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1. Full Text An optogenetic toolbox designed for primates
by Shenoy, Krishna V and Diester, Ilka and Mogri, Murtaza and Pashaie, Ramin and Goo, Werapong and Ramakrishnan, Charu and Yizhar, Ofer and Deisseroth, Karl and Kaufman, Matthew T
Nature neuroscience, ISSN 1097-6256, 03/2011, Volume 14, Issue 3, pp. 387 - 397
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Macaca mulatta - physiology | Dependovirus - genetics | Gene Transfer Techniques | Promoter Regions, Genetic | Dependovirus - metabolism | Opsins - genetics | Primates - physiology | Humans | Genetic Vectors - metabolism | Macaca mulatta - anatomy & histology | Primates - anatomy & histology | Recombinant Fusion Proteins - metabolism | Synapsins - genetics | Genetic Vectors - genetics | Synapsins - metabolism | Lentivirus - metabolism | Primates - genetics | Animals | Photic Stimulation - methods | Light | Macaca mulatta - genetics | Opsins - metabolism | Recombinant Fusion Proteins - genetics | Lentivirus - genetics | Usage | Opsins | Analysis | Motor cortex | Primates | Physiological aspects | Genetic aspects | Research | Brain stimulation | Index Medicus
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2. Full Text Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator
by Qiu-Hong Wan Sheng-Kai Pan Li Hu Ying Zhu Peng-Wei Xu Jin-Quan Xia Hui Chen Gen-Yun He Jing He Xiao-Wei Ni Hao-Long Hou Sheng-Guang Liao Hai-Qiong Yang Ying Chen Shu-Kun Gao Yun-Fa Ge Chang-Chang Cao Peng-Fei Li Li-Ming Fang Li Liao Shu Zhang Meng-Zhen Wang Wei Dong Sheng-Guo Fang
Cell research, ISSN 1001-0602, 2013, Volume 23, Issue 9, pp. 1091 - 1105
基因组序列 | 潜水 | 中国 | 基因组分析 | 感官特性 | 扬子鳄 | 血红蛋白基因 | 灭绝 | FISH | olfaction | immunity | SNP | diving hypoxia | oxidative phosphorylation | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Visual Perception - genetics | Opsins - genetics | Smell - genetics | Muscle Contraction - genetics | Night Vision - genetics | Sex Determination Processes - genetics | Genome - genetics | Hemoglobins - genetics | Transcription Factors - genetics | Sequence Analysis, DNA | Oxygen - metabolism | Alligators and Crocodiles - classification | Animals | Immune System | Base Sequence | Olfactory Pathways - cytology | DNA Transposable Elements - genetics | Bicarbonates - metabolism | Biological Transport - genetics | Base Composition - genetics | Alligators and Crocodiles - genetics | Energy Metabolism - genetics | Alligators and Crocodiles - metabolism | Index Medicus | Original
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3. Full Text RELAX: Detecting relaxed selection in a phylogenetic framework
by Wertheim, Joel O and Murrell, Ben and Smith, Martin D and Pond, Sergei L. Kosakovsky and Scheffler, Konrad
Molecular biology and evolution, ISSN 0737-4038, 2015, Volume 32, Issue 3, pp. 820 - 832
Bornavirus | Molecular evolution | Endosymbionts | Daphnia pulex | Relaxed selection | Phylogenetics | Opsin | Codon models | Echolocation | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Evolutionary Biology | Science & Technology | Computational Biology - methods | Opsins - genetics | Bornaviridae - genetics | Phylogeny | Sequence Analysis, DNA | Selection, Genetic - genetics | Animals | Computer Simulation | Gammaproteobacteria - genetics | Models, Genetic | Codon - genetics | Chiroptera - genetics | Daphnia - genetics | Evolution, Molecular | Bats | Bacteria | Simulation | Genes | Index Medicus | relaxed selection | echolocation | endosymbionts | bornavirus | opsin | phylogenetics | molecular evolution | Methods | codon models
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4. Full Text A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice
by Haifeng Ye and Marie Daoud-El Baba and Ren-Wang Peng and Martin Fussenegger
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2011, Volume 332, Issue 6037, pp. 1565 - 1568
Cell culture techniques | Diabetes complications | HEK293 cells | Bioreactors | Medical treatment | REPORTS | Cell lines | Mice | Diabetes | Gene expression | Transgenes | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | Health. Pharmaceutical industry | Genetic technics applied to diagnosis | Industrial applications and implications. Economical aspects | Diabetes Mellitus, Type 2 - genetics | Humans | Alkaline Phosphatase - metabolism | Homeostasis | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Glucagon-Like Peptide 1 - genetics | Rod Opsins - genetics | Light Signal Transduction | Transfection | Isoenzymes - metabolism | Light | Rod Opsins - metabolism | Transcription, Genetic | Genes, Reporter | Genetic Engineering - methods | Cell Line | Alkaline Phosphatase - genetics | Glucagon-Like Peptide 1 - metabolism | Signal Transduction | Isoenzymes - genetics | NFATC Transcription Factors - metabolism | Gene Expression Regulation | GPI-Linked Proteins - metabolism | Animals | Synthetic Biology - methods | Cell Line, Tumor | Optical Fibers | Blood Glucose - metabolism | GPI-Linked Proteins - genetics | NFATC Transcription Factors - genetics | Blood sugar | Physiological aspects | Cellular signal transduction | Genetic aspects | Synthetic biology | Research | Genetic transcription | Glucose | Chemical synthesis | Rodents | Blood | Index Medicus | Optical fibers | Circuit design | Peptides | Cascade control | Illumination | Devices | Fiber optics
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5. Full Text The manner of decay of genetically defective EYS gene transcripts in photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients depends on the type of mutation
by Seko, Yuko and Iwanami, Masaki and Miyamoto-Matsui, Kiyoko and Takita, Shimpei and Aoi, Noriyuki and Umezawa, Akihiro and Kato, Seishi
Stem cell research & therapy, ISSN 1757-6512, 10/2018, Volume 9, Issue 1, pp. 279 - 279
disease modeling | phenotypic variation | photoreceptor | truncating mutation | retinitis pigmentosa | genotype-phenotype relationship | nonsense-mediated mRNA decay (NMD) | Redirect differentiation | dermal fibroblast | EYS | Cell & Tissue Engineering | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Homeodomain Proteins - metabolism | Humans | Middle Aged | Otx Transcription Factors - metabolism | Male | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Rhodopsin - metabolism | Case-Control Studies | Rod Opsins - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Otx Transcription Factors - genetics | Rod Opsins - metabolism | Trans-Activators - genetics | Female | Cell Differentiation | Eye Proteins - genetics | Arrestin - metabolism | Recoverin - genetics | Fibroblasts - metabolism | Arrestin - genetics | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | RNA, Messenger - genetics | Gene Expression Regulation | Retinitis Pigmentosa - genetics | Retinitis Pigmentosa - metabolism | Transcription Factors - genetics | Fibroblasts - pathology | RNA Stability | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Homozygote | Rhodopsin - genetics | Eye Proteins - metabolism | Heterozygote | Trans-Activators - metabolism | Aged | Mutation | Photoreceptor Cells, Vertebrate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Retinitis Pigmentosa - pathology | Recoverin - metabolism | Photoreceptors | Genetic aspects | Research | Genetic transcription | Gene mutations | Retinitis pigmentosa | Rhodopsin | Messenger RNA | Analysis | Genes | Genetic research | NeuroD protein | Phenotypes | Disease | mRNA turnover | Phenotypic variations | Retina | Recoverin | Nonsense-mediated mRNA decay | Gene expression | Defects | Polymerase chain reaction | Fibroblasts | Retinal degeneration | Otx2 protein | Retinitis | Skin | Index Medicus
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6. Full Text Gene delivery to mitotic and postmitotic photoreceptors Via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa
by Cai, Xue and Conley, Shannon M and Nash, Zack and Fliesler, Steven J and Cooper, Mark J and Naash, Muna I
The FASEB journal, ISSN 0892-6638, 04/2010, Volume 24, Issue 4, pp. 1178 - 1191
mouse opsin promoter | gene replacement therapy | retinal degeneration slow protein | Gene replacement therapy | Retinal degeneration slow protein | Mouse opsin promoter | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Genetic Therapy | Macrophage Activation - genetics | Retinal Rod Photoreceptor Cells - ultrastructure | Opsins - genetics | Mitosis | Humans | Membrane Glycoproteins - biosynthesis | Tumor Necrosis Factor-alpha - genetics | Retinal Rod Photoreceptor Cells - metabolism | Promoter Regions, Genetic - genetics | Retinal Cone Photoreceptor Cells - ultrastructure | Nanoparticles | Time Factors | Intermediate Filament Proteins - genetics | Nerve Tissue Proteins - biosynthesis | Disease Models, Animal | Macrophages - ultrastructure | Peripherins | Transduction, Genetic | Interleukin-6 - genetics | DNA - pharmacology | Intermediate Filament Proteins - biosynthesis | Retinitis Pigmentosa - genetics | Retinitis Pigmentosa - metabolism | Nerve Tissue Proteins - genetics | Membrane Glycoproteins - genetics | DNA - genetics | Macrophages - metabolism | Animals | Retinitis Pigmentosa - therapy | Opsins - metabolism | Interleukin-6 - biosynthesis | Mice | Mutation | Macrophage Activation - drug effects | Retinal Cone Photoreceptor Cells - metabolism | Retinitis Pigmentosa - pathology | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus | Research Communications
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7. Full Text The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
by Lagman, David and Ocampo Daza, Daniel and Widmark, Jenny and Abalo, Xesús M and Sundström, Görel and Larhammar, Dan
BMC evolutionary biology, ISSN 1471-2148, 2013, Volume 13, Issue 1, pp. 238 - 238
Visual opsins | Voltage-gated calcium channels | G-protein alpha transducing subunits | Opsin evolution | Chromosome rearrangements | Vasopressin receptors | Oxytocin receptors | Whole genome duplications | Genetics & Heredity | Life Sciences & Biomedicine | Evolutionary Biology | Science & Technology | Gene Duplication | Fishes - genetics | Transducin - genetics | Opsins - genetics | Receptors, Oxytocin - genetics | Vertebrates - genetics | Genomics | Synteny | Phylogeny | Animals | Receptors, Vasopressin - genetics | Oxytocin - genetics | Genome | Evolution, Molecular | Animal genetics | Vertebrates | Calcium channels | Opsins | Oxytocin | Analysis | Vision | Genetic research | Transducin | Vasopressin | Studies | Evolution | Chromosomes | Genes | Index Medicus
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8. Full Text Gene therapy for red-green colour blindness in adult primates
by Mancuso, Katherine and Neitz, Jay and Neitz, Maureen and Hauswirth, William W and Connor, Thomas B and Li, Qiuhong and Kuchenbecker, James A and Mauck, Matthew C
Nature, ISSN 0028-0836, 10/2009, Volume 461, Issue 7265, pp. 784 - 787
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Vision disorders | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Transfusions. Complications. Transfusion reactions. Cell and gene therapy | Applied cell therapy and gene therapy | Biological and medical sciences | Medical sciences | Ophthalmology | Genetic Therapy | Retina - metabolism | Opsins - genetics | Color Vision - genetics | Humans | Transgenes - genetics | Male | Treatment Outcome | Color Vision Defects - therapy | Color Vision Defects - genetics | Color Vision Defects - physiopathology | Genetic Vectors - genetics | Saimiri - genetics | Animals | Retina - cytology | Color Vision Defects - congenital | Color Vision - physiology | Opsins - metabolism | Aging | Color Perception - genetics | Female | Saimiri - physiology | Color Perception - physiology | Care and treatment | Genetic aspects | Research | Gene therapy | Color blindness | Monoclonal antibodies | Medical research | Females | Monkeys & apes | Index Medicus
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