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1. Full Text Quantitative Genetic Analysis of Retinal Degeneration in the Blind Cavefish Astyanax mexicanus
by O'Quin, Kelly E and Yoshizawa, Masato and Doshi, Pooja and Jeffery, William R
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e57281
The retina is the light-sensitive tissue of the eye that facilitates vision. Mutations within genes affecting eye development and retinal function cause a host... 
AMACRINE CELLS | USHER-SYNDROME | MULTIDISCIPLINARY SCIENCES | MOUSE RETINA | HOMEOBOX GENE | RETINITIS-PIGMENTOSA | OPSIN GENE | EXPRESSION | ZEBRAFISH RETINA | REGRESSIVE EVOLUTION | EYE DEGENERATION | Darkness | Retina - metabolism | Morphogenesis - genetics | Retinal Degeneration - genetics | Chromosome Mapping | Blindness - genetics | Biological Evolution | Characidae - genetics | Animals | Alleles | Caves | Genome | Quantitative Trait Loci | Retinal Degeneration - pathology | Retina - pathology | Crosses, Genetic | Genetic Linkage | Animal genetics | Quantitative genetics | Genetic markers | Genomics | Genetic research | Physiological aspects | Retinal degeneration | Genetic aspects | Animal models | Retinitis pigmentosa | Genes | Biological evolution | Photopigments | Retina | Genomes | Mapping | Biology | Gene sequencing | Eye | Proteins | Genetic analysis | Eye (anatomy) | Fish | Genetics | Degeneration | Genetic disorders | Microsatellites | Albinism | Markers | Zebrafish | Gene expression | Quantitative trait loci | Thickness | Progeny | Genetic crosses | Photoreceptors | Retinitis | Mutation | Anophthalmia | Gene mapping | Microphthalmia | Apoptosis
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2. Full Text An optogenetic toolbox designed for primates
by Shenoy, Krishna V and Diester, Ilka and Mogri, Murtaza and Pashaie, Ramin and Goo, Werapong and Ramakrishnan, Charu and Yizhar, Ofer and Deisseroth, Karl and Kaufman, Matthew T
Nature Neuroscience, ISSN 1097-6256, 03/2011, Volume 14, Issue 3, pp. 387 - 397
Optogenetics is a technique for controlling subpopulations of neurons in the intact brain using light. This technique has the potential to enhance basic... 
OPTICAL CONTROL | MONKEY | CORTICAL-NEURONS | NONHUMAN PRIMATE | SENSORY-MOTOR CORTEX | IN-VIVO CONTROL | ADENOASSOCIATED VIRUS | MILLISECOND-TIMESCALE | GENE-THERAPY | NEURAL CIRCUITRY | NEUROSCIENCES | Macaca mulatta - physiology | Dependovirus - genetics | Gene Transfer Techniques | Promoter Regions, Genetic | Dependovirus - metabolism | Opsins - genetics | Primates - physiology | Humans | Genetic Vectors - metabolism | Macaca mulatta - anatomy & histology | Primates - anatomy & histology | Recombinant Fusion Proteins - metabolism | Synapsins - genetics | Genetic Vectors - genetics | Synapsins - metabolism | Lentivirus - metabolism | Primates - genetics | Animals | Photic Stimulation - methods | Light | Macaca mulatta - genetics | Opsins - metabolism | Recombinant Fusion Proteins - genetics | Lentivirus - genetics | Usage | Opsins | Analysis | Motor cortex | Primates | Physiological aspects | Genetic aspects | Research | Brain stimulation
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3. Full Text Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator
by Qiu-Hong Wan Sheng-Kai Pan Li Hu Ying Zhu Peng-Wei Xu Jin-Quan Xia Hui Chen Gen-Yun He Jing He Xiao-Wei Ni Hao-Long Hou Sheng-Guang Liao Hai-Qiong Yang Ying Chen Shu-Kun Gao Yun-Fa Ge Chang-Chang Cao Peng-Fei Li Li-Ming Fang Li Liao Shu Zhang Meng-Zhen Wang Wei Dong Sheng-Guo Fang
细胞研究：英文版, ISSN 1001-0602, 2013, Volume 23, Issue 9, pp. 1091 - 1105
Crocodilians are diving reptiles that can hold their breath under water for long periods of time and are crepuscular animals with excellent sensory abilities.... 
基因组序列 | 潜水 | 中国 | 基因组分析 | 感官特性 | 扬子鳄 | 血红蛋白基因 | 灭绝 | FISH | olfaction | immunity | SNP | diving hypoxia | oxidative phosphorylation | PHYSIOLOGY | CROCODILE | FAMILY | CELL BIOLOGY | DM-DOMAIN GENE | EVOLUTION | SUBMERGENCE | ADAPTATION | SEQUENCE | SEX DETERMINATION | AMERICAN ALLIGATOR | Visual Perception - genetics | Opsins - genetics | Smell - genetics | Muscle Contraction - genetics | Night Vision - genetics | Sex Determination Processes - genetics | Genome - genetics | Hemoglobins - genetics | Transcription Factors - genetics | Sequence Analysis, DNA | Oxygen - metabolism | Alligators and Crocodiles - classification | Animals | Immune System | Base Sequence | Olfactory Pathways - cytology | DNA Transposable Elements - genetics | Bicarbonates - metabolism | Biological Transport - genetics | Base Composition - genetics | Alligators and Crocodiles - genetics | Energy Metabolism - genetics | Alligators and Crocodiles - metabolism | Original
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4. Full Text Gene therapy for red-green colour blindness in adult primates
by Mancuso, Katherine and Neitz, Jay and Neitz, Maureen and Hauswirth, William W and Connor, Thomas B and Li, Qiuhong and Kuchenbecker, James A and Mauck, Matthew C
Nature, ISSN 0028-0836, 10/2009, Volume 461, Issue 7265, pp. 784 - 787
Red-green colour blindness, which results from the absence of either the long- (L) or the middle- (M) wavelength-sensitive visual photopigments, is the most... 
MOLECULAR-GENETICS | VISION | MULTIDISCIPLINARY SCIENCES | RETINA | EXPRESSION | PIGMENTS | DEFICIENCY | Genetic Therapy | Retina - metabolism | Opsins - genetics | Color Vision - genetics | Humans | Transgenes - genetics | Male | Treatment Outcome | Color Vision Defects - therapy | Color Vision Defects - genetics | Color Vision Defects - physiopathology | Genetic Vectors - genetics | Saimiri - genetics | Animals | Retina - cytology | Color Vision Defects - congenital | Color Vision - physiology | Opsins - metabolism | Aging | Color Perception - genetics | Female | Saimiri - physiology | Color Perception - physiology | Care and treatment | Genetic aspects | Research | Gene therapy | Color blindness | Monoclonal antibodies | Medical research | Females | Monkeys & apes
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5. Full Text A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice
by Haifeng Ye and Marie Daoud-El Baba and Ren-Wang Peng and Martin Fussenegger
Science, ISSN 0036-8075, 6/2011, Volume 332, Issue 6037, pp. 1565 - 1568
Synthetic biology has advanced the design of genetic devices that can be used to reprogram metabolic activities in mammalian cells. By functionally linking the... 
Cell culture techniques | Diabetes complications | HEK293 cells | Bioreactors | Medical treatment | REPORTS | Cell lines | Mice | Diabetes | Gene expression | Transgenes | RETINAL GANGLION-CELLS | RESPONSES | VISUAL FUNCTION | MELANOPSIN | ROD | MULTIDISCIPLINARY SCIENCES | LIGHT | ECTOPIC EXPRESSION | PHOTOPIGMENT | MAMMALIAN-CELLS | DEGENERATION | Diabetes Mellitus, Type 2 - genetics | Humans | Alkaline Phosphatase - metabolism | Homeostasis | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Glucagon-Like Peptide 1 - genetics | Rod Opsins - genetics | Light Signal Transduction | Transfection | Isoenzymes - metabolism | Light | Rod Opsins - metabolism | Transcription, Genetic | Genes, Reporter | Genetic Engineering - methods | Cell Line | Alkaline Phosphatase - genetics | Glucagon-Like Peptide 1 - metabolism | Signal Transduction | Isoenzymes - genetics | NFATC Transcription Factors - metabolism | Gene Expression Regulation | GPI-Linked Proteins - metabolism | Animals | Synthetic Biology - methods | Cell Line, Tumor | Optical Fibers | Blood Glucose - metabolism | GPI-Linked Proteins - genetics | NFATC Transcription Factors - genetics | Blood sugar | Physiological aspects | Cellular signal transduction | Genetic aspects | Synthetic biology | Research | Genetic transcription | Glucose | Chemical synthesis | Rodents | Blood
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6. Full Text Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa
by Cai, Xue and Conley, Shannon M and Nash, Zack and Fliesler, Steven J and Cooper, Mark J and Naash, Muna I
FASEB Journal, ISSN 0892-6638, 04/2010, Volume 24, Issue 4, pp. 1178 - 1191
The purpose of the present study was to test the therapeutic efficiency and safety of compacted-DNA nanoparticle-mediated gene delivery into the sub-retinal... 
Gene replacement therapy | Retinal degeneration slow protein | Mouse opsin promoter | DEGENERATION SLOW RDS | RETINAL DEGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | OUTER SEGMENT MORPHOGENESIS | mouse opsin promoter | CELL BIOLOGY | gene replacement therapy | ROD PHOTORECEPTORS | MUTANT MICE | DISK MEMBRANE | IN-VIVO | BIOLOGY | REPLACEMENT THERAPY | R172W MUTATION | retinal degeneration slow protein | TRANSGENIC MICE | Genetic Therapy | Macrophage Activation - genetics | Retinal Rod Photoreceptor Cells - ultrastructure | Opsins - genetics | Mitosis | Humans | Membrane Glycoproteins - biosynthesis | Tumor Necrosis Factor-alpha - genetics | Retinal Rod Photoreceptor Cells - metabolism | Promoter Regions, Genetic - genetics | Retinal Cone Photoreceptor Cells - ultrastructure | Nanoparticles | Time Factors | Intermediate Filament Proteins - genetics | Nerve Tissue Proteins - biosynthesis | Disease Models, Animal | Macrophages - ultrastructure | Peripherins | Transduction, Genetic | Interleukin-6 - genetics | DNA - pharmacology | Intermediate Filament Proteins - biosynthesis | Retinitis Pigmentosa - genetics | Retinitis Pigmentosa - metabolism | Nerve Tissue Proteins - genetics | Membrane Glycoproteins - genetics | DNA - genetics | Macrophages - metabolism | Animals | Retinitis Pigmentosa - therapy | Opsins - metabolism | Interleukin-6 - biosynthesis | Mice | Mutation | Macrophage Activation - drug effects | Retinal Cone Photoreceptor Cells - metabolism | Retinitis Pigmentosa - pathology | Tumor Necrosis Factor-alpha - biosynthesis | Research Communications
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7. Full Text RELAX: Detecting relaxed selection in a phylogenetic framework
by Wertheim, Joel O and Murrell, Ben and Smith, Martin D and Pond, Sergei L. Kosakovsky and Scheffler, Konrad
Molecular Biology and Evolution, ISSN 0737-4038, 2015, Volume 32, Issue 3, pp. 820 - 832
Relaxation of selective strength, manifested as a reduction in the efficiency or intensity of natural selection, can drive evolutionary innovation and presage... 
Bornavirus | Molecular evolution | Endosymbionts | Daphnia pulex | Relaxed selection | Phylogenetics | Opsin | Codon models | Echolocation | EVOLUTIONARY ORIGIN | echolocation | CODON-SUBSTITUTION MODELS | endosymbionts | NUCLEOTIDE SUBSTITUTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | opsin | INDIVIDUAL SITES | TASTE RECEPTOR GENES | FACULTATIVE SYMBIONTS | PURIFYING SELECTION | molecular evolution | COLOR-VISION | EVOLUTIONARY BIOLOGY | relaxed selection | BACTERIAL ENDOSYMBIONTS | bornavirus | SEQUENCE ALIGNMENT | GENETICS & HEREDITY | phylogenetics | codon models | Computational Biology - methods | Opsins - genetics | Bornaviridae - genetics | Phylogeny | Sequence Analysis, DNA | Selection, Genetic - genetics | Animals | Computer Simulation | Gammaproteobacteria - genetics | Models, Genetic | Codon - genetics | Chiroptera - genetics | Daphnia - genetics | Evolution, Molecular | Methods
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8. Full Text The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
by Lagman, David and Ocampo Daza, Daniel and Widmark, Jenny and Abalo, Xesús M and Sundström, Görel and Larhammar, Dan and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för medicinsk biokemi och mikrobiologi and Farmakologi and Uppsala universitet and Institutionen för neurovetenskap
BMC Evolutionary Biology, ISSN 1471-2148, 2013, Volume 13, Issue 1, pp. 238 - 238
Background: Vertebrate color vision is dependent on four major color opsin subtypes: RH2 (green opsin), SWS1 (ultraviolet opsin), SWS2 (blue opsin), and LWS... 
Visual opsins | Voltage-gated calcium channels | G-protein alpha transducing subunits | Opsin evolution | Chromosome rearrangements | Vasopressin receptors | Oxytocin receptors | Whole genome duplications | GENE DUPLICATION | ROD | PIGMENT GENE | FUNCTIONAL-CHARACTERIZATION | NEUROPEPTIDE-Y-FAMILY | COLOR-VISION | EVOLUTIONARY BIOLOGY | EVOLUTION | GENETICS & HEREDITY | MOLECULAR-CLONING | CHROMOSOME DUPLICATIONS | TELEOST | Gene Duplication | Fishes - genetics | Transducin - genetics | Opsins - genetics | Receptors, Oxytocin - genetics | Vertebrates - genetics | Genomics | Synteny | Phylogeny | Animals | Receptors, Vasopressin - genetics | Oxytocin - genetics | Genome | Evolution, Molecular | Animal genetics | Vertebrates | Opsins | Oxytocin | Vision | Transducin | Genetic aspects | Research | Natural history | Vasopressin | Calcium channels | Analysis | Genetic research | Studies | Evolution | Chromosomes | Genes | Medical and Health Sciences | Medicin och hälsovetenskap
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9. Full Text Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
by William A. Beltran and Artur V. Cideciyan and Alfred S. Lewin and Simone Iwabe and Hemant Khanna and Alexander Sumaroka and Vince A. Chiodo and Diego S. Fajardo and Alejandro J. Román and Wen-Tao Deng and Malgorzata Swider and Tomas S. Alemán and Sanford L. Boye and Sem Genini and Anand Swaroop and William W. Hauswirth and Samuel G. Jacobson and Gustavo D. Aguirre
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2012, Volume 109, Issue 6, pp. 2132 - 2137
Hereditary retinal blindness is caused by mutations in genes expressed in photoreceptors or retinal pigment epithelium. Gene therapy in mouse and dog models of... 
Retinal degeneration | Retina | MUTATION ANALYSIS | retinal degeneration | LEBER CONGENITAL AMAUROSIS | CHILDHOOD BLINDNESS | CANINE MODEL | retina | CONE VISION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | RPGR EXON ORF15 | GTPASE REGULATOR RPGR | DISEASE EXPRESSION | Genetic Therapy | Retinal Bipolar Cells - pathology | Humans | Retinitis Pigmentosa - genetics | Genotype | Eye Proteins - therapeutic use | Mutation - genetics | Open Reading Frames - genetics | Blindness - genetics | Protein Transport | Phenotype | Animals | Retinitis Pigmentosa - therapy | Dogs | Opsins - metabolism | Genetic Diseases, X-Linked - genetics | Mice | Blindness - therapy | Eye Proteins - genetics | Photoreceptor Cells, Vertebrate - pathology | Genetic Diseases, X-Linked - therapy | Care and treatment | Retinitis pigmentosa | Blindness | Physiological aspects | Photoreceptors | Genetic aspects | Research | Gene therapy | Health aspects | Biological Sciences
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10. Full Text Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform
by Pretorius, Pamela R and Baye, Lisa M and Nishimura, Darryl Y and Searby, Charles C and Bugge, Kevin and Yang, Baoli and Mullins, Robert F and Stone, Edwin M and Sheffield, Val C and Slusarski, Diane C
PLoS Genetics, ISSN 1553-7390, 03/2010, Volume 6, Issue 3, p. e1000884
Bardet-Biedl Syndrome (BBS) is a heterogeneous syndromic form of retinal degeneration. We have identified a novel transcript of a known BBS gene, BBS3 (ARL6),... 
DANIO-RERIO | HUMAN OBESITY SYNDROME | VERTEBRATE PHOTORECEPTORS | MOUSE MODEL | GENETICS & HEREDITY | BARDET-BIEDL-SYNDROME | GENE-EXPRESSION ANALYSIS | GTP-BINDING PROTEINS | HOMEOBOX GENE | INTRAFLAGELLAR TRANSPORT PROTEIN | CILIA DEFECTS | Organ Specificity - drug effects | Ganglia - metabolism | Humans | Photoreceptor Cells, Vertebrate - drug effects | Molecular Sequence Data | Protein Transport - drug effects | Vision, Ocular - drug effects | RNA, Messenger - metabolism | Gene Knockdown Techniques | Protein Isoforms - metabolism | Mice, Mutant Strains | Protein Isoforms - chemistry | Bardet-Biedl Syndrome - pathology | Rod Opsins - metabolism | Reflex, Startle - drug effects | Bardet-Biedl Syndrome - genetics | ADP-Ribosylation Factors - metabolism | ADP-Ribosylation Factors - genetics | Bardet-Biedl Syndrome - complications | Amino Acid Sequence | Oligonucleotides, Antisense - pharmacology | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | RNA, Messenger - genetics | Zebrafish | Ganglia - pathology | Bardet-Biedl Syndrome - physiopathology | ADP-Ribosylation Factors - deficiency | Gene Expression Regulation - drug effects | Ganglia - drug effects | ADP-Ribosylation Factors - chemistry | Phenotype | Animals | Eye Abnormalities - pathology | Eye Abnormalities - physiopathology | Mice | Photoreceptor Cells, Vertebrate - metabolism | Zebrafish Proteins - genetics | Photoreceptor Cells, Vertebrate - pathology | Eye Abnormalities - complications | Protein Isoforms - genetics | Retinal degeneration | Physiological aspects | Development and progression | Genetic aspects | Genetic transcription | Vision | Proteins | Hypertension | Obesity | Genotype & phenotype | Scholarships & fellowships | Genes | Colleges & universities | Retina | Diabetes | Eyes & eyesight | Embryos | Defects
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11. Full Text Molecular variation across populations of a widespread North American firefly, Photinus pyralis, reveals that coding changes do not underlie flash color variation or associated visual sensitivity
by Lower, Sarah E and Stanger-Hall, Kathrin F and Hall, David W
BMC Evolutionary Biology, ISSN 1471-2148, 08/2018, Volume 18, Issue 1, pp. 129 - 14
Background: Genes underlying signal production and reception are expected to evolve to maximize signal detection in specific environments. Fireflies vary in... 
Sensory drive | Fst outlier | Bioluminescence | Lampyridae | Population genomics | JAPANESE FIREFLIES | OPSIN GENES | BIOLUMINESCENT REPORTER APPLICATIONS | SPECTRAL SENSITIVITY | CRYSTAL-STRUCTURE | DNA POLYMORPHISM | LUCIFERASE GENE | OPTIMIZATION MODEL | SCINTILLANS COLEOPTERA | EVOLUTIONARY BIOLOGY | GENETICS & HEREDITY | LUCIOLA-LATERALIS | Geography | Genetics, Population | Gene Frequency - genetics | Visual Perception - genetics | Gene Flow | United States | Selection, Genetic | Signal Transduction - genetics | Fireflies - genetics | Genetic Loci | Open Reading Frames - genetics | Luciferases - genetics | Biological Evolution | Genetic Variation | Animals | Pigmentation - genetics | Genetic variation | Identification and classification | Luciferase | Physiological aspects | Genomics | Divergence | Populations | Genes | Biological evolution | Photopigments | Visual pigments | Amino acids | Genomes | Population genetics | Proteins | Color matching | Coding | Light | Pigments | Evolution | Bioinformatics | Species | Signal detection | Deoxyribonucleic acid--DNA | Enzymes | Color sensitivity | Color | Visual signals | Amino acid sequence | Pigmentation | Loci | Sensitivity | Hypotheses | Opsins | Software | Fireflies | Differentiation | Variation
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