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1. Full Text The Influence of Chitosan on the Oral Bioavailability of Acyclovir-a Comparative Bioavailability Study in Humans
by Kubbinga, M and Nguyen, M.A and Staubach, P and Teerenstra, S and Langguth, P
Pharmaceutical Research, ISSN 0724-8741, 2015, Volume 32, Issue 7, pp. 2241 - 2249
PURPOSE: The effects of chitosan hydrochloride on the oral absorption of acyclovir in humans were studied to confirm the absorption enhancing effects reported... 
Biochemistry, general | Biomedical Engineering | Biomedicine | bioavailability | Pharmacy | biowaiver | biopharmaceutics classification system | excipient interactions | pharmacokinetics | Medical Law | Pharmacology/Toxicology | ABSORPTION ENHANCERS | MOLECULAR-WEIGHT | DELIVERY SYSTEMS | PERMEABILITY | MIXED MICELLES | CHEMISTRY, MULTIDISCIPLINARY | TRANSPORT | IN-VITRO EVALUATION | PHARMACOLOGY & PHARMACY | EPITHELIAL-CELLS CACO-2 | POORLY ABSORBABLE DRUGS | PERMEATION | Data Interpretation, Statistical | Antiviral Agents - pharmacokinetics | Administration, Oral | Antiviral Agents - blood | Humans | Biological Availability | Male | Chromatography, High Pressure Liquid | Healthy Volunteers | Antiviral Agents - administration & dosage | Drug Carriers - chemistry | Acyclovir - pharmacokinetics | Acyclovir - blood | Chitosan - chemistry | Adult | Female | Acyclovir - administration & dosage | Acyclovir | Comparative analysis | Pharmaceutical sciences | Bioavailability | Index Medicus | Research Paper
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2. Oral bioavailability assessment
: basics and strategies for drug discovery and development
by El-Kattan, Ayman F
2017, ISBN 9781118916933
Toxicokinetics | Administration, Oral | Biological Availability | Drug Evaluation, Preclinical
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3. Full Text Oral bioavailability of cyclosporine: Solid lipid nanoparticles (SLN ®) versus drug nanocrystals
by Müller, R.H and Runge, S and Ravelli, V and Mehnert, W and Thünemann, A.F and Souto, E.B
International Journal of Pharmaceutics, ISSN 0378-5173, 2006, Volume 317, Issue 1, pp. 82 - 89
For the development of an optimized oral formulation for cyclosporine A, 2% of this drug has been formulated in solid lipid nanoparticles (SLN™, mean size 157... 
Sandimmun Neoral/Optoral | SLN | Solid lipid nanoparticles | Drug nanocrystals | Oral administration | CARRIER SYSTEM | SURFACTANTS | solid lipid nanoparticles | FORMULATION | P-GLYCOPROTEIN | DELIVERY | oral administration | DISSOLUTION | Sandimmun Neoral/Optoral (R) | ENHANCEMENT | PHARMACOLOGY & PHARMACY | drug nanocrystals | ABSORPTION | ENZYMATIC DEGRADATION | TECHNOLOGY | Cyclosporine - blood | Nanoparticles | Particle Size | Animals | Administration, Oral | Swine | Crystallization | Cyclosporine - administration & dosage | Cyclosporine - pharmacokinetics | Biological Availability | Intestinal Absorption | Drug Delivery Systems | Drugs | Drug delivery systems | Cyclosporine | Analysis | Vehicles | Index Medicus
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4. Full Text A pilot cross-over study to evaluate human oral bioavailability of BCM-95® CG (Biocurcumax™), a novel bioenhanced preparation of curcumin
by Antony, B and Merina, B and Iyer, V and Judy, N and Lennertz, K and Joyal, S
Indian Journal of Pharmaceutical Sciences, ISSN 0250-474X, 02/2008, Volume 70, Issue 4, pp. 445 - 449
Curcumin, the bioactive component of turmeric, Curcuma longa has an exceptionally wide spectrum of activities including antioxidant, anti-inflammatory and... 
Curcumin | Bioavailability | Biocurcumax | Anticancer | Antioxidant | Curcuma longa | antioxidant | RAT | PIPERINE | CHEMOPREVENTIVE AGENT CURCUMIN | ENCAPSULATED CURCUMIN | biocurcumax | I CLINICAL-TRIAL | CANCER | anticancer | METABOLISM | PHARMACOKINETICS | bioavailability | PHARMACOLOGY & PHARMACY | MICE | NF-KAPPA-B | Turmeric | Usage | Sarcoma | Research | Drug therapy | Health aspects | Oral medication | Antioxidants | Pharmacology | Research Paper
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5. Full Text Oral bioavailability of dabigatran etexilate (Pradaxa®) after co‐medication with verapamil in healthy subjects
by Härtter, Sebastian and Sennewald, Regina and Nehmiz, Gerhard and Reilly, Paul
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2013, Volume 75, Issue 4, pp. 1053 - 1062
Aim To investigate the effect of the P-glycoprotein inhibitor verapamil on the pharmacokinetics and pharmacodynamics of dabigatran etexilate (DE). Method In... 
pharmacokinetics | dabigatran etexilate | radaxa®, verapamil | drug interaction | Verapamil | Dabigatran etexilate | Drug interaction | Pharmacokinetics | Pradaxa | ENOXAPARIN | DIRECT THROMBIN INHIBITOR | verapamil | PREVENTION | INDUCTION | DISPOSITION | P-GLYCOPROTEIN | TRIAL | REPLACEMENT | Pradaxa (R) | VENOUS THROMBOEMBOLISM | PHARMACOLOGY & PHARMACY | Humans | Middle Aged | Pyridines - pharmacokinetics | Biological Availability | Male | Dabigatran | Verapamil - administration & dosage | Delayed-Action Preparations - administration & dosage | Dose-Response Relationship, Drug | Pyridines - adverse effects | Drug Interactions | Benzimidazoles - administration & dosage | Fibrinolytic Agents - pharmacokinetics | Time Factors | Verapamil - adverse effects | Adult | Female | Benzimidazoles - adverse effects | Pyridines - administration & dosage | Administration, Oral | Benzimidazoles - pharmacokinetics | Verapamil - pharmacokinetics | Cross-Over Studies | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | Blood Coagulation - drug effects | Adolescent | Calcium Channel Blockers - administration & dosage | Fibrinolytic Agents - administration & dosage | Index Medicus | Pradaxa®, verapamil
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6. Full Text A bioavailability score
by Martin, Yvonne C
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2005, Volume 48, Issue 9, pp. 3164 - 3170
Responding to a demonstrated need for scientists to forecast the permeability and bioavailability (F) properties of compounds before their purchase, synthesis,... 
TRANSPORT PHENOMENA | CHEMISTRY, MEDICINAL | MOLECULAR-SURFACE PROPERTIES | MEMBRANE-PERMEABILITY | BRAIN-BARRIER PENETRATION | ORAL BIOAVAILABILITY | HUMAN INTESTINAL-ABSORPTION | PHARMACOKINETIC PROPERTIES | DRUG ABSORPTION | THEORETICAL CALCULATION | MOLSURF PARAMETRIZATION | Caco-2 Cells | Anions | Animals | Humans | Probability | Rats | Biological Availability | Permeability | Quantitative Structure-Activity Relationship | Index Medicus
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7. Full Text Improved oral bioavailability and anticancer efficacy on breast cancer of paclitaxel via Novel Soluplus®—Solutol® HS15 binary mixed micelles system
by Hou, Jian and Sun, E and Sun, Congyong and Wang, Jing and Yang, Lei and Jia, Xiao-bin and Zhang, Zhen-hai
International Journal of Pharmaceutics, ISSN 0378-5173, 10/2016, Volume 512, Issue 1, pp. 186 - 193
The aim of this study was to develop a novel drug delivery system using two biocompatible copolymers of Solutol HS15 and Soluplus to improve solubility, oral... 
Solutol®HS15 | Oral bioavailability | Anti-tumor | Micelles | HE staining | Paclitaxel | Caco-2 monolayer | Soluplus | Solutol | HS15 | CELLS | PERMEABILITY | MECHANISM | POLYMERIC MICELLES | Soluplus (R) | SOLUBILITY | REVERSAL | DELIVERY-SYSTEM | IN-VITRO | ENHANCEMENT | Solutol (R) HS15 | PHARMACOLOGY & PHARMACY | LIPOSOMES | Cell Survival - drug effects | Paclitaxel - pharmacology | Administration, Oral | Drug Carriers - administration & dosage | Rats | Biological Availability | Male | Polyethylene Glycols - chemistry | Paclitaxel - pharmacokinetics | Stearic Acids - chemistry | Drug Carriers - chemistry | Drug Carriers - pharmacology | Xenograft Model Antitumor Assays | Paclitaxel - chemistry | Animals | Cell Line, Tumor | Drug Liberation | Polymers - chemistry | Drug Carriers - pharmacokinetics | Mice | Paclitaxel - administration & dosage | Polyvinyls - chemistry | Index Medicus
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8. Full Text Polyphenols and bioavailability: an update
by Teng, Hui and Chen, Lei
Critical Reviews in Food Science and Nutrition, ISSN 1040-8398, 07/2019, Volume 59, Issue 13, pp. 2040 - 2051
Based on many cell culture, animal and human studies, it is well known that the most challenge issue for developing polyphenolics as chemoprevention or... 
Polyphenols | colon metabolites | catabolism | bioavailability | FOOD SCIENCE & TECHNOLOGY | ORANGE JUICE | ANTHOCYANINS | GUT MICROBIOTA | FLAVANONES | PLASMA BIOAVAILABILITY | RED RASPBERRY | NUTRITION & DIETETICS | ORAL BIOAVAILABILITY | GREEN TEA FLAVAN-3-OLS | PHASE-II METABOLITES | ISOFLAVONE GLYCOSIDES | Medical research | Cell culture | Liver | Clinical trials | Microflora | Bioavailability | Tissues | Phenolic compounds | Small intestine | Biological activity | Molecular weight | Chemotherapy | Metabolites | Low molecular weights | Phenols | In vivo methods and tests | Circulatory system
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9. Full Text Vitamin B-12 sources and Bioavailability
by Watanabe, F
EXPERIMENTAL BIOLOGY AND MEDICINE, ISSN 1535-3702, 11/2007, Volume 232, Issue 10, pp. 1266 - 1274
The usual dietary sources of vitamin B-12 are animal foods, meat, milk, egg, fish, and shellfish. As the intrinsic factor-mediated intestinal absorption system... 
MEDICINE, RESEARCH & EXPERIMENTAL | MICROBIOLOGICAL ASSAY | PURPLE LAVER | FISH SAUCE | COMPOUND | food source | ALGAL HEALTH FOOD | vitamin B-12 | cobalamin | deficiency | bioavailability | PURIFICATION | CORRINOID-COMPOUNDS | EDIBLE CYANOBACTERIUM | ORAL VITAMIN-B-12 | human | B-VITAMINS
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10. Full Text Poly(ε-benzyloxycarbonyl-L-lysine)-grafted branched polyethylenimine as efficient nanocarriers for indomethacin with enhanced oral bioavailability and anti-inflammatory efficacy
by Lu, Chao and Lu, Siheng and Li, Xin and Xia, Wenquan and Luo, Hongjun and Ye, Danyan and Zhang, Yanmei and Liu, Daojun
Acta Biomaterialia, ISSN 1742-7061, 02/2017, Volume 49, pp. 434 - 443
Star-block copolymers PEI PZLL with a branched polyethylenimine (PEI) core and multiple grafted poly(ε-benzyloxycarbonyl- -lysine) (PZLL) peripheral chains... 
Ischemia-reperfusion injury | Drug delivery | Indomethacin | Bioavailability | Star-block copolymer | MATERIALS SCIENCE, BIOMATERIALS | GENE DELIVERY | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | NANOPARTICLES | SOLID DISPERSIONS | INHIBITION | NANOMEDICINES | DISSOLUTION | INFLAMMATION | NANOTECHNOLOGY | Tumor Necrosis Factor-alpha - metabolism | Nanoparticles - chemistry | Polylysine - analogs & derivatives | Humans | Biological Availability | Male | Polylysine - chemistry | Indomethacin - administration & dosage | Spectroscopy, Fourier Transform Infrared | Drug Carriers - chemistry | Kidney - metabolism | Polyethyleneimine - chemistry | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Cell Death - drug effects | Interleukin-6 - metabolism | Caco-2 Cells | Kidney - drug effects | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Endocytosis - drug effects | Nanoparticles - ultrastructure | Rats, Sprague-Dawley | Indomethacin - pharmacology | Indomethacin - pharmacokinetics | Animals | Drug Liberation | Calorimetry, Differential Scanning | Lysine | Drugs | Drug delivery systems | Hydrogen | Block copolymers | Vehicles | Fourier transformation | Toxicity | L-lysine | X-ray diffraction | Cytotoxicity | Hydrophobicity | pH effects | Hydrogen bonding | Nanoparticles | Copolymers | Polyethylenimine | Reperfusion | Ischemia | Intestine | Chemical bonds | Biocompatibility | Bearing strength | Bonding | Differential scanning calorimetry | Graft copolymers | Kidneys | Pharmacology | Inflammation | Infrared spectra | Electrostatic properties | Calorimetry | In vivo methods and tests | Index Medicus
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11. Full Text Influence of hydrophilic additives on the supersaturation and bioavailability of dutasteride-loaded hydroxypropylβ-cyclodextrin nanostructures
by Kim, Min-Soo
International Journal of Nanomedicine, ISSN 1176-9114, 05/2013, Volume 8, Issue 1, pp. 2029 - 2039
The objectives of this study were to develop a novel solid dutasteride formulation with improved physicochemical properties and oral bioavailability, and to... 
Supercritical antisolvent | Dutasteride | Nanostructure | Bioavailability | Solubility | dutasteride | SUPERCRITICAL ANTISOLVENT PROCESS | nanostructure | NANOSCIENCE & NANOTECHNOLOGY | ORAL ABSORPTION | SAS PROCESS | SELF-ASSOCIATION | NANOPARTICLES | bioavailability | FORMULATIONS | ENHANCEMENT | solubility | PHARMACOLOGY & PHARMACY | supercritical antisolvent | POORLY SOLUBLE DRUGS | ATORVASTATIN CALCIUM | AMORPHOUS SOLID DISPERSION | 2-Hydroxypropyl-beta-cyclodextrin | Rats | Azasteroids - chemistry | Biological Availability | Male | Rats, Sprague-Dawley | Sodium Dodecyl Sulfate | Drug Carriers - chemistry | Azasteroids - pharmacokinetics | Particle Size | Animals | beta-Cyclodextrins - chemistry | Analysis of Variance | Hydrophobic and Hydrophilic Interactions | Nanostructures - chemistry | Kinetics | Cellulose | Index Medicus | Original Research
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12. Full Text Bioavailability of nanoparticles in nutrient and nutraceutical delivery
by Acosta, Edgar
Current Opinion in Colloid & Interface Science, ISSN 1359-0294, 2009, Volume 14, Issue 1, pp. 3 - 15
The field of nanoparticle delivery systems for nutrients and nutraceuticals with poor water solubility has been expanding, almost exponentially, over the last... 
Peyer's patches | Food fortification | BCS dissolution models | Bioavailability | Minerals | Dissolution | Lipid nanoparticles | Uptake | Vitamins | SOFT MATERIALS | BEAGLE DOGS | CHEMISTRY, PHYSICAL | SOLVENT DIFFUSION METHOD | ORAL ABSORPTION | PARTICLE-SIZE REDUCTION | SOLID LIPID NANOPARTICLES | BETA-CAROTENE | SUPERCRITICAL FLUIDS | WATER-SOLUBLE DRUGS | SYSTEMS | Nanoparticles | Thermodynamics | Functional foods | Analysis | Transdermal medication | Nanotechnology
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13. Full Text Development and bioavailability assessment of ramipril nanoemulsion formulation
by Shafiq, Sheikh and Shakeel, Faiyaz and Talegaonkar, Sushma and Ahmad, Farhan J and Khar, Roop K and Ali, Mushir
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 2007, Volume 66, Issue 2, pp. 227 - 243
The objective of our investigation was to design a thermodynamically stable and dilutable nanoemulsion formulation of Ramipril, with minimum surfactant... 
Phase diagrams | SNEDDS | Nanoemulsion | Solubility | Ramipril | Sefsol 218 | Bioavailability | PARTICLE-SIZE ANALYSIS | phase diagrams | FREQUENCY DIELECTRIC-SPECTROSCOPY | DOSAGE FORMS | nanoemulsion | ORAL ABSORPTION | ramipril | MICROEMULSION FORMULATION | SELF-EMULSIFICATION | bioavailability | IN-VIVO | solubility | ENHANCED ABSORPTION | PHARMACOLOGY & PHARMACY | POORLY SOLUBLE DRUGS | DRUG-DELIVERY SYSTEMS | Viscosity | Emulsions | Polysorbates - chemistry | Rats, Wistar | Biological Availability | Male | Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics | Angiotensin-Converting Enzyme Inhibitors - blood | Phase Transition | Pharmaceutical Solutions | Ramipril - administration & dosage | Nanoparticles | Ramipril - blood | Thermodynamics | Capsules | Ethylene Glycols - chemistry | Drug Compounding | Oils - chemistry | Buffers | Administration, Oral | Drug Stability | Rats | Ramipril - pharmacokinetics | Technology, Pharmaceutical - methods | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Chemistry, Pharmaceutical | Angiotensin-Converting Enzyme Inhibitors - chemistry | Ramipril - chemistry | Animals | Models, Biological | Surface-Active Agents - chemistry | Hydrogen-Ion Concentration | Antihypertensive drugs | Analysis | Index Medicus
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14. Full Text Bioavailability of Apigenin from Apiin-Rich Parsley in Humans
by Meyer, Hellen and Bolarinwa, Adrian and Wolfram, Guenther and Linseisen, Jakob
Annals of Nutrition and Metabolism, ISSN 0250-6807, 05/2006, Volume 50, Issue 3, pp. 167 - 172
Aim: Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested. Methods: Eleven healthy subjects (5 women, 6 men)... 
Original Paper | Apigenin | Apigenin, humans | Luteolin-free diet | Apiin | Parsley | Apigenin-free diet | Apigenin, absorption | apigenin-free diet | APOPTOSIS | FRUITS | CELLS | apigenin | luteolin-free diet | FLAVONOIDS | apigenin, absorption | parsley | NUTRITION & DIETETICS | apiin | ENZYMES | ENDOCRINOLOGY & METABOLISM | VEGETABLES | apigenin, humans | Petroselinum - chemistry | Administration, Oral | Area Under Curve | Antioxidants - metabolism | Humans | Apigenin - blood | Biological Availability | Male | Apigenin - pharmacokinetics | Flavonoids - pharmacokinetics | Intestinal Absorption | Dose-Response Relationship, Drug | Apigenin - urine | Adult | Female | Antioxidants - pharmacokinetics | Flavonoids - chemistry | Herbs | Bioavailability | Nutrition | Diet | Digestive system | Food | Index Medicus
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15. Full Text Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats—effect of medium and long chain triglycerides
by Grove, Mette and Pedersen, Gitte P and Nielsen, Jeanet L and Müllertz, Anette
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 08/2005, Volume 94, Issue 8, pp. 1830 - 1838
Simulated intestinal media (SIM) containing bile salt (BS) and phospholipids (PL) with and without medium chain lipolytic products (MC-LP) or long chain... 
lipid-based formulations | simulated intestinal media | seocalcitol | solubility | poorly soluble drug substances | oral bioavailability | oral absorption | lipid‐based formulations | Oral absorption | Oral bioavailability | Lipid-based formulations | Simulated intestinal media | Poorly soluble drug substances | Seocalcitol | Solubility | CHEMISTRY, MEDICINAL | LIPOPHILIC DRUGS | CHEMISTRY, MULTIDISCIPLINARY | HALOFANTRINE | DIGESTION | VEHICLES | DISSOLUTION | GASTROINTESTINAL ABSORPTION | LIPID FORMULATIONS | WATER-SOLUBLE DRUGS | DOGS | PHARMACOLOGY & PHARMACY | DANAZOL | Administration, Oral | Bile Acids and Salts - chemistry | Phospholipids - chemistry | Rats | Biological Availability | Calcitriol - chemistry | Male | Tritium | Calcitriol - pharmacokinetics | Rats, Sprague-Dawley | Intestinal Absorption | Calcitriol - analogs & derivatives | Animals | Excipients - chemistry | Time Factors | Sesame Oil - chemistry | Triglycerides - pharmacology | Propylene Glycol - chemistry | Index Medicus
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