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Journal of Leukocyte Biology, ISSN 0741-5400, 09/2009, Volume 86, Issue 3, pp. 655 - 662
A prototypic mechanism for enhancement of inflammation by an endogenous molecule is described. The nuclear protein HMGB1 has previously been demonstrated to... 
innate cell‐mediated immunity | cell activation | Innate cell-mediated immunity | Cell activation | CELLS | ACTIVATION | RECEPTOR | IMMUNOLOGY | innate cell-mediated immunity | HUMAN MONOCYTES | CELL BIOLOGY | GROUP CHROMOSOMAL-PROTEINS | AMPHOTERIN | DNA | HIGH-MOBILITY-GROUP-BOX-1 | MOBILITY GROUP BOX-1 | HEMATOLOGY | BINDING | Coculture Techniques | Cytokines - analysis | Humans | Synovial Membrane - immunology | HMGB1 Protein - immunology | HMGB1 Protein - isolation & purification | Lipopolysaccharides - immunology | HMGB1 Protein - genetics | Recombinant Proteins - isolation & purification | Toll-Like Receptor 9 - immunology | Signal Transduction - immunology | HMGB1 Protein - pharmacology | Leukocytes, Mononuclear - immunology | Fibroblasts - metabolism | Inflammation Mediators - immunology | Cell Survival - drug effects | Biotinylation | Leukocytes, Mononuclear - drug effects | Oligodeoxyribonucleotides - immunology | Cells, Cultured | Interleukin-1beta - immunology | Rats | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Recombinant Proteins - pharmacology | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Animals | Recombinant Proteins - immunology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Interleukin-6 - biosynthesis | Toll-Like Receptor 2 - immunology | Fibroblasts - immunology | Ligands | Toll-Like Receptor 1 - immunology | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2004, Volume 172, Issue 3, pp. 1777 - 1785
DNA rich in nonmethylated CG motifs (CpGs) greatly facilitates induction of immune responses against coadministered Ags. CpGs are therefore among the most... 
IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDES | CORE PARTICLES | DENDRITIC CELLS | IMMUNE-RESPONSES | TOLL-LIKE RECEPTORS | TH1 IMMUNITY | IMMUNOLOGY | BACTERIAL-DNA | INNATE IMMUNITY | CUTTING EDGE | ANTIGEN | Allolevivirus - immunology | Oligodeoxyribonucleotides - administration & dosage | Dendritic Cells - immunology | Virion - genetics | Lymphocyte Activation - genetics | Oligodeoxyribonucleotides - genetics | Recombination, Genetic | Peptide Fragments - immunology | Viral Proteins - administration & dosage | Peptide Fragments - genetics | Glycoproteins - genetics | Virion - immunology | Oligodeoxyribonucleotides - immunology | Viral Proteins - genetics | Antigen Presentation - genetics | Antigen Presentation - immunology | Virion - metabolism | Glycoproteins - administration & dosage | Hepatitis B Core Antigens - genetics | Hepatitis B Core Antigens - immunology | Antigens, Viral - immunology | Glycoproteins - immunology | B-Lymphocytes - immunology | Virus Assembly - immunology | CpG Islands - genetics | T-Lymphocytes - immunology | Mice | Hepatitis B Core Antigens - administration & dosage | Dose-Response Relationship, Immunologic | Antigens, Viral - administration & dosage | Vaccines, DNA - immunology | Viral Proteins - immunology | RNA, Viral - administration & dosage | Antigens, Viral - genetics | Fibrosarcoma - immunology | Vaccines, DNA - administration & dosage | DNA Methylation | RNA, Viral - genetics | Virus Assembly - genetics | Allolevivirus - genetics | Dendritic Cells - virology | Dendritic Cells - metabolism | Liposomes - immunology | T-Lymphocytes, Cytotoxic - immunology | Thionucleotides - antagonists & inhibitors | Cytotoxicity, Immunologic - genetics | CpG Islands - immunology | T-Lymphocytes, Cytotoxic - virology | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Animals | Thionucleotides - toxicity | Fibrosarcoma - prevention & control | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2015, Volume 194, Issue 6, pp. 2838 - 2846
Histone modifications play critical roles in the regulation of gene expression; however, their roles in the regulation of the innate response remain to be... 
PROTEIN | EPITHELIAL-CELLS | AUTOIMMUNE-DISEASES | NEGATIVE REGULATION | GENE-EXPRESSION | RECEPTOR | MECHANISMS | IMMUNOLOGY | CELL-DIFFERENTIATION | T-CELLS | INNATE IMMUNITY | Polycomb Repressive Complex 2 - genetics | Dendritic Cells - immunology | Immunity, Innate - genetics | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Transcriptome - immunology | Lipopolysaccharides - immunology | Promoter Regions, Genetic - genetics | RNA Interference | Inflammation Mediators - metabolism | Polycomb Repressive Complex 2 - immunology | Lysine - metabolism | Poly I-C - immunology | Toll-Like Receptors - metabolism | Cytokines - genetics | Intracellular Signaling Peptides and Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cytokines - immunology | Inflammation Mediators - immunology | Poly I-C - pharmacology | Oligodeoxyribonucleotides - immunology | Cytokines - metabolism | Histones - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Cells, Cultured | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Toll-Like Receptors - agonists | Immunity, Innate - immunology | Macrophages - metabolism | Animals | Lipopolysaccharides - pharmacology | Histones - metabolism | Promoter Regions, Genetic - immunology | Methylation | Oligodeoxyribonucleotides - pharmacology | Polycomb Repressive Complex 2 - metabolism | Lysine - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2015, Volume 195, Issue 11, pp. 5169 - 5177
Journal Article
European Journal of Immunology, ISSN 0014-2980, 01/2017, Volume 47, Issue 1, pp. 131 - 143
Around 65% of primary immunodeficiencies are antibody deficiencies. Functional tests are useful tools to study B‐cell functions in vitro. However, no accepted... 
Functional tests | B cells | Selective IgA deficiency | Pediatric immunology | Immunodeficiency | GENERATION | IGA DEFICIENCY | DIFFERENTIATION | PROLIFERATE | IMMUNOLOGY | SECRETING CELLS | Age Factors | Humans | Child, Preschool | Infant | Receptors, Antigen, B-Cell - metabolism | Immunoglobulin M - immunology | CD40 Ligand - immunology | Young Adult | Lymphocyte Activation - immunology | CD40 Antigens - metabolism | Adult | B-Lymphocyte Subsets - immunology | Immunologic Deficiency Syndromes - blood | Immunologic Deficiency Syndromes - immunology | Child | Immunoglobulin Class Switching | Oligodeoxyribonucleotides - immunology | Cells, Cultured | Immunophenotyping | Phenotype | Immunoglobulin M - blood | B-Lymphocyte Subsets - metabolism | Immunoglobulin A - immunology | Adolescent | Biomarkers | Immunoglobulin A - blood | Immunologic Deficiency Syndromes - metabolism | Protein Binding | Immunologic Memory | Immunoglobulin A | Cell differentiation | Immunoglobulin M | Cell proliferation | Lymphocyte receptors | Memory cells | Immunological memory | Differentiation (biology) | T cell receptors | Patients | CD40L protein | Cell activation | Lymphocytes B | Plasma cells | Children | Immune system | CpG islands | Index Medicus | Reumatologi och inflammation | CD40/metabolism | Immunoglobulin A/blood/immunology | Oligodeoxyribonucleotides/immunology | Rheumatology and Autoimmunity | Receptors | Immunoglobulin M/blood/immunology | Cultured | Immunologic Deficiency Syndromes/blood/immunology/metabolism | Antigens | B-Lymphocyte Subsets/immunology/metabolism | Preschool | Cells | B-Cell/metabolism | Antigen | CD40 Ligand/immunology | Lymphocyte Activation/immunology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 21, pp. 8947 - 8952
The use of recombinant tumor antigen proteins is a realistic approach for the development of generic cancer vaccines, but the potential of this type of... 
T lymphocytes | Cancer vaccines | Antigens | Cross priming | B lymphocytes | Plasmids | Vaccination | Melanoma | Antibodies | Tumors | Cancer vaccine | PLASMACYTOID DENDRITIC CELLS | B-CELLS | IMMUNIZATION | CANCER-PATIENTS | EPITOPE | cancer vaccine | CANCER/TESTIS ANTIGENS | IMMUNE-RESPONSES | DNA | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | TUMOR-ANTIGEN | Recombinant Proteins - therapeutic use | Mannitol - blood | Humans | Membrane Proteins - adverse effects | Epitopes, B-Lymphocyte - immunology | Membrane Proteins - therapeutic use | Recombinant Proteins - adverse effects | Th1 Cells - immunology | Oleic Acids - blood | Oligodeoxyribonucleotides - blood | Antigens, Neoplasm - therapeutic use | Antigens, Neoplasm - blood | Antibodies - immunology | Oligodeoxyribonucleotides - adverse effects | Antigens, Neoplasm - adverse effects | Oleic Acids - adverse effects | Membrane Proteins - blood | Oligodeoxyribonucleotides - therapeutic use | Mannitol - adverse effects | Oligodeoxyribonucleotides - immunology | Antigens, Neoplasm - immunology | Oleic Acids - therapeutic use | Mannitol - therapeutic use | Membrane Proteins - immunology | Immunotherapy - adverse effects | Mannitol - analogs & derivatives | Neoplasms - drug therapy | Recombinant Proteins - blood | Cancer Vaccines - immunology | Cross-Priming - immunology | Recombinant Proteins - immunology | Mannitol - immunology | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Oleic Acids - immunology | Research | T cells | Tumor antigens | Proteins | Immunization | Immunology | Vaccines | Cancer | Index Medicus | Biological Sciences
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2008, Volume 181, Issue 11, pp. 7948 - 7957
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2002, Volume 169, Issue 1, pp. 350 - 358
Peptide-based vaccines aimed at the induction of effective T cell responses against established cancers have so far only met with limited clinical success and... 
CANCER-PATIENTS | DENDRITIC CELLS | CTL EPITOPES | IN-VIVO | CERVICAL LESIONS | MONOPHOSPHORYL LIPID-A | GENITAL WARTS | IMMUNOLOGY | NATURAL-HISTORY | YOUNG-WOMEN | CYTOTOXIC T-LYMPHOCYTES | Oncogene Proteins, Viral - administration & dosage | Oligodeoxyribonucleotides - administration & dosage | Adjuvants, Immunologic - administration & dosage | Dendritic Cells - immunology | Humans | Molecular Sequence Data | Papillomavirus E7 Proteins | Th1 Cells - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Papillomaviridae - immunology | CD40 Antigens - metabolism | CD40 Ligand - metabolism | Immunization, Secondary | Injections, Subcutaneous | Peptide Fragments - immunology | Tumor Virus Infections - immunology | Papillomavirus Infections - immunology | Epitopes, T-Lymphocyte - immunology | Tumor Cells, Cultured | Dendritic Cells - metabolism | Disease Models, Animal | Amino Acid Sequence | Oligodeoxyribonucleotides - immunology | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Cells, Cultured | Vaccines, Subunit - immunology | Oncogene Proteins, Viral - biosynthesis | Tumor Virus Infections - prevention & control | Mice, Knockout | Viral Vaccines - administration & dosage | Animals | Histocompatibility Antigens Class II - immunology | Papillomavirus Infections - prevention & control | Vaccines, Subunit - administration & dosage | Mice | Oncogene Proteins, Viral - immunology | CD8-Positive T-Lymphocytes - immunology | Viral Vaccines - immunology | Cell Line, Transformed | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2002, Volume 196, Issue 4, pp. 541 - 549
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2014, Volume 15, Issue 1, pp. 54 - 62
miR-126 is a microRNA expressed predominately by endothelial cells and controls angiogenesis. We found miR-126 was required for the innate response to... 
PLASMACYTOID DENDRITIC CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | VASCULAR INTEGRITY | MICRORNA MIR-126 | PREDENDRITIC CELLS | RECEPTOR | INDUCTION | IMMUNOLOGY | EXPRESSION | I INTERFERON | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Humans | Immunity, Innate - genetics | Toll-Like Receptor 9 - genetics | Immunoblotting | MicroRNAs - metabolism | Transcriptome - immunology | NF-kappa B p50 Subunit - genetics | Vascular Endothelial Growth Factor Receptor-2 - immunology | Vascular Endothelial Growth Factor Receptor-2 - genetics | NF-kappa B p50 Subunit - immunology | Toll-Like Receptor 9 - immunology | HIV Infections - immunology | Flow Cytometry | Oligodeoxyribonucleotides - genetics | Toll-Like Receptor 7 - immunology | Dendritic Cells - metabolism | Toll-Like Receptor 7 - genetics | Interferon-alpha - metabolism | Oligodeoxyribonucleotides - immunology | Toll-Like Receptor 7 - metabolism | NF-kappa B p50 Subunit - metabolism | HIV Infections - virology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Nucleic Acids - metabolism | MicroRNAs - immunology | Reverse Transcriptase Polymerase Chain Reaction | Interferon-alpha - immunology | Mice, Knockout | Immunity, Innate - immunology | Animals | Interferon-alpha - blood | Mice | MicroRNAs - genetics | Nucleic Acids - immunology | Toll-Like Receptor 9 - metabolism | Host-parasite relationships | Physiological research | MicroRNA | Immune response | Research | Identification and classification | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2004, Volume 172, Issue 4, pp. 2137 - 2146
Ideal vaccines should be stable, safe, molecularly defined, and out-of-shelf reagents efficient at triggering effector and memory Ag-specific T cell-based... 
DOUBLE-STRANDED-RNA | NECROSIS-FACTOR | HUMAN DENDRITIC CELLS | CLINICAL-TRIAL | IMMUNE-RESPONSES | IN-VIVO | TOLL-LIKE RECEPTORS | IMMUNOLOGY | SYNTHETIC IMMUNOMODULATOR MURABUTIDE | BACTERIAL-DNA | MURAMYL PEPTIDES | Endosomes - immunology | HLA-A2 Antigen - genetics | Oligodeoxyribonucleotides - administration & dosage | Toll-Like Receptor 3 | Adjuvants, Immunologic - administration & dosage | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - biosynthesis | Neoplasm Proteins - immunology | Toll-Like Receptor 9 | Interphase - immunology | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | gp100 Melanoma Antigen | Toll-Like Receptors | Melanoma, Experimental - prevention & control | HLA-A2 Antigen - biosynthesis | Melanoma, Experimental - immunology | Adjuvants, Immunologic - metabolism | T-Lymphocytes, Regulatory - cytology | Membrane Glycoproteins - immunology | Neoplasm Proteins - genetics | Oligodeoxyribonucleotides - metabolism | Cell-Free System - immunology | T-Lymphocytes, Cytotoxic - immunology | CpG Islands - immunology | Oligodeoxyribonucleotides - immunology | HLA-A2 Antigen - immunology | Neoplasm Proteins - biosynthesis | Cancer Vaccines - administration & dosage | Receptors, Cell Surface - metabolism | Vaccines, Subunit - immunology | Cell-Free System - transplantation | Endosomes - transplantation | Membrane Glycoproteins - genetics | Cancer Vaccines - immunology | Animals | T-Lymphocytes, Cytotoxic - metabolism | Vaccines, Subunit - administration & dosage | RNA, Double-Stranded - immunology | Ligands | Mice | Graft Rejection - immunology | T-Lymphocytes, Cytotoxic - cytology | Exosomes | CD8 antigen | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2015, Volume 195, Issue 9, pp. 4396 - 4405
Synthetic oligodeoxyribonucleotides (ODNs) containing unmethylated CpG recapitulate the activation of TLR9 by microbial DNA. ODNs are potent stimulators of the... 
PLASMACYTOID DENDRITIC CELLS | TOLL-LIKE-RECEPTOR-9 ACTIVATION | CPG MOTIFS | TOLL-LIKE RECEPTOR-9 | PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE | IMMUNOSTIMULATORY ACTIVITIES | HUMAN B-CELLS | IMMUNOLOGY | ANTISENSE OLIGONUCLEOTIDES | BACTERIAL-DNA | INTERFERON-ALPHA INDUCTION | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | Species Specificity | Nucleotide Motifs - genetics | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | Immunoblotting | Th1 Cells - immunology | Toll-Like Receptor 9 - agonists | Antigens, CD - metabolism | Toll-Like Receptor 9 - immunology | Lectins, C-Type - metabolism | Oligodeoxyribonucleotides - genetics | Base Sequence | HEK293 Cells | Tumor Necrosis Factor-alpha - immunology | Dendritic Cells - drug effects | B7-2 Antigen - immunology | Interleukin-6 - metabolism | Cell Line | Interferon-alpha - metabolism | Th1 Cells - drug effects | Oligodeoxyribonucleotides - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Mice, Inbred C57BL | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Interleukin-12 - metabolism | Interferon-alpha - immunology | Mice, Knockout | B-Lymphocytes - drug effects | B7-2 Antigen - metabolism | Animals | B-Lymphocytes - immunology | Interleukin-12 - immunology | Interleukin-6 - immunology | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2008, Volume 181, Issue 8, pp. 5396 - 5404
Human plasmacytoid dendritic cells (PDCs) can drive naive, allogeneic CD4(+)CD25(-) T cells to differentiate into CD4(+)CD25(+) Foxp3(+) regulatory T cells... 
IMMUNOSUPPRESSIVE PATHWAY | TGF-BETA | IN-VIVO | CD4(+) | INDUCTION | IMMUNOLOGY | EX-VIVO | VERSUS-HOST-DISEASE | DRAINING LYMPH-NODES | TRYPTOPHAN CATABOLISM | CUTTING EDGE | Forkhead Transcription Factors - immunology | Gene Expression Regulation, Enzymologic - drug effects | Adjuvants, Immunologic - pharmacology | Coculture Techniques | Dendritic Cells - immunology | Humans | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | T-Lymphocytes, Regulatory - immunology | Plasma Cells - enzymology | Toll-Like Receptor 9 - immunology | Forkhead Transcription Factors - metabolism | Tryptophan - analogs & derivatives | B7-1 Antigen - biosynthesis | Tryptophan - antagonists & inhibitors | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | B7-1 Antigen - immunology | Kynurenine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Up-Regulation - drug effects | Cell Differentiation - immunology | Up-Regulation - immunology | Cell Differentiation - drug effects | Dendritic Cells - enzymology | Kynurenine - antagonists & inhibitors | HLA-DR Antigens - immunology | Tryptophan - pharmacology | Gene Expression Regulation, Enzymologic - immunology | HLA-DR Antigens - biosynthesis | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | T-Lymphocytes, Regulatory - enzymology | Plasma Cells - immunology | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2006, Volume 177, Issue 3, pp. 1670 - 1678
Journal Article