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Oncogene, ISSN 0950-9232, 1987
Journal
1994, 1, ISBN 0849345731, 310
This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several... 
Jun oncogenes | Fos oncogenes | Transcription factors | Biochemistry
Book
Oncogene research, ISSN 0890-6487, 1987
Journal
British journal of clinical pharmacology, ISSN 0306-5251, 2016, Volume 82, Issue 4, pp. 943 - 956
Journal Article
Critical reviews in oncogenesis, ISSN 0893-9675, 1989
Journal
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2013, Volume 188, Issue 7, pp. 770 - 775
The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR... 
Molecular targeted therapy | Lung cancer | Cancer genomics | RET | GEFITINIB | EML4-ALK FUSION GENE | KINASE INHIBITOR | ALK INHIBITOR | SOMATIC MUTATIONS | EGFR | CHEMOTHERAPY | lung cancer | PHASE-II TRIAL | RESPIRATORY SYSTEM | CRIZOTINIB | cancer genomics | molecular targeted therapy | CRITICAL CARE MEDICINE | Lung Neoplasms - drug therapy | Oncogene Proteins - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma of Lung | Receptor, ErbB-2 - genetics | Genomics | Humans | ErbB Receptors - genetics | Antineoplastic Agents - therapeutic use | ErbB Receptors - therapeutic use | Anaplastic Lymphoma Kinase | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adenocarcinoma - genetics | ras Proteins - drug effects | Receptor, ErbB-2 - drug effects | Molecular Targeted Therapy - methods | Lung Neoplasms - genetics | Proto-Oncogene Proteins - drug effects | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - drug effects | Proto-Oncogene Proteins - genetics | Mutation - genetics | Adenocarcinoma - drug therapy | Oncogene Proteins - drug effects | Proto-Oncogene Proteins c-met - genetics | Mutation - drug effects | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - drug effects | Proto-Oncogene Proteins B-raf - genetics | Receptor Protein-Tyrosine Kinases - therapeutic use | Proto-Oncogene Proteins c-ret - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Proto-Oncogene Proteins c-ret - genetics | Pulmonary
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2009, Volume 101, Issue 19, pp. 1308 - 1324
The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth factor receptor (EGFR) have expanded the range of treatment options for... 
CELL LUNG-CANCER | PHASE-III TRIAL | TYROSINE KINASE INHIBITORS | COLON-CANCER | KRAS MUTATIONS | K-RAS MUTATIONS | PROGRESSION-FREE-SURVIVAL | ONCOLOGY | CETUXIMAB PLUS IRINOTECAN | IN-SITU HYBRIDIZATION | GENE COPY NUMBER | PTEN Phosphohydrolase - drug effects | Predictive Value of Tests | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Antibodies, Monoclonal - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Colorectal Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - drug effects | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Cetuximab | Odds Ratio | PTEN Phosphohydrolase - genetics | Proto-Oncogene Proteins - drug effects | Antibodies, Monoclonal - pharmacology | Proto-Oncogene Proteins - genetics | Randomized Controlled Trials as Topic | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Proto-Oncogene Proteins p21(ras) - drug effects | Animals | Class I Phosphatidylinositol 3-Kinases | Mutation - drug effects | Proto-Oncogene Proteins B-raf - drug effects | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Colorectal Neoplasms - pathology | Neoplasm Staging | Research Design | Usage | Care and treatment | Prognosis | Gene mutations | Colorectal cancer | Monoclonal antibodies | Development and progression | Genetic aspects | Research | Biological markers | Health aspects | Review
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 468, Issue 7326, pp. 968 - 972
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas(1). Pre-clinical studies have... 
TRANSFORMATION | CELLS | ACTIVATION | TUMOR PROGRESSION | GENE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | BRAF | MUTATIONS | CANCER | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer
Journal Article
Molecular cell, ISSN 1097-2765, 2015, Volume 58, Issue 6, pp. 1028 - 1039
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well... 
SELECTIVE-INHIBITION | RECRUITMENT | C/EBP-ALPHA | CREB-BINDING PROTEIN | CHROMATIN | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | C-MYC | P-TEFB | BRD4 | CELL BIOLOGY | Transcriptional Regulator ERG | NIH 3T3 Cells | Oncogene Proteins - genetics | Humans | Leukemia, Myeloid - genetics | Proto-Oncogene Proteins c-myb - genetics | Gene Expression Profiling | Leukemia, Myeloid - pathology | RNA Interference | Proto-Oncogene Protein c-fli-1 - metabolism | Protein Binding - drug effects | Trans-Activators - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Acute Disease | Proto-Oncogene Protein c-fli-1 - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Proto-Oncogene Proteins c-myb - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Acetylation - drug effects | Animals | Hematopoietic System - metabolism | Leukemia, Myeloid - metabolism | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Trans-Activators - metabolism | Mice | Histones - metabolism | DNA binding proteins | Medicine, Experimental | Medical research | Chromatin | Lysine
Journal Article
Lung Cancer, ISSN 0169-5002, 2014, Volume 86, Issue 3, pp. 324 - 328
Highlights • We investigated the presence of mutations in a panel of 6 genes in 113 SCLCs. • We could identify only 7 mutations, 2 in EGFR and 5 in c-MET gene.... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | SCLC | PDGFRa | Gene mutations | c-KIT | c-MET | BRAF | KRAS | EGFR | C-MET | C-KIT | GEFITINIB | EGFR MUTATION | TRIAL | ONCOLOGY | RESPIRATORY SYSTEM | FACTOR RECEPTOR MUTATIONS | JAPANESE | CARCINOMA | EXPRESSION | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins c-met - biosynthesis | Proto-Oncogene Proteins p21(ras) | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Molecular Targeted Therapy | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-kit - biosynthesis | Receptor, Platelet-Derived Growth Factor beta - genetics | Small Cell Lung Carcinoma - drug therapy | ras Proteins - biosynthesis | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Receptor, Epidermal Growth Factor - biosynthesis | Proto-Oncogene Proteins - genetics | Small Cell Lung Carcinoma - genetics | Proto-Oncogene Proteins c-met - genetics | Disease-Free Survival | Small Cell Lung Carcinoma - pathology | Proto-Oncogene Proteins B-raf - biosynthesis | Proto-Oncogene Proteins B-raf - genetics | Aged | Mutation | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Lung cancer | Genes | Genetic research | Genetic aspects | Diagnosis | Cervical cancer | Cancer
Journal Article
1988, Research in., ISBN 0861961617, 271
Book
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 6, pp. 9251 - 9266