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Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2008, Volume 28, Issue 46, pp. 12107 - 12119
Recent studies in adult and weanling rats show that dietary fat, in close association with circulating lipids, can stimulate expression of hypothalamic... 
Lipids | Maternal high-fat diet | Hypothalamus | Food intake | Orexigenic peptides | Neurogenesis | orexigenic peptides | lipids | EMBRYONIC-DEVELOPMENT | LEPTIN RECEPTOR ISOFORMS | CELL GENERATION | DOPAMINERGIC-NEURONS | DIABETIC MOTHER RATS | NEUROSCIENCES | NEUROPEPTIDE-Y | CIRCULATING TRIGLYCERIDES | PARAVENTRICULAR NUCLEUS | MESSENGER-RNA | maternal high-fat diet | neurogenesis | hypothalamus | food intake | Dietary Fats - metabolism | Hypothalamus - secretion | Opioid Peptides - secretion | Cell Proliferation | Fetal Nutrition Disorders - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Galanin - secretion | Melanins - metabolism | Galanin - metabolism | Melanins - secretion | Pituitary Hormones - metabolism | Female | Intracellular Signaling Peptides and Proteins - secretion | Obesity - etiology | Neurons - metabolism | Neuropeptides - secretion | Animals, Newborn | Dietary Fats - adverse effects | Hyperphagia - etiology | Orexins | Pituitary Hormones - secretion | Rats | Neuropeptides - metabolism | Obesity - physiopathology | Prenatal Exposure Delayed Effects - physiopathology | Hyperphagia - metabolism | Hypothalamus - physiopathology | Opioid Peptides - metabolism | Rats, Sprague-Dawley | Prenatal Exposure Delayed Effects - metabolism | Obesity - metabolism | Pregnancy | Hypothalamic Hormones - secretion | Animals | Hypothalamus - metabolism | Hypothalamic Hormones - metabolism | Neurogenesis - physiology | Hyperphagia - physiopathology | Appetite Regulation - physiology | Body Weight - physiology | Fetal Nutrition Disorders - physiopathology | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1513 - 1530
Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE-RELATED PEPTIDE | INTRATHECAL MORPHINE | SYNAPTIC-TRANSMISSION | GPBAR1 TGR5 | LEUCINE-ENKEPHALIN | SPINAL-CORD | SUBSTANCE-P | CEREBROSPINAL-FLUID | SENSORY NEURONS | RAT MODEL | Spinal Cord - secretion | Bile Acids and Salts - pharmacology | Opioid Peptides - physiology | Spinal Cord - metabolism | Cholestasis - complications | Cholestasis - metabolism | Receptors, G-Protein-Coupled - metabolism | Capsaicin - pharmacology | Male | Receptors, G-Protein-Coupled - agonists | Pain - metabolism | Action Potentials | Pain Perception - drug effects | Gastrin-Releasing Peptide - secretion | Pain - etiology | Female | Pruritus - etiology | Neurons - metabolism | Neurons - drug effects | Single-Cell Analysis | Enkephalin, Leucine - secretion | Receptors, G-Protein-Coupled - physiology | Gene Expression | Mice, Inbred C57BL | Cells, Cultured | Rats | Bile Acids and Salts - metabolism | Organ Specificity | Opioid Peptides - metabolism | Rats, Sprague-Dawley | Ganglia, Spinal - secretion | Mice, Knockout | Macrophages - metabolism | Patch-Clamp Techniques | Pruritus - metabolism | Animals | Ganglia, Spinal - pathology | Dermis - pathology | Mice | Receptors, G-Protein-Coupled - genetics | Bile Acids and Salts - physiology | Ganglia, Spinal - drug effects | Ganglia, Spinal - metabolism | Complications and side effects | Jaundice, Obstructive | Bile acids | Pain | Development and progression | Pruritus | Health aspects | Cholestasis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 10/2010, Volume 151, Issue 10, pp. 4756 - 4764
Maternal obesity during pregnancy increases the risk of obesity in the offspring. Obesity, arising from an imbalance of energy intake and expenditure, can be... 
OBESITY | DNA METHYLATION | EARLY-LIFE | APPETITE REGULATORS | PROTEIN RESTRICTION | EPIGENETIC CONTROL | RAT | ENDOCRINOLOGY & METABOLISM | FOOD-STIMULI | RECEPTOR GENE | NUCLEUS-ACCUMBENS | Dopamine Plasma Membrane Transport Proteins - metabolism | Receptors, Opioid - genetics | Gene Expression - drug effects | Food Preferences - physiology | Dopamine - genetics | Energy Intake - genetics | Male | Maternal-Fetal Exchange - genetics | Dietary Fats - pharmacology | Opioid Peptides - genetics | Female | Mice, Inbred DBA | Maternal-Fetal Exchange - drug effects | Dopamine - metabolism | Maternal Nutritional Physiological Phenomena - physiology | Receptors, Opioid - metabolism | Animals, Newborn | Mice, Inbred C57BL | Dopamine Plasma Membrane Transport Proteins - genetics | Opioid Peptides - metabolism | Maternal Nutritional Physiological Phenomena - drug effects | Pregnancy | Animals | Hypothalamus - metabolism | Mice | Reward | DNA Methylation - drug effects | Index Medicus | Abridged Index Medicus | Brain | Animal models | Lactation | Sucrose | Opioid receptors (type mu) | epigenetics | High fat diet | Opioids | DNA methylation | Reinforcement | Dopamine transporter | Sugar | Food | Energy intake | Ventral tegmentum | Cortex (prefrontal) | Obesity | Preproenkephalin | Data processing | Gene expression | Promoters | Nucleus accumbens | Polymerase chain reaction | Progeny | Food preferences | Long-term effects
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2015, Volume 172, Issue 2, pp. 571 - 582
Background and PurposeSingle-prolonged stress (SPS), a rat model of post-traumatic stress disorder (PTSD), also induces long-lasting hyperalgesia associated... 
PTSD | allodynia | rey test | single‐prolonged stress | pain sensitivity | von | hypocortisolism | JTC | nociceptin/orphanin | peptide receptor | 801 | elevated plus maze | nociceptin/orphanin FQ | single-prolonged stress | von Frey test | nociceptin/orphanin FQ peptide receptor | JTC-801 | nociceptin | PROTEIN | orphanin FQ | NEUROPATHIC-PAIN | CEREBROSPINAL-FLUID | NERVE INJURY | ORL1 | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | orphanin FQ peptide receptor | PHARMACOLOGICAL EVALUATION | BRAIN | AGONIST | Receptors, Opioid - genetics | Amygdala - drug effects | Stress Disorders, Post-Traumatic - metabolism | Opioid Peptides - cerebrospinal fluid | Periaqueductal Gray - drug effects | Male | Anxiety - drug therapy | Hippocampus - drug effects | Pain - metabolism | Benzamides - therapeutic use | Pain - drug therapy | Stress Disorders, Post-Traumatic - drug therapy | Benzamides - pharmacology | Aminoquinolines - pharmacology | Anxiety - metabolism | Disease Models, Animal | Receptors, Opioid - metabolism | Hyperalgesia - metabolism | Amygdala - metabolism | Hot Temperature | Opioid Peptides - metabolism | Rats, Sprague-Dawley | Periaqueductal Gray - metabolism | Hippocampus - metabolism | Animals | Hyperalgesia - drug therapy | Narcotic Antagonists - therapeutic use | Narcotic Antagonists - pharmacology | Opioid Peptides - blood | Aminoquinolines - therapeutic use | Polyvinylidene fluoride | Peptides | RNA | Gene expression | Post-traumatic stress disorder | Post traumatic stress disorder | Behavior | Anxieties | Rodents | Index Medicus | Neuropeptides | Anxiety Disorders | Physical Pain | Animal Models | Opioids | Themed Section | New Pathways to Functional Selectivity
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2006, Volume 103, Issue 47, pp. 17979 - 17984
Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal peptide signals at the cell surface, notably those processing sensory... 
Enzymes | Pain | HEK293 cells | Analgesics | Epithelial cells | Rats | Morphine | Cell membranes | Saliva | Vehicles | Dual neutral endopeptidase/aminopeptidase N inhibitor | Peptide mediator | Human saliva | Enkephalins | pain | MICE DEFICIENT | ENKEPHALIN-DEGRADING ENZYMES | MULTIDISCIPLINARY SCIENCES | NEUTRAL ENDOPEPTIDASE | SPINAL-CORD | EMOTIONAL RESPONSES | ENDOGENOUS INHIBITOR | peptide mediator | AMINO-ACID-SEQUENCE | dual neutral enclopepticlase/aminopepticlase N inhibitor | PROSTATE-CANCER | human saliva | AMINOPEPTIDASE-N | SUBSTANCE-P | enkephalins | Dipeptidyl Peptidase 4 - metabolism | Salivary Proteins and Peptides - genetics | Rats, Wistar | Adenosine Deaminase - metabolism | Enkephalins - metabolism | Humans | Glycoproteins - metabolism | Analgesics - metabolism | Male | Saliva - chemistry | Opioid Peptides - genetics | Neprilysin - genetics | Glycoproteins - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Adenosine Deaminase - genetics | CD13 Antigens - antagonists & inhibitors | Oligopeptides - genetics | Behavior, Animal - physiology | Dipeptidyl Peptidase 4 - genetics | Recombinant Proteins - genetics | Neprilysin - metabolism | Oligopeptides - metabolism | Salivary Proteins and Peptides - metabolism | CD13 Antigens - metabolism | Opioid Peptides - metabolism | Animals | CD13 Antigens - genetics | Neprilysin - antagonists & inhibitors | Pain Measurement | Peptide regulatory factors | Research | Peptides | Narcotics | Mammals | Neurons | Index Medicus | Biological Sciences | aminopeptidase N inhibitor | dual neutral endopeptidase
Journal Article
Journal Article