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olodaterol (94) 94
copd (68) 68
tiotropium (59) 59
index medicus (55) 55
humans (50) 50
chronic obstructive pulmonary disease (48) 48
respiratory system (48) 48
pulmonary disease, chronic obstructive - drug therapy (43) 43
obstructive pulmonary-disease (33) 33
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benzoxazines - administration & dosage (28) 28
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fixed-dose combination (28) 28
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aged (27) 27
bronchodilator agents - administration & dosage (27) 27
treatment outcome (25) 25
asthma (24) 24
pharmacology & pharmacy (24) 24
pulmonary disease, chronic obstructive - physiopathology (24) 24
adrenergic beta-2 receptor agonists - administration & dosage (23) 23
bronchodilator agents - adverse effects (23) 23
efficacy (23) 23
adrenergic beta-2 receptor agonists - adverse effects (22) 22
double-blind method (22) 22
original research (22) 22
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benzoxazines - adverse effects (21) 21
forced expiratory volume (20) 20
diseases of the respiratory system (19) 19
respiratory tract diseases (19) 19
drug combinations (18) 18
benzoxazines - therapeutic use (17) 17
bronchodilator agents - therapeutic use (17) 17
double-blind (17) 17
lung - drug effects (17) 17
time factors (17) 17
international journal of chronic obstructive pulmonary disease (16) 16
lung - physiopathology (16) 16
pulmonary disease, chronic obstructive - diagnosis (16) 16
tiotropium bromide (16) 16
tiotropium bromide - administration & dosage (16) 16
respimat (15) 15
tiotropium plus olodaterol (15) 15
adrenergic beta-2 receptor agonists - therapeutic use (14) 14
bronchodilator (14) 14
formoterol (14) 14
indacaterol (14) 14
quality of life (14) 14
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analysis (12) 12
muscarinic antagonists - administration & dosage (12) 12
nebulizers and vaporizers (12) 12
once-daily tiotropium (12) 12
pulmonary and respiratory medicine (12) 12
tiotropium bromide - therapeutic use (12) 12
dose-response relationship, drug (11) 11
gold 2-4 (11) 11
internal medicine (11) 11
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care and treatment (10) 10
cross-over studies (10) 10
drug therapy, combination (10) 10
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muscarinic antagonists - adverse effects (10) 10
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severity of illness index (10) 10
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bronchodilator agents - pharmacokinetics (7) 7
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Respiratory Research, ISSN 1465-9921, 11/2017, Volume 18, Issue 1, pp. 196 - 10
Background: Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA)... 
Tiotropium | Systematic review | Tiotropium/olodaterol fixed dose combination | Metanalysis | Olodaterol | COPD | MANAGEMENT | OBSTRUCTIVE PULMONARY-DISEASE | UMECLIDINIUM/VILANTEROL | RESPIRATORY SYSTEM | PLUS OLODATEROL | DOUBLE-BLIND | RESPIMAT(R) | FIXED-DOSE COMBINATION | FLUTICASONE | SEVERITY | Pulmonary Disease, Chronic Obstructive - diagnosis | Benzoxazines - administration & dosage | Bronchodilator Agents - administration & dosage | Forced Expiratory Volume - drug effects | Forced Expiratory Volume - physiology | Randomized Controlled Trials as Topic - methods | Humans | Administration, Inhalation | Treatment Outcome | Pulmonary Disease, Chronic Obstructive - physiopathology | Muscarinic Antagonists - administration & dosage | Tiotropium Bromide - administration & dosage | Spirometry - methods | Adrenergic beta-2 Receptor Agonists - administration & dosage | Drug Combinations | Pulmonary Disease, Chronic Obstructive - drug therapy | Complications and side effects | Lung diseases, Obstructive | Dosage and administration | Research | Drug therapy | Respiratory function | Acetylcholine receptors (muscarinic) | Prospero protein | Clinical trials | Pharmacology | Patients | Quality of life | Meta-analysis | Web portals | Studies | Literature reviews | Confidence intervals | Randomization | Dyspnea | Lungs | New combinations | Bronchodilators | Chronic obstructive pulmonary disease | Combined treatment | Clinical medicine | Safety | Respiration | olodaterol fixed dose combination
Journal Article
Chinese Journal of New Drugs, ISSN 1003-3734, 02/2018, Volume 27, Issue 4, pp. 483 - 488
Journal Article
Медицинский совет, ISSN 2079-701X, 04/2018, Issue 6, pp. 61 - 65
The paper is devoted to the problem of clinical efficacy and pharmacoeconomic evaluation of Spiolto Respimat. The results of clinical trials prove that Spiolto... 
respimat | tiotropium-olodaterol | copd
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 02/2010, Volume 20, Issue 4, pp. 1410 - 1414
Compound 4p was identified from a series of 6-hydroxy-4H-benzo[1,4]oxazin-3-ones as potent agonist of the human β -adrenoceptor with a high β /β -selectivity.... 
Adrenoceptor agonist | Beta2 | Bronchodilator | Bronchoprotection | LABA | Olodaterol | Asthma | COPD
Journal Article
RESPIRATORY MEDICINE, ISSN 0954-6111, 10/2015, Volume 109, Issue 10, pp. 1312 - 1319
Background: Tiotropium + olodaterol improves lung function and symptoms compared to mono-therapies in chronic obstructive pulmonary disease (COPD). The OTEMTO... 
Tiotropium | CARDIAC & CARDIOVASCULAR SYSTEMS | Long-acting bronchodilator | EFFICACY | SAFETY | RESPIRATORY SYSTEM | RESPIMAT(R) | UMECLIDINIUM/VILANTEROL 62.5/25 MCG | COMBINATION | Olodaterol | COPD | Quality of life
Journal Article
European Respiratory Journal, ISSN 0903-1936, 03/2019, Volume 53, Issue 3
The 3-min constant speed shuttle test (CSST) was used to examine the effect of tiotropium/olodaterol compared with tiotropium at reducing activity-related... 
STANDARDIZATION | ENDURANCE | OLODATEROL | RESPIRATORY SYSTEM | DYSPNEA | PERFORMANCE | FIXED-DOSE COMBINATION | SYMPTOMS | EXERCISE TOLERANCE | IMPROVEMENTS | LUNG HYPERINFLATION
Journal Article
by Ge, XY and Woo, AYH and Xing, G and Lu, YL and Mo, YM and Zhao, Y and Lan, Y and Li, JY and Yan, HN and Pan, L and Zhang, YY and Lin, B and Cheng, MS
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 05/2018, Volume 152, pp. 424 - 435
A new series of beta(2)-adrenoceptor agonists bearing the 2-amino-2-phenylethanol scaffold was synthesized. Evaluation of the compounds using cell assays and... 
DESIGN | CHEMISTRY, MEDICINAL | OLODATEROL | DISEASE | Bronchodilators | ASTHMA | Indacaterol | Trantinterol | beta-Adrenoceptor agonists | DISCOVERY | COPD
Journal Article
Asian Journal of Chemistry, ISSN 0970-7077, 2017, Volume 29, Issue 1, pp. 145 - 148
Journal Article
Tuberculosis and Respiratory Diseases, ISSN 1738-3536, 2018, Volume 81, Issue 1, pp. 13 - 18
Bronchodilator therapy is central to the management of chronic obstructive pulmonary disease and are recommended as the preferred treatment by the Global... 
Pulmonary Disease | Tiotropium | Chronic Obstructive | Olodaterol
Journal Article
Медицинский совет, ISSN 2079-701X, 10/2018, Issue 15, pp. 8 - 17
COPD exacerbations occur in almost all patients, and half of patients in the Russian Federation (52%) have two or more exacerbations per year or require urgent... 
dual bronchodilators | exacerbations | copd | tiotropium/olodaterol
Journal Article
Pulmonologiya, ISSN 0869-0189, 2018, Volume 28, Issue 1, pp. 96 - 103
Journal Article
Annals of Allergy, Asthma and Immunology, ISSN 1081-1206, 09/2018, Volume 121, Issue 3, pp. 328 - 332
Background: Ultra-long-acting β2 agonists (uLABA) are relatively new anti-asthma medications of which there are three different formulations currently... 
BRONCHODILATOR | LUNG | IN-VITRO | RESPONSIVENESS | SALBUTAMOL | ALLERGY | OLODATEROL | TOLERANCE | ACTING BETA-ADRENOCEPTOR AGONIST | INHALED METHACHOLINE | IMMUNOLOGY | SALMETEROL
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 02/2010, Volume 20, Issue 4, pp. 1410 - 1414
Compound 4p was identified from a series of 6-hydroxy-4H-benzo[1,4]oxazin-3-ones as potent agonist of the human beta(2)-adrenoceptor with a high... 
Adrenoceptor agonist | IN-VITRO | CHEMISTRY, MEDICINAL | Beta2 | Bronchodilator | LABA | Bronchoprotection | CHEMISTRY, ORGANIC | Olodaterol | DURATION | Asthma | COPD
Journal Article
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 06/2019, Volume 56, pp. 39 - 50
Combining a long-acting β -agonist (LABA) with a long-acting muscarinic antagonist (LAMA) is the cornerstone to treat patients with chronic obstructive... 
Human airways | Synergy | Olodaterol | Tiotropium bromide | Tiotropium | Lung diseases, Obstructive | Cyclic adenylic acid | Acetylcholine | Adenylic acid | Analysis
Journal Article
International Journal of COPD, ISSN 1176-9106, 10/2014, Volume 9, pp. 1133 - 1144
Background: Combining bronchodilators with different mechanisms of action may improve efficacy and reduce risk of side effects compared to increasing the dose... 
Olodaterol Respimat | Long-acting muscarinic antagonist | Bronchodilator | Long-acting beta2-agonist | Tiotropium HandiHaler | INDACATEROL | TRIALS | OBSTRUCTIVE PULMONARY-DISEASE | MANAGEMENT | long-acting beta2-agonist | RESPIRATORY SYSTEM | tiotropium HandiHaler (R) | long-acting muscarinic antagonist | bronchodilator | olodaterol Respimat (R) | Spirometry | Bronchodilator Agents - administration & dosage | United States | Humans | Middle Aged | Muscarinic Antagonists - adverse effects | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Equipment Design | Forced Expiratory Volume | Time Factors | Adrenergic beta-2 Receptor Agonists - adverse effects | Scopolamine Derivatives - administration & dosage | Female | Surveys and Questionnaires | Bronchodilator Agents - adverse effects | Drug Therapy, Combination | Scopolamine Derivatives - adverse effects | Tiotropium Bromide | Pulmonary Disease, Chronic Obstructive - diagnosis | Benzoxazines - administration & dosage | Double-Blind Method | Drug Administration Schedule | Administration, Inhalation | Benzoxazines - adverse effects | Treatment Outcome | Lung - physiopathology | Muscarinic Antagonists - administration & dosage | Lung - drug effects | Adrenergic beta-2 Receptor Agonists - administration & dosage | Aged | Nebulizers and Vaporizers | Pulmonary Disease, Chronic Obstructive - drug therapy | Tiotropium | Lung diseases, Obstructive | Research | Drug therapy, Combination | Drug therapy | Health aspects
Journal Article
Actualités pharmaceutiques, ISSN 0515-3700, 06/2016, Volume 55, Issue 557, pp. 19 - 21
Deux médicaments pour le traitement de l’asthme et de la bronchopneumopathie chronique obstructive (BPCO), pathologies fréquentes et invalidantes, sont... 
fluticasone | vilanterol | vilantérol | olodatérol | olodaterol
Journal Article
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