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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 72 - 85
Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here, we describe a system to... 
IMMUNE-RESPONSE | SOLID TUMORS | ONCOLOGY | COLORECTAL-CANCER | IFN-GAMMA | MOUSE MODEL | GENE-EXPRESSION | CHRONIC VIRAL-INFECTION | LOSS VARIANTS | ESTABLISHED TUMORS | LYMPHOCYTES | CELL BIOLOGY | Adenocarcinoma - pathology | Cell Proliferation | Genetic Vectors - administration & dosage | Ovalbumin - immunology | Cell Count | Humans | Lung Neoplasms - metabolism | Transplantation, Isogeneic - pathology | Mice, 129 Strain | T-Lymphocytes - transplantation | Histocompatibility Antigens Class I - metabolism | Adenocarcinoma - metabolism | T-Lymphocytes - metabolism | Time Factors | Peptide Fragments - immunology | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Lentivirus - genetics | B-Lymphocytes - pathology | Graft Rejection - pathology | Peptide Fragments - genetics | Antigens, Neoplasm - immunology | Adenocarcinoma - immunology | Mice, Transgenic | Lymph Nodes - immunology | Antigen Presentation - immunology | CD3 Complex - metabolism | Genetic Vectors - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Immunity, Cellular - immunology | B-Lymphocytes - immunology | T-Lymphocytes - immunology | Mice | Graft Rejection - immunology | CD8-Positive T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Adenocarcinoma of Lung | Lentivirus - immunology | Lung Neoplasms - pathology | Adoptive Transfer | Transplantation, Isogeneic - immunology | T-Lymphocytes - pathology | Ovalbumin - genetics | Antigens, Neoplasm - genetics | Lung - pathology | Cytokines - metabolism | Mice, Inbred C57BL | Oligopeptides - genetics | Oligopeptides - immunology | Kaplan-Meier Estimate | Cancer Vaccines - immunology | Lung Neoplasms - immunology | Animals | Apoptosis - immunology | Interleukin-7 Receptor alpha Subunit - metabolism | Programmed Cell Death 1 Receptor | Lung - immunology
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 09/2014, Volume 41, Issue 3, pp. 375 - 388
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0131177
Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal... 
RECOMBINANT IMMUNOTOXIN | IMMUNOGENICITY | MULTIDISCIPLINARY SCIENCES | PURIFICATION | SURFACE-PROTEINS | STAPHYLOCOCCUS-AUREUS | ANTITUMOR-ACTIVITY | MONOCLONAL-ANTIBODIES | FRAGMENTATION | CANCER-THERAPY | PROTEIN LIGATION | Cysteine Endopeptidases - chemistry | Staphylococcus aureus - enzymology | Aminoacyltransferases - immunology | Receptor, ErbB-2 - genetics | Humans | Bacterial Proteins - chemistry | Ovarian Neoplasms - pathology | Ki-1 Antigen - immunology | Maytansine - pharmacology | Immunoconjugates - immunology | Immunoconjugates - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Protein Engineering | Maytansine - chemistry | Female | Antineoplastic Agents - pharmacology | Bacterial Proteins - immunology | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Oligopeptides - chemistry | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Aminoacyltransferases - chemistry | Antineoplastic Agents - immunology | Maytansine - analogs & derivatives | Antibodies, Monoclonal - pharmacology | Oligopeptides - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Staphylococcus aureus - chemistry | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Ki-1 Antigen - antagonists & inhibitors | Mice | Antibodies, Monoclonal, Humanized - immunology | Cysteine Endopeptidases - immunology | Maytansine - immunology | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry | Ki-1 Antigen - genetics | Ovarian Neoplasms - immunology | Monoclonal antibodies | Enzymes | Cysteine | Peptides | Biopharmaceutics | Drugs | Conjugates | Addition polymerization | Ovarian carcinoma | Clinical trials | Pentaglycine | Cancer therapies | Molecular weight | Ovarian cancer | Proteins | Tubulin | CD30 antigen | Xenografts | Medical research | Immunoglobulins | Polypeptides | Cloning | Polymerization | Breast cancer | ErbB-2 protein | Substrates | Chemotherapy | Lysine | Heavy chains | Toxins | Conjugation | Sortase | Tumors | Cancer
Journal Article
Journal Article
Clinical Immunology, ISSN 1521-6616, 2011, Volume 141, Issue 2, pp. 177 - 186
Abstract Common variable immunodeficiency (CVID) is a heterogeneous antibody deficiency syndrome with alterations in T cell regulation and function in a... 
Allergy and Immunology | Cytomegalovirus | Lymphadenopathy | Common Variable Immunodeficiency | Influenza virus | Anti-viral CD8+ T cell response | Epstein -Barr virus | ANTIGEN STIMULATION | ACTIVATION | ABNORMALITIES | Anti-viral CD8+T cell response | SUBGROUPS | IMMUNOLOGY | DEFICIENCY | EFFECTOR | RECEPTOR KLRG1 | INFECTION | MEMORY T-CELLS | EXPRESSION | Immunodominant Epitopes - immunology | Phosphoproteins - immunology | T-Lymphocyte Subsets - immunology | Common Variable Immunodeficiency - immunology | Humans | Middle Aged | Male | Cytomegalovirus Infections - immunology | Orthomyxoviridae - immunology | Young Adult | Peptide Fragments - immunology | Adult | Female | Cell Differentiation | Epstein-Barr Virus Infections - blood | Granuloma - etiology | Epstein-Barr Virus Infections - immunology | Lymphatic Diseases - immunology | Oligopeptides - immunology | Common Variable Immunodeficiency - pathology | Herpesvirus 4, Human - immunology | Histocompatibility Antigens Class I - immunology | Immunophenotyping | Antigens, Viral - immunology | Cytomegalovirus - immunology | Cytomegalovirus Infections - blood | T-Cell Antigen Receptor Specificity | Granuloma - immunology | Viremia - immunology | Lymphatic Diseases - etiology | Viral Matrix Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | Influenza viruses | Antiviral agents | Care and treatment | Histocompatibility antigens | Analysis | Influenza | HLA histocompatibility antigens | Immunological deficiency syndromes | Epstein-Barr virus | T cells
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2013, Volume 27, Issue 8, pp. 3272 - 3283
Dendritic cells (DCs) initiate host immune responses by presenting captured antigens to naive T cells. Hence, DC-binding peptides may be used for antigen... 
Cancer vaccines | Phage display | Cross presentation | SiRNA | CANCER-CELLS | POTENT ANTITUMOR IMMUNITY | PROTEIN | cancer vaccines | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEC-205 | RECEPTOR | siRNA | DELIVERY | TRANSPLANTATION | CELL BIOLOGY | RESPONSES | phage display | cross presentation | BIOLOGY | REGULATORY T-CELLS | EXPRESSION | Phosphoproteins - immunology | Leukocytes, Mononuclear - metabolism | RNA, Small Interfering - genetics | Dendritic Cells - immunology | Humans | Monocytes - metabolism | Monocytes - immunology | Phosphoproteins - metabolism | Lymphocyte Activation - immunology | Flow Cytometry | RNA, Small Interfering - immunology | T-Lymphocytes - metabolism | Leukocytes, Mononuclear - immunology | Viral Matrix Proteins - metabolism | Binding, Competitive - immunology | Carrier Proteins - immunology | Dendritic Cells - metabolism | Amino Acid Sequence | HLA-A2 Antigen - immunology | Oligopeptides - immunology | Cells, Cultured | Antigens - metabolism | Nucleic Acids - metabolism | Oligopeptides - metabolism | Antigen Presentation - immunology | Protein Binding - immunology | Carrier Proteins - metabolism | Antigens - immunology | T-Lymphocytes - immunology | Nucleic Acids - immunology | Viral Matrix Proteins - immunology | HLA-A2 Antigen - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2002, Volume 169, Issue 10, pp. 5424 - 5432
Our study demonstrates that tumor-derived heat shock protein (HSP)70 chaperones a tyrosinase peptide and mediates its transfer to human immature dendritic... 
NATURAL-KILLER-CELLS | RECEPTOR-MEDIATED ENDOCYTOSIS | IN-VIVO | GP96 INDUCES MATURATION | CHAPERONED PEPTIDES | MELANOMA-CELLS | ANTITUMOR IMMUNITY | IMMUNOLOGY | CYTOTOXIC T-LYMPHOCYTES | STRESS PROTEINS | CUTTING EDGE | Receptors, Immunologic - physiology | Monocytes - cytology | Dendritic Cells - immunology | Humans | Antigens, Neoplasm - biosynthesis | Melanoma - enzymology | Monocytes - immunology | Monophenol Monooxygenase - metabolism | Protein Transport - immunology | Signal Transduction - immunology | Antigen Presentation | Antigens, Neoplasm - metabolism | Monophenol Monooxygenase - biosynthesis | Clone Cells | Tumor Cells, Cultured | Dendritic Cells - metabolism | HSP70 Heat-Shock Proteins - immunology | Antigens, Neoplasm - immunology | Lymphocyte Activation | Oligopeptides - immunology | Histocompatibility Antigens Class I - immunology | Oligopeptides - metabolism | Protein Binding - immunology | HSP70 Heat-Shock Proteins - metabolism | Macromolecular Substances | Oligopeptides - biosynthesis | Cell Differentiation - immunology | Cell Membrane - enzymology | Monocytes - enzymology | Monophenol Monooxygenase - immunology | Dendritic Cells - enzymology | Melanoma - immunology | HSP70 Heat-Shock Proteins - physiology | T-Lymphocytes - immunology | Cell Membrane - immunology | Dendritic Cells - cytology | Cell Line, Transformed
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2012, Volume 30, Issue 2, pp. 184 - 189
Journal Article
Stroke, ISSN 0039-2499, 09/2011, Volume 42, Issue 9, pp. 2589 - 2594
Background and Purpose-Activation of Notch worsens ischemic brain damage as antisense knockdown or pharmacological inhibition of the Notch pathway reduces the... 
apoptosis | focal ischemia | brain ischemia | inflammation | neuroregeneration | neuroprotection | CELLS | BRAIN-DAMAGE | PROLIFERATION | DEATH | CLINICAL NEUROLOGY | STROKE | TUMOR-NECROSIS-FACTOR | PERIPHERAL VASCULAR DISEASE | NF-KAPPA-B | UP-REGULATION | Amyloid Precursor Protein Secretases - genetics | Inflammation - pathology | Microglia - metabolism | Coculture Techniques | Brain Ischemia - genetics | Immunity, Innate - genetics | NF-kappa B - metabolism | Brain Ischemia - immunology | Inflammation - metabolism | Cell Nucleus - metabolism | Microglia - pathology | Gliosis - immunology | Active Transport, Cell Nucleus - genetics | Cytokines - genetics | Gliosis - genetics | Mice, Transgenic | Inflammation - therapy | Amyloid Precursor Protein Secretases - metabolism | Cell Nucleus - genetics | Active Transport, Cell Nucleus - immunology | Mice | Receptor, Notch1 - antagonists & inhibitors | Oligopeptides - pharmacology | Receptor, Notch1 - genetics | Cell Nucleus - immunology | Amyloid Precursor Protein Secretases - immunology | Gliosis - therapy | NF-kappa B - immunology | Brain Ischemia - metabolism | Gliosis - pathology | Microglia - immunology | Inflammation Mediators - metabolism | Cytokines - immunology | Inflammation Mediators - immunology | Cell Line | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Brain Ischemia - therapy | Gliosis - metabolism | Receptor, Notch1 - immunology | Inflammation - immunology | Receptor, Notch1 - metabolism | Immunity, Innate - immunology | Animals | NF-kappa B - genetics | Brain Ischemia - pathology | Inflammation - genetics | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Cytokines - biosynthesis | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e55264
The aim of this study was to characterize and identify the mode of action of IC31 (R), a two-component vaccine adjuvant. We found that IC31 (R) was accumulated... 
ADAPTIVE IMMUNITY | RESPONSES | AG85B-ESAT-6 | ACTIVATION | VIVO | SUBTYPES | MULTIDISCIPLINARY SCIENCES | ANTIMYCOBACTERIAL T-CELL | INDUCTION | VACCINE ADJUVANTS | PATTERN-RECOGNITION RECEPTORS | Endosomes - immunology | Phosphorylation | Adjuvants, Immunologic - pharmacology | Interferon-beta - immunology | I-kappa B Proteins - immunology | Dendritic Cells - immunology | Humans | NF-kappa B - immunology | I-kappa B Proteins - biosynthesis | Interferon Type I - immunology | Interferon Type I - biosynthesis | Ligation | Leukocytes, Mononuclear - immunology | Endosomes - drug effects | Tumor Necrosis Factor-alpha - immunology | Dendritic Cells - drug effects | Chemokines - immunology | Interferon Regulatory Factor-3 - immunology | NF-KappaB Inhibitor alpha | Leukocytes, Mononuclear - drug effects | Oligodeoxyribonucleotides - immunology | Oligopeptides - immunology | Toll-Like Receptors - immunology | Cells, Cultured | Cell Differentiation - immunology | Cell Differentiation - drug effects | Interleukin-6 - immunology | Oligodeoxyribonucleotides - pharmacology | Oligopeptides - pharmacology | Drug Combinations | Production management | Interferon | Vaccines | Dendritic cells | Biological response modifiers | Vaccination | Blood transfusions | Peptides | Science | Interleukin 6 | Proteins | Immunology | Bioaccumulation | Peripheral blood | Toll-like receptors | Immune system | NF-κB protein | Antigens | Immune response | TLR7 protein | Blood & organ donations | Cytokines | Incubation | Secretion | Inflammation | T cell receptors | Pattern recognition | Tumor necrosis factor-α | Gene expression | TLR3 protein | TLR9 protein | Mode of action | Signaling | Monocytes | Major histocompatibility complex | Interferon regulatory factor 3 | Ligands | Chemokines | Cancer | Farmakologi och toxikologi | Immunologi inom det medicinska området | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article