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Nature cell biology, ISSN 1476-4679, 02/2010, Volume 12, Issue 3, pp. 247 - 256
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Protein Binding - genetics | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Cadherins - metabolism | Gene Expression - genetics | Humans | 3' Untranslated Regions - genetics | Vascular Endothelial Growth Factor A - genetics | N-Myc Proto-Oncogene Protein | Cadherins - genetics | Oncogene Proteins - metabolism | Vascular Endothelial Growth Factor A - blood | Epithelial Cells - pathology | DNA - metabolism | Neuroblastoma - diagnosis | beta Catenin - metabolism | Down-Regulation - genetics | Cell Line, Tumor | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | Neovascularization, Pathologic - metabolism | Neuroblastoma - metabolism | Proto-Oncogene Proteins c-myc - genetics | Histones - metabolism | MicroRNAs - physiology | Neoplasms - metabolism | Epithelial Cells - metabolism | Vimentin - metabolism | Lung Neoplasms - pathology | Breast Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Neoplasms - blood | Transfection | Lung Neoplasms - secondary | Neoplasm Invasiveness - pathology | Female | Nuclear Proteins - genetics | Gene Expression Regulation, Neoplastic - physiology | Neuroblastoma - pathology | Cell Line | Neuroblastoma - genetics | Nuclear Proteins - metabolism | Gene Dosage | Mice, SCID | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - genetics | Neoplasm Metastasis - genetics | Animals | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Signal Transduction - physiology | Transplantation, Heterologous - pathology | Neoplasm Invasiveness - genetics | Neoplasms - pathology | MicroRNA | Physiological aspects | Cadherins | Development and progression | Genetic aspects | Metastasis | Research | Oncogenes | Index Medicus
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 02/2010, Volume 464, Issue 7287, pp. 427 - 430
.... Here we demonstrate the mechanistic basis for these findings. We used chemical genetic methods to show that drug-mediated transactivation of RAF dimers is responsible for paradoxical activation of the enzyme by inhibitors... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
PLoS pathogens, ISSN 1553-7366, 2016, Volume 12, Issue 1, pp. e1005366 - e1005366
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 07/2011, Volume 108, Issue 36, pp. 14902 - 14907
Epstein-Barr virus nuclear antigen 2 (EBNA2) regulation of transcription through the cell transcription factor RBPJ is essential for resting B-lymphocyte (RBL)... 
T lymphocytes | Up regulation | Chromatin | B lymphocytes | DNA | Nucleosomes | Gene expression regulation | Epstein Barr virus infections | Human herpesvirus 4 | Binding sites | Development | Lymphoma | Leukemia | Notch | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Proliferation | Herpesvirus 4, Human - genetics | Proto-Oncogene Proteins c-ets - genetics | Genome, Viral - genetics | Humans | Transcription Factor RelA - genetics | Viral Proteins - metabolism | Trans-Activators - genetics | B-Lymphocytes - virology | Epstein-Barr Virus Infections - genetics | Core Binding Factor alpha Subunits - metabolism | Transcription, Genetic | Proto-Oncogene Proteins c-ets - metabolism | Epstein-Barr Virus Nuclear Antigens - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | B-Lymphocytes - metabolism | Proto-Oncogene Proteins - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Epstein-Barr Virus Nuclear Antigens - genetics | Response Elements | Nucleosomes - metabolism | Viral Proteins - genetics | Nucleosomes - genetics | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Core Binding Factor alpha Subunits - genetics | Transcription Factor RelA - metabolism | Cell Line, Tumor | Trans-Activators - metabolism | Proto-Oncogene Proteins c-myc - genetics | Herpesvirus 4, Human - metabolism | Epstein-Barr Virus Infections - metabolism | Physiological aspects | Transcription factors | Epstein-Barr virus | Genetic aspects | Lymphocytes | Health aspects | Index Medicus | ETS protein | Lymphoblasts | Introns | Data processing | Genomes | Myc protein | Promoters | Early B-cell factor | Infection | Enhancers | PU.1 protein | Lymphocytes B | Fluorescence in situ hybridization | RelA protein | Conformation | Biological Sciences | leukemia | development | lymphoma
Journal Article
Journal of virology, ISSN 1098-5514, 09/2012, Volume 86, Issue 18, pp. 9875 - 9887
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 4, pp. e19084 - e19084
... terminal repeat (5'LTR) and leader region, by trans-acting factors including the viral transactivating Tat protein and cellular transcription factors that are either... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | tat Gene Products, Human Immunodeficiency Virus | Tetradecanoylphorbol Acetate - pharmacology | Virus Replication - genetics | Humans | Molecular Sequence Data | Genes, pol - genetics | RNA Polymerase II - metabolism | Transcription Factor AP-1 - metabolism | T-Lymphocytes - virology | Point Mutation - genetics | HIV-1 - physiology | Macrophages - virology | T-Lymphocytes - drug effects | Base Sequence | Protein Binding - drug effects | Binding Sites | Jurkat Cells | Proto-Oncogene Proteins c-fos - metabolism | HIV-1 - genetics | Regulatory Sequences, Nucleic Acid - genetics | Monocytes - drug effects | Monocytes - virology | Proto-Oncogene Proteins c-jun - metabolism | Macrophages - drug effects | Enhancer Elements, Genetic - genetics | Genes, Dominant - genetics | RNA | Analysis | Genes | Genomics | Genomes | HIV (Viruses) | Health aspects | Transcription factors | Transcription | Laboratories | Leukemia | Herpes simplex | Viruses | Infections | Thymidine | Pasteur, Louis (1822-95) | Kinases | Macrophages | DNA-directed RNA polymerase | Recruitment | Fragmentation | Proteins | Human papillomavirus | Fos protein | Infectivity | Human immunodeficiency virus--HIV | Pol gene | c-Fos protein | Thymidine kinase | Deoxyribonuclease | Gene expression | Ribonucleic acid--RNA | JunB protein | Virology | Monocytes | Replication | Mutation | Acetic acid | Phorbol 12-myristate 13-acetate | Binding sites | RNA polymerase II | Cervical cancer | Index Medicus | Life Sciences | Cellular Biology | Ribonucleic acid | HIV | Human immunodeficiency virus
Journal Article