X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (8980) 8980
Book Chapter (88) 88
Book / eBook (39) 39
Conference Proceeding (17) 17
Magazine Article (13) 13
Web Resource (7) 7
Dissertation (5) 5
Newspaper Article (3) 3
Publication (3) 3
Government Document (2) 2
Data Set (1) 1
Newsletter (1) 1
Reference (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (5747) 5747
index medicus (4183) 4183
animals (4129) 4129
antisense oligonucleotides (2327) 2327
mice (1995) 1995
oligonucleotides (1809) 1809
oligonucleotides, antisense - therapeutic use (1788) 1788
male (1568) 1568
biochemistry & molecular biology (1496) 1496
gene expression (1424) 1424
expression (1358) 1358
pharmacology & pharmacy (1338) 1338
oncology (1319) 1319
female (1239) 1239
cancer (1222) 1222
oligonucleotides, antisense - pharmacology (1075) 1075
medicine, research & experimental (1055) 1055
proteins (1029) 1029
oligonucleotide array sequence analysis (1015) 1015
research (986) 986
rna (963) 963
apoptosis (934) 934
in-vivo (855) 855
cell line, tumor (820) 820
gene-expression (793) 793
cell biology (779) 779
biotechnology & applied microbiology (769) 769
antisense (767) 767
dna (753) 753
base sequence (743) 743
inhibition (741) 741
antisense oligonucleotide (732) 732
oligonucleotides, antisense - genetics (728) 728
analysis (699) 699
health aspects (669) 669
rats (667) 667
genetic aspects (666) 666
messenger-rna (658) 658
multidisciplinary sciences (652) 652
cells (620) 620
in-vitro (618) 618
genetics & heredity (614) 614
research article (608) 608
gene therapy (606) 606
gene expression profiling (602) 602
genes (568) 568
rna interference (568) 568
care and treatment (555) 555
transfection (548) 548
mutation (544) 544
ribonucleic acid--rna (542) 542
oligonucleotides, antisense - administration & dosage (532) 532
medicine (528) 528
reverse transcriptase polymerase chain reaction (526) 526
gene (517) 517
rna, messenger - metabolism (511) 511
disease models, animal (507) 507
rna, messenger - genetics (507) 507
genetic therapy - methods (505) 505
therapy (493) 493
antineoplastic agents - therapeutic use (472) 472
chemistry, multidisciplinary (467) 467
deoxyribonucleic acid--dna (465) 465
molecular sequence data (457) 457
genetic therapy (456) 456
physiological aspects (455) 455
sirna (450) 450
oligonucleotides, antisense - chemistry (444) 444
neurosciences (437) 437
cell line (429) 429
microrna (428) 428
oligonucleotide (425) 425
middle aged (423) 423
science (421) 421
rodents (420) 420
down-regulation (419) 419
cells, cultured (413) 413
genetics (413) 413
oligonucleotides - therapeutic use (413) 413
micrornas - genetics (411) 411
delivery (410) 410
tumors (403) 403
oligodeoxynucleotides (400) 400
tumor cells, cultured (399) 399
adult (398) 398
oligonucleotides, antisense - metabolism (394) 394
gene expression regulation, neoplastic (390) 390
oligonucleotides - chemistry (390) 390
protein (388) 388
activation (387) 387
biology (387) 387
drug delivery systems (384) 384
chemistry, medicinal (378) 378
antineoplastic agents - pharmacology (371) 371
signal transduction (371) 371
nucleic acids (370) 370
apoptosis - drug effects (356) 356
clinical trials as topic (345) 345
neoplasms - drug therapy (344) 344
molecular biology (340) 340
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9021) 9021
Japanese (50) 50
Chinese (34) 34
German (31) 31
French (30) 30
Spanish (17) 17
Polish (9) 9
Russian (9) 9
Italian (3) 3
Danish (2) 2
Dutch (2) 2
Hebrew (2) 2
Hungarian (2) 2
Swedish (2) 2
Finnish (1) 1
Romanian (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1995, 1, ISBN 0849347785, 305
With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids... 
Drugs | Antisense nucleic acids | Dosage forms | Therapeutic use | Oligonucleotides | Pharmacology | Biopharmaceutics | Drug Design & Development
Book
Nucleic Acids Research, ISSN 0305-1048, 08/2016, Volume 44, Issue 14, pp. 6549 - 6563
Splice-switching oligonucleotides (SSOs) are short, synthetic, antisense, modified nucleic acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of the transcript by blocking the RNA-RNA base-pairing or protein-RNA... 
TOXICOLOGY EVALUATION | SYSTEMIC DELIVERY | RESTORES DYSTROPHIN EXPRESSION | SPINAL MUSCULAR-ATROPHY | SURVIVAL MOTOR-NEURON | BUBBLE LIPOSOMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2'-O-METHYL PHOSPHOROTHIOATE | PREMESSENGER RNA | SINGLE NUCLEOTIDE | PRE-MESSENGER-RNA | Genetic Therapy | Gene Expression | Animals | Humans | Oligonucleotides, Antisense - therapeutic use | RNA Splicing - genetics | Clinical Trials as Topic | Survey and Summary
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 02/2012, Volume 11, Issue 2, pp. 125 - 140
Here, we discuss three RNA-based therapeutic technologies exploiting various oligonucleotides that bind to RNA by base pairing in a sequence-specific manner yet have different mechanisms of action and effects... 
SYSTEMIC DELIVERY | COLI-IN-VITRO | MORPHOLINO OLIGOMERS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ESCHERICHIA-COLI | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | DUCHENNE MUSCULAR-DYSTROPHY | VIRUS-INFECTIONS | MOTOR-NEURON | CELL-CULTURES | PRE-MESSENGER-RNA | RNA, Small Interfering - genetics | RNA Interference - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Phosphorothioate Oligonucleotides - genetics | Gene Expression - drug effects | Morpholinos - genetics | Antiviral Agents - therapeutic use | Gene Expression - genetics | Muscular Dystrophy, Duchenne - drug therapy | Alternative Splicing - genetics | Humans | Morpholinos - therapeutic use | RNA, Messenger - genetics | beta-Thalassemia - genetics | Oligodeoxyribonucleotides, Antisense - therapeutic use | beta-Thalassemia - drug therapy | Anti-Bacterial Agents - therapeutic use | Alternative Splicing - drug effects | Animals | Myotonic Dystrophy - drug therapy | Myotonic Dystrophy - genetics | Muscular Dystrophy, Duchenne - genetics | Phosphorothioate Oligonucleotides - therapeutic use | Physiological aspects | Messenger RNA | Research | Gene expression | Health aspects | Oligonucleotides | Alternative splicing | Therapeutic applications | Duchenne's muscular dystrophy | RNA-mediated interference | Clinical trials | Recovery of function | Antisense oligonucleotides
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2015, Volume 35, Issue 3, pp. 689 - 699
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 3, pp. 222 - 232
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2007, Volume 357, Issue 26, pp. 2677 - 2686
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2015, Volume 372, Issue 12, pp. 1104 - 1113
Journal Article