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oncotic necrosis (45) 45
animals (33) 33
apoptosis (33) 33
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injury (8) 8
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analgesics, non-narcotic - toxicity (7) 7
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chemical and drug induced liver injury - pathology (7) 7
cholestasis (7) 7
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injuries (7) 7
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aged (4) 4
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Journal Article
Hepatology Research, ISSN 1386-6346, 06/2010, Volume 40, Issue 6, pp. 605 - 612
Aim:  The significance of cytokelatin‐18 fragment cleaved by caspase‐3 (CK‐18‐fr) and high mobility group box‐1 (HMGB‐1) were evaluated experimentally and... 
apoptosis | cytokelatin ‐18 | oncotic necrosis | HMGB‐1 | Oncotic necrosis | Cytokelatin -18 | Apoptosis | HMGB-1 | FULMINANT-HEPATITIS | FAILURE | cytokelatin-18 | PREDICTION | ENCEPHALOPATHY | CLINICAL EPIDEMIOLOGY | JAPAN | COAGULATION | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | SEVERITY
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2013, Volume 273, Issue 3, pp. 524 - 531
. While the predominant hypothesis in cholestatic liver injury remains hepatocyte apoptosis due to direct toxicity of hydrophobic bile acid exposure, recent... 
microRNA-122 | Biomarkers | High mobility group box-1 | Bile duct ligation | Cytokeratin-18 | Apoptosis | MicroRNA-122 | RAT HEPATOCYTES | PARENCHYMAL-CELL APOPTOSIS | ACID-INDUCED APOPTOSIS | DEATH | ACETAMINOPHEN HEPATOTOXICITY | HEPATIC ISCHEMIA-REPERFUSION | BILE-DUCT LIGATION | CHROMATIN PROTEIN HMGB1 | ONCOTIC NECROSIS | MOUSE MODEL | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Inflammation - pathology | Liver - pathology | Liver Diseases - pathology | Hepatocytes - pathology | Alanine Transaminase - blood | Necrosis - pathology | Caspase 3 - blood | Ligation | Keratin-18 - blood | Neutrophils - pathology | Liver Diseases - blood | Galactosamine - adverse effects | Liver - metabolism | Mice, Inbred C57BL | Bile Acids and Salts - metabolism | Necrosis - blood | Bile Ducts - surgery | Biomarkers - blood | Bile Acids and Salts - adverse effects | Cholestasis - blood | Cholestasis - pathology | Animals | Mice | MicroRNAs - blood | HMGB1 Protein - blood | Keratin | Jaundice, Obstructive | Chromosomal proteins | Liver | Inflammation | Biological markers | Liver cirrhosis | Cholestasis | Index Medicus | APOPTOSIS | INJURIES | MACROPHAGES | MONOCYTES | BILIARY TRACT | TOXICITY | 60 APPLIED LIFE SCIENCES | NECROSIS | ALANINES | BIOLOGICAL MARKERS | INFLAMMATION | LIVER | MICE | BILE ACIDS | necrosis | cholestasis | biomarkers | apoptosis | cytokeratin-18 | high mobility group box-1
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 02/2007, Volume 292, Issue 2, pp. 639 - 646
Cholestasis, an impairment of bile outflux, frequently occurs in liver diseases. In this process, an overaccumulation of bile acids causes hepatocyte necrosis... 
Regeneration | Cholestasis | Apoptosis | Necrosis | ISCHEMIA/REPERFUSION INJURY | PHYSIOLOGY | DUCT-LIGATED RAT | regeneration | apoptosis | INDUCED LIVER-INJURY | cholestasis | necrosis | ONCOTIC NECROSIS | FAS | DELETED FORM | MICE | GASTROENTEROLOGY & HEPATOLOGY | BILIARY ATRESIA | Proto-Oncogene Proteins c-met - metabolism | Liver - pathology | Apoptosis - drug effects | Gene Expression - genetics | Hepatitis, Animal - prevention & control | Caspase 3 - metabolism | Hepatocytes - pathology | Alanine Transaminase - blood | Hepatocytes - metabolism | Cholestasis, Extrahepatic - complications | Hepatocyte Growth Factor - pharmacology | Hepatitis, Animal - metabolism | Liver - drug effects | Hepatitis, Animal - etiology | Hepatocyte Growth Factor - genetics | Female | Phosphorylation - drug effects | Hepatocytes - drug effects | Disease Models, Animal | Cholestasis, Extrahepatic - prevention & control | Hepatocyte Growth Factor - immunology | Liver - metabolism | Recombinant Proteins - pharmacology | Mice, Inbred ICR | Necrosis - prevention & control | Proto-Oncogene Proteins c-met - genetics | Antibodies - pharmacology | Bilirubin - blood | Intercellular Adhesion Molecule-1 - metabolism | Animals | Transaminases - blood | Mice | Cholestasis, Extrahepatic - metabolism | bcl-X Protein - metabolism | Liver Regeneration - drug effects
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 03/2015, Volume 283, Issue 3, pp. 168 - 177
Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition between humans and rodents is... 
Biomarkers | Inflammation | Bile acids | HMGB1 | Primary human hepatocytes | Obstructive cholestasis | RAT HEPATOCYTES | ACETAMINOPHEN HEPATOTOXICITY | INDUCED LIVER-INJURY | CELL-DEATH | DUCT-LIGATED MICE | RECEPTOR TGR5 | URSODEOXYCHOLIC ACID | ONCOTIC NECROSIS | PRIMARY BILIARY-CIRRHOSIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PRIMARY SCLEROSING CHOLANGITIS | Bile Acids and Salts - blood | Species Specificity | Bile Acids and Salts - toxicity | Humans | Mice, Inbred C57BL | Cells, Cultured | Hepatocytes - pathology | Biomarkers - blood | Hepatocytes - metabolism | Jaundice, Obstructive - pathology | Necrosis | Dose-Response Relationship, Drug | Animals | Cholestasis, Extrahepatic - blood | Jaundice, Obstructive - blood | Glycochenodeoxycholic Acid - toxicity | Acetylation | Primary Cell Culture | Keratin-18 - blood | Cholestasis, Extrahepatic - pathology | HMGB1 Protein - blood | Hepatocytes - drug effects | Keratin | Care and treatment | Jaundice, Obstructive | Analysis | Cholestasis | Deoxycholic acid | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | GLYCINE | PATIENTS | INJURIES | RODENTS | BILIARY TRACT | TOXICITY | LEVELS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | POLYPEPTIDES | NECROSIS | CHOLIC ACID | INFLAMMATION | LIVER | LIVER CELLS | AMINOTRANSFERASES | BILE | bile acids | primary human hepatocytes | inflammation | biomarkers | obstructive cholestasis | apoptosis
Journal Article
Journal Article
Journal Article
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, ISSN 0277-2116, 07/2006, Volume 43, pp. S4 - S9
Journal Article
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