X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (173370) 173370
Book Chapter (189) 189
Dissertation (97) 97
Book / eBook (94) 94
Publication (88) 88
Magazine Article (66) 66
Conference Proceeding (64) 64
Newsletter (50) 50
Reference (47) 47
Government Document (26) 26
Web Resource (9) 9
Book Review (4) 4
Streaming Video (4) 4
Newspaper Article (3) 3
Journal / eJournal (1) 1
Video Recording (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (123304) 123304
animals (85954) 85954
mice (51545) 51545
female (45870) 45870
male (42593) 42593
oncology (41797) 41797
cell biology (34201) 34201
biochemistry & molecular biology (32819) 32819
expression (31207) 31207
apoptosis (28875) 28875
cancer (27372) 27372
proto-oncogene proteins - genetics (26945) 26945
cell line, tumor (25163) 25163
mutation (24736) 24736
signal transduction (24702) 24702
phosphorylation (21923) 21923
middle aged (20919) 20919
gene expression (20579) 20579
proto-oncogene proteins c-akt - metabolism (18540) 18540
adult (18499) 18499
proteins (18375) 18375
proto-oncogene proteins - metabolism (18196) 18196
activation (18180) 18180
cell line (17151) 17151
research (17076) 17076
molecular sequence data (17062) 17062
rats (16490) 16490
aged (16062) 16062
genetic aspects (15962) 15962
cells, cultured (15373) 15373
base sequence (15090) 15090
gene expression regulation, neoplastic (13740) 13740
transfection (13299) 13299
tumors (13113) 13113
oncogenes (13040) 13040
gene (12990) 12990
genetics & heredity (12722) 12722
immunohistochemistry (12674) 12674
apoptosis - drug effects (12444) 12444
cell proliferation (12166) 12166
analysis (11760) 11760
research article (11702) 11702
protein (11481) 11481
cells (11132) 11132
multidisciplinary sciences (10689) 10689
tumor cells, cultured (10688) 10688
amino acid sequence (10346) 10346
prognosis (10277) 10277
genes (10237) 10237
hematology (10170) 10170
rna, messenger - genetics (9967) 9967
proto-oncogene proteins c-bcl-2 - metabolism (9945) 9945
dna-binding proteins - genetics (9921) 9921
rna, messenger - metabolism (9745) 9745
signal transduction - drug effects (9642) 9642
kinases (9541) 9541
gene expression regulation (9432) 9432
gene-expression (9363) 9363
mice, inbred c57bl (9253) 9253
proto-oncogene proteins c-bcl-2 - genetics (9164) 9164
blotting, western (9094) 9094
pathology (9022) 9022
growth (8830) 8830
transcription factors - genetics (8759) 8759
physiological aspects (8684) 8684
phosphatidylinositol 3-kinases - metabolism (8655) 8655
reverse transcriptase polymerase chain reaction (8577) 8577
transcription, genetic (8506) 8506
health aspects (8446) 8446
protein binding (8427) 8427
dna-binding proteins - metabolism (8210) 8210
cell cycle (8103) 8103
mice, knockout (7888) 7888
transcription factors - metabolism (7762) 7762
transcription factors (7649) 7649
polymerase chain reaction (7481) 7481
differentiation (7467) 7467
promoter regions, genetic (7442) 7442
proliferation (7334) 7334
oncogene (7297) 7297
metastasis (7187) 7187
down-regulation (7083) 7083
inhibition (7068) 7068
survival (7063) 7063
aged, 80 and over (7039) 7039
cell proliferation - drug effects (6999) 6999
mutations (6968) 6968
p53 (6964) 6964
mice, transgenic (6881) 6881
medicine, research & experimental (6805) 6805
oncogene proteins, fusion - genetics (6732) 6732
antineoplastic agents - pharmacology (6722) 6722
neurosciences (6717) 6717
medicine (6629) 6629
proto-oncogene proteins b-raf - genetics (6581) 6581
biology (6550) 6550
time factors (6449) 6449
immunology (6418) 6418
identification (6405) 6405
dna (6401) 6401
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (55) 55
Online Resources - Online (14) 14
Collection Dvlpm't (Acquisitions) - Closed Orders (8) 8
Collection Dvlpm't (Acquisitions) - Vendor file (8) 8
UofT at Mississauga - Stacks (5) 5
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (3) 3
Gerstein Science - Circulation Desk (2) 2
St. Michael's Hospital - Circulation Desk (2) 2
St. Michael's Hospital - Stacks (2) 2
UofT at Scarborough - Stacks (2) 2
Chemistry (A D Allen) - Stacks (1) 1
Gerstein Science - Bindery (1) 1
Gerstein Science - Periodical Stacks (1) 1
Gerstein Science - Reference (1) 1
Media Commons - Audio Visual (1) 1
UTL at Downsview - May be requested (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (171597) 171597
Chinese (2353) 2353
Japanese (1309) 1309
French (497) 497
German (358) 358
Russian (320) 320
Spanish (164) 164
Portuguese (111) 111
Polish (72) 72
Hungarian (47) 47
Italian (45) 45
Czech (41) 41
Norwegian (27) 27
Dutch (24) 24
Korean (13) 13
Ukrainian (12) 12
Danish (11) 11
Swedish (9) 9
Finnish (8) 8
Hebrew (8) 8
Croatian (5) 5
Serbian (5) 5
Bulgarian (4) 4
Romanian (4) 4
Slovak (4) 4
Turkish (3) 3
Welsh (3) 3
Latin (2) 2
Persian (2) 2
Arabic (1) 1
Nauru (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of clinical oncology, ISSN 1527-7755, 2013, Volume 31, Issue 34, pp. 4333 - 4342
Journal Article
PLoS genetics, ISSN 1553-7404, 2010, Volume 6, Issue 2, p. e1000841
Journal Article
PLoS genetics, ISSN 1553-7404, 2013, Volume 9, Issue 5, p. e1003532
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 562, Issue 7725, pp. 69 - 75
Primary liver cancer represents a major health problem. It comprises hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ... 
PATHOGENESIS | HEPATOCELLULAR-CARCINOMA | READ ALIGNMENT | HEPATOCYTES | DNA | INFLAMMATION | PACKAGE | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | BINDING | DISCOVERY | Humans | Tumor Microenvironment | Apoptosis - genetics | Hepatocytes - pathology | Male | Gene Expression Profiling | Genes, myc | Hepatocytes - metabolism | Proto-Oncogene Proteins c-akt - genetics | DNA-Binding Proteins - metabolism | Carcinoma, Hepatocellular - genetics | DNA Transposable Elements - genetics | Female | Liver Neoplasms - pathology | Cell Differentiation | Cell Lineage - genetics | Disease Models, Animal | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Cytokines - metabolism | Liver Neoplasms - genetics | Carcinogenesis - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Transcription Factors - metabolism | Cholangiocarcinoma - pathology | Animals | Epigenesis, Genetic - genetics | Carcinoma, Hepatocellular - pathology | Cholangiocarcinoma - genetics | Mosaicism | Mice | Necrosis - genetics | Genes, ras | Liver cancer | Research | Carcinogenesis | Oncology, Experimental | Apoptosis | Cancer | Animal models | Cytokines | Liver | Hepatocellular carcinoma | Genomes | Metastasis | Risk analysis | Gene expression | Risk factors | Metastases | Hepatocytes | Morphology | DNA methylation | Tumorigenesis | Bioinformatics | Cholangiocarcinoma | Deoxyribonucleic acid--DNA | Tumors | T-Box Domain Proteins/metabolism | Hepatocytes/pathology | DNA-Binding Proteins/metabolism | Life Sciences | Cholangiocarcinoma/pathology | Transcription Factors/metabolism | Necrosis/genetics | Cytokines/metabolism | Epigenesis, Genetic/genetics | Cyclin-Dependent Kinase Inhibitor p16/deficiency | Carcinoma, Hepatocellular/pathology | DNA Transposable Elements/genetics | Cell Lineage/genetics | T-Box Domain Proteins/genetics | Transcription Factors/genetics | Apoptosis/genetics | Proto-Oncogene Proteins c-akt/genetics | Liver Neoplasms/genetics | Cholangiocarcinoma/genetics | Liver Neoplasms/pathology | DNA-Binding Proteins/genetics | Hepatocytes/metabolism | Carcinoma, Hepatocellular/genetics | Carcinogenesis/genetics
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7413, pp. 660 - 664
.... We have identified 36,303 protein-altering somatic changes that include several new recurrent mutations in the Wnt pathway gene TCF7L2, chromatin-remodelling genes such as TET2 and TET3 and receptor... 
HUMAN BREAST | SEQUENCES | WNT/BETA-CATENIN | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | ALGORITHM | MUTATIONS | RECEPTORS | LGR5 | CIRCULAR BINARY SEGMENTATION | DISCOVERY | Colonic Neoplasms - genetics | Thrombospondins - genetics | Humans | Molecular Sequence Data | Gene Expression Profiling | Wnt Proteins - metabolism | Colonic Neoplasms - metabolism | Genes, APC | Insulin-Like Growth Factor II - genetics | Base Sequence | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Genes, Neoplasm - genetics | Gene Expression Regulation, Neoplastic - genetics | Transcription Factor 7-Like 2 Protein - genetics | Intercellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | Receptor, ErbB-3 - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Gene Fusion - genetics | Exome - genetics | Dioxygenases - genetics | Sequence Analysis, RNA | Colonic Neoplasms - pathology | Polymorphism, Single Nucleotide - genetics | Care and treatment | Colon cancer | Gene mutations | Genomics | Patient outcomes | Genetic aspects | Research | Proteins | Mutation | Colon | Genes
Journal Article
Nature (London), ISSN 1476-4687, 2004, Volume 431, Issue 7010, pp. 873 - 878
.... The complex, termed hPRC1L (human Polycomb repressive complex 1-like), is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2... 
CORE | RECRUITMENT | TRANSCRIPTIONAL ACTIVATION | COMPLEX | LIGASE ACTIVITY | MULTIDISCIPLINARY SCIENCES | RAD6 | H3 LYSINE-27 METHYLATION | UBIQUITYLATION | RING FINGER PROTEINS | DROSOPHILA | Nuclear Proteins - isolation & purification | Nucleosomes - chemistry | Humans | Multiprotein Complexes | Ubiquitin - metabolism | Molecular Sequence Data | Drosophila melanogaster - genetics | Promoter Regions, Genetic - genetics | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Protein Subunits - isolation & purification | Repressor Proteins - isolation & purification | Response Elements - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - isolation & purification | Repressor Proteins - metabolism | Protein Subunits - genetics | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Catalytic Domain | Repressor Proteins - chemistry | Gene Silencing | Ubiquitin-Protein Ligases - metabolism | Nucleosomes - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Polycomb-Group Proteins | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - isolation & purification | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Animals | Polycomb Repressive Complex 1 | Transcription Factors - isolation & purification | Ubiquitin-Protein Ligases - isolation & purification | Protein Subunits - chemistry | Drosophila Proteins - genetics | HeLa Cells | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Proteins | Enzymes | Cell culture | Chromatin | Biochemistry
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2008, Volume 283, Issue 9, pp. 5496 - 5509
... (protein kinase A /PK G /PK C ) kinases. It is a tumor suppressor gene originally isolated from Drosophila and recently isolated from mice and humans... 
YES-ASSOCIATED PROTEIN | APOPTOSIS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | KINASE | HIPPO PATHWAY | CELL-PROLIFERATION | DROSOPHILA LATS | PROMOTES | HUMAN HOMOLOG | Oncogene Proteins - genetics | Phosphorylation | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Nuclear Proteins - genetics | Active Transport, Cell Nucleus - genetics | Intracellular Signaling Peptides and Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Drosophila | Oncogene Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Animals | Cell Nucleus - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Drosophila Proteins - genetics | HeLa Cells | Transcription, Genetic - genetics | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Motifs - genetics
Journal Article
Molecular cell, ISSN 1097-2765, 2005, Volume 17, Issue 3, pp. 393 - 403
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins... 
CYTOCHROME-C | COMPLEX | SURVIVAL FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | BIM | RELEASE | PEPTIDE | CELL-DEATH | FAMILY | MEMBER | CELL BIOLOGY | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | Genetic Complementation Test | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Carrier Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Peptide Fragments - genetics | Cell Survival - physiology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | bcl-X Protein | Peptide Fragments - metabolism | Membrane Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Biosensing Techniques | Ligands | Mice | Apoptosis - physiology | Proteins - chemistry | In Vitro Techniques | Proto-Oncogene Proteins c-bcl-2 - genetics
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2016, Volume 167, Issue 1, pp. 233 - 247.e17
...) enables targeted DNA methylation editing. Targeting of the dCas9-Tet1 or -Dnmt3a fusion protein to methylated or unmethylated promoter sequences caused activation or silencing, respectively, of an endogenous reporter... 
CELLS | CRISPR | DEPENDENT PHOSPHORYLATION | 3D GENOME | DEMETHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | DISEASE | TRANSCRIPTION | GENE-EXPRESSION | REGULATORY LANDSCAPE | CELL BIOLOGY | Brain-Derived Neurotrophic Factor - genetics | Endonucleases - genetics | Epigenesis, Genetic | Endonucleases - metabolism | Recombinant Fusion Proteins - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Neurons - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Promoter Regions, Genetic | Bacterial Proteins - genetics | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | MyoD Protein - metabolism | DNA-Binding Proteins - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Enhancer Elements, Genetic | CCCTC-Binding Factor | CpG Islands | Protein Binding | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Gene Editing - methods | Mice | Genome | Animal genetics | Epigenetic inheritance | Promoters (Genetics) | Methyltransferases | Genes | Genomics | DNA | Genetic research | Methylation | Gene expression | Medical research | Neurons | Medicine, Experimental
Journal Article