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Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2016, Volume 311, Issue 5, pp. E836 - E849
...; its dysregulation may provoke apoptosis and lead to muscle atrophy. We investigated the acute effects of alcohol ingestion on autophagic cell signaling responses to a bout of concurrent... 
Alcohol | Exercise | Autophagy | Protein | Apoptosis | alcohol | ACTIVATION | PHYSIOLOGY | autophagy | MITOCHONDRIAL BIOGENESIS | INCREASES | exercise | apoptosis | HUMAN SKELETAL-MUSCLE | MTOR | CELL-DEATH | DIRECT PHOSPHORYLATION | P53 | MESSENGER-RNA | RESISTANCE EXERCISE | protein | ENDOCRINOLOGY & METABOLISM | Molecular Chaperones - metabolism | Apoptosis - drug effects | Humans | Male | Autophagy - physiology | Alcohol Drinking | Carrier Proteins - drug effects | Autophagy - drug effects | Electron Transport Complex IV - metabolism | Transcription Factors - drug effects | Central Nervous System Depressants - pharmacology | Mitochondrial Proteins - drug effects | Young Adult | Organelle Biogenesis | Mitochondrial Proteins - metabolism | Dietary Proteins - pharmacology | Nuclear Respiratory Factor 1 - metabolism | Mitochondrial Proton-Translocating ATPases - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - drug effects | Voltage-Dependent Anion Channel 1 - drug effects | Mitochondrial Degradation - physiology | Mitochondrial Proton-Translocating ATPases - metabolism | Cross-Over Studies | Signal Transduction - drug effects | Mitochondrial Degradation - drug effects | Adolescent | Electron Transport Complex IV - drug effects | Membrane Proteins - drug effects | Exercise - physiology | RNA-Binding Proteins - metabolism | Protein Kinases - metabolism | Muscle Fibers, Skeletal - drug effects | Healthy Volunteers | DNA-Binding Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Adult | Molecular Chaperones - drug effects | Membrane Proteins - metabolism | DNA Fragmentation - drug effects | Muscle Fibers, Skeletal - physiology | Proto-Oncogene Proteins - metabolism | Protein Kinases - drug effects | Proto-Oncogene Proteins - drug effects | Dietary Carbohydrates - pharmacology | DNA-Binding Proteins - drug effects | Tumor Suppressor Protein p53 - metabolism | Voltage-Dependent Anion Channel 1 - metabolism | Tumor Suppressor Protein p53 - drug effects | Nuclear Respiratory Factor 1 - drug effects | RNA-Binding Proteins - drug effects | Transcription Factors - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - drug effects | Ethanol - pharmacology | Carrier Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Apoptosis - physiology | Autophagy (Cytology) | Cell research | Alcoholic beverages | Physiological aspects | Cellular signal transduction | Research
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Anaplastic Lymphoma Kinase | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | ErbB Receptors - antagonists & inhibitors | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies
Journal Article
Nature (London), ISSN 0028-0836, 04/2014, Volume 508, Issue 7494, pp. 118 - 22
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably... 
Antineoplastic Agents/administration & dosage | Transforming Growth Factor beta/metabolism | Humans | Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors | Indoles/administration & dosage | Flow Cytometry | Receptor, Platelet-Derived Growth Factor beta/biosynthesis | Proto-Oncogene Proteins B-raf/antagonists & inhibitors | ErbB Receptors/biosynthesis | Melanoma/drug therapy | Female | Cell Proliferation/drug effects | Sulfonamides/administration & dosage | Gene Library | Cellular Senescence/drug effects | Receptor Protein-Tyrosine Kinases/biosynthesis | Drug Resistance, Neoplasm/drug effects | Gene Expression Regulation, Neoplastic/drug effects | SOXE Transcription Factors/deficiency | Signal Transduction/drug effects | Protein Kinase Inhibitors/administration & dosage | Vemurafenib | Animals | Mice | RNA, Small Interfering | GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 09/2016, Volume 5, Issue 9, p. n/a
...‐density lipoprotein (oxLDL) promotes immune activation and inflammation. We studied the effects of statins... 
atherosclerosis | dendritic cells | statin | immune system | microRNA | oxidized low‐density lipoprotein | T cells | MicroRNA | Dendritic cells | Oxidized low-density lipoprotein | Atherosclerosis | Statin | Immune system | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | INDUCTION | CANCER | ARTERIOSCLEROSIS | HEAT-SHOCK-PROTEIN | THERAPY | INHIBITION | INFLAMMATION | oxidized low-density lipoprotein | ASSOCIATION | LYMPHOCYTES | Interleukin-1beta - drug effects | Extracellular Signal-Regulated MAP Kinases - drug effects | Atorvastatin Calcium - pharmacology | Dendritic Cells - immunology | Humans | Interferon-gamma - drug effects | Interleukin-17 - immunology | Chaperonin 60 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Simvastatin - pharmacology | Th1 Cells - immunology | Mitochondrial Proteins - drug effects | Endarterectomy, Carotid | Lymphocyte Activation - immunology | Th17 Cells - drug effects | HSP90 Heat-Shock Proteins - immunology | T-Lymphocytes - drug effects | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Tumor Necrosis Factor-alpha - immunology | Dendritic Cells - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | T-Box Domain Proteins - drug effects | Th1 Cells - drug effects | HSP90 Heat-Shock Proteins - drug effects | Interleukin-1beta - immunology | Lipoproteins, LDL - pharmacology | HSP27 Heat-Shock Proteins - immunology | Plaque, Atherosclerotic - immunology | MicroRNAs - immunology | Reverse Transcriptase Polymerase Chain Reaction | HSP27 Heat-Shock Proteins - drug effects | T-Box Domain Proteins - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - drug effects | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-6 - immunology | MicroRNAs - drug effects | Th17 Cells - immunology | T-Lymphocytes - immunology | Chaperonin 60 - drug effects | Mitochondrial Proteins - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - drug effects | Proto-Oncogene Proteins c-akt - drug effects
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7658, pp. 431 - 435
Therapies that target signalling molecules that are mutated in cancers can often have substantial short-term effects, but the emergence of resistant cancer cells is a major barrier to full cures(1,2... 
METASTATIC MELANOMA | BRAF INHIBITOR | SUBPOPULATIONS | CHROMATIN | MULTIDISCIPLINARY SCIENCES | SINGLE MAMMALIAN-CELLS | STATE | MECHANISMS | MUTATIONS | VEMURAFENIB | PLASTICITY | Transcription, Genetic - drug effects | Humans | Male | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Single-Cell Analysis | Cellular Reprogramming - genetics | ErbB Receptors - metabolism | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Signal Transduction - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Cellular Reprogramming - drug effects | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Genetic Markers - drug effects | Vemurafenib | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Genetic Markers - genetics | Cell Line, Tumor | Oncogene Protein p65(gag-jun) - metabolism | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Antimitotic agents | Cell interaction | Dosage and administration | Antineoplastic agents | Drug resistance | Observations | Health aspects | Subpopulations | Transcription factors | Substance abuse treatment | Variability | Activator protein 1 | Melanoma | Genomes | Kinases | Gene expression | Sox10 protein | Signal transduction | Signaling | Converting | Population | Mutation | Differentiation | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Autophagy, ISSN 1554-8627, 05/2012, Volume 8, Issue 5, pp. 812 - 825
.... Furthermore, our results revealed that curcumin causes some novel cellular mechanisms that promote autophagy as a protective effect... 
autophagy | endothelial cell | FOXO1 | oxidative stress | curcumin | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Oxidative stress | Endothelial cell | Curcumin | Autophagy | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Protein Transport - drug effects | Autophagy - drug effects | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Forkhead Transcription Factors - metabolism | Protective Agents - pharmacology | Protein Binding - drug effects | Cytoprotection - drug effects | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Beclin-1 | Hydrogen Peroxide - toxicity | rab GTP-Binding Proteins - metabolism | Cell Survival - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Curcumin - pharmacology | Down-Regulation - drug effects | Ubiquitin-Activating Enzymes - metabolism | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Acetylation - drug effects | Autophagy-Related Protein 7 | Human Umbilical Vein Endothelial Cells - enzymology | Signal Transduction - drug effects | Models, Biological | Human Umbilical Vein Endothelial Cells - pathology | Forkhead Box Protein O1 | Oxidative Stress - drug effects | Cell Nucleus - drug effects | CELL BIOLOGY
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1064 - 1079
It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation. The... 
mTOR | translation | sensitivity | PI3K | therapy | resistance | TUMOR-SUPPRESSOR CANDIDATE | PROTEIN-KINASE | INITIATION-FACTOR 4E | ACUTE MYELOID-LEUKEMIA | GROWTH-FACTOR RECEPTOR | BONE-MARROW MICROENVIRONMENT | ONCOLOGY | AKT/PROTEIN-KINASE-B | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | CHRONIC LYMPHOCYTIC-LEUKEMIA | HEMATOLOGY | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | PTEN Phosphohydrolase - physiology | Apoptosis - genetics | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Gene Expression Regulation, Leukemic - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Transcription Factors - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | PTEN Phosphohydrolase - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Protein Processing, Post-Translational - drug effects | Drug Design | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Leukemia - genetics | Multiprotein Complexes - drug effects | PTEN Phosphohydrolase - genetics | Proteins - physiology | Transcription Factors - physiology | RNA, Messenger - genetics | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - physiology | Multiprotein Complexes - physiology | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Pseudogenes | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Proteins - drug effects | RNA, Neoplasm - genetics | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Genes | Leukemia | Physiological aspects | Development and progression | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects
Journal Article