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The FEBS Journal, ISSN 1742-464X, 02/2018, Volume 285, Issue 3, pp. 416 - 431
Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and... 
BCL‐2 family | mitochondria | apoptosis | BAX | mitochondrial outer membrane permeabilization | BAK | DRP1 | BCL-2 family | OUTER-MEMBRANE | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PORE FORMATION | BH3 DOMAINS | CELL-DEATH | PROSURVIVAL BCL-2 PROTEINS | CYTOCHROME-C | CONFORMATIONAL-CHANGES | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | Mitochondrial Dynamics | Mitochondria - enzymology | bcl-2-Associated X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - agonists | Humans | Protein Multimerization | bcl-2-Associated X Protein - agonists | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondrial Membranes - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Mitochondrial Membranes - enzymology | Protein Interaction Domains and Motifs | Mitochondria - chemistry | Dimerization | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Lipid Mobilization | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Models, Biological | Apoptosis Regulatory Proteins - agonists | Protein Conformation | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Porosity | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | bcl-2 Homologous Antagonist-Killer Protein - agonists | Mitochondria | Regulators | Oligomerization | Bax protein | Bcl-2 protein | Spatial discrimination | Organelles
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2002, Volume 8, Issue 8, pp. 808 - 815
A major concern in cancer therapy is resistance of tumors such as glioblastoma to current treatment protocols. Here, we report that transfer of the gene... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CD95 APO-1/FAS | SMAC/DIABLO | DEATH RECEPTOR | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CELL-DEATH | CELL BIOLOGY | INHIBITION | TRAIL-INDUCED APOPTOSIS | TUMORICIDAL ACTIVITY | Neoplasm Transplantation | Apoptosis - drug effects | Humans | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Mitochondrial Proteins - genetics | Mitochondrial Proteins - agonists | Antineoplastic Agents - metabolism | Brain - metabolism | Carrier Proteins - agonists | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Flow Cytometry | Peptides - metabolism | TNF-Related Apoptosis-Inducing Ligand | Mitochondrial Proteins - metabolism | Glioma - pathology | X-Linked Inhibitor of Apoptosis Protein | Tumor Cells, Cultured | Brain - cytology | Enzyme Inhibitors - metabolism | Brain - physiopathology | Intracellular Signaling Peptides and Proteins | Mitochondria - metabolism | Remission Induction | Peptides - pharmacology | Carrier Proteins - genetics | Tumor Necrosis Factor-alpha - therapeutic use | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Membrane Glycoproteins - therapeutic use | Proteins - metabolism | Mice, Nude | Brain - pathology | Ligands | Mice | Apoptosis - physiology | Glioma - physiopathology | Glioma - drug therapy | Research | Gliomas | Analysis | Apoptosis
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 2014, Volume 54, Issue 1, pp. 435 - 456
Protein-protein interactions (PPIs) are critical regulatory events in physiology and pathology, and they represent an important target space for... 
Allosteric inhibitors | Interfacial binders | Orthosteric inhibitors | Small-molecule inhibitors | Protein-protein interactions | PPIs | interfacial binders | PYRUVATE-KINASE M2 | DRUG DISCOVERY | protein-protein interactions | AGGRESSIVE CARCINOMA | SIGNAL-TRANSDUCTION | STRUCTURAL BASIS | IN-VIVO | NUCLEOTIDE EXCHANGE FACTOR | CANCER METABOLISM | PHARMACOLOGY & PHARMACY | allosteric inhibitors | BREFELDIN-A | TOXICOLOGY | orthosteric inhibitors | B-RAF | small-molecule inhibitors | SOS1 Protein - antagonists & inhibitors | ras Proteins - genetics | Humans | ras Proteins - metabolism | Molecular Targeted Therapy | Proto-Oncogene Proteins c-akt - genetics | Carrier Proteins - agonists | SOS1 Protein - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Protein Interaction Domains and Motifs - drug effects | Membrane Proteins - genetics | SOS1 Protein - metabolism | ras Proteins - antagonists & inhibitors | Models, Molecular | Thyroid Hormones - agonists | Thyroid Hormones - genetics | Membrane Proteins - agonists | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Carrier Proteins - genetics | Carrier Proteins - metabolism | Proto-Oncogene Proteins B-raf - genetics | Thyroid Hormones - metabolism | Protein Binding | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Proteins | Protein binding
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 07/2009, Volume 16, Issue 7, pp. 1018 - 1029
Journal Article
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 06/2017, Volume 5, Issue 1, pp. 47 - 12
Background: The expansion of antigen-specific CD8 T cells is important in generating an effective and long-lasting immune response to tumors and viruses.... 
GITR | GITRL-FP | Antigen-specific | CD8 | Memory | T cell | Vaccine | ACTIVATION | STIMULATION | RECEPTOR | IMMUNOLOGY | MAB | ONCOLOGY | IMMUNOTHERAPY | IN-VIVO | EXPANSION | COSTIMULATION | ANTITUMOR IMMUNITY | Tumor Necrosis Factors - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Oncogene Proteins, Fusion - immunology | T-Lymphocytes, Regulatory - immunology | Colonic Neoplasms - immunology | Female | Disease Models, Animal | Receptors, Tumor Necrosis Factor - genetics | Antigens, Neoplasm - immunology | Cancer Vaccines - administration & dosage | Glucocorticoid-Induced TNFR-Related Protein - agonists | Glucocorticoid-Induced TNFR-Related Protein - genetics | Tumor Necrosis Factors - immunology | Cancer Vaccines - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Signal Transduction - drug effects | Oncogene Proteins, Fusion - genetics | CD8-Positive T-Lymphocytes - drug effects | Colonic Neoplasms - pathology | Oncogene Proteins, Fusion - antagonists & inhibitors | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Receptors, Tumor Necrosis Factor - immunology | Antigens | Corticosteroids | Research | T cells | Tumor necrosis factor | Tumor necrosis factor-TNF | Human papillomavirus | T cell receptors | Vaccines | Rodents
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2017, Volume 292, Issue 33, pp. 13688 - 13701
Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among... 
EPITHELIAL-MESENCHYMAL TRANSITION | MIGRATION | CELLS | CYCLIN D1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS | EXPRESSION | BINDING | TISSUE FACTOR | INSIGHTS | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Receptor, PAR-2 - metabolism | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Breast - metabolism | Proto-Oncogene Proteins c-akt - genetics | Thromboplastin - agonists | Breast Neoplasms - metabolism | Breast Neoplasms - enzymology | Factor VIIIa - metabolism | Receptor, PAR-2 - antagonists & inhibitors | RNA Interference | Neoplasm Invasiveness - pathology | Female | Glycogen Synthase Kinase 3 beta - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Breast - pathology | Phosphatidylinositol 3-Kinase - metabolism | Receptor, PAR-2 - genetics | Recombinant Proteins - metabolism | Breast - cytology | beta Catenin - agonists | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Glycogen Synthase Kinase 3 beta - antagonists & inhibitors | Factor VIIIa - genetics | Glycogen Synthase Kinase 3 beta - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Phosphatidylinositol 3-Kinase - chemistry | Cell Movement - drug effects | Neoplasm Proteins - agonists | Signal Transduction - drug effects | Breast Neoplasms - pathology | beta Catenin - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - agonists | Thromboplastin - genetics | Receptor, PAR-2 - agonists | Cell Line, Tumor | Genes, Reporter - drug effects | Thromboplastin - metabolism | Oligopeptides - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | coagulation factor | β-catenin | breast cancer | signaling | Signal Transduction | tissue factor
Journal Article
Immunity, ISSN 1074-7613, 08/2009, Volume 31, Issue 2, pp. 245 - 258
Effective clearance of apoptotic cells by macrophages is essential for immune homeostasis. The transcriptional pathways that allow macrophages to sense and... 
MOLIMMUNO | CELLIMMUNO | SIGNALING PATHWAYS | IN-VITRO | PHAGOCYTOSIS | PHOSPHATIDYLSERINE RECEPTOR | LIPID-METABOLISM | MER TYROSINE KINASE | CHOLESTEROL EFFLUX | TAM RECEPTORS | IMMUNOLOGY | LIVER-X-RECEPTORS | MICE LACKING | Spleen - immunology | Receptor Protein-Tyrosine Kinases - immunology | Signal Transduction - immunology | Receptors, Cytoplasmic and Nuclear - immunology | DNA-Binding Proteins - agonists | Autoimmunity - immunology | Immune Tolerance - immunology | Liver X Receptors | c-Mer Tyrosine Kinase | Proto-Oncogene Proteins - immunology | Orphan Nuclear Receptors | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Macrophages - immunology | Proto-Oncogene Proteins - metabolism | DNA-Binding Proteins - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Phagocytosis - immunology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Spleen - cytology | Macrophages - cytology | DNA-Binding Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Mice, Knockout | Animals | Apoptosis - immunology | Spleen - metabolism | Mice | Tyrosine | Autoimmunity | Autoantibodies | Analysis | Development and progression | Macrophages | Apoptosis | Studies | Flow cytometry | Statistical analysis | Rodents | Software | Gene expression | Variance analysis | Cholesterol | Immune system
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 2013, Volume 219, Issue 1, pp. R13 - R35
The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled receptor gene family. Neural gene expression patterns of APJ, and its cognate... 
G protein-coupled receptor | Homeostasis | APJ | Apelin | ENDOGENOUS LIGAND APELIN | apelin | MESSENGER-RNA EXPRESSION | RIBONUCLEIC-ACID EXPRESSION | ANGIOTENSIN-CONVERTING ENZYME | VASCULAR SMOOTH-MUSCLE | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | INSULIN-RESISTANT MICE | homeostasis | PROTEIN-COUPLED RECEPTOR | CENTRALLY-ADMINISTERED APELIN-13 | ENDOCRINOLOGY & METABOLISM | IMMUNODEFICIENCY-VIRUS TYPE-1 | Central Nervous System - metabolism | Reactive Oxygen Species - metabolism | Humans | Protein Multimerization | Neovascularization, Pathologic | Intercellular Signaling Peptides and Proteins - biosynthesis | Intercellular Signaling Peptides and Proteins - physiology | Tissue Distribution | Homeostasis - drug effects | Extracellular Signal-Regulated MAP Kinases - physiology | Receptors, G-Protein-Coupled - physiology | Amino Acid Sequence | Obesity | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Pituitary-Adrenal System - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Rats | Receptors, G-Protein-Coupled - biosynthesis | Cardiovascular System - drug effects | Proto-Oncogene Proteins c-akt - physiology | Hypothalamo-Hypophyseal System - metabolism | Intercellular Signaling Peptides and Proteins - agonists | Animals | Apelin Receptors | Homeostasis - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Mice | Nitric Oxide Synthase - metabolism | Receptors, G-Protein-Coupled - genetics | Receptors, G-Protein-Coupled - chemistry
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2015, Volume 465, Issue 1, pp. 71 - 76
Shikonin, a natural naphthoquinone isolated from the Chinese traditional medicine Zi Cao ( ), is known to suppress the growth of several cancer cell types. In... 
Shikonin | p73 | p16INK4A | ICBP90 | Tumor suppressor gene | Apoptosis | p16 | UHRF1 | CCAAT-BINDING-PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | INDUCTION | II-ALPHA EXPRESSION | IN-VITRO | BIOPHYSICS | GENE | PATHWAY | COLORECTAL-CANCER | SRA DOMAIN | p16(INK4A) | Luciferases - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Luciferases - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Proteolysis - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | DNA-Binding Proteins - agonists | MCF-7 Cells | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - genetics | Caspase 3 - genetics | Female | CCAAT-Enhancer-Binding Proteins - genetics | Nuclear Proteins - genetics | Genes, Reporter | CCAAT-Enhancer-Binding Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - agonists | Signal Transduction | DNA (Cytosine-5-)-Methyltransferase 1 | Cyclin-Dependent Kinase Inhibitor p16 - agonists | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Naphthoquinones - pharmacology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Poly(ADP-ribose) Polymerases - metabolism | Tumor Protein p73 | Poly(ADP-ribose) Polymerases - genetics | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Tumor Suppressor Proteins - agonists | Sugars | Cancer | Monosaccharides | Protein binding
Journal Article
Oncogene, ISSN 0950-9232, 09/2011, Volume 30, Issue 37, pp. 3918 - 3929
The BH3 mimetic ABT737 induces autophagy by competitively disrupting the inhibitory interaction between the BH3 domain of Beclin 1 and the anti-apoptotic... 
autophagy | ABT737 | Bcl-2 family protein | Beclin 1 | CELLS | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | IKK | INDUCTION | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | BCL-2 FAMILY | BH3-ONLY PROTEINS | Phosphorylation | Nitriles - pharmacology | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Autophagy - drug effects | Biphenyl Compounds - pharmacology | I-kappa B Kinase - metabolism | Nitrophenols - pharmacology | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Benzopyrans - pharmacology | Oncogene Protein v-akt - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Beclin-1 | Tumor Suppressor Protein p53 - metabolism | Glycogen Synthase Kinase 3 - metabolism | Sulfonamides - pharmacology | Membrane Proteins - agonists | Piperazines - pharmacology | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - agonists | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Sirtuins - metabolism | Acetyl-CoA Carboxylase - metabolism | Autophagy (Cytology) | Cellular proteins | Care and treatment | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Cancer | Proteins | Signal transduction | Biomimetics | Cellular biology | Gene expression | Sirtuins | TOR protein | MDM2 protein | Bcl-2 protein | Glycogen synthase kinase 3 | AKT protein | Dephosphorylation | IKK protein | p53 protein | Allosteric properties | NF- Kappa B protein | Bcl-x protein | I Kappa B kinase | Lipid kinase | Phagocytosis | Ubiquitin-protein ligase
Journal Article