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Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1530 - 1534
Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor KB (NF-KB)-dependent... 
T lymphocytes | Molecules | Cytokines | Microscopy | Genes | REPORTS | Toll like receptors | Agonists | Macrophages | Cells | Endosomes | LOCALIZATION | ACTIVATION | DENDRITIC CELLS | TRAF3 | MULTIDISCIPLINARY SCIENCES | TLR9 | TOLL-LIKE-RECEPTOR-9 | INDUCTION | INTERFERON-ALPHA PRODUCTION | I INTERFERON | AP-3 ADAPTER | Recombinant Fusion Proteins - immunology | Dendritic Cells - immunology | Transcriptional Activation | Interferon Type I - immunology | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - immunology | Cytoplasmic Vesicles - metabolism | Interferon Type I - metabolism | Membrane Transport Proteins - metabolism | Cytokines - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cytokines - immunology | Oligodeoxyribonucleotides - immunology | Cytokines - metabolism | Signal Transduction | Vesicle-Associated Membrane Protein 3 - metabolism | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 3 - metabolism | Adaptor Protein Complex beta Subunits | Interferon Regulatory Factor-7 - metabolism | Adaptor Protein Complex 3 - metabolism | Protein Transport | Animals | Adaptor Protein Complex 3 - genetics | Interferon Type I - genetics | Mice | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Cellular control mechanisms | Physiological aspects | TLR7 | Research | Health aspects | Immune system | Proteins | Signal transduction | Interferon | Cellular biology | Receptors | Compartments | Bifurcations | Activation
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2010, Volume 207, Issue 4, pp. 721 - 730
Plasmacytoid dendritic cells (pDCs) play a key role in antiviral immunity, but also contribute to the pathogenesis of certain autoimmune diseases, by producing... 
MEDICINE, RESEARCH & EXPERIMENTAL | CPG MOTIFS | LYMPHOCYTE MIGRATION | PROTEIN DOCK2 | RECOGNITION | PREDENDRITIC CELLS | NEUTROPHIL CHEMOTAXIS | KAPPA-B | IMMUNOLOGY | INTERFERON-ALPHA PRODUCTION | BACTERIAL-DNA | MOTILITY | Interferon-alpha - pharmacology | Interleukin-1 Receptor-Associated Kinases - metabolism | Dendritic Cells - immunology | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Interleukin-12 Subunit p40 - blood | Male | GTPase-Activating Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - agonists | Interferon Type I - biosynthesis | Signal Transduction - immunology | STAT1 Transcription Factor - metabolism | I-kappa B Kinase - metabolism | rac GTP-Binding Proteins - genetics | Interferon Type I - metabolism | Dendritic Cells - drug effects | Female | Influenza A virus - immunology | Neuropeptides - genetics | Phosphorylation - drug effects | Oligodeoxyribonucleotides - metabolism | Dendritic Cells - metabolism | Toll-Like Receptor 7 - agonists | Interferon-alpha - metabolism | Interleukin-12 Subunit p40 - metabolism | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Membrane Glycoproteins - agonists | Neuropeptides - metabolism | Imidazoles - pharmacology | Interferon Regulatory Factor-7 - metabolism | Toll-Like Receptors - agonists | Mice, Knockout | Animals | Herpesvirus 2, Human - immunology | Interferon-beta - metabolism | Signal Transduction - drug effects | Interferon-alpha - blood | Mice | rac1 GTP-Binding Protein | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Brief Definitive Report
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 1852
CpG-rich oligodeoxynucleotides activate the immune system, leading to innate and acquired immune responses. The immune-stimulatory effects of CpG-rich... 
PLASMACYTOID DENDRITIC CELLS | IMMUNOSUPPRESSIVE PATHWAY | ACTIVATION | INDOLEAMINE 2,3-DIOXYGENASE IDO | INDUCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | NF-KAPPA-B | TRYPTOPHAN CATABOLISM | CUTTING EDGE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Immunomodulation - drug effects | Membrane Glycoproteins - metabolism | Humans | Interferon Regulatory Factors - metabolism | Pneumonia - pathology | NF-kappa B - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Antigens, CD - metabolism | Interleukin-23 - genetics | Signal Transduction - immunology | Interleukin-23 - metabolism | Interferon Type I - metabolism | Pneumonia - immunology | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Immune Tolerance - drug effects | Skin Tests | Toll-Like Receptor 3 - metabolism | Aspergillosis, Allergic Bronchopulmonary - pathology | Toll-Like Receptor 4 - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Gene Expression Regulation - drug effects | Animals | Transforming Growth Factor beta - genetics | Signal Transduction - drug effects | Aspergillosis, Allergic Bronchopulmonary - immunology | Mice | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Transforming Growth Factor beta - metabolism
Journal Article
Immunity, ISSN 1074-7613, 06/2016, Volume 44, Issue 6, pp. 1325 - 1336
Journal Article
Brain, ISSN 0006-8950, 2012, Volume 135, Issue 4, pp. 1237 - 1252
MicroRNAs have been shown to effectively regulate gene expression at the translational level. Recently, we identified novel microRNAs that were upregulated in... 
spinal cord injury | neuroprotection | miR 486 | SITE | MOUSE | MITOCHONDRIA | ISCHEMIA | NEUROSCIENCES | DAMAGE | CLINICAL NEUROLOGY | CYTOCHROME-C | RECOVERY | EMBRYONIC STEM-CELLS | MICE | Oligodeoxyribonucleotides, Antisense - pharmacology | Reactive Oxygen Species - metabolism | Recovery of Function - drug effects | Caspase 3 - metabolism | Motor Activity - drug effects | MicroRNAs - metabolism | Glial Fibrillary Acidic Protein - metabolism | Nerve Degeneration - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Adenosine Triphosphate - metabolism | Recovery of Function - physiology | Female | Nitric Oxide Synthase Type III - metabolism | Spinal Cord Injuries - therapy | Motor Neurons - drug effects | Disease Models, Animal | Recovery of Function - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Cytokines - metabolism | Myelin Basic Protein - metabolism | Spinal Cord Injuries - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Neural Stem Cells - drug effects | Gene Expression Regulation - physiology | Mice, Inbred ICR | Gene Expression Regulation - drug effects | Motor Neurons - metabolism | Animals | Analysis of Variance | Mice | MicroRNAs - genetics | Spinal Cord Injuries - physiopathology | Nerve Degeneration - etiology | Neurofilament Proteins - metabolism | Neural Stem Cells - metabolism | Nerve Degeneration - drug therapy | Nitric Oxide Synthase Type II - metabolism | Peroxidase - metabolism | Glutathione peroxidase | Motor neurons | Neuroprotection | Animal models | Reactive oxygen species | Translation | Inflammation | Regulatory sequences | Gene expression | Spinal cord injury | Conserved sequence | Neurodegeneration | miRNA | Brain injury | Apoptosis
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2004, Volume 75, Issue 6, pp. 995 - 1000
We report that mitochondrial DNA (mtDNA) is inflammatogenic in vitro and in vivo as a result of the presence of unmethylated CpG sequences and its oxidative... 
monocytes/macrophages | inflammation | rheumatoid arthritis | Rheumatoid arthritis | Inflammation | Monocytes/macrophages | RHEUMATOID-ARTHRITIS | OXIDATIVE STRESS | ACTIVATION | MACROPHAGES | JOINTS | IMMUNOLOGY | DAMAGE | CELL-DEATH | CELL BIOLOGY | CPG MOTIFS | NUCLEAR-DNA | HEMATOLOGY | BACTERIAL-DNA | Tumor Necrosis Factor-alpha - metabolism | Mitochondria, Muscle | Oligodeoxyribonucleotides - administration & dosage | Humans | Monocytes - metabolism | NF-kappa B - metabolism | Synovial Fluid - chemistry | Mitochondria, Liver | Arthritis, Rheumatoid - metabolism | DNA Adducts | DNA Methylation | T-Lymphocytes - metabolism | Female | B-Lymphocytes - metabolism | DNA, Mitochondrial - metabolism | Oxidation-Reduction | Arthritis, Rheumatoid - pathology | Macrophages - metabolism | Animals | CpG Islands | Mice | Mice, Inbred BALB C | DNA Damage | Arthritis, Rheumatoid - immunology | In Vitro Techniques | Inbred BALB C | Synovial Fluid/chemistry | B-Lymphocytes/metabolism | Macrophages/metabolism | Liver | Arthritis | MEDICIN OCH HÄLSOVETENSKAP | Mitochondria | Tumor Necrosis Factor-alpha/metabolism | T-Lymphocytes/metabolism | Muscle | Mitochondrial/metabolism | Rheumatoid/immunology/metabolism/pathology | MEDICAL AND HEALTH SCIENCES | Oligodeoxyribonucleotides/administration & dosage | DNA | NF-kappa B/metabolism | Monocytes/metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24748 - 24759
The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids,... 
ACTIVATION | ESCHERICHIA-COLI LIPOPOLYSACCHARIDE | INDUCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID RAFTS | ENDOTHELIAL-CELLS | LOW-DENSITY-LIPOPROTEIN | HEME OXYGENASE-1 | MONOCYTE CHEMOTACTIC PROTEIN-1 | OXIDATION-PRODUCTS | T-LYMPHOCYTES | Phosphatidylcholines - immunology | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Macrophages, Peritoneal - cytology | Flagellin - pharmacology | Lymphocyte Antigen 96 - agonists | Oxidation-Reduction - drug effects | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Carrier Proteins - immunology | Guanosine - analogs & derivatives | Poly I-C - pharmacology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | I-kappa B Kinase - immunology | Mice | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Oligodeoxyribonucleotides - pharmacology | Immunologic Factors - pharmacology | Lymphocyte Antigen 96 - immunology | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 - agonists | Acute-Phase Proteins - genetics | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Carrier Proteins - agonists | I-kappa B Kinase - metabolism | Reactive Oxygen Species - immunology | Female | Membrane Glycoproteins - immunology | Cell Line | Acute-Phase Proteins - metabolism | Phosphatidylcholines - pharmacology | Membrane Glycoproteins - agonists | p38 Mitogen-Activated Protein Kinases - genetics | I-kappa B Kinase - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phosphatidylcholines - genetics | Animals | Carrier Proteins - metabolism | RNA - pharmacology | Guanosine - pharmacology | Lipopolysaccharide Receptors - genetics | Signal Transduction - physiology | Acute-Phase Proteins - agonists | Acute-Phase Proteins - immunology | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2006, Volume 172, Issue 7, pp. 1057 - 1068
Toll-like receptors (TLRs) recognize molecular patterns preferentially expressed by pathogens. In endosomes, TLR9 is activated by unmethylated bacterial DNA,... 
Phosphorylation | Monocytes | Receptors | Cytokines | B lymphocytes | Secretion | Cell adhesion | Actins | Cellular immunity | Macrophages | SIGNAL-TRANSDUCTION | KINASE-ACTIVITY | CELLS | ACTIVATION | MACROPHAGES | TOLL-LIKE RECEPTORS | INTERLEUKIN-1 RECEPTOR | NF-KAPPA-B | DEPENDENT MANNER | BACTERIAL-DNA | CELL BIOLOGY | RNA, Small Interfering - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Toll-Like Receptor 9 - physiology | Antigens, CD - metabolism | Chloroquine - pharmacology | Actin Cytoskeleton - drug effects | Cell Membrane - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Syk Kinase | Cell Membrane - drug effects | NF-KappaB Inhibitor alpha | Actin Cytoskeleton - metabolism | Proto-Oncogene Proteins c-hck - metabolism | Pyrimidines - pharmacology | Cell Adhesion - drug effects | Mice, Knockout | Monocytes - drug effects | Macrophages - metabolism | Tyrosine - metabolism | Models, Biological | Cell Line, Tumor | CpG Islands | Cytoskeleton - metabolism | Mice | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | src-Family Kinases - genetics | Toll-Like Receptor 9 - genetics | Monocytes - metabolism | I-kappa B Proteins - metabolism | Quinacrine - pharmacology | src-Family Kinases - metabolism | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Pyrazoles - pharmacology | Interferon-alpha - metabolism | src-Family Kinases - antagonists & inhibitors | Cytokines - secretion | Myeloid Differentiation Factor 88 | Animals | Androstadienes - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Macrophages - drug effects | Proto-Oncogene Proteins c-hck - genetics | Protein Kinase Inhibitors - pharmacology | Cytoskeleton - drug effects | Proteins | Cellular biology | Cyclin-dependent kinases | Cell adhesion & migration
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2009, Volume 12, Issue 4, pp. 399 - 408
Journal Article
Journal Article
Journal Article
BLOOD, ISSN 0006-4971, 09/2007, Volume 110, Issue 6, pp. 1970 - 1981
Journal Article