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Expert opinion on drug metabolism & toxicology, ISSN 1744-7607, 2009, Volume 5, Issue 4, pp. 381 - 391
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2017, Volume 377, Issue 3, pp. 222 - 232
Journal Article
Journal Article
Journal Article
Development (Cambridge), ISSN 1477-9129, 2008, Volume 135, Issue 10, pp. 1735 - 1743
Journal Article
Clinical and experimental pharmacology & physiology, ISSN 1440-1681, 05/2006, Volume 33, Issue 5-6, pp. 533 - 540
SUMMARY • An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide analogue that hybridizes with the complementary mRNA in a sequence-specific manner via Watson–Crick base pairing... 
locked nucleic acid | phosphorothioate | antisense oligonucleotide design | dendrimer | gapmer antisense oligonucleotide | RNase H | phosphoroamidate morpholino oligomer | cell-penetrating peptide | liposome | peptide nucleic acid | cell‐penetrating peptide | Dendrimer | Gapmer antisense oligonucleotide | Phosphoroamidate morpholino oligomer | Liposome | Peptide nucleic acid | Phosphorothioate | Locked nucleic acid | Antisense oligonucleotide design | Cell-penetrating peptide | PHYSIOLOGY | LOCKED NUCLEIC-ACID | C-MYC | PREDICTION | DELIVERY | MORPHOLINO OLIGOMER | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | RNA SECONDARY STRUCTURE | PHASE-I | WEB SERVER | ACCESSIBLE SITES | Neoplasms - metabolism | Oligodeoxyribonucleotides | Clusterin - genetics | Thionucleotides - chemical synthesis | Humans | RNA, Messenger - genetics | Gene Silencing | Oligonucleotides, Antisense - metabolism | Thionucleotides - genetics | RNA, Messenger - metabolism | Antineoplastic Agents - metabolism | Clusterin - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Thionucleotides - metabolism | Animals | Oligonucleotides, Antisense - genetics | Neoplasms - genetics | Oligonucleotides, Antisense - chemical synthesis | Ribonucleotide Reductases - metabolism | Gene Targeting - trends | RNA, Messenger - chemistry | Ribonucleotide Reductases - genetics | Nucleic Acid Conformation | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Antisense | Peptide Nucleic Acids | Thermodynamics | Oligonucleotides, Antisense, metabolism | RNA Processing, Post-Transcriptional | Oligonucleotides, Antisense, chemistry | Models, Biological | Drug Design | Ribonuclease H, Calf Thymus | Oligonucleotides, Antisense, pharmacokinetics
Journal Article
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2018, Volume 128, Issue 12, pp. 5479 - 5488
.... Functionally, STAT3 inhibition by a clinical, antisense oligonucleotide, AZD9150, led to reduced viability and increased apoptosis in leukemic cell lines... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | ACTIVATION | PROTEIN | THERAPEUTIC STRATEGY | MCL-1 | SHOW IMPROVED POTENCY | GROWTH | RISK | OLIGONUCLEOTIDES | Humans | Leukemia, Myeloid, Acute - metabolism | Cell Survival - genetics | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplastic Stem Cells - metabolism | Oligonucleotides - pharmacology | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Neoplasm Proteins - genetics | Myelodysplastic Syndromes - drug therapy | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell Survival - drug effects | Myelodysplastic Syndromes - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, SCID | Mice, Knockout | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice, Inbred NOD | Myelodysplastic Syndromes - genetics | Myelodysplastic Syndromes - pathology | STAT3 Transcription Factor - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | Genetic aspects | Prognosis | Research | Myelodysplastic syndromes | Stem cells | CD34 antigen | Disease | Hematology | Myeloid leukemia | Leukemia | Stat3 protein | Antisense oligonucleotides | Gene expression | Kinases | Progenitor cells | Myelodysplastic syndrome | Mcl-1 protein | Hemopoiesis | Medical prognosis | Lymphomas | Mutation | Acute myeloid leukemia | Cancer | Apoptosis | Tumors
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2015, Volume 373, Issue 5, pp. 438 - 447
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2014, Volume 73, Issue 2, pp. 343 - 348
Journal Article