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Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6099, pp. 1231 - 1235
The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors... 
Exons | Neurons | Genes | REPORTS | Stem cells | Aneuploidy | Chromosomes | Cells | Tumors | Daughter cells | Cancer | ANEUPLOIDY | SELECTIVE INHIBITOR | POTENT | MULTIDISCIPLINARY SCIENCES | CANCER | RECEPTOR TYROSINE KINASE | DISCOVERY | CHROMOSOMAL INSTABILITY | FAMILY | Microtubule-Associated Proteins - chemistry | Neoplasm Transplantation | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Fetal Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Brain Neoplasms - metabolism | Oncogene Proteins, Fusion - chemistry | Spindle Apparatus - metabolism | Glioblastoma - genetics | Oncogene Fusion | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Nuclear Proteins - genetics | Chromosomal Instability | Pyrazoles - pharmacology | Protein Structure, Tertiary | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Enzyme Inhibitors - pharmacology | Brain Neoplasms - genetics | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Nuclear Proteins - chemistry | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Fetal Proteins - genetics | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Fetal Proteins - chemistry | Physiological aspects | Development and progression | Fibroblast growth factors | Genetic aspects | Research | Health aspects | Glioblastoma multiforme | Proteins | Kinases | Brain cancer | Genomics | Pharmaceutical sciences | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2007, Volume 448, Issue 7153, pp. 561 - 566
Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we... 
ANAPLASTIC LYMPHOMA KINASE | FACTOR-RECEPTOR | ALK | GEFITINIB | TRANSLOCATIONS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | COMMON | PROLIFERATION | MUTATIONS | INHIBITOR | Lung Neoplasms - drug therapy | Oncogene Proteins, Fusion - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Molecular Sequence Data | Lung Neoplasms - pathology | Chromosomes, Human, Pair 2 - genetics | Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - chemistry | Cell Transformation, Neoplastic - genetics | Serine Endopeptidases - genetics | Cell Cycle Proteins - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Amino Acid Sequence | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Cell Cycle Proteins - metabolism | Mutation - genetics | Receptor Protein-Tyrosine Kinases | Animals | Oncogene Proteins, Fusion - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Serine Endopeptidases - metabolism | Carcinoma, Non-Small-Cell Lung - drug therapy | Cell Transformation, Neoplastic - pathology | 3T3 Cells | Chromosome Inversion - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | Genetics | Molecular biology | Kinases | Lung cancer | Rodents | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 5, pp. 664 - 678
Recurrent fusions of ETS genes are considered driving mutations in a diverse array of cancers, including Ewing's sarcoma, acute myeloid leukemia, and prostate... 
TRANSCRIPTION FACTORS | ANDROGEN RECEPTOR | EWS GENE | ONCOLOGY | TMPRSS2-ERG FUSION | EWINGS-SARCOMA TRANSLOCATION | DNA-LIGASE IV | ERG | EXPRESSION | TUMORS | PROGRESSION | CELL BIOLOGY | Oncogene Proteins, Fusion - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Male | Recombinant Fusion Proteins - metabolism | Oncogene Proteins, Fusion - chemistry | Prostatic Neoplasms - genetics | Transfection | Chromatin Immunoprecipitation | RNA Interference | Time Factors | DNA-Activated Protein Kinase - metabolism | Mass Spectrometry | HEK293 Cells | Antineoplastic Agents - pharmacology | Genes, Reporter | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Catalytic Domain | Neoplasm Invasiveness | Enzyme Inhibitors - pharmacology | Models, Molecular | Gene Fusion | Tumor Burden | Mice, SCID | Chick Embryo | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Protein Conformation | Mice | Mice, Inbred BALB C | DNA Damage | Poly (ADP-Ribose) Polymerase-1 | Cell Movement | Enzymes | Sarcoma | Leukemia | DNA | Genetic aspects | Prostate cancer | Protein kinases | Cancer | Index Medicus | DNA-PKcs | PARP1 | TMPRSS2 | Prostate | Rearrangement
Journal Article
Nature Communications, ISSN 2041-1723, 01/2015, Volume 6, Issue 1, pp. 6087 - 6087
Journal Article
Blood, ISSN 0006-4971, 09/2012, Volume 120, Issue 11, pp. 2280 - 2289
Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes with 5-year overall survival rates of only similar to 35%. Improvement... 
LUNG-CANCER | OVEREXPRESSION | CANCER DEVELOPMENT | P53 PROTEIN | TRANSLOCATIONS | MUTATIONS | P63 | IDENTIFICATION | HEMATOLOGY | EXPRESSION | CARCINOMA | Oncogene Proteins, Fusion - metabolism | Transcription Factors - chemistry | Oligonucleotide Array Sequence Analysis | United States | Humans | Male | Lymphoma, Large B-Cell, Diffuse - metabolism | Oxidoreductases - chemistry | Tumor Suppressor Protein p53 - genetics | Oncogene Proteins, Fusion - chemistry | WW Domain-Containing Oxidoreductase | DNA Mutational Analysis | Lymphoma, T-Cell, Peripheral - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Repressor Proteins - metabolism | Genome-Wide Association Study | Repressor Proteins - chemistry | Tumor Suppressor Proteins - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Oxidoreductases - metabolism | Oxidoreductases - genetics | Lymphoma, T-Cell, Peripheral - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Repressor Proteins - genetics | Mutant Proteins - metabolism | Transcription Factors - genetics | Sequence Homology, Nucleic Acid | Lymphoma, Large B-Cell, Diffuse - mortality | Transcription Factors - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - chemistry | Oncogene Proteins, Fusion - genetics | Gene Rearrangement | Lymphoma, T-Cell, Peripheral - pathology | Mutant Proteins - chemistry | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Tumor Suppressor Protein p53 - chemistry | Mutation | Lymphoma, Large B-Cell, Diffuse - genetics | Lymphoma, T-Cell, Peripheral - mortality | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Nature, ISSN 0028-0836, 06/2009, Volume 459, Issue 7248, pp. 847 - 851
Histone H3 lysine 4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities.... 
PROTEIN STRUCTURES | GENE REPRESSION | METHYLATION | NMR | DEVELOPMENTAL REGULATORS | HISTONE H3 | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | PLANT HOMEODOMAIN | DIFFERENTIATION | LYSINE-4 TRIMETHYLATION | Chromatin - metabolism | Oncogene Proteins, Fusion - metabolism | Histones - chemistry | Epigenesis, Genetic | Humans | Nuclear Pore Complex Proteins - chemistry | Hematopoietic Stem Cells - pathology | Hematologic Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Genes, Homeobox - genetics | Nuclear Pore Complex Proteins - genetics | Oncogene Proteins, Fusion - chemistry | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Transcription, Genetic | Lysine - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Hematologic Neoplasms - metabolism | Tumor Suppressor Proteins - metabolism | Magnetic Resonance Spectroscopy | Nuclear Pore Complex Proteins - metabolism | Cells, Cultured | Models, Molecular | Hematopoiesis - genetics | Hematopoietic Stem Cells - metabolism | Amino Acid Motifs - physiology | Animals | Cell Transformation, Neoplastic | Intracellular Signaling Peptides and Proteins - chemistry | Oncogene Proteins, Fusion - genetics | Protein Binding | Protein Conformation | Hematologic Neoplasms - genetics | Mice | Retinoblastoma-Binding Protein 2 | Histones - metabolism | Amino Acid Motifs - genetics | Methylation | Leukemia | Genetic aspects | Research | DNA binding proteins | Gene expression | Health aspects | Risk factors | Chromatin | Binding sites | Index Medicus
Journal Article
Nanoscale, ISSN 2040-3364, 09/2018, Volume 10, Issue 36, pp. 17227 - 17235
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