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index medicus (4196) 4196
okadaic acid (3069) 3069
animals (3005) 3005
phosphorylation (1951) 1951
okadaic acid - pharmacology (1875) 1875
humans (1593) 1593
enzyme inhibitors - pharmacology (1383) 1383
biochemistry & molecular biology (1322) 1322
phosphoprotein phosphatases - antagonists & inhibitors (1294) 1294
rats (1104) 1104
ethers, cyclic - pharmacology (1103) 1103
mice (890) 890
cell biology (803) 803
phosphoprotein phosphatases - metabolism (731) 731
cells, cultured (699) 699
male (638) 638
pharmacology & pharmacy (573) 573
cell line (490) 490
activation (477) 477
kinetics (443) 443
phosphatases (437) 437
female (434) 434
oxazoles - pharmacology (430) 430
toxicology (412) 412
signal transduction (410) 410
tumor cells, cultured (408) 408
phosphorylation - drug effects (406) 406
neurosciences (396) 396
tetradecanoylphorbol acetate - pharmacology (389) 389
cells (379) 379
dose-response relationship, drug (379) 379
molecular sequence data (359) 359
in vitro techniques (356) 356
protein phosphatase 2 (352) 352
apoptosis (334) 334
expression (317) 317
rats, sprague-dawley (310) 310
enzyme activation (297) 297
proteins (296) 296
time factors (293) 293
protein phosphatase (292) 292
protein phosphatase 1 (288) 288
physiology (277) 277
amino acid sequence (271) 271
calcium - metabolism (263) 263
biophysics (259) 259
oncology (258) 258
inhibition (253) 253
kinase (245) 245
apoptosis - drug effects (244) 244
protein kinase c - metabolism (242) 242
blotting, western (240) 240
rats, wistar (240) 240
transfection (237) 237
identification (231) 231
phosphatase (217) 217
protein phosphatases (213) 213
signal transduction - drug effects (213) 213
protein-kinase-c (204) 204
enzyme activation - drug effects (202) 202
cell line, tumor (201) 201
research (201) 201
calyculin-a (200) 200
protein kinase c - antagonists & inhibitors (194) 194
phosphoproteins - metabolism (193) 193
protein phosphatase 2a (184) 184
protein kinases - metabolism (179) 179
neurons - drug effects (177) 177
phosphoprotein phosphatases - physiology (176) 176
protein-serine-threonine kinases - metabolism (176) 176
base sequence (173) 173
calcium (173) 173
physiological aspects (173) 173
protein (157) 157
endocrinology & metabolism (156) 156
protein phosphatase 2 - metabolism (156) 156
binding (154) 154
tyrosine phosphorylation (154) 154
vanadates - pharmacology (153) 153
hela cells (152) 152
calcium-calmodulin-dependent protein kinases - metabolism (151) 151
okadaic acid - toxicity (151) 151
gene-expression (148) 148
rna, messenger - metabolism (147) 147
analysis (144) 144
dephosphorylation (143) 143
protein binding (143) 143
cyclic amp-dependent protein kinases - metabolism (142) 142
microcystins (142) 142
colforsin - pharmacology (141) 141
cell survival - drug effects (140) 140
induction (139) 139
gene expression (138) 138
protein kinases (137) 137
catalytic subunit (136) 136
mitosis (136) 136
abridged index medicus (135) 135
chemistry, medicinal (135) 135
alzheimer's disease (134) 134
tau proteins - metabolism (133) 133
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Nature Neuroscience, ISSN 1097-6256, 07/2004, Volume 7, Issue 7, pp. 711 - 718
Voltage-dependent Kv2.1 K+ channels, which mediate delayed rectifier Kv currents (I-K), are expressed in large clusters on the somata and dendrites of... 
ALPHA-SUBUNITS | RAT HIPPOCAMPAL-NEURONS | MAMMALIAN BRAIN | ACTIVATION | GATED POTASSIUM CHANNELS | RECEPTOR | NEOCORTICAL PYRAMIDAL NEURONS | IDENTIFICATION | KV2.1 K+ CHANNEL | BINDING | NEUROSCIENCES | Potassium - metabolism | Okadaic Acid - pharmacology | Potassium Channels, Voltage-Gated | Pyramidal Cells - metabolism | Cyclosporine - pharmacology | Cell Count | Neuronal Plasticity - drug effects | Pyrethrins - pharmacology | Translocation, Genetic - drug effects | Patch-Clamp Techniques - methods | Seizures - chemically induced | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Phosphoprotein Phosphatases - pharmacology | Seizures - physiopathology | Drug Interactions | Neuronal Plasticity - physiology | Time Factors | Dendrites - physiology | Potassium Chloride - pharmacology | Nitriles | Pyramidal Cells - drug effects | Phosphorylation - drug effects | Cadmium Chloride - pharmacology | Ionophores - pharmacology | Potassium Channel Blockers - pharmacology | Disease Models, Animal | Animals, Newborn | Membrane Potentials - drug effects | Dendrites - drug effects | Translocation, Genetic - physiology | Glutamic Acid - pharmacology | Kainic Acid - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Nitrendipine - pharmacology | Calcium Channel Blockers - pharmacology | Delayed Rectifier Potassium Channels | Hippocampus - cytology | Membrane Potentials - physiology | Shab Potassium Channels | Calcimycin - pharmacology | Blotting, Western | Animals | Ion Channel Gating - drug effects | Physiological aspects | Phosphorylation | Ion channels | Research | Neurons | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2013, Volume 238, pp. 97 - 113
Journal Article
Plant Physiology, ISSN 0032-0889, 6/2012, Volume 159, Issue 2, pp. 632 - 641
The phytohormone auxin is a major regulator of diverse aspects of plant growth and development. The ubiquitin-ligase complex SCF TIR1/AFB (for Skp1-Cull-F-box... 
Hypocotyls | Phosphorylation | Receptors | Phosphatases | Adenosine triphosphatases | Auxins | CELL BIOLOGY AND SIGNAL TRANSDUCTION | Cell membranes | Plants | Insulin antibodies | Plant cells | CALYCULIN-A | AVENA-COLEOPTILE | STOMATAL GUARD-CELLS | INDUCED GROWTH | BOX PROTEIN TIR1 | OKADAIC-ACID | PLANT DEVELOPMENT | BINDING PROTEIN | BLUE-LIGHT | ZEA-MAYS-L | PLANT SCIENCES | Okadaic Acid - pharmacology | Arabidopsis - enzymology | Arabidopsis - growth & development | Hypocotyl - genetics | Cell Membrane - genetics | F-Box Proteins - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Threonine - metabolism | Arabidopsis Proteins - metabolism | Proton-Translocating ATPases - metabolism | Proteasome Endopeptidase Complex - drug effects | Proton-Translocating ATPases - genetics | Time Factors | Gene Expression Regulation, Plant | Transcription, Genetic | Proton-Translocating ATPases - antagonists & inhibitors | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Indoleacetic Acids - metabolism | Signal Transduction | F-Box Proteins - metabolism | Hypocotyl - growth & development | Receptors, Cell Surface - metabolism | Hypocotyl - enzymology | Arabidopsis - genetics | Gene Expression Regulation, Enzymologic | Cell Membrane - enzymology | Indoleacetic Acids - antagonists & inhibitors | Leupeptins - pharmacology | Indoleacetic Acids - pharmacology | Hypocotyl - drug effects | Oxazoles - pharmacology | Enzyme Activation | Proteasome Endopeptidase Complex - metabolism | F-Box Proteins - genetics | Arabidopsis Proteins - antagonists & inhibitors | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2003, Volume 171, Issue 6, pp. 3278 - 3286
Betulinic acid (BA), a pentacyclic triterpene isolated from the bark of the white birch tree, has been reported to be a selective inducer of apoptosis in tumor... 
SIGNAL-TRANSDUCTION PATHWAYS | TUMOR-NECROSIS-FACTOR | ANTIINFLAMMATORY ACTIVITY | CONSTITUTIVE ACTIVATION | HUMAN-MELANOMA CELLS | DRUG DEVELOPMENT | CHEMOPREVENTIVE AGENT | P53-INDEPENDENT APOPTOSIS | TNF-ALPHA | IMMUNOLOGY | TRANSCRIPTION FACTOR | Matrix Metalloproteinase 9 - physiology | Okadaic Acid - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Triterpenes - pharmacology | Apoptosis - drug effects | Cyclooxygenase 2 | Humans | Transcription Factor RelA | NF-kappa B - metabolism | Carcinogens - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Isoenzymes - physiology | Caco-2 Cells | NF-kappa B - antagonists & inhibitors | Smoke - adverse effects | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Down-Regulation - drug effects | Enzyme Activation - drug effects | I-kappa B Kinase | Down-Regulation - genetics | Tobacco - toxicity | Interleukin-1 - pharmacology | Membrane Proteins | Tumor Necrosis Factor-alpha - pharmacology | NF-kappa B - genetics | Active Transport, Cell Nucleus - drug effects | NF-kappa B - physiology | Cell Line, Tumor | Matrix Metalloproteinase Inhibitors | Genes, Reporter - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Cell Nucleus - drug effects | Isoenzymes - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Prostaglandin-Endoperoxide Synthases - physiology | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 11, pp. 7977 - 7985
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 52, Issue 3, pp. 461 - 474
is an immediate-early gene whose expression levels are increased by strong synaptic activation, including synapse-strengthening activity patterns. mRNA is... 
MOLNEURO | SIGNALING | HIPPOCAMPAL ORGANOTYPIC CULTURES | CYTOSKELETON-ASSOCIATED PROTEIN | VISUAL-CORTEX | C-FOS | PYRAMIDAL CELLS | EXCITATORY SYNAPSES | LONG-TERM POTENTIATION | RAT-BRAIN | ARC MESSENGER-RNA | AREA CA1 | NEUROSCIENCES | Okadaic Acid - pharmacology | Synaptic Transmission - physiology | Cytoskeletal Proteins - genetics | Long-Term Synaptic Depression - drug effects | Patch-Clamp Techniques - methods | N-Methylaspartate - pharmacology | Time Factors | Gene Expression - physiology | Neurons - physiology | Statistics, Nonparametric | Cytoskeletal Proteins - physiology | Neurons - drug effects | RNA Interference - physiology | Electric Stimulation - methods | Animals, Newborn | Green Fluorescent Proteins - metabolism | Long-Term Synaptic Depression - physiology | Blotting, Western - methods | Nerve Tissue Proteins - physiology | Receptors, AMPA - physiology | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Agonists - pharmacology | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Animals | Models, Biological | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Biotinylation - methods | Mutagenesis - physiology | In Vitro Techniques | Neurons - radiation effects | Long-Term Synaptic Depression - radiation effects | Glutamate | Depression, Mental | Messenger RNA | Proteins | Medical research | Gene expression | Neurons | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12564 - 12569
Here we show that the functional human ortholog of Greatwall protein kinase (Gwl) is the microtubule-associated serine/threonine kinase-like protein, MAST-L.... 
Phosphorylation | Phenotypes | Phosphatases | Mitosis | Metaphase | HeLa cells | Small interfering RNA | Cell separation | Cyclins | Daughter cells | Slippage | Phosphatase | Kinase | Spindle assembly checkpoint | Cell cycle | XENOPUS EGG EXTRACTS | ACTIVATION | cell cycle | spindle assembly checkpoint | MULTIDISCIPLINARY SCIENCES | MITOSIS | kinase | PATHWAY | THROMBOCYTOPENIA | phosphatase | CHECKPOINT | slippage | EXIT | PROGRESSION | Cell Cycle - genetics | Okadaic Acid - pharmacology | RNA, Small Interfering - genetics | Phosphoric Monoester Hydrolases - genetics | Humans | Okadaic Acid - metabolism | Protein-Serine-Threonine Kinases - genetics | Cyclin B1 | Proteins - genetics | Mitosis - drug effects | Proteins - metabolism | Protein Phosphatase 2 - metabolism | Cell Cycle - physiology | Cyclin B - metabolism | Cell Cycle - drug effects | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA, Small Interfering - metabolism | Spindle (Cell division) | Genetic aspects | Properties | Protein kinases | Cell division | Enzymes | Cytokines | Kinases | Enzyme kinetics | Cells | Index Medicus | Protein-Serine-Threonine Kinases | Biochemistry, Molecular Biology | Okadaic Acid | Proteins | Life Sciences | Phosphoric Monoester Hydrolases | Cell Cycle | Cyclin B | RNA, Small Interfering | Protein Phosphatase 2 | Biological Sciences
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2004, Volume 566, Issue 1, pp. 261 - 269
Memantine, an N ‐methyl‐ d ‐aspartate (NMDA) receptor antagonist, reduces the clinical deterioration in moderate‐to‐severe Alzheimer disease (AD) for which... 
Protein phosphatase-2A | Tau hyperphosphorylation | Memantine | Neurofibrillary degeneration | NMDA receptor | Alzheimer disease | MAP, microtubule associated protein | OA, okadaic acid | (−)-2-amino-5-phosphonopentanoic acid | LDH, lactate dehydrogenase | PP, protein phosphatase | cdk5, cyclin dependent protein kinase 5 | DK, 5,7-dichlorokynurenic acid | AD, Alzheimer disease | AD P-tau, AD cytosolic abnormally hyperphosphorylated tau | CaMKII, calcium, calmodulin-dependent protein kinase II | NMDA | methyl | PHF, paired helical filaments | PMSF, phenylmethyl sulfonyl fluoride | NF-H/M, neurofilament-heavy/medium | aspartate | MAPK, mitogen-activated protein kinase | AP, D(-)-2-amino-5-phosphonopentanoic acid | HIPPOCAMPAL SLICES | neurofibrillary degeneration | MICROTUBULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE BRAIN | RECEPTOR | PROTEIN PHOSPHATASE 2A | CELL BIOLOGY | tau hyperphosphorylation | BIOPHYSICS | PHOSPHORYLATED-TAU | DEPHOSPHORYLATION | protein phosphatase-2A | RAT FOREBRAIN | TRANSGENIC MICE | Okadaic Acid - pharmacology | Rats, Wistar | Microtubule-Associated Proteins - metabolism | Phosphoprotein Phosphatases - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Nerve Degeneration - physiopathology | tau Proteins - metabolism | Nerve Degeneration - metabolism | Neuroprotective Agents - pharmacology | Kynurenic Acid - analogs & derivatives | Hippocampus - enzymology | Kynurenic Acid - pharmacology | Phosphorylation - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Neurofibrils - drug effects | Alzheimer Disease - physiopathology | Memantine - pharmacology | Glutamic Acid - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Phosphoprotein Phosphatases - antagonists & inhibitors | Neurofibrils - pathology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Animals | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Nerve Degeneration - drug therapy | Index Medicus
Journal Article
Plant Physiology and Biochemistry, ISSN 0981-9428, 06/2019, Volume 139, pp. 540 - 547
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 50, pp. 21830 - 21835
Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer's disease (AD) and related... 
Brain | Phosphorylation | Phosphatases | Neurons | Antibodies | Actins | Physiological regulation | Epitopes | Alzheimers disease | Insulin | MAMMALIAN TARGET | RAPAMYCIN | RESPIRATORY-CHAIN | HELICAL FILAMENT-TAU | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DISEASE BRAIN | CELL-GROWTH | ALZHEIMER NEUROFIBRILLARY DEGENERATION | EXPRESSION | Okadaic Acid - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes | tau Proteins - metabolism | Neurons - cytology | Alzheimer Disease - pathology | Mechanistic Target of Rapamycin Complex 1 | Neurofibrillary Tangles - metabolism | TOR Serine-Threonine Kinases - genetics | tau Proteins - genetics | Adenylate Kinase - metabolism | Neurons - metabolism | Neurofibrillary Tangles - pathology | Alzheimer Disease - physiopathology | Metformin - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Protein Phosphatase 2 - genetics | Mice, Transgenic | Hypoglycemic Agents - pharmacology | Animals | Proteins - metabolism | Signal Transduction - drug effects | Alzheimer Disease - metabolism | Protein Phosphatase 2 - metabolism | Mice | HeLa Cells | Care and treatment | Physiological aspects | Research | Chemical properties | Metformin | Alzheimer's disease | Proteins | Signal transduction | Kinases | Index Medicus | Biological Sciences
Journal Article