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Journal Article
Analytical Biochemistry, ISSN 0003-2697, 12/2015, Volume 490, pp. 66 - 72
.... Here we present a click chemistry armed enzyme-linked immunosorbent assay (click–ELISA) for assessment of Hhat activity through acylation of biotinylated Shh peptide with an alkyne-tagged palmitoyl-CoA... 
MBOAT | Click chemistry | Hedgehog acyltransferase | Protein palmitoylation | CHEMISTRY, ANALYTICAL | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PROBES | PROTEIN LIPIDATION | PATHWAY | INHIBITORS | CANCER PROGRESSION | SONIC-HEDGEHOG | Acyltransferases - antagonists & inhibitors | Hedgehog Proteins - chemistry | Detergents - chemistry | Humans | Hedgehog Proteins - metabolism | Substrate Specificity | Acyltransferases - metabolism | Acyltransferases - genetics | Recombinant Fusion Proteins - metabolism | Maltose - chemistry | Protein Processing, Post-Translational - drug effects | HEK293 Cells | Palmitoyl Coenzyme A - analogs & derivatives | Oligopeptides - chemistry | Streptavidin - chemistry | Peptide Fragments - metabolism | Biotinylation | Immobilized Proteins - chemistry | Enzyme-Linked Immunosorbent Assay | Click Chemistry | Enzyme Inhibitors - pharmacology | Lipoylation - drug effects | Solubility | Palmitoyl Coenzyme A - metabolism | Fatty Acids, Unsaturated - pharmacology | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Peptide Fragments - chemistry | Maltose - analogs & derivatives | Streptavidin - metabolism | Immobilized Proteins - metabolism | Acyltransferases - chemistry | Measurement | Post-translational modification | Embryonic development | Detergents, Synthetic | Thiols | Peptides | Analysis | Fatty acids | Enzyme-linked immunosorbent assay | Acylation | OTG, n-octyl β-d-glucopyranoside | PTM, posttranslational modification | SDS, sodium dodecyl sulfate | GOAT, ghrelin-O-acyltransferase | YnC15, heptadec-16-ynoic acid | click–ELISA, click chemistry armed enzyme-linked immunosorbent assay | TBTA, tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine | MBOAT, membrane bound O-acyltransferase | HRP, horseradish peroxidase | PBS, phosphate-buffered saline | Hh, hedgehog | PAGE, polyacrylamide gel electrophoresis | HEK293a, human embryonic kidney 293a | RT, room temperature | BSA, bovine serum albumin | TCEP, tris(2-carboxyethyl)phosphine | CoA, coenzyme A | Shh, sonic hedgehog | CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate | HTS, high-throughput screen | cat–ELCCA, catalytic assay using an enzyme-linked click chemistry assay | DDM, n-dodecyl β-d-maltopyranoside | Hhat, hedgehog acyltransferase | PCR, polymerase chain reaction
Journal Article
Journal Article
Langmuir, ISSN 0743-7463, 01/2016, Volume 32, Issue 2, pp. 551 - 559
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 5, pp. 2535 - 2546
Journal Article
PLoS pathogens, ISSN 1553-7374, 2012, Volume 8, Issue 7, p. e1002832
Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and... 
WILD-TYPE | TELAPREVIR | RAPID VIRAL RESPONSE | ENZYMATIC-ACTIVITIES | PRECLINICAL PROFILE | MICROBIOLOGY | DISCOVERY | INTERFERON | REPLICATION | VIROLOGY | ANTIVIRAL EFFICACY | BOCEPREVIR | PARASITOLOGY | Hepatitis C - drug therapy | Proline - metabolism | Humans | Hepacivirus - genetics | Structure-Activity Relationship | Antiviral Agents - metabolism | Protease Inhibitors - pharmacology | Indoles - metabolism | Viral Nonstructural Proteins - chemistry | Antiviral Agents - chemistry | Lactams - pharmacology | Proline - pharmacology | Indoles - pharmacology | Protease Inhibitors - therapeutic use | Oligopeptides - chemistry | Hepacivirus - drug effects | Protein Structure, Tertiary | Antiviral Agents - pharmacology | Proline - analogs & derivatives | Sulfonamides - chemistry | Models, Molecular | Protease Inhibitors - chemistry | Protease Inhibitors - metabolism | Oligopeptides - metabolism | Sulfonamides - pharmacology | Lactams - metabolism | Proline - chemistry | Drug Resistance, Viral - genetics | Hepatitis C - virology | Sulfonamides - metabolism | Oligopeptides - pharmacology | Viral Nonstructural Proteins - antagonists & inhibitors | Indoles - chemistry | Lactams - chemistry | Virus diseases | Viral drug resistance | Research | Protease inhibitors | Properties | Observations | Hepatitis | Liver cancer | Liver diseases | Ligands | Genetic diversity | Drug resistance | Pharmaceutical industry | Cancer therapies | Viral infections
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 50, Issue 1, pp. 30 - 37
Journal Article