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Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 33, pp. 14621 - 14626
.... Available methods are inefficient and are not able to support network pharmacology. We developed an automatic and robust approach that exploits similarity in gene... 
Community structure | Datasets | Communities | Genes | Cell lines | Antineoplastics | Signatures | Dosage | Gene expression | Mode of action | Drug repurposing | Chemotherapy | Systems biology | Computational drug discovery | systems biology | TARGET | NETWORK | computational drug discovery | MULTIDISCIPLINARY SCIENCES | CONNECTIVITY MAP | EXPRESSION PROFILES | KAPPA-B | AUTOPHAGY | chemotherapy | CANCER | CELL-DEATH | drug repurposing | CAMPTOTHECIN | DISEASE | Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Drug Discovery - methods | Gene Expression Profiling | RNA Polymerase II - metabolism | Autophagy - drug effects | Neoplasms - genetics | Piperidines - pharmacology | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Antineoplastic Agents - classification | Fuzzy Logic | Camptothecin - analogs & derivatives | Pyrazoles - pharmacology | Drug Screening Assays, Antitumor - methods | Blotting, Western | Pyrroles - pharmacology | Algorithms | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Line, Tumor | HeLa Cells | Neoplasms - pathology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Dose-response relationship (Biochemistry) | Physiological aspects | Research | Observations | Methods | Cancer | Cyclin-dependent kinase 2 | Drugs | Enhancers | Neurodegenerative diseases | Transcription | Pharmacology | Drug discovery | Nodes | Phagocytosis | Rho-associated kinase | Biological Sciences
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2008, Volume 14, Issue 20, pp. 6456 - 6468
Purpose: It was the aim of our study to establish an extensive panel of non-small cell lung cancer (NSCLC) xenograft models useful for the testing of novel... 
xenograft | NSCLC | erlotinib | mutational analysis | anti-EGFR therapy | cetuximab | biomarker | KRAS MUTATIONS | GROWTH-FACTOR RECEPTOR | GEFITINIB | ONCOLOGY | GENE-EXPRESSION | RESISTANCE | EGFR MUTATIONS | KINASE INHIBITORS | ANTITUMOR-ACTIVITY | CHEMOTHERAPY | ZD1839 | Carcinoma, Large Cell - drug therapy | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Adenocarcinoma - pathology | Oligonucleotide Array Sequence Analysis | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Middle Aged | Drug Resistance, Neoplasm | Immunoblotting | Male | Gene Expression Profiling | Adenocarcinoma - metabolism | Biomarkers, Tumor - metabolism | Cetuximab | Disease Models, Animal | Genes, ras - genetics | Antibodies, Monoclonal - pharmacology | Carcinoma, Non-Small-Cell Lung - metabolism | Etoposide - pharmacology | Mutation - genetics | Adenocarcinoma - drug therapy | Small Cell Lung Carcinoma - pathology | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Carboplatin - pharmacology | Quinazolines - pharmacology | Deoxycytidine - analogs & derivatives | Erlotinib Hydrochloride | Paclitaxel - pharmacology | Prognosis | Carcinoma, Squamous Cell - metabolism | Deoxycytidine - pharmacology | Lung Neoplasms - pathology | Small Cell Lung Carcinoma - drug therapy | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Vinblastine - analogs & derivatives | Polymerase Chain Reaction | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Large Cell - metabolism | Radiation-Sensitizing Agents - pharmacology | Tumor Suppressor Protein p53 - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Protein Kinase Inhibitors - pharmacology | Vinblastine - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Antineoplastic Agents, Phytogenic - pharmacology
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 07/2005, Volume 16, Issue 6, pp. 601 - 607
Journal Article