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humans (87) 87
male (86) 86
animals (85) 85
oral adsorbent (85) 85
indoxyl sulfate (83) 83
index medicus (78) 78
urology & nephrology (77) 77
rats (73) 73
administration, oral (67) 67
ast-120 (61) 61
adsorption (58) 58
carbon - administration & dosage (54) 54
oxides - administration & dosage (54) 54
progression (50) 50
female (47) 47
carbon - therapeutic use (45) 45
oxides - therapeutic use (45) 45
oxidative stress (44) 44
carbon - pharmacology (39) 39
oxides - pharmacology (39) 39
chronic kidney disease (36) 36
chronic-renal-failure (36) 36
middle aged (33) 33
rats, sprague-dawley (31) 31
chronic renal failure (30) 30
chronic kidney-disease (28) 28
creatinine - blood (27) 27
disease progression (27) 27
aged (26) 26
glomerular sclerosis (26) 26
indican - metabolism (26) 26
kidney failure, chronic - drug therapy (26) 26
uremic toxins (24) 24
oral adsorbent ast-120 (22) 22
uremic toxin (22) 22
adult (21) 21
nephrology (21) 21
sorbent (21) 21
uremia - metabolism (21) 21
kidney diseases (20) 20
chronic kidney failure (19) 19
indican - blood (18) 18
sulfates (18) 18
expression (17) 17
microspheres (17) 17
oral sorbent (17) 17
disease models, animal (16) 16
fibrosis (16) 16
gene-expression (16) 16
kidney failure, chronic - physiopathology (16) 16
pharmacology & pharmacy (16) 16
renal-failure (15) 15
original paper (14) 14
oxidative stress - drug effects (14) 14
treatment outcome (14) 14
kidney failure, chronic - blood (13) 13
nf-kappa-b (13) 13
serum (13) 13
sulfate (13) 13
transplantation (13) 13
uremia - blood (13) 13
kidney - pathology (12) 12
medicine (12) 12
nephropathy (12) 12
organic anion transporters (12) 12
toxins (12) 12
blood urea nitrogen (11) 11
cardiovascular disease (11) 11
diabetic nephropathy (11) 11
experimental uremic rats (11) 11
hematology (11) 11
hemodialysis (11) 11
hemodialysis-patients (11) 11
interstitial fibrosis (11) 11
kidney - drug effects (11) 11
kidney failure, chronic - prevention & control (11) 11
kidney failure, chronic - therapy (11) 11
p-cresyl sulfate (11) 11
renal insufficiency, chronic - drug therapy (11) 11
time factors (11) 11
uremia (11) 11
uremia - drug therapy (11) 11
cardiovascular diseases (10) 10
cells, cultured (10) 10
ckd (10) 10
kidney failure, chronic - metabolism (10) 10
kidney function tests (10) 10
mice (10) 10
nephrectomy (10) 10
proximal tubular cells (10) 10
rats, inbred strains (10) 10
renal insufficiency, chronic - metabolism (10) 10
toxins, biological - metabolism (10) 10
uremia - physiopathology (10) 10
analysis (9) 9
development and progression (9) 9
disease (9) 9
dose-response relationship, drug (9) 9
failure (9) 9
glomerular filtration rate (9) 9
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Journal Article
Atherosclerosis, ISSN 0021-9150, 2015, Volume 243, Issue 1, pp. 248 - 256
Journal Article
Renal Failure, ISSN 0886-022X, 01/2019, Volume 41, Issue 1, pp. 47 - 56
AST-120 (KREMEZIN®) consists of oral, spherical carbon particles that adsorb uremic toxins and their precursors within the gastrointestinal tract, allowing them to be excreted in the feces... 
clinical trial | spherical carbon adsorbent | AST-120 | uremic toxin | CKD | MODERATE | MANAGEMENT | UREMIC TOXINS | CARDIOVASCULAR OUTCOMES | FAILURE | INDOXYL SULFATE | DIETARY-PROTEIN RESTRICTION | UROLOGY & NEPHROLOGY | EPPIC TRIALS | ORAL ADSORBENT AST-120 | PROGRESSION | Creatinine | Renal function | Kidneys | Epidermal growth factor receptors | Clinical trials | Gastrointestinal tract | Kidney diseases | Sulfate | Cardiovascular diseases | Patients | Glomerular filtration rate | ast-120 | ckd
Journal Article
American Journal of Nephrology, ISSN 0250-8095, 06/2013, Volume 37, Issue 6, pp. 518 - 525
Journal Article
Journal Article
Toxins, ISSN 2072-6651, 01/2018, Volume 10, Issue 1, p. 19
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2007, Volume 59, Issue 3, pp. 321 - 328
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 7/2007, Volume 24, Issue 7, pp. 1283 - 1289
The effect of AST-120, an oral adsorbent, on oxidative stress in the systemic circulation in chronic renal failure (CRF... 
Biomedical Engineering | Biochemistry, general | albumin oxidation | Biomedicine | chronic renal failure | indoxyl sulfate | Pharmacy | AST-120 | Medical Law | Pharmacology/Toxicology | Chronic renal failure | Albumin oxidation | Indoxyl sulfate | OVERLOAD | INJURY | SORBENT | SERUM | ORGANIC ANION TRANSPORTERS | CHEMISTRY, MULTIDISCIPLINARY | UREMIC TOXIN | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | KIDNEY | Organic Anion Transport Protein 1 - metabolism | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | Rats, Wistar | Humans | Transforming Growth Factor beta1 - metabolism | Male | Indican - blood | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Nephrectomy | Time Factors | Oxides - administration & dosage | Carbon - pharmacology | Disease Models, Animal | Oxides - therapeutic use | Carbon - therapeutic use | Oxidation-Reduction | Administration, Oral | Endothelial Cells - metabolism | Kidney Failure, Chronic - drug therapy | Cells, Cultured | Rats | Organic Anion Transport Protein 1 - genetics | Carbon - administration & dosage | Transforming Growth Factor beta1 - genetics | Antioxidants - pharmacology | Biomarkers - blood | Kidney Failure, Chronic - metabolism | Kidney Failure, Chronic - genetics | Oxides - pharmacology | Antioxidants - therapeutic use | Animals | Indican - pharmacology | Antioxidants - administration & dosage | Oxidative Stress - drug effects | Endothelial Cells - drug effects | Serum Albumin - metabolism | Albumin | Oxidative stress | Development and progression | Kidney failure | Oxidation | Pharmacology | Toxins | Kidney diseases | Adsorbents
Journal Article
Journal of Korean Medical Science, ISSN 1011-8934, 04/2019, Volume 34, Issue 15, pp. e117 - 9
Background: Removal of uremic toxins such as indoxyl sulfate by AST-120 is known to improve renal function and delay the initiation of dialysis in patients with advanced chronic kidney disease... 
Antioxidants | Creatinine | Oxidative Stress | Indoxyl Sulfate | Diabetic Nephropathy | DETERMINANTS | RENAL-FUNCTION | SORBENT | MEDICINE, GENERAL & INTERNAL | ORAL ADSORBENT | CHRONIC KIDNEY-DISEASE | EPPIC TRIALS | PROGRESSION | 의학일반
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 11/2016, Volume 72, Issue 11, pp. 1353 - 1361
Journal Article
Nephron, ISSN 1660-8151, 02/2017, Volume 135, Issue 3, pp. 201 - 206
Journal Article