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1. Full Text Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
by Geary, Richard S and Norris, Daniel and Yu, Rosie and Bennett, C. Frank
Advanced drug delivery reviews, ISSN 0169-409X, 06/2015, Volume 87, pp. 46 - 51
Cell uptake | Oligonucleotide | Pharmacokinetics | Biodistribution | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Injections, Spinal | Neoplasms - metabolism | Injections, Intravenous | Species Specificity | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - chemistry | Blood Proteins - metabolism | Organ Specificity | Neoplasms - drug therapy | Tissue Distribution | Endocytosis | Animals | Biological Transport | Injections, Subcutaneous | Oligonucleotides, Antisense - therapeutic use | Drug Design | Protein Binding | Oligonucleotides, Antisense - administration & dosage | Sulfur compounds | RNA | Protein binding | Blood proteins | Index Medicus
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2. Full Text Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro®): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B
by Geary, Richard S and Geary, Richard S and Baker, Brenda F and Baker, Brenda F and Crooke, Stanley T and Crooke, Stanley T
Clinical pharmacokinetics, ISSN 0312-5963, 2/2015, Volume 54, Issue 2, pp. 133 - 146
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Apolipoproteins B - antagonists & inhibitors | Oligonucleotides - chemistry | Oligodeoxyribonucleotides, Antisense - pharmacology | Humans | Models, Molecular | Anticholesteremic Agents - chemistry | Clinical Trials as Topic | Oligonucleotides - pharmacokinetics | Anticholesteremic Agents - pharmacokinetics | Animals | Oligonucleotides - pharmacology | Base Sequence | Hyperlipoproteinemia Type I - drug therapy | Hyperlipoproteinemia Type I - metabolism | Anticholesteremic Agents - pharmacology | Oligodeoxyribonucleotides, Antisense - pharmacokinetics
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3. Full Text Antisense oligonucleotide pharmacokinetics and metabolism
by Geary, Richard S
Expert opinion on drug metabolism & toxicology, ISSN 1742-5255, 04/2009, Volume 5, Issue 4, pp. 381 - 391
pharmacokinetics | mRNA | ADME | oligoneucleotide | Oligoneucleotide | Pharmacokinetics | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Tissue Distribution - physiology | Animals | Species Specificity | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - chemistry | Oligonucleotides, Antisense - metabolism | Index Medicus
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4. Full Text Pharmacokinetics, pharmacodynamics and safety of aptamers
by Kovacevic, Katarina D and Gilbert, James C and Jilma, Bernd
Advanced drug delivery reviews, ISSN 0169-409X, 09/2018, Volume 134, pp. 36 - 50
Modification | Spiegelmer | Pegylation | Oligonucleotides | Aptamer | Half-life | Clearance | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Macular degeneration | Proteins | Medical research | Medical colleges | Safety and security measures | RNA | Monoclonal antibodies | Medicine, Experimental | Chronic diseases | Protein binding | Index Medicus
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5. Full Text Clinical pharmacokinetics of second generation antisense oligonucleotides
by Yu, Rosie Z and Grundy, John S and Geary, Richard S
Expert opinion on drug metabolism & toxicology, ISSN 1742-5255, 02/2013, Volume 9, Issue 2, pp. 169 - 182
clinical | urinary excretion | bioanalytical methods | pharmacokinetics | plasma protein binding | drug-drug interaction | human | second generation antisense oligonucleotide | Human | Plasma protein binding | Clinical | Bioanalytical methods | Drug-drug interaction | Pharmacokinetics | Second generation antisense oligonucleotide | Urinary excretion | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Pharmaceutical Preparations - metabolism | Animals | Humans | Oligonucleotides, Antisense - pharmacokinetics | Drug Interactions - physiology | Oligonucleotides, Antisense - chemistry | Pharmaceutical Preparations - chemistry | Protein Binding - physiology | Index Medicus
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6. Full Text Global Transcriptional Analysis of Streptococcus mutans Sugar Transporters Using Microarrays
by Dragana Ajdić and Vi T. T. Pham
Journal of Bacteriology, ISSN 0021-9193, 07/2007, Volume 189, Issue 14, pp. 5049 - 5059
Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Miscellaneous | Bacteriology | Raffinose - pharmacokinetics | Galactose - metabolism | Phosphoenolpyruvate Sugar Phosphotransferase System - physiology | Carbohydrates - pharmacokinetics | Gene Expression Profiling | Streptococcus mutans - genetics | Sucrose - pharmacokinetics | ATP-Binding Cassette Transporters - physiology | Fructose - metabolism | Mannose - metabolism | Lactose - metabolism | ATP-Binding Cassette Transporters - genetics | Sucrose - metabolism | ATP-Binding Cassette Transporters - metabolism | Transcription, Genetic | Biological Transport - genetics | Trisaccharides - metabolism | Phosphoenolpyruvate Sugar Phosphotransferase System - genetics | Oligosaccharides - pharmacokinetics | Galactose - pharmacokinetics | Lactose - pharmacokinetics | Maltose - metabolism | Streptococcus mutans - metabolism | Fructose - pharmacokinetics | Oligonucleotide Array Sequence Analysis - methods | Cellobiose - metabolism | Oligosaccharides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cellobiose - pharmacokinetics | Maltose - pharmacokinetics | Mannose - pharmacokinetics | Glucose - pharmacokinetics | Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism | Glucose - metabolism | Trisaccharides - pharmacokinetics | Gene Expression Regulation, Bacterial | Raffinose - metabolism | Genetic aspects | Adenosine triphosphatase genes | Research | Genetic transcription | Phosphotransferases | Streptococcus mutans | Gram-positive bacteria | ABC transporters | Biochemistry | Adenosine triphosphatase | Sugar | Index Medicus | Genetics and Molecular Biology
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7. Full Text Pharmacokinetics and Biodistribution of Novel Aptamer Compositions
by Healy, Judith M and Lewis, Scott D and Kurz, Markus and Boomer, Ryan M and Thompson, Kristin M and Wilson, Charles and McCauley, Thomas G
Pharmaceutical research, ISSN 0724-8741, 12/2004, Volume 21, Issue 12, pp. 2234 - 2246
Biochemistry, general | Biomedical Engineering | biodistribution | Biomedicine | Pharmacy | pharmacokinetics | Medical Law | Pharmacology/Toxicology | naptamer | conjugation | Aptamer | Conjugation | Pharmacokinetics | Biodistribution | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Dose-Response Relationship, Drug | Tissue Distribution - physiology | Oligonucleotides - chemistry | Oligonucleotides - metabolism | Tissue Distribution - drug effects | Animals | Rats | Biological Availability | Male | Rats, Sprague-Dawley | Chemistry, Pharmaceutical | Oligonucleotides - pharmacokinetics | Index Medicus
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8. Immunogenicity Assessment of Inotersen, a 2 '-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety
by Yu, Rosie Z and Wang, Yanfeng and Norris, Dan A and Kim, Tae-Won and Narayanan, Padma and Geary, Richard S and Monia, Brett P and Henry, Scott P
Nucleic acid therapeutics, ISSN 2159-3337, 10/2020, Volume 30, Issue 5, pp. 265 - 275
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Plasma | Toxicity | Antibodies | Monkeys | mRNA | Dosage | Polyneuropathy | Histopathology | Safety | Evaluation | Pharmacodynamics | Hematology | Transthyretin | Antisense therapy | Antisense oligonucleotides | Pharmacology | Exposure | Patients | Dilution | Complement activation | Animals | Immunogenicity | Amyloidosis | Pharmacokinetics | Platelets
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9. The Pharmacokinetics of 2 '-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy
by Bosgra, Sieto and Sipkens, Jessica and de Kimpe, Sjef and den Besten, Cathaline and Datson, Nicole and van Deutekom, Judith
Nucleic acid therapeutics, ISSN 2159-3337, 12/2019, Volume 29, Issue 6, pp. 305 - 322
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Pharmacodynamics | Oligonucleotides | Clinical trials | Muscles | Antisense oligonucleotides | Pharmacology | Ribonucleic acid--RNA | Metabolism | Muscular dystrophy | Organic chemistry | Biopsy | Exon skipping | Duchenne's muscular dystrophy | Phosphorothioate | Dystrophy | Pharmacokinetics | Index Medicus
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10. Full Text Pharmacokinetics of a tumor necrosis factor-α phosphorothioate 2′-O-(2-methoxyethyl) modified antisense oligonucleotide: Comparison across species
by Geary, Richard S and Yu, Rosie Z and Watanabe, Tanya and Henry, Scott P and Hardee, Greg E and Chappell, Alfred and Matson, John and Sasmor, Henri and Cummins, Len and Levin, Arthur A
Drug metabolism and disposition, ISSN 0090-9556, 11/2003, Volume 31, Issue 11, pp. 1419 - 1428
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Miscellaneous | Medical sciences | Pharmacology. Drug treatments | Species Specificity | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - chemistry | Macaca fascicularis | Rats | Male | Macaca mulatta | Phosphorothioate Oligonucleotides | Rats, Sprague-Dawley | Mice, Inbred ICR | Oligoribonucleotides | Phosphorous Acids - chemistry | Animals | Tumor Necrosis Factor-alpha - chemistry | Phosphorous Acids - pharmacokinetics | RNA, Antisense - pharmacokinetics | RNA, Antisense - chemistry | Dogs | Female | Mice | Tumor Necrosis Factor-alpha - pharmacokinetics | Index Medicus
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