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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12722 - 12727
Local drug delivery depots have significant clinical utility, but there is currently no noninvasive technique to refill these systems once their payload is... 
Nanoparticles | Gels | Calcium | Hydrogels | Antineoplastics | Fluorescence | Alginates | Polymers | Pharmacokinetics | Tumors | DNA nanotechnology | Targeting | Nanoparticle | Controlled release | Biomaterials | ALGINATE | MULTIDISCIPLINARY SCIENCES | nanoparticle | BIODISTRIBUTION | THERAPEUTIC ANGIOGENESIS | TUMORS | CANCER-THERAPY | NUCLEIC-ACIDS | NANOPARTICLES | targeting | controlled release | L-DNA | PHARMACOKINETICS | IN-VIVO | biomaterials | Doxorubicin - blood | Neoplasm Transplantation | Injections, Intravenous | Humans | Melanoma, Experimental - drug therapy | Hydrogels - pharmacokinetics | Hexuronic Acids - pharmacokinetics | Antibiotics, Antineoplastic - blood | Oligodeoxyribonucleotides - blood | Injections, Intralesional | Tumor Cells, Cultured | Antibiotics, Antineoplastic - pharmacokinetics | Hydrazones - pharmacokinetics | Alginates - pharmacokinetics | Disease Models, Animal | Hydrazones - blood | Hexuronic Acids - blood | Mice, Inbred C57BL | Glucuronic Acid - blood | Glucuronic Acid - pharmacokinetics | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Oligodeoxyribonucleotides - pharmacokinetics | Mice | Drug Delivery Systems - methods | Drugs | Pharmaceutical research | Drug delivery systems | Research | Drug interactions | Vehicles | Biological Sciences | Physical Sciences
Journal Article
European journal of immunology, ISSN 0014-2980, 2018, Volume 48, Issue 2, pp. 283 - 292
Class-switching of B cells to IgA can be induced via both T-cell-dependent and T-cell-independent mechanisms. IgA is most predominantly produced mucosally and... 
Leerstoelgroep Fysiologie van mens en dier | Leerstoelgroep Celbiologie en immunologie | Celbiologie en Immunologie | WIAS | Cell Biology and Immunology | Human and Animal Physiology | Fysiologie van Mens en Dier | CD38 | Class switch recombination | Retinoic acid | CpG‐ODN | Plasma cell | CpG-ODN | Toll-Like Receptor 7 - agonists | Immunoglobulin A - metabolism | Toll-Like Receptor 7 - metabolism | Infection - immunology | Lymphocyte Activation | Humans | Cells, Cultured | B-Lymphocytes - physiology | Hypersensitivity - immunology | Imidazoles - pharmacology | Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism | Blood Cells - immunology | Animals | B-Cell Activating Factor - metabolism | Mucous Membrane - immunology | B-Cell Activating Factor - genetics | Interleukin-10 - metabolism | T-Lymphocytes - immunology | Mice | Oligodeoxyribonucleotides - pharmacology | Immunoglobulin Class Switching | Toll-Like Receptor 8 - metabolism | Toll-Like Receptor 8 - agonists | Virus diseases | B cells | T cells | Immunoglobulin A | Immunotherapy | Tretinoin | Mucosa | Oligonucleotides | Infections | Lymphocytes T | Blood | Mimicry | APRIL protein | Animal tissues | Peripheral blood | Toll-like receptors | Bacteria | CpG islands | Cell survival | Bacterial infections | TLR7 protein | Immunoregulation | Allergies | Switching | TLR9 protein | Class switching | Lymphocytes B | BLyS protein | Interleukin 10 | Viability | Viral infections | Basic | Adaptive immunity
Journal Article
Vaccine, ISSN 0264-410X, 2009, Volume 27, Issue 31, pp. 4104 - 4109
Abstract A Phase 1 study was conducted in 24 malaria naïve adults to assess the safety and immunogenicity of the recombinant protein vaccine apical membrane... 
Allergy and Immunology | Malaria | Falciparum | Apical membrane antigen 1 | APICAL MEMBRANE ANTIGEN-1 | MEDICINE, RESEARCH & EXPERIMENTAL | CONTROLLED-TRIAL | EFFICACY | PROTECTION | NORMAL VOLUNTEERS | AMA1 VACCINE | IMMUNOLOGY | PLASMODIUM-FALCIPARUM MALARIA | CHILDREN | IN-VITRO | ANTIBODY-PRODUCTION | Oligodeoxyribonucleotides - administration & dosage | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Antigens, Protozoan - immunology | Humans | Middle Aged | Male | Aluminum Hydroxide - administration & dosage | Plasmodium falciparum - immunology | Vaccines, Synthetic - immunology | Young Adult | Antibodies, Protozoan - blood | Vaccines, Synthetic - adverse effects | Malaria Vaccines - adverse effects | Malaria Vaccines - immunology | Adult | Female | Immunization Schedule | Vaccines, Subunit - adverse effects | Aluminum Hydroxide - pharmacology | Membrane Proteins - immunology | Vaccines, Subunit - immunology | Chemistry, Pharmaceutical | Malaria - prevention & control | Animals | Malaria Vaccines - administration & dosage | Vaccines, Subunit - administration & dosage | Adolescent | Vaccines, Synthetic - administration & dosage | Oligodeoxyribonucleotides - pharmacology | Protozoan Proteins - immunology | Proteins | Hepatitis | Headaches | Nausea | Vaccines | Family medical history | Drug dosages | Blood | Fever
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2017, Volume 198, Issue 4, pp. 1512 - 1520
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2002, Volume 168, Issue 9, pp. 4531 - 4537
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 21, pp. 8947 - 8952
The use of recombinant tumor antigen proteins is a realistic approach for the development of generic cancer vaccines, but the potential of this type of... 
T lymphocytes | Cancer vaccines | Antigens | Cross priming | B lymphocytes | Plasmids | Vaccination | Melanoma | Antibodies | Tumors | Cancer vaccine | PLASMACYTOID DENDRITIC CELLS | B-CELLS | IMMUNIZATION | CANCER-PATIENTS | EPITOPE | cancer vaccine | CANCER/TESTIS ANTIGENS | IMMUNE-RESPONSES | DNA | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | TUMOR-ANTIGEN | Recombinant Proteins - therapeutic use | Mannitol - blood | Humans | Membrane Proteins - adverse effects | Epitopes, B-Lymphocyte - immunology | Membrane Proteins - therapeutic use | Recombinant Proteins - adverse effects | Th1 Cells - immunology | Oleic Acids - blood | Oligodeoxyribonucleotides - blood | Antigens, Neoplasm - therapeutic use | Antigens, Neoplasm - blood | Antibodies - immunology | Oligodeoxyribonucleotides - adverse effects | Antigens, Neoplasm - adverse effects | Oleic Acids - adverse effects | Membrane Proteins - blood | Oligodeoxyribonucleotides - therapeutic use | Mannitol - adverse effects | Oligodeoxyribonucleotides - immunology | Antigens, Neoplasm - immunology | Oleic Acids - therapeutic use | Mannitol - therapeutic use | Membrane Proteins - immunology | Immunotherapy - adverse effects | Mannitol - analogs & derivatives | Neoplasms - drug therapy | Recombinant Proteins - blood | Cancer Vaccines - immunology | Cross-Priming - immunology | Recombinant Proteins - immunology | Mannitol - immunology | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Oleic Acids - immunology | Research | T cells | Tumor antigens | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e15041
Newborns and young infants suffer increased infectious morbidity and mortality as compared to older children and adults. Morbidity and mortality due to... 
VACCINE DEVELOPMENT | INFECTIONS | HUMAN NEWBORN | MIFLOWCYT | BIOLOGY | INNATE IMMUNE-RESPONSE | FLOW-CYTOMETRY | BIRTH | INFANT | CHILDHOOD | AGE | Leukocytes, Mononuclear - metabolism | Toll-Like Receptor 2 - agonists | Age Factors | Lipopeptides - pharmacology | Dendritic Cells - immunology | Humans | Middle Aged | Child, Preschool | Infant | Toll-Like Receptor 9 - agonists | Toll-Like Receptor 9 - immunology | Young Adult | Toll-Like Receptor 8 - immunology | Leukocytes, Mononuclear - immunology | Toll-Like Receptor 7 - immunology | Toll-Like Receptor 4 - agonists | Adult | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Infant, Newborn | Cytokines - immunology | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Antigen-Presenting Cells - metabolism | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Antigen-Presenting Cells - drug effects | Toll-Like Receptors - immunology | Toll-Like Receptor 4 - immunology | Antigen-Presenting Cells - immunology | Toll-Like Receptors - agonists | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Oligodeoxyribonucleotides - pharmacology | Cohort Studies | Infants (Newborn) | Cytokines | Mortality | Vaccines | B cells | Comparative analysis | Health aspects | Neonates | Flow cytometry | Pediatrics | Helper cells | Leukocytes (mononuclear) | Stimulation | Interleukin 23 | Infants | Lymphocytes T | Infections | Ontogeny | Birth | Immunity | Interleukin 6 | Proteins | Immunology | Newborn babies | Toll-like receptors | Children | Age | Immune system | Medical research | Antigens | Immune response | Fetuses | Interleukin 12 | T cell receptors | Tumor necrosis factor-α | Morbidity | Childbirth & labor | Herpes viruses | γ-Interferon | Interleukin 10 | Interferon | Adults | Human behavior
Journal Article
Journal Article