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1. Full Text Antisense antimicrobial therapeutics
by Sully, Erin K and Geller, Bruce L
Current opinion in microbiology, ISSN 1369-5274, 2016, Volume 33, pp. 47 - 55
Pathology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antiviral Agents - pharmacology | Oligodeoxyribonucleotides, Antisense - pharmacology | Viruses - genetics | Bacterial Infections - drug therapy | Bacteria - drug effects | Parasitic Diseases - drug therapy | Drug Discovery - methods | Viruses - drug effects | Oligoribonucleotides, Antisense - pharmacology | Bacteria - genetics | Parasites - genetics | Parasites - drug effects | Animals | Virus Diseases - drug therapy | Phosphorothioate Oligonucleotides - pharmacology | Anti-Bacterial Agents - pharmacology | Antiviral agents | Therapeutics | Drug resistance | Hepatitis C virus | Hepatitis C | Homeopathy | Materia medica and therapeutics | Index Medicus
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2. Full Text Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro®): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B
by Geary, Richard S and Geary, Richard S and Baker, Brenda F and Baker, Brenda F and Crooke, Stanley T and Crooke, Stanley T
Clinical pharmacokinetics, ISSN 0312-5963, 2/2015, Volume 54, Issue 2, pp. 133 - 146
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Apolipoproteins B - antagonists & inhibitors | Oligonucleotides - chemistry | Oligodeoxyribonucleotides, Antisense - pharmacology | Humans | Models, Molecular | Anticholesteremic Agents - chemistry | Clinical Trials as Topic | Oligonucleotides - pharmacokinetics | Anticholesteremic Agents - pharmacokinetics | Animals | Oligonucleotides - pharmacology | Base Sequence | Hyperlipoproteinemia Type I - drug therapy | Hyperlipoproteinemia Type I - metabolism | Anticholesteremic Agents - pharmacology | Oligodeoxyribonucleotides, Antisense - pharmacokinetics
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3. Full Text RNA therapeutics: Beyond RNA interference and antisense oligonucleotides
by Kole, Ryszard and Krainer, Adrian R and Altman, Sidney
Nature reviews. Drug discovery, ISSN 1474-1776, 02/2012, Volume 11, Issue 2, pp. 125 - 140
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | RNA, Small Interfering - genetics | RNA Interference - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Phosphorothioate Oligonucleotides - genetics | Gene Expression - drug effects | Morpholinos - genetics | Antiviral Agents - therapeutic use | Gene Expression - genetics | Muscular Dystrophy, Duchenne - drug therapy | Alternative Splicing - genetics | Humans | Morpholinos - therapeutic use | RNA, Messenger - genetics | beta-Thalassemia - genetics | Oligodeoxyribonucleotides, Antisense - therapeutic use | beta-Thalassemia - drug therapy | Anti-Bacterial Agents - therapeutic use | Alternative Splicing - drug effects | Animals | Myotonic Dystrophy - drug therapy | Myotonic Dystrophy - genetics | Muscular Dystrophy, Duchenne - genetics | Phosphorothioate Oligonucleotides - therapeutic use | Physiological aspects | Messenger RNA | Research | Gene expression | Health aspects | Oligonucleotides | Alternative splicing | Therapeutic applications | Duchenne's muscular dystrophy | RNA-mediated interference | Clinical trials | Recovery of function | Antisense oligonucleotides | Index Medicus
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4. Full Text Antisense Oligonucleotides Targeting Lipoprotein(a)
by Langsted, Anne and Nordestgaard, Børge G
Current atherosclerosis reports, ISSN 1523-3804, 8/2019, Volume 21, Issue 8, pp. 1 - 7
Apolipoprotein B | Apolipoprotein(a) | Medicine & Public Health | Mipomersen | Angiology | Cardiology | AKCEA-APO(a)-L Rx | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Apolipoproteins B - antagonists & inhibitors | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Oligodeoxyribonucleotides, Antisense - pharmacology | Oligonucleotides - therapeutic use | Antibodies, Monoclonal - pharmacology | Humans | Apoprotein(a) - antagonists & inhibitors | Oligodeoxyribonucleotides, Antisense - therapeutic use | Antibodies, Monoclonal - therapeutic use | Oligonucleotides - pharmacology | Proprotein Convertase 9 - antagonists & inhibitors | RNA Interference | Hyperlipoproteinemias - drug therapy | Atherosclerosis - prevention & control | Index Medicus
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5. Pharmacology of a central nervous system delivered 2′-O-methoxyethyl- modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates
by Rigo, Frank and Chun, Seung J and Norris, Daniel A and Hung, Gene and Lee, Sam and Matson, John and Fey, Robert A and Gaus, Hans and Hua, Yimin and Grundy, John S and Krainer, Adrian R and Henry, Scott P and Bennett, C. Frank
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 2014, Volume 350, Issue 1, pp. 46 - 55
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | RNA Splicing - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Oligodeoxyribonucleotides, Antisense - administration & dosage | Oligonucleotides - therapeutic use | Injections, Intraventricular | Macaca fascicularis | Oligodeoxyribonucleotides, Antisense - therapeutic use | Male | Oligonucleotides - pharmacokinetics | Mice, Knockout | Brain - drug effects | Brain - metabolism | Muscular Atrophy, Spinal - genetics | Animals | Oligonucleotides - pharmacology | Survival of Motor Neuron 2 Protein - genetics | Female | Muscular Atrophy, Spinal - drug therapy | Mice | Oligonucleotides - administration & dosage | Infusions, Intraventricular | Oligodeoxyribonucleotides, Antisense - pharmacokinetics
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6. Full Text Effects of mipomersen, an apolipoprotein B100 antisense, on lipoprotein (a) metabolism in healthy subjects
by Nandakumar, Renu and Matveyenko, Anastasiya and Thomas, Tiffany and Pavlyha, Marianna and Ngai, Colleen and Holleran, Stephen and Ramakrishnan, Rajasekhar and Ginsberg, Henry N and Karmally, Wahida and Marcovina, Santica M and Reyes-Soffer, Gissette
Journal of lipid research, ISSN 0022-2275, 2018, Volume 59, Issue 12, pp. 2397 - 2402
ApoB antisense treatment | Fractional clearance rate | Production rate | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Oligodeoxyribonucleotides, Antisense - pharmacology | Humans | Middle Aged | Apolipoprotein B-100 - blood | Male | Oligonucleotides - pharmacology | Mass Spectrometry | Lipid Metabolism - drug effects | Chromatography, Liquid | Adult | Cholesterol, LDL - blood | Female | Lipoprotein(a) - blood | Index Medicus | fractional clearance rate | Patient-Oriented and Epidemiological Research | production rate | apoB antisense treatment
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7. Full Text Antimicrobial activity of antisense peptide-peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms
by Otsuka, Taketo and Brauer, Aimee L and Kirkham, Charmaine and Sully, Erin K and Pettigrew, Melinda M and Kong, Yong and Geller, Bruce L and Murphy, Timothy F
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 2017, Volume 72, Issue 1, pp. 137 - 144
Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biofilms - drug effects | Microbial Sensitivity Tests | Peptide Nucleic Acids - pharmacology | Bacterial Proteins - antagonists & inhibitors | Oligodeoxyribonucleotides, Antisense - pharmacology | Haemophilus influenzae - drug effects | Haemophilus influenzae - physiology | Drug Resistance, Bacterial | Acyl Carrier Protein - antagonists & inhibitors | Anti-Bacterial Agents - pharmacology | Serial Passage | Index Medicus | Original Research
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8. Full Text PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates
by Lindholm, Marie W and Elmén, Joacim and Fisker, Niels and Hansen, Henrik F and Persson, Robert and Møller, Marianne R and Rosenbohm, Christoph and Ørum, Henrik and Straarup, Ellen M and Koch, Troels
Molecular therapy, ISSN 1525-0016, 02/2012, Volume 20, Issue 2, pp. 376 - 381
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Proprotein Convertases - antagonists & inhibitors | Oligonucleotides - chemistry | Oligodeoxyribonucleotides, Antisense - pharmacology | Oligodeoxyribonucleotides, Antisense - administration & dosage | Humans | Proprotein Convertases - metabolism | Macaca fascicularis | Male | Proprotein Convertases - genetics | Animals | Injections, Subcutaneous | Serine Endopeptidases - genetics | Cholesterol, LDL - metabolism | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Index Medicus | Original
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9. Full Text Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis
by Eric C. LaCasse and Gabriele G. Cherton-Horvat and Kimberley E. Hewitt and Lori J. Jerome and Stephen J. Morris and Ekambar R. Kandimalla and Dong Yu and Hui Wang and Wei Wang and Ruiwen Zhang and Sudhir Agrawal and John W. Gillard and Jon P. Durkin
Clinical cancer research, ISSN 1078-0432, 09/2006, Volume 12, Issue 17, pp. 5231 - 5241
XIAP | MBO | preclinical | cancer therapeutic | antisense | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Oligodeoxyribonucleotides, Antisense - pharmacology | Apoptosis - drug effects | Humans | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Structure-Activity Relationship | Dose-Response Relationship, Drug | Taxoids - therapeutic use | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Oligonucleotides - pharmacology | Reverse Transcriptase Polymerase Chain Reaction - methods | Sensitivity and Specificity | Antineoplastic Agents - pharmacology | Disease Models, Animal | RNA, Messenger - drug effects | RNA, Messenger - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Mice | Drug Screening Assays, Antitumor | Index Medicus
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10. Full Text Antisense inhibition of survivin expression as a cancer therapeutic
by Carrasco, Rosa A and Stamm, Nancy B and Marcusson, Eric and Sandusky, George and Iversen, Philip and Patel, Bharvin K. R
Molecular cancer therapeutics, ISSN 1535-7163, 02/2011, Volume 10, Issue 2, pp. 221 - 232
Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Oligodeoxyribonucleotides, Antisense - pharmacology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | HCT116 Cells | Humans | Caspase 3 - metabolism | Down-Regulation - drug effects | Cell Division - drug effects | Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Mice | Gene Expression Regulation, Neoplastic - drug effects | HeLa Cells | Neoplasms - physiopathology | Cell Cycle - drug effects | Antisense oligonucleotides | Index Medicus
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