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optineurin (184) 184
humans (141) 141
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transcription factor tfiiia - genetics (83) 83
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optn (19) 19
prevalence (19) 19
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gene expression (18) 18
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polymorphism, single nucleotide (18) 18
cytoskeletal proteins - genetics (17) 17
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mitophagy (17) 17
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selective autophagy (17) 17
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Journal Article
Acta Neuropathologica, ISSN 0001-6322, 2015, Volume 130, Issue 1, pp. 77 - 92
Journal Article
Autophagy, ISSN 1554-8627, 04/2015, Volume 11, Issue 4, pp. 685 - 700
OPTN (optineurin) is an autophagy receptor and mutations in the OPTN gene result in familial glaucoma (E50K) and amyotrophic lateral sclerosis (ALS) (E478G).... 
CCD, coiled-coil domain | FT, filter-trap assay | Ab, antibody | E | TUBA, alpha tubulin | Ub, ubiquitin B/C/D | WB, western blot | UbBD, ubiquitin-binding domain | UPS, ubiquitin-proteasome system | ALS, amyotrophic lateral sclerosis | BafA1, bafilomycin A | PBS, phosphate-buffered saline | huntingtin | dominant-negative | mHTT, mutant huntingtin | autophagy | f | K63, lysine 63 | WT, wild type | FRET efficiency | IBs, inclusion bodies | MYO6, myosin VI | IP, immunoprecipitation | TARDBP/TDP-43 | 1 | HD, Huntington disease | LIR, LC3-interacting region | K48, lysine 48 | optineurin | TARDBP/TDP-43, TAR DNA-binding protein | PFA, paraformaldehyde | TBK1, TANK-binding kinase 1 | OPTN, optineurin | Optineurin | Dominant-negative | Huntingtin | Autophagy | NEURODEGENERATIVE DISEASE | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | SELECTIVE AUTOPHAGY | CELL BIOLOGY | TRANSFERRIN RECEPTOR | GLAUCOMA | HUNTINGTONS-DISEASE | MYOSIN-VI | GOLGI-COMPLEX | Protein Binding - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Mutant Proteins - genetics | Transcription Factor TFIIIA - genetics | Cytoplasm - metabolism | Mutant Proteins - metabolism | Autophagy - physiology | Mutation - genetics | Transcription Factor TFIIIA - metabolism | Protein Folding | DNA-Binding Proteins - metabolism | Animals | Eye Proteins - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Cytoplasm - genetics | Mice | Autophagy - genetics | Eye Proteins - genetics | Binding Sites
Journal Article
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 11/2018, Volume 9, p. 2647
Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary... 
ALS | Inflammation | Optineurin | Cytokines | Cell death | ACTIVATION | cell death | optineurin | inflammation | RISK | cytokines | AMYOTROPHIC-LATERAL-SCLEROSIS | IMMUNOLOGY | NF-KAPPA-B | ONSET | SUPEROXIDE-DISMUTASE GENE | Gene mutations | Neurons | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Research | Health aspects
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 5, p. e0197543
Journal Article