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Journal of Food Science, ISSN 0022-1147, 08/2016, Volume 81, Issue 8, pp. H2049 - H2058
Contents of total flavonoids, total phenolics, total triterpenes, total condensed tannin and total saponins in peels, flesh and endocarps of Chaenomeles... 
digestion | antioxidant | endocarp | α‐glucosidase inhibitory | Chaenomeles | in vitro | α-glucosidase inhibitory | in vitro digestion | ANTIOXIDANT ACTIVITY | APOPTOSIS | TRITERPENOIDS | FOOD SCIENCE & TECHNOLOGY | PYRUS SPP | OLEANOLIC ACID | alpha-glucosidase inhibitory | POLYPHENOLS | IN-VITRO DIGESTION | MICE | EXTRACTS | TUMOR-GROWTH | Plant Extracts - chemistry | Flavonoids - analysis | Gallic Acid - pharmacology | Triterpenes - pharmacology | Species Specificity | Plant Extracts - pharmacology | Rutin - pharmacology | Oleanolic Acid - pharmacology | Glycoside Hydrolase Inhibitors - analysis | Chromatography, High Pressure Liquid | Biphenyl Compounds - metabolism | Vanillic Acid - pharmacology | Catechin - analysis | Proanthocyanidins - pharmacology | China | Gallic Acid - analysis | Proanthocyanidins - analysis | Flavonoids - pharmacology | Vanillic Acid - analysis | Catechin - pharmacology | Antioxidants - analysis | Phenols - pharmacology | Coumaric Acids - analysis | Fruit - chemistry | Picrates - metabolism | Rutin - analysis | Saponins - analysis | Antioxidants - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Oleanolic Acid - analysis | Rosaceae - chemistry | Triterpenes - analysis | Phenols - analysis | Propionates | alpha-Glucosidases - metabolism | Coumaric Acids - pharmacology | Saponins - pharmacology | Composition | Methods | Rosaceae | Food | Testing | Phenols | Flavonoids | Food science | Fruits | Triterpenes | Saponins | Catechin | Gallic acid | Principal components analysis | Mass spectroscopy | Chlorogenic acid | Glucosidase | Colorimetry | Liquid chromatography | Rutin | High-performance liquid chromatography | Epicatechin | Oleanolic acid | Antioxidants | Acids | Correlation analysis | Vanillic acid | Ursolic acid | Mass spectrometry | High performance liquid chromatography | Index Medicus | Catechins | Tannins | Condensing | Digestion
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | Index Medicus | stress response | reactive cysteine
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 32, pp. 22942 - 22960
TGR5 is a G protein-coupled receptor that mediates bile acid (BA) effects on energy balance, inflammation, digestion, and sensation. The mechanisms and... 
GROWTH-FACTOR RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GPBAR1 TGR5 | DEPENDENT ENDOCYTOSIS | PROTEIN-COUPLED RECEPTORS | RESONANCE ENERGY-TRANSFER | KINASE ACTIVATION | MU-OPIOID RECEPTOR | BETA-ADRENERGIC RECEPTOR | ACTIVATED RECEPTOR-2 | EGF RECEPTOR | Receptor, Epidermal Growth Factor - genetics | Cholagogues and Choleretics - pharmacology | Phenylalanine - analogs & derivatives | Receptors, G-Protein-Coupled - metabolism | Membrane Microdomains - metabolism | Phenylalanine - pharmacology | Humans | Oleanolic Acid - pharmacology | Arrestins - genetics | Protein Transport - physiology | Protein Transport - drug effects | G-Protein-Coupled Receptor Kinase 2 - genetics | G-Protein-Coupled Receptor Kinase 2 - metabolism | Arrestins - metabolism | beta-Cyclodextrins - pharmacology | Endosomes - metabolism | Receptor, Epidermal Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | Cyclic AMP - genetics | Cyclic AMP - metabolism | Endosomes - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Tyrphostins - pharmacology | Endocytosis - physiology | Arrestins - antagonists & inhibitors | G-Protein-Coupled Receptor Kinase 5 - metabolism | Deoxycholic Acid - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | beta-Arrestin 2 | beta-Arrestin 1 | beta-Arrestins | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Receptors, G-Protein-Coupled - genetics | Quinazolines - pharmacology | G-Protein-Coupled Receptor Kinase 5 - genetics | Membrane Microdomains - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Lipid Raft | Bile Acid | Endocytosis | G Protein-coupled Receptors (GPCR) | Arrestin | Signal Transduction
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132791 - e0132791
Recently, extracts of Dalbergia trichocarpabark have been shown to disrupt P. aeruginosa-PAO1 quorum sensing (QS) mechanisms, which are key regulators of... 
BACTERIAL PATHOGENS | CAENORHABDITIS-ELEGANS | SMALL RNAS | ACYLHOMOSERINE LACTONES | EXTRACELLULAR POLYMERIC SUBSTANCES | TWITCHING MOTILITY | MULTIDISCIPLINARY SCIENCES | HOMOSERINE LACTONE | TRANSCRIPTIONAL REGULATION | INFECTION MODEL | URSOLIC ACIDS | Triterpenes - pharmacology | Coumaric Acids - chemistry | Paralysis - drug therapy | Plant Extracts - pharmacology | Oleanolic Acid - analogs & derivatives | Tobramycin - pharmacology | Triterpenes - therapeutic use | Biofilms - growth & development | Oleanolic Acid - pharmacology | Pseudomonas aeruginosa - physiology | Plant Bark - chemistry | Triterpenes - chemistry | Pseudomonas aeruginosa - pathogenicity | Tropical Climate | Aldehydes - pharmacology | Acyl-Butyrolactones - metabolism | Polysaccharides - chemistry | Oleanolic Acid - therapeutic use | Coumaric Acids - therapeutic use | Biofilms - drug effects | Oleanolic Acid - isolation & purification | Genes, Bacterial | Movement - drug effects | Quorum Sensing - drug effects | Pseudomonas aeruginosa - drug effects | Drug Synergism | Gene Expression Regulation, Bacterial - drug effects | Phenotype | Animals | Caenorhabditis elegans - drug effects | Pseudomonas aeruginosa - genetics | Coumaric Acids - isolation & purification | Dalbergia - chemistry | Oleanolic Acid - chemistry | Triterpenes - isolation & purification | Virulence Factors - metabolism | Anti-Bacterial Agents - pharmacology | Coumaric Acids - pharmacology | Legumes | Polysaccharides | Beans | Mimosaceae | Antibacterial agents | Lactones | Regulators | Pyocyanin | Virulence | Bark | Esters | Infections | Swarming | Drug resistance | Endangered & extinct species | Virulence factors | Bioactive compounds | Extracellular matrix | Pseudomonas aeruginosa | Bacteria | Elastase | Inhibition | Paralysis | Saccharides | Pathogens | Bacterial infections | Nutrition | Cultures | Antimicrobial agents | Rhamnolipids | Twitching | Chromatography | Bactericidal activity | Biofilms | Acids | Antibiotics | Regulation | Tobramycin | Index Medicus
Journal Article
Journal of Psychopharmacology, ISSN 0269-8811, 10/2014, Volume 28, Issue 10, pp. 923 - 934
Our study sought to evaluate the anxiolytic and antidepressant activities of oleanolic acid as well as the neural mechanisms involved. Animal models such as... 
metabolic enzymes | anxiolytic | neurotrophic factor | monoamine | antidepressant | Oleanolic acid | MONOAMINE-OXIDASE | TAIL SUSPENSION TEST | PSYCHIATRY | FORCED SWIMMING TEST | ELEVATED PLUS-MAZE | NEUROSCIENCES | CLINICAL NEUROLOGY | ANTIDEPRESSANT ACTIVITY | NEUROTROPHIC FACTORS | NITRIC-OXIDE PRODUCTION | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | GABA(A) RECEPTORS | MOUSE MACROPHAGES | Fenclonine - analogs & derivatives | Motor Activity - drug effects | Oleanolic Acid - pharmacology | Male | Hippocampus - drug effects | Diazepam - pharmacology | Brain - metabolism | Dose-Response Relationship, Drug | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | alpha-Methyltyrosine - pharmacology | Fenclonine - pharmacology | Pentylenetetrazole - pharmacology | Disease Models, Animal | Fluoxetine - pharmacology | Anti-Anxiety Agents - pharmacology | Piperazines - pharmacology | Oleanolic Acid - antagonists & inhibitors | Brain - drug effects | Hippocampus - metabolism | Animals | Mice | Pyridines - pharmacology | Imipramine - pharmacology | Monoamine Oxidase - metabolism | Psychotropic drugs | Pharmacology, Experimental | Terpenoids | Depression, Mental | Physiological aspects | Anxiety | Research | Drug therapy | Health aspects | Neurotrophic functions | Mental depression | Acids | Antidepressants | Anxieties | Psychopharmacology | Index Medicus
Journal Article