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Frontiers of Medicine, ISSN 2095-0217, 4/2019, Volume 13, Issue 2, pp. 277 - 284
The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been... 
pKa calculation | Medicine & Public Health | adverse effect | toxicological mechanism | pharmacological mechanism | Medicine/Public Health, general | proton-pump inhibitor | MEDICINE, RESEARCH & EXPERIMENTAL | OMEPRAZOLE | ENUMERATION | PREDICTION | DATABASE | ONCOLOGY | T3DB | PK(A) | Nitrogen | Pyrimidines | Medical research | Side effects | Inhibitor drugs
Journal Article
Journal of Clinical Epidemiology, ISSN 0895-4356, 2004, Volume 57, Issue 4, pp. 422 - 428
Journal Article
Lancet, The, ISSN 0140-6736, 2011, Volume 377, Issue 9769, pp. 905 - 913
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2010, Volume 363, Issue 20, pp. 1909 - 1917
Journal Article
JAMA, ISSN 0098-7484, 05/2011, Volume 305, Issue 19, pp. 1969 - 1977
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 01/2011, Volume 89, Issue 1, pp. 65 - 74
Four randomized, placebo‐controlled, crossover studies were conducted among 282 healthy subjects to investigate whether an interaction exists between... 
VARIABILITY | LANSOPRAZOLE | RABEPRAZOLE | THERAPY | CARDIOVASCULAR EVENTS | STENT PLACEMENT | PHARMACOLOGY & PHARMACY | OUTCOMES | ANTIPLATELET ACTION | PROTON-PUMP INHIBITORS | DRUG-INTERACTION | Proton Pump Inhibitors - pharmacology | Ticlopidine - pharmacology | Humans | Middle Aged | Half-Life | Male | 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology | Enzyme Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - blood | Young Adult | Drug Interactions | Proton Pump Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Omeprazole - pharmacology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Enzyme Inhibitors - adverse effects | Proton Pump Inhibitors - adverse effects | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Double-Blind Method | Drug Administration Schedule | 2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects | Omeprazole - administration & dosage | Enzyme Inhibitors - pharmacology | Omeprazole - adverse effects | Ticlopidine - analogs & derivatives | Cross-Over Studies | Prodrugs - adverse effects | Prodrugs - pharmacokinetics | Cytochrome P-450 CYP2C19 | Platelet Activation - drug effects | 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage | Prodrugs - pharmacology | Ticlopidine - blood | Omeprazole | Pantoprazole | Drug interactions | Analysis | Dosage and administration | Research | Patients | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9736, pp. 173 - 179
Summary Background Cyclo-oxygenase (COX)-2-selective non-steroidal anti-inflammatory drugs (NSAIDs) and non-selective NSAIDs plus a proton-pump inhibitor (PPI)... 
Internal Medicine | GASTROINTESTINAL TOXICITY | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | MUCOSAL INJURY | OARSI RECOMMENDATIONS | RISK | NAPROXEN | PLUS OMEPRAZOLE | KNEE OSTEOARTHRITIS | EVIDENCE-BASED RECOMMENDATIONS | Lower Gastrointestinal Tract - drug effects | Osteoarthritis - ethnology | Humans | Middle Aged | Peptic Ulcer - prevention & control | Male | Osteoarthritis - drug therapy | Cyclooxygenase 2 Inhibitors - adverse effects | Arthritis, Rheumatoid - drug therapy | Adult | Female | Drug Therapy, Combination | Pyrazoles - adverse effects | Anti-Ulcer Agents - therapeutic use | Omeprazole - therapeutic use | Double-Blind Method | Drug Administration Schedule | Risk Assessment | Diclofenac - adverse effects | Risk Factors | Treatment Outcome | Celecoxib | Pyrazoles - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Upper Gastrointestinal Tract - drug effects | Arthritis, Rheumatoid - ethnology | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Sulfonamides - adverse effects | Diclofenac - administration & dosage | Peptic Ulcer - chemically induced | Research Design | Sulfonamides - administration & dosage | Omeprazole | Rheumatoid arthritis | Dosage and administration | Research | Comparative analysis | Drug therapy | Diclofenac | Heart failure | Likert scale | Inflammatory bowel disease | Arthritis | Clinical medicine | Index Medicus | Abridged Index Medicus
Journal Article