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Nature Medicine, ISSN 1078-8956, 2015, Volume 21, Issue 3, pp. 270 - 275
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 05/2006, Volume 33, Issue 5, pp. 533 - 540
SUMMARY • An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide analogue that hybridizes with the complementary mRNA in a... 
locked nucleic acid | phosphorothioate | antisense oligonucleotide design | dendrimer | gapmer antisense oligonucleotide | RNase H | phosphoroamidate morpholino oligomer | cell-penetrating peptide | liposome | peptide nucleic acid | cell‐penetrating peptide | Dendrimer | Gapmer antisense oligonucleotide | Phosphoroamidate morpholino oligomer | Liposome | Peptide nucleic acid | Phosphorothioate | Locked nucleic acid | Antisense oligonucleotide design | Cell-penetrating peptide | PHYSIOLOGY | SOLID TUMORS | LOCKED NUCLEIC-ACID | C-MYC | MORPHOLINO OLIGOMER | MESSENGER-RNA | PROSTATE-CANCER | PHARMACOLOGY & PHARMACY | RNA SECONDARY STRUCTURE | PHASE-I | WEB SERVER | ACCESSIBLE SITES | Neoplasms - metabolism | Oligodeoxyribonucleotides | Clusterin - genetics | Thionucleotides - chemical synthesis | Humans | RNA, Messenger - genetics | Gene Silencing | Oligonucleotides, Antisense - metabolism | Thionucleotides - genetics | RNA, Messenger - metabolism | Antineoplastic Agents - metabolism | Clusterin - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Thionucleotides - metabolism | Animals | Oligonucleotides, Antisense - genetics | Neoplasms - genetics | Oligonucleotides, Antisense - chemical synthesis | Ribonucleotide Reductases - metabolism | Gene Targeting - trends | RNA, Messenger - chemistry | Ribonucleotide Reductases - genetics | Nucleic Acid Conformation | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Antisense | Peptide Nucleic Acids | Thermodynamics | Oligonucleotides, Antisense, metabolism | RNA Processing, Post-Transcriptional | Oligonucleotides, Antisense, chemistry | Models, Biological | Drug Design | Ribonuclease H, Calf Thymus | Oligonucleotides, Antisense, pharmacokinetics
Journal Article
Neuron, ISSN 0896-6273, 2011, Volume 70, Issue 3, pp. 427 - 440
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2002, Volume 30, Issue 9, pp. 1911 - 1918
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied DNA oligonucleotides,... 
PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES | RECOGNITION | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | COLI RNASE H1 | DUPLEXES | GROWTH-FACTOR | RECEPTORS | CLEAVAGE | LNA
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2004, Volume 113, Issue 11, pp. 1571 - 1581
Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated in the... 
HYPERGLUCAGONEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | HYPERGLYCEMIA | ANTAGONIST | ALPHA-CELL HYPERPLASIA | RATS | PROLIFERATION | MELLITUS | DIFFERENTIATION | KNOCKOUT MICE | GLUCOSE-PRODUCTION
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2012, Volume 19, Issue 8, pp. 845 - 852
Journal Article
Methods, ISSN 1046-2023, 04/2017, Volume 118-119, pp. 93 - 100
Journal Article
The Lancet, ISSN 0140-6736, 08/2001, Volume 358, Issue 9280, pp. 489 - 497
There is a potential role for antisense oligonucleotides in the treatment of disease. The principle of antisense technology is the sequence-specific binding of... 
ANTI-APOPTOSIS GENE | MEDICINE, GENERAL & INTERNAL | RNA INHIBITS PROLIFERATION | MESSENGER-RNA | OLIGOMER COMPLEMENTARY | PROTEIN EXPRESSION | NON-HODGKINS-LYMPHOMA | ISIS-5132 CGP 69846A | CPG DNA | PHASE-I | OLIGONUCLEOTIDE THERAPEUTICS | Oligonucleotides - therapeutic use | Thionucleotides - therapeutic use | Humans | Oligonucleotides, Antisense - metabolism | Oligodeoxyribonucleotides, Antisense - therapeutic use | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | RNA, Messenger - metabolism | Phosphorothioate Oligonucleotides | Neoplasms - drug therapy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Isoenzymes - metabolism | Protein Kinase C - metabolism | Oligonucleotides, Antisense - therapeutic use | Drug Design | In Vitro Techniques | Protein Kinase C-alpha | Oncology | Antisense nucleic acids | Research | Growth | Health aspects | Tumors | Medical research | Side effects | Drug therapy | Genes | Cancer | Pathogenesis | Leukemia | Lung cancer | Medical services | Oligonucleotides | Clinical trials | Raf protein | Genomes | mRNA | Kinases | Cancer therapies | Skin cancer | Proteins | Signal transduction | Fibroblasts | Drug dosages | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytomegalovirus | Medical treatment | Melanoma | Antisense RNA | Antisense oligonucleotides | FDA approval | Gene expression | Molecular chains | Protein synthesis | Lymphomas | Genetic engineering | Retinitis | Gene therapy | Apoptosis | Pharmaceuticals
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