & dosage | Timolol - administration & dosage | Male | Treatment Outcome | Ocular Hypertension - drug therapy | Dose-Response Relationship, Drug | Time Factors | Aged, 80 and over | Tonometry, Ocular | Adult | Female | Aged | Patient Compliance | Drug Therapy, Combination | Adrenergic beta-Antagonists - administration & dosage | Travoprost - administration & dosage | Hypertension | Glaucoma | Clinical trials | Patient compliance | Prescription drugs | Health literacy | Compliance | Laboratories | Review boards | Pharmacy | Clinical medicine | Health education | Patients | Index Medicus | Abridged Index Medicus
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6. Full Text Ocular Hypotensive Effect of the Rho Kinase Inhibitor AR-12286 in Patients With Glaucoma and Ocular Hypertension
by Williams, Robert D and Novack, Gary D and van Haarlem, Thomas and Kopczynski, Casey and AR-12286 Phase 2A Study Grp and AR-12286 Phase 2A Study Group
American Journal of Ophthalmology, ISSN 0002-9394, 2011, Volume 152, Issue 5, pp. 834 - 841.e1
Purpose To evaluate the ocular hypotensive efficacy of 0.05%, 0.1% and 0.25% AR-12286 Ophthalmic Solutions in patients diagnosed with ocular hypertension or... 
Ophthalmology | OPEN-ANGLE GLAUCOMA | RABBITS | Y-27632 | EFFICACY | PROTEIN-KINASE | OUTFLOW FACILITY | OPHTHALMOLOGY | INTRAOCULAR-PRESSURE | CELL-SURVIVAL | MONKEYS | TIMOLOL | Enzyme Inhibitors - adverse effects | Intraocular Pressure - drug effects | Isoquinolines - adverse effects | Double-Blind Method | Ophthalmic Solutions - therapeutic use | Humans | Middle Aged | Ophthalmic Solutions - adverse effects | Male | Treatment Outcome | Antihypertensive Agents - therapeutic use | Enzyme Inhibitors - therapeutic use | rho-Associated Kinases - antagonists & inhibitors | Antihypertensive Agents - adverse effects | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Aged, 80 and over | Isoquinolines - therapeutic use | Tonometry, Ocular | Adult | Female | Aged | Glaucoma | Proteins | Therapy | Eyes & eyesight | Index Medicus | Abridged Index Medicus
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7. Full Text Intra‐ocular pressure‐lowering effects of a Rho kinase inhibitor, ripasudil (K‐115), over 24 hours in primary open‐angle glaucoma and ocular hypertension: a randomized, open‐label, crossover study
by Tanihara, Hidenobu and Inoue, Toshihiro and Yamamoto, Tetsuya and Kuwayama, Yasuaki and Abe, Haruki and Suganami, Hideki and Araie, Makoto and K-115 Clinical Study Grp and K-115 Clinical Study Group and the K-115 Clinical Study Group
Acta Ophthalmologica, ISSN 1755-375X, 06/2015, Volume 93, Issue 4, pp. e254 - e260
Purpose: To investigate the intra-ocular pressure (IOP)-lowering effects of a selective Rho kinase inhibitor, ripasudil (K-115), over 24 hr in patients with... 
Rho kinase inhibitor | intra‐ocular pressure | K‐115 | ripasudil | glaucoma | intra-ocular pressure | K-115 | OPTIC-NERVE | TRABECULAR MESHWORK | PROTEIN-KINASE | HUMOR OUTFLOW FACILITY | TIMOLOL | RETINAL GANGLION-CELLS | RABBIT EYES | ROCK INHIBITOR | Y-27632 | OPHTHALMOLOGY | ACTIN CYTOSKELETON | Enzyme Inhibitors - adverse effects | Intraocular Pressure - drug effects | Isoquinolines - adverse effects | Prospective Studies | Humans | Middle Aged | Male | Circadian Rhythm | Enzyme Inhibitors - therapeutic use | rho-Associated Kinases - antagonists & inhibitors | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Cross-Over Studies | Sulfonamides - therapeutic use | Isoquinolines - therapeutic use | Sulfonamides - adverse effects | Tonometry, Ocular | Adult | Female | Hypertension | Clinical trials | Open-angle glaucoma | Index Medicus
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8. Full Text Sustained delivery of latanoprost by thermosensitive chitosan–gelatin-based hydrogel for controlling ocular hypertension
by Cheng, Yung-Hsin and Hung, Kuo-Hsuan and Tsai, Tung-Hu and Lee, Chia-Jung and Ku, Ruy-Yu and Chiu, Allen Wen-hsiang and Chiou, Shih-Hwa and Liu, Catherine Jui-ling
Acta Biomaterialia, ISSN 1742-7061, 10/2014, Volume 10, Issue 10, pp. 4360 - 4366
Glaucoma is an irreversible ocular disease that may lead to progressive visual field loss and eventually to blindness with inadequately controlled intraocular... 
Glaucoma | Drug delivery | Hydrogel | Latanoprost | OPHTHALMIC SOLUTION | MATERIALS SCIENCE, BIOMATERIALS | MANAGEMENT | EFFICACY | GELS | DRUG-DELIVERY | SAFETY | ENGINEERING, BIOMEDICAL | INTRAOCULAR-PRESSURE | TRIAMCINOLONE ACETONIDE | IN-VITRO CHARACTERIZATION | Rabbits | Antihypertensive Agents - pharmacology | Prostaglandins F, Synthetic - chemistry | Anti-Inflammatory Agents - pharmacology | Gelatin - pharmacology | Humans | Delayed-Action Preparations - chemistry | Male | Triamcinolone Acetonide - pharmacology | Ocular Hypertension - drug therapy | Antihypertensive Agents - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Chitosan - chemistry | Delayed-Action Preparations - pharmacokinetics | Chitosan - pharmacology | Prostaglandins F, Synthetic - pharmacology | Hydrogels - pharmacology | Drug Evaluation, Preclinical | Triamcinolone Acetonide - chemistry | Gelatin - chemistry | Hydrogels - chemistry | Hypertension | Index Medicus | Surgical implants | Therapy | Biomedical materials | Hydrogels | Thermosensitive | Biocompatibility | In vitro testing
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9. Full Text Mucoadhesive olaminosomes: A novel prolonged release nanocarrier of agomelatine for the treatment of ocular hypertension
by Abd-Elsalam, Wessam H and ElKasabgy, Nermeen A
International Journal of Pharmaceutics, ISSN 0378-5173, 04/2019, Volume 560, pp. 235 - 245
Mucoadhesive olaminosomes are novel nanocarriers designed to control agomelatine release and enhance its bioavailability. Olaminosomes were prepared using... 
Agomelatine | Mucoadhesive olaminosomes | Percent decrease in intraocular pressure | Oleylamine | Histopathological studies | DRUG | CHITOSAN | OLEIC-ACID | INTRAOCULAR-PRESSURE | DELIVERY | CORNEAL PERMEABILITY | NANOPARTICLES | IN-VITRO | MECHANISTIC INSIGHT | PHARMACOLOGY & PHARMACY | OPHTHALMIC FORMULATIONS | Amines - chemistry | Administration, Ophthalmic | Rabbits | Chemistry, Pharmaceutical - methods | Intraocular Pressure - drug effects | Solubility | Acetamides - pharmacology | Biological Availability | Male | Drug Carriers - chemistry | Adhesives - chemistry | Drug Delivery Systems | Ocular Hypertension - drug therapy | Particle Size | Acetamides - chemistry | Animals | Chitosan - chemistry | Drug Liberation | Hexoses - chemistry | Oleic Acid - chemistry | Acetamides - administration & dosage | Hypertension | Thin films | Monounsaturated fatty acids | Pharmacy | Drugstores | Dielectric films | Drug therapy
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10. Full Text Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre, randomised controlled trial: design and methodology
by Gazzard, Gus and Konstantakopoulou, Evgenia and Garway-Heath, David and Barton, Keith and Wormald, Richard and Morris, Stephen and Hunter, Rachael and Rubin, Gary and Buszewicz, Marta and Ambler, Gareth and Bunce, Catey and LiGHT Trial Study Grp and LiGHT Trial Study Group
British Journal of Ophthalmology, ISSN 0007-1161, 05/2018, Volume 102, Issue 5, pp. 593 - 598
PurposeThe Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is... 
intraocular pressure | treatment lasers | glaucoma | MEDICATION | MANAGEMENT | OPHTHALMOLOGY | TRABECULOPLASTY | RISK | QUALITY-OF-LIFE | INTRAOCULAR-PRESSURE | INDEX | Ocular Hypertension - surgery | Glaucoma, Open-Angle - surgery | Prospective Studies | Trabeculectomy - economics | Humans | Middle Aged | Intraocular Pressure - physiology | Male | Treatment Outcome | Antihypertensive Agents - therapeutic use | Laser Therapy - economics | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Quality of Life | Female | Laser Therapy - methods | Aged | Research Design | Visual Acuity - physiology | Trabeculectomy - methods | Glaucoma | Hypertension | Diabetic retinopathy | Lasers | Light | Clinical medicine | Cost analysis | Quality of life | Index Medicus
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11. Full Text Selective Laser Trabeculoplasty Versus Medical Therapy as Initial Treatment of Glaucoma: A Prospective, Randomized Trial
by Katz, L Jay and Steinmann, William C and Kabir, Azad and Molineaux, Jeanne and Wizov, Sheryl S and Marcellino, George and SLT Med Study Grp and SLT/Med Study Group
Journal of Glaucoma, ISSN 1057-0829, 09/2012, Volume 21, Issue 7, pp. 460 - 468
PURPOSETo compare outcomes of selective laser trabeculoplasty (SLT) with drug therapy for glaucoma patients in a prospective randomized clinical trial.... 
glaucoma medications | glaucoma | laser trabeculoplasty | UNITED-STATES | COMPARATIVE CLINICAL-TRIAL | TRABECULAR MESHWORK CELLS | FOLLOW-UP | TOPICAL ANTIGLAUCOMA MEDICATION | ARGON | OPEN-ANGLE GLAUCOMA | INTRAOCULAR-PRESSURE ELEVATIONS | OCULAR HYPERTENSION | OPHTHALMOLOGY | LONG-TERM EFFICACY | Trabeculectomy | Lasers, Solid-State - therapeutic use | Ocular Hypertension - surgery | Glaucoma, Open-Angle - surgery | Prospective Studies | Follow-Up Studies | Humans | Laser Therapy | Middle Aged | Intraocular Pressure - physiology | Male | Treatment Outcome | Antihypertensive Agents - therapeutic use | Glaucoma, Open-Angle - drug therapy | Ocular Hypertension - drug therapy | Glaucoma, Open-Angle - therapy | Ocular Hypertension - therapy | Aged, 80 and over | Tonometry, Ocular | Adult | Female | Aged | Drug Therapy, Combination | Visual Acuity - physiology | Index Medicus
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