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1. Pharmacology of a central nervous system delivered 2′-O-methoxyethyl- modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates
by Rigo, Frank and Chun, Seung J and Norris, Daniel A and Hung, Gene and Lee, Sam and Matson, John and Fey, Robert A and Gaus, Hans and Hua, Yimin and Grundy, John S and Krainer, Adrian R and Henry, Scott P and Bennett, C. Frank
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 2014, Volume 350, Issue 1, pp. 46 - 55
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | RNA Splicing - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Oligodeoxyribonucleotides, Antisense - administration & dosage | Oligonucleotides - therapeutic use | Injections, Intraventricular | Macaca fascicularis | Oligodeoxyribonucleotides, Antisense - therapeutic use | Male | Oligonucleotides - pharmacokinetics | Mice, Knockout | Brain - drug effects | Brain - metabolism | Muscular Atrophy, Spinal - genetics | Animals | Oligonucleotides - pharmacology | Survival of Motor Neuron 2 Protein - genetics | Female | Muscular Atrophy, Spinal - drug therapy | Mice | Oligonucleotides - administration & dosage | Infusions, Intraventricular | Oligodeoxyribonucleotides, Antisense - pharmacokinetics
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2. Full Text Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro®): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B
by Geary, Richard S and Geary, Richard S and Baker, Brenda F and Baker, Brenda F and Crooke, Stanley T and Crooke, Stanley T
Clinical pharmacokinetics, ISSN 0312-5963, 2/2015, Volume 54, Issue 2, pp. 133 - 146
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Apolipoproteins B - antagonists & inhibitors | Oligonucleotides - chemistry | Oligodeoxyribonucleotides, Antisense - pharmacology | Humans | Models, Molecular | Anticholesteremic Agents - chemistry | Clinical Trials as Topic | Oligonucleotides - pharmacokinetics | Anticholesteremic Agents - pharmacokinetics | Animals | Oligonucleotides - pharmacology | Base Sequence | Hyperlipoproteinemia Type I - drug therapy | Hyperlipoproteinemia Type I - metabolism | Anticholesteremic Agents - pharmacology | Oligodeoxyribonucleotides, Antisense - pharmacokinetics
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3. Full Text CpG ODN‐induced matrix metalloproteinase‐13 expression is mediated via activation of the ERK and NF‐κB signalling pathways in odontoblast cells
by Zhang, J and Zhu, Q. L and Huang, P and Yu, Q and Wang, Z. H and Cooper, P. R and Smith, A. J and He, W
International endodontic journal, ISSN 0143-2885, 07/2013, Volume 46, Issue 7, pp. 666 - 674
odontoblasts | bacteria | DNA | metalloproteinase | NF‐kappaB | ERK | Bacteria | Metalloproteinase | NF-kappaB | Odontoblasts | Phosphorylation | Extracellular Signal-Regulated MAP Kinases - drug effects | Nitriles - pharmacology | Odontoblasts - enzymology | Sulfones - pharmacology | Pyrrolidines - pharmacology | Chloroquine - pharmacology | Thiocarbamates - pharmacology | Dental Pulp - enzymology | Real-Time Polymerase Chain Reaction | Tosylphenylalanyl Chloromethyl Ketone - pharmacology | Cell Line | NF-kappa B - antagonists & inhibitors | I-kappa B Proteins - pharmacology | Dental Pulp - drug effects | Transcription Factor RelA - pharmacology | Imidazoles - pharmacology | Matrix Metalloproteinase 13 - drug effects | Toll-Like Receptor 9 - drug effects | Anthracenes - pharmacology | Myeloid Differentiation Factor 88 - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Odontoblasts - drug effects | CpG Islands | Mice | Pyridines - pharmacology | Oligodeoxyribonucleotides - pharmacology | NF-kappa B - drug effects | Dentistry | Chloroquine
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4. Full Text Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs
by Huijbregts, Richard P.H and Michel, Katherine G and Hel, Zdenek
Contraception (Stoneham), ISSN 0010-7824, 2014, Volume 90, Issue 2, pp. 123 - 129
Obstetrics and Gynecology | HIV-1 | LNG | Progestins | AIDS | ETG | DMPA | Hormonal contraception | NET | Life Sciences & Biomedicine | Obstetrics & Gynecology | Science & Technology | Immunopathology | Gynecology. Andrology. Obstetrics | Infectious diseases | Pharmacology. Drug treatments | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Genital system. Reproduction | Medical sciences | Human viral diseases | Immunodeficiencies. Immunoglobulinopathies | Immunodeficiencies | Contraceptive Agents, Female - adverse effects | Contraceptive Agents, Female - pharmacology | Progestins - metabolism | Desogestrel - adverse effects | Dendritic Cells - immunology | Humans | Progestins - adverse effects | Medroxyprogesterone Acetate - pharmacology | Delayed-Action Preparations - chemistry | Medroxyprogesterone Acetate - metabolism | Desogestrel - metabolism | Lymphocytes - immunology | Delayed-Action Preparations - pharmacology | Norethindrone - adverse effects | Toll-Like Receptors - antagonists & inhibitors | Contraceptive Agents, Female - antagonists & inhibitors | Medroxyprogesterone Acetate - adverse effects | Adult | Dendritic Cells - drug effects | Female | Contraceptive Agents, Female - metabolism | Toll-Like Receptors - metabolism | Dendritic Cells - metabolism | Immune Tolerance - drug effects | Lymphocytes - metabolism | Levonorgestrel - pharmacology | Cytokines - metabolism | Cells, Cultured | Progestins - pharmacology | Imidazoles - pharmacology | Lymphocytes - cytology | Toll-Like Receptors - agonists | Desogestrel - pharmacology | Delayed-Action Preparations - metabolism | HIV-1 - immunology | Progestins - antagonists & inhibitors | Delayed-Action Preparations - adverse effects | Levonorgestrel - adverse effects | Lymphocyte Activation - drug effects | Lymphocytes - drug effects | Norethindrone - pharmacology | Medroxyprogesterone Acetate - antagonists & inhibitors | Dendritic Cells - cytology | Oligodeoxyribonucleotides - pharmacology | Progestational hormones, Synthetic | Contraceptive drugs | Progestational hormones | T cells | Analysis | Index Medicus | hormonal contraception | progestins
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5. Full Text Pedal peptide/orcokinin‐type neuropeptide signaling in a deuterostome: The anatomy and pharmacology of starfish myorelaxant peptide in Asterias rubens
by Lin, Ming and Egertová, Michaela and Zampronio, Cleidiane G and Jones, Alexandra M and Elphick, Maurice R
Journal of comparative neurology (1911), ISSN 0021-9967, 12/2017, Volume 525, Issue 18, pp. 3890 - 3917
deuterostome | pedal peptide | starfish myorelaxant peptide | orcokinin | echinoderm | neuropeptide | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Zoology | Science & Technology | Oligodeoxyribonucleotides, Antisense - pharmacology | Asterias - anatomy & histology | Digestive System - metabolism | Neuropeptides - metabolism | RNA, Messenger - metabolism | Animals | Signal Transduction - drug effects | Mass Spectrometry | Neuropeptides - pharmacology | Sense Organs - anatomy & histology | Sense Organs - drug effects | Neuromuscular Agents - pharmacology | Signal Transduction - physiology | Sense Organs - metabolism | Muscle Relaxation - drug effects | Asterias - metabolism | Immunohistochemistry | Neuropeptides | Mass spectrometry | Regulators | Divergence | Body wall | Peptides | Genomes | Mollusks | Cords | Transmitters | Nerves | Arthropods | Appendages | Heart diseases | Stomach | Nucleotide sequence | Digestive system | Muscles | Mass spectroscopy | Pharmacology | Anatomy | Gene expression | Muscle contraction | Feet | Invertebrates | Index Medicus
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6. Full Text Synergistic Effect of Nod1 and Nod2 Agonists with Toll-Like Receptor Agonists on Human Dendritic Cells To Generate Interleukin-12 and T Helper Type 1 Cells
by Hiroyuki Tada and Setsuya Aiba and Ken-Ichiro Shibata and Toshiaki Ohteki and Haruhiko Takada
Infection and Immunity, ISSN 0019-9567, 12/2005, Volume 73, Issue 12, pp. 7967 - 7976
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Microbiology | Biological and medical sciences | Adjuvants, Immunologic - pharmacology | Diaminopimelic Acid - pharmacology | Dendritic Cells - immunology | Humans | RNA, Messenger - analysis | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Th1 Cells - immunology | Th1 Cells - metabolism | Dendritic Cells - drug effects | Toll-Like Receptors - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Polylysine - pharmacology | Poly I-C - pharmacology | Cytokines - metabolism | Interleukin-12 - metabolism | Nod2 Signaling Adaptor Protein | Adaptor Proteins, Signal Transducing - agonists | Toll-Like Receptors - agonists | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Drug Synergism | Diaminopimelic Acid - analogs & derivatives | Intracellular Signaling Peptides and Proteins - agonists | Toll-Like Receptors - genetics | Adaptor Proteins, Signal Transducing - genetics | Lipid A - pharmacology | Nod1 Signaling Adaptor Protein | Adaptor Proteins, Signal Transducing - metabolism | Oligodeoxyribonucleotides - pharmacology | Oligopeptides - pharmacology | Index Medicus | Host Response and Inflammation
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7. Full Text Zymosan Induces Immune Responses Comparable with Those of Adults in Monocytes, Dendritic Cells, and Monocyte-Derived Dendritic Cells from Cord Blood
by Nohmi, Kyoko, MD and Tokuhara, Daisuke, MD, PhD and Tachibana, Daisuke, MD, PhD and Saito, Mika, MD, PhD and Sakashita, Yuko and Nakano, Akemi, MD, PhD and Terada, Hiroyuki, MD, PhD and Katayama, Hiroko, MD, PhD and Koyama, Masayasu, MD, PhD and Shintaku, Haruo, MD, PhD
The Journal of pediatrics, ISSN 0022-3476, 2015, Volume 167, Issue 1, pp. 155 - 162.e2
Pediatrics | Life Sciences & Biomedicine | Science & Technology | Poly I-C - pharmacology | Adjuvants, Immunologic - pharmacology | Cytokines - metabolism | Lipopeptides - pharmacology | Dendritic Cells - immunology | Humans | Cells, Cultured | Monocytes - immunology | Fetal Blood - cytology | Zymosan - pharmacology | Flagellin - pharmacology | Flow Cytometry | Lipopolysaccharides - pharmacology | Adult | Oligodeoxyribonucleotides - pharmacology | Aminoquinolines - pharmacology | Infant, Newborn | Index Medicus | Abridged Index Medicus
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8. Full Text AS1411 Aptamer and Folic Acid Functionalized pH-Responsive ATRP Fabricated pPEGMA–PCL–pPEGMA Polymeric Nanoparticles for Targeted Drug Delivery in Cancer Therapy
by Lale, Shantanu V and R. G, Aswathy and Aravind, Athulya and Kumar, D. Sakthi and Koul, Veena
Biomacromolecules, ISSN 1525-7797, 05/2014, Volume 15, Issue 5, pp. 1737 - 1752
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Polymer Science | Science & Technology | Polymers with particular properties | Chemotherapy | Exact sciences and technology | Pharmacology. Drug treatments | Applied sciences | Biological and medical sciences | Organic polymers | Physicochemistry of polymers | Medical sciences | Preparation, kinetics, thermodynamics, mechanism and catalysts | Antineoplastic agents | Oligodeoxyribonucleotides - administration & dosage | Folic Acid - pharmacology | Nanoparticles - chemistry | Apoptosis - drug effects | Biocompatible Materials - chemistry | Humans | Oligodeoxyribonucleotides - chemistry | Doxorubicin - chemistry | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Folic Acid - administration & dosage | Drug Delivery Systems | Dose-Response Relationship, Drug | MCF-7 Cells | Surface Properties | Antineoplastic Agents - pharmacology | Molecular Structure | Doxorubicin - administration & dosage | Cell Line | Cell Survival - drug effects | Folic Acid - chemistry | Polymerization | Biocompatible Materials - pharmacology | Antineoplastic Agents - chemistry | Particle Size | Biocompatible Materials - administration & dosage | Cell Proliferation - drug effects | Nanoparticles - administration & dosage | Oligodeoxyribonucleotides - pharmacology | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Hydrogen-Ion Concentration | Index Medicus
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9. Full Text Oxidized phospholipid inhibition of Toll-Like Receptor (TLR) signaling is restricted to TLR2 and TLR4: Roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition
by Erridge, Clett and Kennedy, Simon and Spickett, Corinne M and Webb, David J
The Journal of biological chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24748 - 24759
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphatidylcholines - immunology | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Macrophages, Peritoneal - cytology | Flagellin - pharmacology | Lymphocyte Antigen 96 - agonists | Oxidation-Reduction - drug effects | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Carrier Proteins - immunology | Guanosine - analogs & derivatives | Poly I-C - pharmacology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | I-kappa B Kinase - immunology | Mice | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Oligodeoxyribonucleotides - pharmacology | Immunologic Factors - pharmacology | Lymphocyte Antigen 96 - immunology | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 - agonists | Acute-Phase Proteins - genetics | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Carrier Proteins - agonists | I-kappa B Kinase - metabolism | Reactive Oxygen Species - immunology | Female | Membrane Glycoproteins - immunology | Cell Line | Acute-Phase Proteins - metabolism | Phosphatidylcholines - pharmacology | Membrane Glycoproteins - agonists | p38 Mitogen-Activated Protein Kinases - genetics | I-kappa B Kinase - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phosphatidylcholines - genetics | Animals | Carrier Proteins - metabolism | RNA - pharmacology | Guanosine - pharmacology | Lipopolysaccharide Receptors - genetics | Signal Transduction - physiology | Acute-Phase Proteins - agonists | Acute-Phase Proteins - immunology | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
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10. Full Text Toll-like receptors mediate proliferation and survival of multiple myeloma cells
by Bohnhorst, Janne and Rasmussen, T and Moen, S.H and Fløttum, M and Knudsen, L and Børset, M and Espevik, T and Sundan, A
Leukemia, ISSN 0887-6924, 06/2006, Volume 20, Issue 6, pp. 1138 - 1144
Plasma cells | Proliferation | Survival | Toll-like receptor | Multiple myeloma | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Immunopathology | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Immunoglobulinopathies | Medical sciences | Immunodeficiencies. Immunoglobulinopathies | RNA, Messenger - immunology | Interleukin-6 - antagonists & inhibitors | Humans | Multiple Myeloma - immunology | Gene Expression Profiling | Proteoglycans - drug effects | Flagellin - pharmacology | Toll-Like Receptors - drug effects | Membrane Glycoproteins - immunology | Interleukin-6 - metabolism | RNA, Messenger - drug effects | Cell Survival - drug effects | Poly I-C - pharmacology | Syndecans | Proteoglycans - immunology | Dipeptides - pharmacology | RNA, Messenger - genetics | Toll-Like Receptors - immunology | Imidazoles - pharmacology | Cell Survival - immunology | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-6 - pharmacology | Lipoproteins - pharmacology | Toll-Like Receptors - genetics | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Membrane Glycoproteins - drug effects | Ligands | Cell Proliferation - drug effects | Oligodeoxyribonucleotides - pharmacology | Oligopeptides - pharmacology | Lipopeptides | Multiple Myeloma - genetics | Index Medicus
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