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Blood, ISSN 0006-4971, 12/2018, Volume 132, Issue 24, pp. 2564 - 2574
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular proliferation and metabolism. Depending on its binding partners, mTOR is at the... 
TERMINAL HYDROLASE | ONCOGENE | METABOLISM | PHOSPHORYLATION | UBIQUITIN | C-MYC | COMPONENTS | AKT | TRANSLATION | SUPPRESSION | HEMATOLOGY | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2400 - 2407
Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, in part, to de novo and... 
TARGET | STEM-CELLS | GROWTH INHIBITION | INVASION | TUMOR PROGRESSION | ONCOLOGY | PROSTATE-CANCER | TAMOXIFEN RESISTANCE | DOWN-REGULATION | E-CADHERIN | NF-KAPPA-B | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Receptors, Notch - metabolism | Humans | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Intercellular Signaling Peptides and Proteins - biosynthesis | NF-kappa B - metabolism | Receptor, Notch2 - genetics | Receptors, Notch - genetics | Proto-Oncogene Proteins - biosynthesis | Cell Movement - physiology | Pancreatic Neoplasms - drug therapy | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Calcium-Binding Proteins - biosynthesis | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Pancreatic Neoplasms - pathology | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Membrane Proteins - biosynthesis | Phenotype | Receptor, Notch2 - biosynthesis | Mesoderm - pathology | RNA, Messenger | Deoxycytidine - analogs & derivatives | Receptor, Notch4 | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 48, pp. 33394 - 33405
Micro-RNAs are similar to 21-25-nucleotide-long noncoding RNAs that regulate gene expression primarily at the post-transcriptional level in animals. Here, we... 
SURVIVAL | C/EBP-ALPHA | MICRORNA FUNCTION | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TUMOR-SUPPRESSOR | TARGETS | DEGRADATION | HUMAN HEPATOCELLULAR CARCINOMAS | EXPRESSION | Lung Neoplasms - drug therapy | Histone Deacetylases - biosynthesis | Antibiotics, Antineoplastic - pharmacology | Caspase 7 - biosynthesis | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | MicroRNAs - metabolism | Proto-Oncogene Proteins - biosynthesis | RNA, Neoplasm - metabolism | Receptors, Growth Factor - genetics | Caspase 3 - genetics | Caspase 3 - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Lung Neoplasms - genetics | Forkhead Transcription Factors - biosynthesis | Histone Deacetylases - genetics | Caspase 7 - genetics | Cell Survival | Proto-Oncogene Proteins c-met | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Poly(ADP-ribose) Polymerases - biosynthesis | Down-Regulation - drug effects | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Down-Regulation - genetics | Animals | Poly(ADP-ribose) Polymerases - genetics | Repressor Proteins - biosynthesis | Mice, Nude | Myeloid Cell Leukemia Sequence 1 Protein | Receptors, Growth Factor - biosynthesis | Cell Line, Tumor | Proto-Oncogene Proteins c-pim-1 - genetics | RNA, Neoplasm - genetics | Mice | MicroRNAs - genetics | Poly (ADP-Ribose) Polymerase-1 | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-pim-1 - biosynthesis | Doxorubicin - pharmacology | Cell Movement | Index Medicus | RNA-Mediated Regulation and Noncoding Rnas
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2750 - 2760
This study addresses the role of PTEN loss in intrinsic resistance to the BRAF inhibitor PLX4720. Immunohistochemical staining of a tissue array covering all... 
METASTATIC MELANOMA | APOPTOSIS | PROTEIN | ONCOLOGY | PHOSPHORYLATION | CUTANEOUS MELANOMA | RAF KINASE | CANCER | MEDIATES RESISTANCE | LINES | ERK | RNA, Small Interfering - genetics | Up-Regulation | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Bcl-2-Like Protein 11 | Melanoma - genetics | Apoptosis Regulatory Proteins - genetics | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Melanoma - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - deficiency | Membrane Proteins - genetics | PTEN Phosphohydrolase - biosynthesis | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Membrane Proteins - biosynthesis | Membrane Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | Mutation | RNA, Small Interfering - administration & dosage | Index Medicus | PTEN | melanoma | BRAF | PLX4032 | therapy | resistance
Journal Article
Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 1, pp. 12 - 21
Journal Article
PLoS Genetics, ISSN 1553-7390, 2015, Volume 11, Issue 12, pp. e1005634 - e1005634
Epithelial renewal in the Drosophila intestine is orchestrated by Intestinal Stem Cells (ISCs). Following damage or stress the intestinal epithelium produces... 
ACTIVATION | CANCER GENOMICS | PATHWAY | MIDGUT | GROWTH | TORSO | GENETICS & HEREDITY | PROTEINS | EXPRESSION | RECEPTOR TYROSINE KINASE | TRANSCRIPTIONAL RESPONSE | Proto-Oncogene Proteins c-ets - genetics | ErbB Receptors - genetics | Stem Cells - cytology | HMGB Proteins - biosynthesis | Proto-Oncogene Proteins - biosynthesis | Drosophila Proteins - biosynthesis | RNA, Messenger - biosynthesis | Receptors, Invertebrate Peptide - genetics | Gene Expression Regulation, Developmental | HMGB Proteins - genetics | Nerve Tissue Proteins - biosynthesis | Drosophila - genetics | Cell Proliferation - genetics | Intestines - growth & development | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Animals | Repressor Proteins - biosynthesis | Drosophila Proteins - genetics | DNA-Binding Proteins - biosynthesis | Intestines - cytology | Cell proliferation | Cellular signal transduction | Genetic aspects | Observations | Drosophila | Stem cells | Index Medicus | Medical research | Transcription factors | Genes | Cell division | Homeostasis | Infections | Proteins | Studies | Cell growth | Epidermal growth factor | Insects | Ligands | Mutation
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1239 - 1247
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR ACTIVITY | STAPLED P53 | BRAF | MALIGNANT-MELANOMA | P53 PATHWAY | CELL-DEATH | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | IN-VIVO | Up-Regulation | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Male | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - transplantation | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - physiology | Cell-Penetrating Peptides - pharmacology | Nuclear Proteins - biosynthesis | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Melanoma - chemistry | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Stem Cell Assay | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - etiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Melanoma, Experimental - genetics | GTP Phosphohydrolases - genetics | Keratinocytes - metabolism | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Melanoma | Diagnosis | Research | Gene expression | Identification and classification | Skin cancer | Proteins | Cell growth | Mutation | Cell cycle | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2013, Volume 210, Issue 2, pp. 269 - 285
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | Index Medicus | 309
Journal Article
Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23, pp. 8844 - 8852
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells.... 
SURVIVAL | THERAPY | BECLIN-1 | ONCOLOGY | INDUCED APOPTOSIS | MESANGIAL CELLS | PAI-1 GENE-EXPRESSION | INDUCTION | TUMORIGENESIS | CANCER | LC3 | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Cell Growth Processes - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Autophagy - physiology | Proto-Oncogene Proteins - biosynthesis | Transforming Growth Factor beta - biosynthesis | Breast Neoplasms - metabolism | Transfection | Bcl-2-Like Protein 11 | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Apoptosis Regulatory Proteins - biosynthesis | Beclin-1 | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Membrane Proteins - genetics | Transforming Growth Factor beta - physiology | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - biosynthesis | Autophagy-Related Protein 7 | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Autophagy-Related Protein 5 | Membrane Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Breast Neoplasms - pathology | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Smad Proteins - metabolism | Carcinoma, Hepatocellular - metabolism | Index Medicus
Journal Article
Prostate, ISSN 0270-4137, 2009, Volume 69, Issue 15, pp. 1683 - 1693
BACKGROUND: According to the cancer stem cell hypothesis, tumor growth is sustained by a subpopulation of cancer stem/progenitor-like cells. Self-renewal and... 
Cancer stem/progenitor-like cells | Self-renewal | PSCA | Prostaspheres | CD49f | PROGENITOR CELLS | POPULATION | PROSPECTIVE IDENTIFICATION | prostaspheres | self-renewal | TUMOR-INITIATING CELLS | MURINE | EPITHELIAL STEM-CELLS | ENDOCRINOLOGY & METABOLISM | UROLOGY & NEPHROLOGY | cancer stem/progenitor-like cells | DIFFERENTIATION | PROGRESSION | CD133 | Immunohistochemistry | Prostatic Neoplasms - metabolism | Nestin | Proto-Oncogene Proteins c-met - biosynthesis | Antigens, CD - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | GPI-Linked Proteins | Octamer Transcription Factor-3 - biosynthesis | Cell Growth Processes - physiology | Intercellular Signaling Peptides and Proteins - biosynthesis | Male | Gene Expression Profiling | Proto-Oncogene Proteins - biosynthesis | Antigens, CD - genetics | Octamer Transcription Factor-3 - genetics | RNA, Messenger - biosynthesis | Prostatic Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | Intermediate Filament Proteins - genetics | Nerve Tissue Proteins - biosynthesis | Neoplastic Stem Cells - pathology | Retrospective Studies | Neoplasm Proteins - genetics | Jagged-1 Protein | Prostatic Neoplasms - pathology | Antigens, Neoplasm | Calcium-Binding Proteins - biosynthesis | Homeodomain Proteins - biosynthesis | Nanog Homeobox Protein | Keratin-14 - biosynthesis | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Intermediate Filament Proteins - biosynthesis | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Keratin-14 - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Proto-Oncogene Proteins c-met - genetics | Membrane Proteins - biosynthesis | Clone Cells - pathology | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article